Tue.Nov 26, 2024

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Many Drinkers Cut Back After Starting Obesity Meds, Study Finds

Med Page Today

(MedPage Today) -- Nearly half of participants in a weight-loss program who consumed alcohol at baseline began drinking less after adding an obesity drug into their weight-management regimen, a cohort study indicated. Among the 7,491 participants.

Obesity 118
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World's most common heart valve disease linked to insulin resistance in large national study

Science Daily - Heart Disease

A large new population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease -- aortic stenosis (AS).

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Link Identified Between Obesity, Inflammatory Skin Diseases Such as Psoriasis

HCPLive

The investigators of this study noted an association between obesity and conditions such as rosacea, psoriasis, and lichen simplex chronicus.

Obesity 114
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Brain Volume Changes Come 10 Years Sooner for Men With Cardiovascular Risks

Med Page Today

(MedPage Today) -- Men at high risk of cardiovascular disease had brain volume changes a decade earlier than women, U.K. Biobank data showed. Cardiovascular risk and obesity had the strongest relationship with lower gray matter volume in men between.

Obesity 111
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Long-Term Aspirin vs Clopidogrel After Coronary Stenting by Bleeding Risk and Procedural Complexity

JAMA Cardiology

This study compares clopidogrel vs aspirin monotherapy in patients with high bleeding risk and/or percutaneous coronary intervention complexity.

Stents 111
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FDA Accepts Alnylam’s sNDA for Vutrisiran for ATTR-CM

HCPLive

The FDA set the Prescription Drug User Fee Act (PDUFA) date for the investigational RNAi therapeutic as March 23, 2025.

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The link between sleep and blood pressure: New research sheds light on gender differences

Science Daily - Heart Disease

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders -- strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes. Sleep differences have been reported for some time in men and women, but it is not well known whether the characteristics of sleep serve different functions in one gender over the other, especially as it relates to the heart.

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The link between sleep and blood pressure: New research sheds light on gender differences

Medical Xpress - Cardiology

You may have heard sleep described as something of a magic pill for the body. With the right amount, timing, and quality, it can work wonders—strengthen the immune system, improve blood sugar, even decrease the risk of heart attacks and strokes. Sleep differences have been reported for some time in men and women, but it is not well known whether the characteristics of sleep serve different functions in one gender over the other, especially as it relates to the heart.

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Emory hospital 1st in US to transplant magnet heart pump

Becker's Hospital Review - Cardiology

An Atlanta-based Emory University Hospital team became the first in the U.S. to perform a surgical implantation of magnetically levitated ventricular assist device.

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Hunting & Heart Attacks; Cardiologist's Whistleblower Suit; Algorithm Predicts Death

Med Page Today

(MedPage Today) -- The American Heart Association said that hunters should be advised that physical exertion, colder temperatures, and the thrill of the hunt can put them at risk for heart attack or stroke. Merck announced positive topline results.

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Researchers reprogram skin cells to create human-compatible pig heart valve

Medical Xpress - Cardiology

Human skin cells have been reprogrammed into heart valve cells and then used to successfully transplant a pig heart valve into a rodent, led by the research of a Northeastern University professor.

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Healing the gut can reduce long-term impact of stroke

Science Daily - Stroke

Healing the gut may be the key to improving long-term recovery in stroke patients, scientists have found. The latest of multiple studies highlights the potential of this novel avenue of treatment, which takes advantage of the link between the brain and digestive system to curb cognitive impairment and other lingering impacts of a stroke or brain trauma.

Stroke 79
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Managing Drug-Drug Interactions with Mavacamten: a Focus on Combined Use of Anti-Arrhythmic Drugs and Anticoagulants

HeartRhythm

Mavacamten is a selective, allosteric, and reversible cardiac myosin inhibitor, representing the first disease-specific treatment for obstructive hypertrophic cardiomyopathy (HCM) that targets the core pathophysiological mechanism of this condition. Clinical evidence supports its efficacy in improving symptoms, cardiac function and remodeling, thereby supplementing established treatment regimes.

