Sun.Nov 17, 2024

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Spironolactone Misses the Mark in Acute MI Without HF

Med Page Today

(MedPage Today) -- CHICAGO -- A mineralocorticoid receptor antagonist (MRA) was unable to further improve 3-year outcomes of acute myocardial infarction (MI) in the modern era, based on the CLEAR OASIS 9 trial. Among heart attack survivors without.

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Spironolactone, a blood pressure medication, may help reduce risk of new heart failure

American Heart News - Heart News

Research Highlights: The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart attack or stroke. More research is needed to further.

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Mapping the intersection of sudden cardiac death and COVID-19: a comprehensive bibliometric analysis (2020–2024)

Frontiers in Cardiovascular Medicine

IntroductionA direct causal link between Sudden Cardiac Death (SCD) and COVID-19 is unproven, although current data suggest a plausible association.AimThis study aims to map and analyze the intersection of research on sudden cardiac death and COVID-19 through a comprehensive bibliometric analysis.MethodologyThis study searched the literature by applying the keywords “COVID-19” AND “Sudden Cardiac Death (SCD)”.

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Obesity-Related Heart Disease Deaths Rose Roughly 180% Since 1999

HCPLive

Obesity-related ischemic heart disease deaths rose from 1999 to 2020, particularly in middle-aged men and Black adults, per CDC WONDER data.

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Big Blow to Anticoagulation Strategy Against Afib-Related Cognition Problems

Med Page Today

(MedPage Today) -- CHICAGO -- Researchers failed to prevent cognitive impairment in people with existing atrial fibrillation (Afib) by going the route of anticoagulation to mitigate subclinical brain infarcts, according to the BRAIN-AF trial.

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Barry A. Borlaug, MD: Impact of Tirzepatide on Cardiorenal End-Organ Damage in HFpEF

HCPLive

Barry A. Borlaug, MD describes the beneficial effect of tirzepatide on circulatory pressure-volume overload and end-organ damage in patients with HFpEF and obesity.

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Email reminders improved flu shot rates in Denmark, notably among heart attack survivors

American Heart News - Heart News

Research Highlights: An electronic message to "nudge" patients to get a flu vaccine highlighting the cardiovascular benefits of flu shots improved vaccination rates among more than two million adults in three clinical trials in Denmark. The research.

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Acute chest pain and an abnormal ECG. Do precordial leads show benign T-wave inversion or ischemia?

Dr. Smith's ECG Blog

Written by Willy Frick A 51 year old man with hypertension presented with three hours of acute onset, severe midsternal chest pain associated with two episodes of nausea and vomiting. ECG 1 What do you think? Smith : Inferior leads have subtle ST Elevation with reciprocal STD in aVL. The end of the T-wave in all of II, III, aVF has a rapid downturn, suggesting early T-wave inversion.

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Emapalumab May Improve Response Rates in MAS Treatment

HCPLive

Findings from the first and only controlled study for macrophage activation syndrome were presented at the ACR Convergence.

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Two-medication combo pill lowered blood pressure among adults in India

American Heart News - Heart News

Research Highlights: A study of three pills that combined two types of blood-pressure-lowering medications into one pill found that all combinations worked equally well among adults in India. Results from the TOPSPIN trial found that any.

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Shreena K. Gandhi, MBBS: Recognizing Fibromyalgia as a Continuous Variable, Trait Diagnosis

HCPLive

Gandhi discussed examining social security disability rates and how SSD criteria may clash with a trait disease like fibromyalgia.

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Exenatide, a GLP-1 analog, by IV during cardiac surgery did not reduce organ injury or death

American Heart News - Heart News

Research Highlights: The GLORIOUS trial found that an intravenous infusion of exenatide, a glucagon-like peptide-1 (GLP-1) during heart surgeries involving bypass did not result in significant benefits at preventing death, stroke or organ injury.

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Sodium-Glucose Cotransporter-2 Inhibitor in Patients With Heart Failure and Mildly Reduced or Preserved Ejection Fraction

JAMA Cardiology

This cohort study evaluated adoption rates of sodium-glucose cotransporter-2 inhibitors at US hospitals for patients with heart failure and mildly reduced or preserved left ventribular ejection fraction.

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Patients taking edoxoban after heart valve surgery had lower risk of stroke, blood clots

American Heart News - Heart News

Research Highlights: Edoxaban, a medication taken orally to prevent blood clots from forming, was found to be as effective and safe for stroke and blood clot prevention in patients after heart valve replacement surgery as warfarin, the current.

