Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Mineralocorticoid excess commonly leads to hypertension (HTN) and kidney disease. In our study, we used single-cell expression and chromatin accessibility tools to characterize the mineralocorticoid target genes and cell types. We demonstrated that mineralocorticoid effects were established through open chromatin and target gene expression, primarily in principal and connecting tubule cells and, to a lesser extent, in segments of the distal convoluted tubule cells.

Kidney Disease 132

Kidney Disease Blood Pressure Hypertension 132

Med Page Today

JANUARY 2, 2024

(MedPage Today) -- The newborn that received the world's first partial heart transplant in 2022 continued to do well a year later, according to a case report from the transplant team. Born with type A2 persistent truncus arteriosus and irreparable.

Heart Transplant 115

Heart Transplant Transplant Heart Valves 115

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

BACKGROUND Systemic administration of adeno-associated virus (AAV) can trigger life-threatening inflammatory responses, including thrombotic microangiopathy (TMA), acute kidney injury due to atypical hemolytic uremic syndrome–like complement activation, immune-mediated myocardial inflammation, and hepatic toxicity.METHODS We describe the kinetics of immune activation following systemic AAV serotype 9 (AAV9) administration in 38 individuals following 2 distinct prophylactic immunomodulation regim

121

121

HCPLive

JANUARY 2, 2024

Various factors related to demographics, psychosocial behavior variables, and clinical characteristics were linked to health-related quality of life in patients with gout.

Quality of Life 116

Quality of Life 116

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture by autophagic machinery remain poorly understood. Here, we identified cyclin-dependent kinase–like 5 (CDKL5), known to function in neurodevelopment, as an essential regulator of virophagy.

119

119

Cardiology Update

JANUARY 2, 2024

As we step into 2024, the field of cardiology continues to offer exciting opportunities for knowledge exchange and networking at in-person conferences. Here is a preview of the upcoming cardiology conferences planned for 2024. 1. ESC Acute CardioVascular Care (ACVC) Date: March 8-10, 2024 Location: Athens, Greece Overview: ACVC offers the latest science, networking, and simulation workshops for managing acute and critical cardiovascular conditions.

Heart Failure 111

Heart Failure Atherosclerosis Cardiovascular Imaging Non-Invasive Cardiology 111

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a restriction on cytotoxic T cell immunity if DCs are not present in sufficient numbers in the tumor and draining lymph nodes to take up and present relevant cancer antigens.

Cancer 111

Cancer 111

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Several poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved by FDA to treat cancer with BRCA mutations. BRCA mutations are considered to fuel a PARPi killing effect by inducing apoptosis. However, resistance to PARPi is frequently observed in the clinic due to an incomplete understanding on the molecular basis of PARPi function and a lack of good markers, beyond BRCA mutations, to predict response.

Cancer 105

Cancer 105

ECG Cases

JANUARY 2, 2024

Based on a blend of number of listens, feedback from listeners, website visits and personal faves, EM Cases Best of 2023 Top 10. The post EM Cases Best of 2023 Top 10 appeared first on Emergency Medicine Cases.

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103

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

ASXL1 mutation frequently occurs in all forms of myeloid malignancies and is associated with aggressive disease and poor prognosis. ASXL1 recruits Polycomb repressive complex 2 (PRC2) to specific gene loci to repress transcription through trimethylation of histone H3 on lysine 27 (H3K27me3). ASXL1 alterations reduce H3K27me3 levels, which results in leukemogenic gene expression and the development of myeloid malignancies.

105

105

Nature Reviews - Cardiology

JANUARY 2, 2024

Nature Reviews Cardiology, Published online: 03 January 2024; doi:10.1038/s41569-023-00964-1 In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, which can help to identify new targets for therapeutic interventions.

Hypertension 98

Hypertension Blood Pressure 98

HCPLive

JANUARY 2, 2024

These data on ixekizumab in real-world settings shed light on drug survival information for both those with psoriasis and those with psoriatic arthritis.