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Consensus on Platelet Function and Genetic Testing in PCI: Key Points

American College of Cardiology

The following are key points to remember from a 2024 updated international consensus statement on platelet function and genetic testing in percutaneous coronary intervention (PCI).

Article 75
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Discontinuation and reinitiation of mineralocorticoid receptor antagonists in patients with heart failure and reduced ejection fraction

European Journal of Heart Failure

Discontinuation and reinitiation of mineralocorticoid receptor antagonists (MRA) in patients with heart failure and reduced ejection fraction (HFrEF). BMI, body mass index; eGFR, estimated glomerular filtration rate; NYHA, New York Heart Association. Abstract Aims Mineralocorticoid receptor antagonists (MRA) improve outcomes in heart failure with reduced ejection fraction (HFrEF) but are underused.

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Lactate metabolism and lactylation in cardiovascular disease: novel mechanisms and therapeutic targets

Frontiers in Cardiovascular Medicine

Cardiovascular disease (CVD) is responsible for approximately 30% of annual global mortality rates, yet existing treatments for this condition are considered less than ideal. Despite being previously overlooked, lactate, a byproduct of glycolysis, is now acknowledged for its crucial role in the cellular functions of the cardiovascular system. Recent studies have shown that lactate influences the proliferation, differentiation, and activation of immune cells through its modulation of post-transla

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Recovery of testing for heart disease risk factors post-COVID remains patchy

Science Daily - Heart Disease

Routine screening to detect risk factors for heart disease dropped sharply during the COVID-19 pandemic in England, and some key measurements, such as blood pressure readings, may still lag behind pre-pandemic levels, according to a new study.

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Ablation as First-Line Treatment in Tolerated VT and LVEF >35%

American College of Cardiology

What are the outcomes of patients referred for ventricular tachycardia (VT) ablation according to left ventricular ejection fraction (LVEF), tolerance of VT, and acute ablation outcome?

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Study Shows Many with Treatment-Resistant Schizophrenia Have a Poor Diet

HCPLive

A study demonstrates many people with treatment-resistant schizophrenia do not comply with nutritional recommendations, which can contribute to increased mortality risk.

Diet 64
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Do CVD Events Precede a Diagnosis of T2D?

American College of Cardiology

Individuals with type 2 diabetes (T2D) experienced two-fold more cardiovascular disease events than matched comparisons in the general population as much as 30 years before their diagnosis of T2D, according to results from a large, contemporary, nationwide registry-based study published Nov. 25 in JACC.

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Obesity Drug MariTide Achieves Up to 20% Weight Loss in Phase 2 Trial

HCPLive

Amgen’s MariTide achieved up to 20% average weight loss at 52 weeks without hitting a plateau in individuals with obesity or overweight.

Obesity 64
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STS 2025 Coding Workshop

Society of Thoracic Surgeons - Allied Health

Event STS 2025 Coding Workshop gmckinney Tue, 11/26/2024 - 10:25 Event dates Feb 28 – Mar 1, 2025 Location Virtual Register Now Early Bird registration deadline: Jan. 17 Description The STS 2025 Coding Workshop: Best Practices for Cardiothoracic Surgery is a 2-day virtual event that provides coders, surgeons, and billing professionals with the latest updates to CPT and physician coding and reimbursement.

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What Are the Concerns of Patients with Aspirin-Exacerbated Respiratory Disease?

HCPLive

In this segment of the latest Lungcast episode, the characteristics of AERD and the concerns of patients were highlighted.

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AHA: Variation seen in rates of SGLT2i rx for heart failure, LVEF >40 percent

Medical Xpress - Cardiology

From 2021 to 2023, there was an increase in prescription rates of a sodium-glucose cotransporter-2 inhibitor (SGLT2i) for patients with heart failure and a left ventricular ejection fraction (LVEF) greater than 40 percent, according to a study published online Nov. 18 in JAMA Cardiology to coincide with the American Heart Association Scientific Sessions 2024, held from Nov. 16 to 18 in Chicago.

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Gideon Hirshfield, FRCP, PhD: Developing Therapies to Address Pruritus in PBC

HCPLive

Hirschfield describes the need for therapies that address itch in PBC and explains what linerixibat, an IBAT inhibitor, may offer for pruritus.

