Tue.Nov 26, 2024

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Can Antipsychotics Increase Mortality Risk? A New Study Shows It Might

HCPLive

A study showed high-dose antipsychotics and benzodiazepines were linked to an increased mortality risk for those with schizophrenia. High-dose antidepressants lowered the risk.

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Emory hospital 1st in US to transplant magnet heart pump

Becker's Hospital Review - Cardiology

An Atlanta-based Emory University Hospital team became the first in the U.S. to perform a surgical implantation of magnetically levitated ventricular assist device.

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FDA Accepts Alnylam’s sNDA for Vutrisiran for ATTR-CM

HCPLive

The FDA set the Prescription Drug User Fee Act (PDUFA) date for the investigational RNAi therapeutic as March 23, 2025.

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Many Drinkers Cut Back After Starting Obesity Meds, Study Finds

Med Page Today

(MedPage Today) -- Nearly half of participants in a weight-loss program who consumed alcohol at baseline began drinking less after adding an obesity drug into their weight-management regimen, a cohort study indicated. Among the 7,491 participants.

Obesity 69
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World's most common heart valve disease linked to insulin resistance in large national study

Science Daily - Heart Disease

A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease -- aortic stenosis (AS).

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Brain Volume Changes Come 10 Years Sooner for Men With Cardiovascular Risks

Med Page Today

(MedPage Today) -- Men at high risk of cardiovascular disease had brain volume changes a decade earlier than women, U.K. Biobank data showed. Cardiovascular risk and obesity had the strongest relationship with lower gray matter volume in men between.

Obesity 59
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The link between sleep and blood pressure: New research sheds light on gender differences

Science Daily - Heart Disease

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders -- strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes. Sleep differences have been reported for some time in men and women, but it is not well known whether the characteristics of sleep serve different functions in one gender over the other, especially as it relates to the heart.

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Recovery of testing for heart disease risk factors post-COVID remains patchy

Science Daily - Heart Disease

Routine screening to detect risk factors for heart disease dropped sharply during the COVID-19 pandemic in England, and some key measurements, such as blood pressure readings, may still lag behind pre-pandemic levels, according to a new study.

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Do CVD Events Precede a Diagnosis of T2D?

American College of Cardiology

Individuals with type 2 diabetes (T2D) experienced two-fold more cardiovascular disease events than matched comparisons in the general population as much as 30 years before their diagnosis of T2D, according to results from a large, contemporary, nationwide registry-based study published Nov. 25 in JACC.

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ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location

Frontiers in Cardiovascular Medicine

BackgroundVentricular fibrillation (VF) is the deadliest arrhythmia, often caused by myocardial ischaemia. VF patients require urgent intervention planned quickly and non-invasively. However, the accuracy with which electrocardiographic (ECG) markers reflect the underlying arrhythmic substrate is unknown.MethodsWe analysed how ECG metrics reflect the fibrillatory dynamics of electrical excitation and ischaemic substrate.

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Hunting & Heart Attacks; Cardiologist's Whistleblower Suit; Algorithm Predicts Death

Med Page Today

(MedPage Today) -- The American Heart Association said that hunters should be advised that physical exertion, colder temperatures, and the thrill of the hunt can put them at risk for heart attack or stroke. Merck announced positive topline results.

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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Frontiers in Cardiovascular Medicine

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now acknowledged for its crucial role in the cellular functions of the cardiovascular system. Recent studies have shown that lactate influences the proliferation, differentiation, and activation of immune cells through its modulation of post-transla

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GLP-1s reduced risk of major cardiac event by 13%: 5 things to know

Becker's Hospital Review - Cardiology

GLP-1 medications reduced the risk of major adverse cardiovascular events by 13% compared to a placebo, according to a study published Nov. 25 in The Lancet Diabetes & Endocrinology.