105

105

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Myotonic dystrophy type 1 (DM1) involves misregulated alternative splicing for specific genes. We used exon or nucleotide deletion to mimic altered splicing of genes central to muscle excitation-contraction coupling in mice. Mice with forced skipping of exon 29 in the CaV1.1 calcium channel combined with loss of ClC-1 chloride channel function displayed markedly reduced lifespan, whereas other combinations of splicing mimics did not affect survival.

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102

HCPLive

JANUARY 2, 2024

A new analysis suggests up to 3 in 10 patients who have an abnormal CT scan experience complications in follow-up procedures.

Cancer 113

Cancer 113

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

BACKGROUND. In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. Biomarkers are needed to identify central LBDs in a preclinical phase, when neurorescue strategies might forestall symptomatic disease.

Risk Factors 96

Risk Factors Dementia Biomarkers Research 96

Nature Reviews - Cardiology

JANUARY 2, 2024

Nature Reviews Cardiology, Published online: 03 January 2024; doi:10.1038/s41569-023-00972-1 In this Review, Bosworth and colleagues describe the causes of medication non-adherence, discuss interventions that have been clinically shown to improve adherence and identify areas for future research.

Cardiovascular Disease 87

Cardiovascular Disease Research 87

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Following a period of slow progress, the completion of genome sequencing and the paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led to a new perspective on the biology and therapeutic solutions for this deadly cancer. Experimental models were revisited to address old questions, and improved tools were generated.

Cancer 119

Cancer Research 119

Medical Xpress - Cardiology

JANUARY 2, 2024

Because athletes young and old can suffer cardiac arrest, some states have mandated the placement of automated external defibrillators (AEDs) in gyms, stadiums and other sports venues. But a new study finds the use of AEDs by bystanders for cardiac arrest at athletic sites didn't improve much after states enacted these laws.

Defibrillator 89

Defibrillator Cardiac Arrest 89

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Physiologic activation of estrogen receptor α (ERα) is mediated by estradiol (E2) binding in the ligand-binding pocket of the receptor, repositioning helix 12 (H12) to facilitate binding of coactivator proteins in the unoccupied coactivator binding groove. In breast cancer, activation of ERα is often observed through point mutations that lead to the same H12 repositioning in the absence of E2.

Cancer 91

Cancer Physiology 91

Dr. Paddy Barrett

JANUARY 2, 2024

“What should my blood pressure be?” This is one of the most common questions I get. The answer is: It depends. Subscribe now If I were answering this question in the early 1930s, the figure I would give you would probably be far higher than it would be today. The US President, Franklin D Roosevelt, had his blood pressure tracked throughout his term in office, and the numbers are pretty stark.

Blood Pressure 87

Blood Pressure Hypertension Heart Attack Heart attacks 87

HCPLive

JANUARY 2, 2024

Young adults aged 18 – 19 are the age range who discontinues ADHD medication the most, according to a new study.

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109

Medical Xpress - Cardiology

JANUARY 2, 2024

Because athletes young and old can suffer cardiac arrest, some states have mandated the placement of automated external defibrillators (AEDs) in gyms, stadiums and other sports venues. But a new study finds the use of AEDs by bystanders for cardiac arrest at athletic sites didn't improve much after states enacted these laws.

Defibrillator 86

Defibrillator Cardiac Arrest 86

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Although most CD8+ T cells are equipped to kill infected or transformed cells, a subset may regulate immune responses and preserve self-tolerance. Here, we describe a CD8 lineage that is instructed to differentiate into CD8 T regulatory cells (Tregs) by a surprisingly restricted set of T cell receptors (TCRs) that recognize MHC-E (mouse Qa-1) and several dominant self-peptides.

89

89

Science Daily - Heart Disease

JANUARY 2, 2024

Higher levels of omega-3, the healthy fat found in fish and nuts, were associated with better lung function and longer transplant-free survival.

Pulmonary 99

Pulmonary Transplant 99

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

The infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 men undergoing a fertility workup, using a simple motility-based test. We identified a group of men with normal semen parameters but defective CatSper function.

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83

Journal of Cardiothoracic Surgery

JANUARY 2, 2024

While the role of low-dose computed tomography (CT) in lung cancer screening is established, its limitations in detailing pulmonary vascular variations are less emphasized. Three-dimensional reconstruction tec.