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Cholesterol crystals in the pathogenesis of atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 18 November 2024; doi:10.1038/s41569-024-01100-3 Cholesterol crystals (CCs) have a pathogenic role in various cardiovascular diseases, particularly atherosclerosis. In this Review, Boisvert and colleagues describe the mechanisms underlying CC formation and the role of CCs in cardiovascular disease, as well as therapeutic approaches aimed at reducing CC-mediated atherosclerotic burden.

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Novel CRISPR-Cas9-Based Promising in ATTR Cardiomyopathy

Med Page Today

(MedPage Today) -- CHICAGO – A CRISPR-Cas9-based investigational therapy was linked with a drop in serum transthyretin (TTR) levels in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), according to phase I data. A single.

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Reconditioned pacemakers worked as well as new ones

American Heart News - Heart News

Research Highlights: Pacemakers reconditioned with an FDA-approved protocol worked as well as new devices in a study of nearly 300 people in seven low- and middle-income countries. The study compared the function and safety of reconditioned pacemakers.

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Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease

The New England Journal of Medicine

In a study involving patients with Danon disease, AAV9.LAMP2B gene therapy appeared to be safe, increased cardiac LAMP2 expression, and was associated with clinical improvement over 24 to 54 months.

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Ups, downs, and going with the flow of diagnosis

Heart Sisters

The ebbs and flows of diagnosis: 'Learning you have a serious medical condition might qualify as an immediate crushing ebb, but oddly enough, I felt instead an overwhelming flow of relief. These people were taking me seriously.

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Christian T. Ruff, MD, MPH: Abelacimab Cuts Bleeding Risk Versus Rivaroxaban

HCPLive

Christian. T. Ruff, MD, MPH describes an analysis of AZALEA-TIMI 71 demonstrating the substantial benefit of abelacimab on bleeding outcomes in patients on antiplatelet therapy.

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A simple goiter of the right ventricle: case report and literature review

Frontiers in Cardiovascular Medicine

BackgroundCardiac teratoma is extremely rare, accounting for less than 1% of adult cardiac tumors. These teratomas typically occur in the pericardium and myocardium, with intracardiac teratomas being even rarer. Given the limited number of cases, diagnosing and treating intracardiac teratomas remains challenging.Case demonstrationA 50-year-old man was admitted to the hospital with a 1-month history of chest tightness and shortness of breath after exertion.

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Composition of cardiac troponin release differs after marathon running and myocardial infarction

Open Heart

Objectives Elevations of cardiac troponin T (cTnT) levels are common after strenuous exercise. We assessed whether the composition of cTnT release after marathon race differs from that of acute myocardial infarction (MI). Methods Troponin composition was analysed in plasma samples taken from 45 runners after marathon race and from 84 patients with type 1 MI.

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Case Report: Zero-contrast balloon pulmonary angioplasty guided by real-time fusion of CT angiography with x-ray fluoroscopy

Frontiers in Cardiovascular Medicine

BackgroundAllergy to iodine contrast agents has long been a contraindication for balloon pulmonary angioplasty (BPA). We report the successful zero-contrast BPA procedure of a patient with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and severe iodine allergy using real-time fusion of computed tomography angiography (CTA) with x-ray fluoroscopy.Case presentationA 62-year-old woman with CTEPH who developed a severe allergic reaction after the first BPA procedure.

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Is DOAC a Viable Option After Bioprosthetic Valve Surgery Even in Sinus Rhythm?

Med Page Today

(MedPage Today) -- CHICAGO -- Edoxaban (Savaysa) appeared at least on par with warfarin for 12-week thromboembolic prophylaxis after bioprosthetic valve surgical implant in a Japanese trial with a population largely in sinus rhythm, but small.

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Integration of the systemic inflammatory response index with pulse pressure enhances prognostication of cardiovascular mortality in the general population of the United States: insights from the NHANES database

Frontiers in Cardiovascular Medicine

BackgroundThe prognostic significance of utilizing both the systemic inflammatory response index (SIRI) and pulse pressure (PP) collectively in assessing cardiovascular mortality (CVM) across populations remains to be elucidated.MethodsMultivariate Cox proportional hazards analysis investigated the SIRI, PP, and CVM association. Receiver operating characteristic (ROC) curves evaluated the predictive performance of the combined SIRI and PP for CVM in the broader demographic.