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The interaction between triglyceride-glucose index and visceral adiposity in cardiovascular disease risk: findings from a nationwide Chinese cohort

Cardiovascular Diabetology

Globally, cardiovascular disease (CVD) constitutes the primary cause of death, with insulin resistance (IR), measured by the triglyceride-glucose (TyG) index, and visceral obesity, reflected by the Chinese Vis.

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Clinical application of standardization right thoracic incision for thoracoscopic thymic tumor resection

Journal of Cardiothoracic Surgery

With the continuous development of minimally invasive thoracic surgery, thoracoscopic thymectomy has become a routine operation. This method, now widely recognized, better protects lung function, reduces intra.

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Anifrolumab Delayed Onset of Organ Damage in Patients With SLE

HCPLive

Patients in the anifrolumab arm also had lower rates of damage accrual.

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GLP-1s reduced risk of major cardiac event by 13%: 5 things to know

Becker's Hospital Review - Cardiology

GLP-1 medications reduced the risk of major adverse cardiovascular events by 13% compared to a placebo, according to a study published Nov. 25 in The Lancet Diabetes & Endocrinology.

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Pavel Strnad, MD: The Underlying Molecular Mechanisms of PI*ZZ AATD Liver Disease

HCPLive

Strnad reviews findings from a proteomic analysis about AATD-associated liver disease and how they may aid future disease monitoring and drug development.

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CathPCI Registry: Safety and Feasibility of IVL as a Treatment For In-Stent Restenosis

American College of Cardiology

Use of intravascular lithotripsy (IVL) for the treatment of in-stent restenosis (ISR), although off-label, may be safe and feasible, according to a study reviewing data from the ACC's CathPCI Registry published in JACC: Cardiovascular Interventions.

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Philip Conaghan, MBBS, PhD: Investigating NT3 Inhibition for Improving Osteoarthritis

HCPLive

Conaghan discussed findings from a phase 2 trial at the ACR 2024 Convergence.

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ACCEL Lite: Top Takeaways from 2024: CV Imaging with Thomas H. Marwick, MD, PhD, FACC

American College of Cardiology

In this interview, Thomas H. Marwick, MD, PhD, FACC, and Alison L. Bailey, MD FACC, discuss the Top Takeaways from 2024 in Cardiovascular (CV) Imaging. Dr. Marwick discusses the SCOT-HEART trial, patient-echo reports augmented by AI, tricuspid valve regurgitation, and more.

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Overview of Stool DNA Test for CRC

HCPLive

Vivek Kaul, MD, discusses the benefits of using a stool DNA test for colorectal cancer screening, emphasizing its sensitivity, guideline recommendations, and its potential to reduce the screening burden for patients, as well as explaining the test's mechanism of action.

Cancer 52
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TUM4Health, a holistic student health prevention program. Screening of cardiovascular risk factors in university students

Frontiers in Cardiovascular Medicine

Cardio Vascular risk prevention in Germany has a gap between the ages of 20 and 30 years. We established a program for risk group identification in students and analyzed the screenings according to the ACCF/AHA Stages and NYHA functional classification. In a cross-sectional design, 596 participants completed a sports medical and motor performance check-up.

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Mesenchymal precursor cells reduce mortality and major morbidity in ischaemic heart failure with inflammation: DREAM‐HF

European Journal of Heart Failure

( A ) The cumulative incidence rate for cardiovascular death (CVD) was higher in the same control patients when analysed using baseline inflammatory plasma biomarkers high-sensitivity C-reactive protein (hsCRP) 2mg/L ( left panel ) and interleukin (IL)-6 3.4pg/ml ( right panel ). The effect of mesenchymal precursor cells (MPCs) on ( B ) 2-point major adverse cardiovascular events (MACE) (myocardial infarction [MI] or stroke) and ( C ) 3-point MACE (MI or stroke or CVD) in all patients with hear

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Pilot study shows cryoablation is safe and effective for cardiac repair in patients with atrial fibrillation

Medical Xpress - Cardiology

New research shows that cryoablation is a safe and effective approach to close congenital patent foramen ovale (PFO, a small hole in the heart) in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI) in a single procedure.