Pulmonary 78

Pulmonary Cancer 78

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Mutations in the BRCA2 tumor suppressor gene have been associated with an increased risk of developing prostate cancer. One of the paradoxes concerning BRCA2 is the fact that its inactivation affects genetic stability and is deleterious for cellular and organismal survival, while BRCA2-mutated cancer cells adapt to this detriment and malignantly proliferate.

Cancer 80

Cancer Research 80

Journal of Cardiothoracic Surgery

JANUARY 2, 2024

The morbidity and mortality rates associated with vascular disease (VD) have been gradually increasing. Currently, the most common treatment for VD is surgery, with the progress in drug therapy remaining slow.

Research 81

Research 81

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Hormone receptor–positive breast cancer (HR+) is immunologically cold and has not benefited from advances in immunotherapy. In contrast, subsets of triple-negative breast cancer (TNBC) display high leukocytic infiltration and respond to checkpoint blockade. CD8+ T cells, the main effectors of anticancer responses, recognize MHC I–associated peptides (MAPs).

Cancer 69

Cancer 69

Becker's Hospital Review - Cardiology

JANUARY 2, 2024

Nearly a year after a newborn received the world's first partial heart transplant, the transplanted valves and arteries are functioning well and growing along with the child's heart — a key measure of success in the procedure paving the way for future advancements.

Heart Transplant 69

Heart Transplant Transplant 69

American College of Cardiology

JANUARY 2, 2024

The goal of the MINT trial was to compare the effect of a liberal vs. restrictive blood transfusion strategy on acute myocardial infarction (MI) in patients with concomitant anemia.

Ischemia 75

Ischemia Myocardial Infarction Article 75

JAMA Cardiology

JANUARY 2, 2024

This secondary analysis evaluates antihyperglycemic treatments, hypoglycemic episodes, and risk for cardiovascular events and mortality in 2 randomized clinical trials involving adults with type 2 diabetes.

Outcomes 75

Outcomes Diabetes 75

Medical Xpress - Cardiology

JANUARY 2, 2024

A two-step screening protocol that combines clinical risk assessment with biomarker testing can more effectively identify which patients with type 2 diabetes need medication to prevent heart failure, according to a study led by UT Southwestern Medical Center researchers.

Heart Failure 70

Heart Failure Diabetes Biomarkers Research 70

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

We have previously demonstrated that cystatin E/M (CST6), which is elevated in a subset of patients with multiple myeloma (MM) lacking osteolytic lesions (OLs), suppresses MM bone disease by blocking osteoclast differentiation and function. CST6 is a secreted type 2 cystatin, a cysteine protease inhibitor that regulates lysosomal cysteine proteases and the asparaginyl endopeptidase legumain.

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64

Frontiers in Cardiovascular Medicine

JANUARY 2, 2024

Bicuspid aortic valve (BAV) is a common congenital heart condition that can lead to some valve-related complications, such as aortic stenosis and/or regurgitation, and is often associated with aortic root dilation. With the development and refinement of BAV repair techniques over the past three decades, surgical repair of BAV has emerged as an effective treatment option, offering symptomatic relief and improved outcomes.

Aortic valve 64

Aortic valve Bicuspid/Mitral Aortic Outcomes 64

HCPLive

JANUARY 2, 2024

Among more than 3 million adults, a team of investigators observed an increased risk of both falls and fractures among people with cataract, age-related macular degeneration, and glaucoma.

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64

Frontiers in Cardiovascular Medicine

JANUARY 2, 2024

Artificial intelligence (AI) has emerged as a promising field in cardiovascular disease (CVD) research, offering innovative approaches to enhance diagnosis, treatment, and patient outcomes. In this study, we conducted bibliometric analysis combined with topic modeling to provide a comprehensive overview of the AI research landscape in CVD. Our analysis included 23,846 studies from Web of Science and PubMed, capturing the latest advancements and trends in this rapidly evolving field.

Research 64

Research Cardiovascular Disease Biomarkers Innovation 64