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Differences between echocardiography and cardiac nuclear magnetic resonance parameters in children with bicuspid aortic valve-related aortopathy

Frontiers in Cardiovascular Medicine

ObjectivesThe bicuspid aortic valve (BAV) is the most common congenital heart defect. Patients with BAV frequently develop aortopathy, which depends on the dysfunction and morphotype of the BAV.AimThe aim of our study was to compare the echocardiography and cardiac magnetic resonance (CMR) findings in BAV patients, and to define the risks of BAV dysfunction and aortopathy.MethodsThe retrospective study included 50 patients (68% male) with BAV, with an average age of 13.6 ± 3.9 years, who underwe

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Overview of Stool DNA Test for CRC

HCPLive

Vivek Kaul, MD, discusses the benefits of using a stool DNA test for colorectal cancer screening, emphasizing its sensitivity, guideline recommendations, and its potential to reduce the screening burden for patients, as well as explaining the test's mechanism of action.

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Consensus on Platelet Function and Genetic Testing in PCI: Key Points

American College of Cardiology

The following are key points to remember from a 2024 updated international consensus statement on platelet function and genetic testing in percutaneous coronary intervention (PCI).

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Gideon Hirshfield, FRCP, PhD: Developing Therapies to Address Pruritus in PBC

HCPLive

Hirschfield describes the need for therapies that address itch in PBC and explains what linerixibat, an IBAT inhibitor, may offer for pruritus.

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Unexpected Response to a Common Pacing Maneuver During Tachycardia

HeartRhythm

A 70-year-old male underwent an electrophysiologic (EP) study for episodic palpitations. Baseline HV interval was 54 msec. Atrial extra stimulus testing induced a short- RP tachycardia initiated by prolongation of the AH interval. The response of the tachycardia to ventricular overdrive pacing (VOP) from the right ventricular (RV) apex is shown in figure 1A and the response to atrial overdrive pacing (AOP) is shown in figure 1B.

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What Are the Concerns of Patients with Aspirin-Exacerbated Respiratory Disease?

HCPLive

In this segment of the latest Lungcast episode, the characteristics of AERD and the concerns of patients were highlighted.

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Cardiac magnetic resonance feature tracking reveals abnormalities in patients with idiopathic ventricular fibrillation

HeartRhythm

The cause of sudden cardiac arrest remains undefined in approximately 5% of patients, the latter receiving the diagnosis of ‘idiopathic ventricular fibrillation’ (IVF). Unraveling the mechanisms underlying the arrest is a clinical need for these often young patients who may be negatively impacted by uncertainties about their prognosis, including the risk for recurrences.1 By definition, IVF patients lack specific structural abnormalities.

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Link Identified Between Obesity, Inflammatory Skin Diseases Such as Psoriasis

HCPLive

The investigators of this study noted an association between obesity and conditions such as rosacea, psoriasis, and lichen simplex chronicus.

Obesity 59
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Managing Drug-Drug Interactions with Mavacamten: a Focus on Combined Use of Anti-Arrhythmic Drugs and Anticoagulants

HeartRhythm

Mavacamten is a selective, allosteric, and reversible cardiac myosin inhibitor, representing the first disease-specific treatment for obstructive hypertrophic cardiomyopathy (HCM) that targets the core pathophysiological mechanism of this condition. Clinical evidence supports its efficacy in improving symptoms, cardiac function and remodeling, thereby supplementing established treatment regimes.

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Pavel Strnad, MD: The Underlying Molecular Mechanisms of PI*ZZ AATD Liver Disease

HCPLive

Strnad reviews findings from a proteomic analysis about AATD-associated liver disease and how they may aid future disease monitoring and drug development.

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High density electro-anatomical mapping of atrio-fascicular pathways using multipolar mapping catheters can identify oblique pathways and avoid mechanical bump termination

HeartRhythm

Atriofascicular fibers (AFF) are rare accessory pathways that have higher recurrence rates after ablation due to either failure to identify AFF (M) potentials and/or mechanical termination with contact.

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Obesity Drug MariTide Achieves Up to 20% Weight Loss in Phase 2 Trial

HCPLive

Amgen’s MariTide achieved up to 20% average weight loss at 52 weeks without hitting a plateau in individuals with obesity or overweight.