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AI Can Do Whole Echo Reports, Improve Efficiency

Med Page Today

(MedPage Today) -- CHICAGO -- Artificial intelligence (AI) assistance for echocardiography is becoming better validated and proving mettle for clinical use. AI-fed echocardiography videos were able to complete 18 tasks at once, classifying patients.

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Association between lactate/albumin ratio and 28-day mortality in ICU critical patients with coronary heart disease: a retrospective analysis of the MIMIC-IV database

Frontiers in Cardiovascular Medicine

BackgroundThe serum lactate/albumin ratio (LAR) is commonly employed for monitoring and evaluating the prognosis of critically ill patients. Both elevated lactate levels and decreased albumin levels may reflect the body's stress response and inflammatory reaction. Coronary heart disease (CHD), with common complications including myocardial infarction, arrhythmia, heart failure, is one of the leading causes of global death.

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ENBALV: Edoxaban vs. Warfarin Following Bioprosthetic Valve Surgery in Patients With Non-Valvular AFib

American College of Cardiology

Edoxaban was comparable to warfarin in preventing stroke or systemic embolism and intracardiac thrombus in patients with non-valvular atrial fibrillation (AFib) within three months after bioprosthetic valve surgery, based on preliminary findings from the ENBALV trial presented at AHA 2024.

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Right ventricular function and anemia in heart failure with preserved ejection fraction

Frontiers in Cardiovascular Medicine

BackgroundAnemia is a common complication in patients with heart failure and is associated with left ventricular systolic dysfunction. However, its role in right ventricular (RV) function has not been evaluated.MethodsWe retrospectively analyzed the electronic medical data of 1,014 Heart Failure with Preserved Ejection Fraction (HFpEF) patients to evaluate the relationship between anemia and RV dysfunction in patients with HFpEF and whether this relationship is influenced by classical risk facto

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Søren Andreas Just, MD, PhD: Developing AI to Mitigate Rheumatologist Shortages for Disease Assessment

HCPLive

Just discussed data from 2 studies demonstrating efficacy of AI assessment compared to clinician assessment.

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Association between weight-adjusted waist circumference index and myocardial infarction: results from the national health and nutrition examination survey, 1999–2014

Frontiers in Cardiovascular Medicine

BackgroundWeight-adjusted waist circumference index (WWI) is a novel index related to obesity and has been associated with the risk and prognosis of several diseases. The aim of the study was to determine the association between WWI and myocardial infarction.MethodsThe study analyzed cross-sectional data from 31,535 participants derived from the 1999–2014 National Health and Nutrition Examination Survey (NHANES) dataset.

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NUDGE-FLU and ZODIAC Findings Explore Electronic 'Nudges' and Decision-Support to Improve Patient Care

American College of Cardiology

Do electronic "nudges" or decision-support systems impact patient and clinician decision-making? Two separate studies presented at AHA 2024 explore answers to this question, specifically in the areas of flu vaccination rates and optimization of lipid-lowering therapies.

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Minjee Kim, MD: Understanding Sleep’s Impact on Post-Liver Transplant Outcomes

HCPLive

Kim explains how poor sleep is linked to negative impacts on mental health, physical health, and frailty after liver transplantation.

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Semaglutide Eligibility Across All Current Indications for US Adults

JAMA Cardiology

This cross-sectional study uses National Health and Nutrition Examination Survey data to examine the number of US adults eligible for semaglutide across all current indications.

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NUDGE-FLU Analysis Finds History of Heart Attack Increases Effectiveness of CV Gain Frame Letter

HCPLive

Electronic messages highlighting cardiovascular benefits of flu shots increased vaccination rates by 1.8% in heart attack survivors.

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CLEAR SYNERGY (OASIS 9): Spironolactone vs. Placebo and Colchicine vs. Placebo in Patients With MI

American College of Cardiology

New findings from CLEAR SYNERGY (OASIS 9) comparing spironolactone vs. placebo in patients with myocardial infarction (MI) found that the mineralocorticoid receptor antagonist did not reduce the incidence of death from cardiovascular causes.

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Study Highlights Racial, Ethnic Disparities in Liver Transplant Waitlisting, Allocation

HCPLive

Compared with non-Hispanic White patients, racial/ethnic minority patients were more likely to be removed from the waitlist and not receive a transplant.