Obesity 52
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Risk of Incident Genitourinary Cancer Following Hematuria in Patients with Atrial Fibrillation Receiving Oral Anticoagulants

HeartRhythm

Hematuria is common in patients with atrial fibrillation (AF) on oral anticoagulants (OAC). However, risks of incident genitourinary (GU) malignancy and detailed etiologies of hematuria have not been well studied.

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Discontinuation and reinitiation of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction

European Journal of Heart Failure

Discontinuation and reinitiation of mineralocorticoid receptor antagonists (MRA) in patients with heart failure and reduced ejection fraction (HFrEF). BMI, body mass index; eGFR, estimated glomerular filtration rate; NYHA, New York Heart Association. Abstract Aims Mineralocorticoid receptor antagonists (MRA) improve outcomes in heart failure with reduced ejection fraction (HFrEF) but are underused.

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TUM4Health, a holistic student health prevention program. Screening of cardiovascular risk factors in university students

Frontiers in Cardiovascular Medicine

Cardio Vascular risk prevention in Germany has a gap between the ages of 20 and 30 years. We established a program for risk group identification in students and analyzed the screenings according to the ACCF/AHA Stages and NYHA functional classification. In a cross-sectional design, 596 participants completed a sports medical and motor performance check-up.

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Ablation as First-Line Treatment in Tolerated VT and LVEF >35%

American College of Cardiology

What are the outcomes of patients referred for ventricular tachycardia (VT) ablation according to left ventricular ejection fraction (LVEF), tolerance of VT, and acute ablation outcome?

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How do you manage “one & a half”cm² mitral stenosis ?

Dr. S. Venkatesan MD

Right from the days we entered medical schools, severe mitral stenosis was defined by less than 1 cm² MVO by echocardiography. It has been sacredly followed in most countries where RHD is prevalent. But, as western data (often derived with eastern patients) redefined the cut off for severe MS to 1.5 cm² in recent years ,Many of us are amused, rather confused.

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CathPCI Registry: Safety and Feasibility of IVL as a Treatment For In-Stent Restenosis

American College of Cardiology

Use of intravascular lithotripsy (IVL) for the treatment of in-stent restenosis (ISR), although off-label, may be safe and feasible, according to a study reviewing data from the ACC's CathPCI Registry published in JACC: Cardiovascular Interventions.

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Abbreviated Duke Activity Status Index for Risk Stratification in Heart Failure: Abbreviated Duke Activity Status Index

The American Journal of Cardiology

Publication date: Available online 26 November 2024 Source: The American Journal of Cardiology Author(s): Silvio Nunes Augusto, Yuping Wu, Thanat Chaikijurajai, Stanley L. Hazen, W. H.

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ACCEL Lite: Top Takeaways from 2024: CV Imaging with Thomas H. Marwick, MD, PhD, FACC

American College of Cardiology

In this interview, Thomas H. Marwick, MD, PhD, FACC, and Alison L. Bailey, MD FACC, discuss the Top Takeaways from 2024 in Cardiovascular (CV) Imaging. Dr. Marwick discusses the SCOT-HEART trial, patient-echo reports augmented by AI, tricuspid valve regurgitation, and more.

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Philip Conaghan, MBBS, PhD: Investigating NT3 Inhibition for Improving Osteoarthritis

HCPLive

Conaghan discussed findings from a phase 2 trial at the ACR 2024 Convergence.

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FDA Update: Acoramidis Approved to Reduce CV Death, Hospitalization in Patients With ATTR-CM

American College of Cardiology

The U.S. Food and Drug Administration (FDA) has approved acoramidis as a treatment to help reduce cardiovascular death and cardiovascular-related hospitalization in patients with transthyretin amyloid cardiomyopathy (ATTR-CM).

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Anifrolumab Delayed Onset of Organ Damage in Patients With SLE

HCPLive

Patients in the anifrolumab arm also had lower rates of damage accrual.

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Risk of death and thrombosis in patients admitted to the emergency department with supraventricular tachycardias

HeartRhythm

Few data are available on the clinical course of patients with supraventricular tachycardia (SVT).