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Nature Reviews Cardiology, Published online: 18 November 2024; doi:10.1038/s41569-024-01100-3 Cholesterol crystals (CCs) have a pathogenic role in various cardiovascular diseases, particularly atherosclerosis. In this Review, Boisvert and colleagues describe the mechanisms underlying CC formation and the role of CCs in cardiovascular disease, as well as therapeutic approaches aimed at reducing CC-mediated atherosclerotic burden.
(MedPage Today) -- CHICAGO -- A mineralocorticoid receptor antagonist (MRA) was unable to further improve 3-year outcomes of acute myocardial infarction (MI) in the modern era, based on the CLEAR OASIS 9 trial. Among heart attack survivors without.
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This cross-sectional study uses National Health and Nutrition Examination Survey data to examine the number of US adults eligible for semaglutide across all current indications.
(MedPage Today) -- CHICAGO -- Researchers failed to prevent cognitive impairment in people with existing atrial fibrillation (Afib) by going the route of anticoagulation to mitigate subclinical brain infarcts, according to the BRAIN-AF trial.
(MedPage Today) -- CHICAGO -- Researchers failed to prevent cognitive impairment in people with existing atrial fibrillation (Afib) by going the route of anticoagulation to mitigate subclinical brain infarcts, according to the BRAIN-AF trial.
Barry A. Borlaug, MD describes the beneficial effect of tirzepatide on circulatory pressure-volume overload and end-organ damage in patients with HFpEF and obesity.
Research Highlights: Pacemakers reconditioned with an FDA-approved protocol worked as well as new devices in a study of nearly 300 people in seven low- and middle-income countries. The study compared the function and safety of reconditioned pacemakers.
Research Highlights: An electronic message to "nudge" patients to get a flu vaccine highlighting the cardiovascular benefits of flu shots improved vaccination rates among more than two million adults in three clinical trials in Denmark. The research.
In a study involving patients with Danon disease, AAV9.LAMP2B gene therapy appeared to be safe, increased cardiac LAMP2 expression, and was associated with clinical improvement over 24 to 54 months.
This cohort study evaluated adoption rates of sodium-glucose cotransporter-2 inhibitors at US hospitals for patients with heart failure and mildly reduced or preserved left ventribular ejection fraction.
Research Highlights: A study of three pills that combined two types of blood-pressure-lowering medications into one pill found that all combinations worked equally well among adults in India. Results from the TOPSPIN trial found that any.
(MedPage Today) -- CHICAGO – A CRISPR-Cas9-based investigational therapy was linked with a drop in serum transthyretin (TTR) levels in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), according to phase I data. A single.
Research Highlights: Edoxaban, a medication taken orally to prevent blood clots from forming, was found to be as effective and safe for stroke and blood clot prevention in patients after heart valve replacement surgery as warfarin, the current.
BackgroundAnemia is a common complication in patients with heart failure and is associated with left ventricular systolic dysfunction. However, its role in right ventricular (RV) function has not been evaluated.MethodsWe retrospectively analyzed the electronic medical data of 1,014 Heart Failure with Preserved Ejection Fraction (HFpEF) patients to evaluate the relationship between anemia and RV dysfunction in patients with HFpEF and whether this relationship is influenced by classical risk facto
BackgroundWeight-adjusted waist circumference index (WWI) is a novel index related to obesity and has been associated with the risk and prognosis of several diseases. The aim of the study was to determine the association between WWI and myocardial infarction.MethodsThe study analyzed cross-sectional data from 31,535 participants derived from the 1999–2014 National Health and Nutrition Examination Survey (NHANES) dataset.
The ebbs and flows of diagnosis: 'Learning you have a serious medical condition might qualify as an immediate crushing ebb, but oddly enough, I felt instead an overwhelming flow of relief. These people were taking me seriously.
Compared with non-Hispanic White patients, racial/ethnic minority patients were more likely to be removed from the waitlist and not receive a transplant.
(MedPage Today) -- CHICAGO -- Edoxaban (Savaysa) appeared at least on par with warfarin for 12-week thromboembolic prophylaxis after bioprosthetic valve surgical implant in a Japanese trial with a population largely in sinus rhythm, but small.
(MedPage Today) -- CHICAGO -- Artificial intelligence (AI) assistance for echocardiography is becoming better validated and proving mettle for clinical use. AI-fed echocardiography videos were able to complete 18 tasks at once, classifying patients.
Christian. T. Ruff, MD, MPH describes an analysis of AZALEA-TIMI 71 demonstrating the substantial benefit of abelacimab on bleeding outcomes in patients on antiplatelet therapy.
Do electronic "nudges" or decision-support systems impact patient and clinician decision-making? Two separate studies presented at AHA 2024 explore answers to this question, specifically in the areas of flu vaccination rates and optimization of lipid-lowering therapies.
The goal of the CLEAR SYNERGY (OASIS 9) spironolactone trial was to determine the potential cardiovascular (CV) benefit of spironolactone following percutaneous coronary intervention (PCI) for ST-segment or large non–ST-segment elevation myocardial infarction (STEMI or NSTEMI, respectively) regardless of post-MI left ventricular ejection fraction (LVEF).
Patients with PBC and moderate/severe pruritus face a greater health-related quality of life burden and impaired activity than those with no/mild itch.
Edoxaban was comparable to warfarin in preventing stroke or systemic embolism and intracardiac thrombus in patients with non-valvular atrial fibrillation (AFib) within three months after bioprosthetic valve surgery, based on preliminary findings from the ENBALV trial presented at AHA 2024.
Three dual combinations of hypertension medications in one polypill – amlodipine and perindopril; perindopril and indapamide; or amlodipine and indapamide – were equally effective in reducing blood pressure (BP) in Indian adults to 140/90 mmHg or less.
Structural remodeling has been associated with increased incidence of atrial fibrillation, but how fibrotic regions allow atrial fibrillation to be sustained remains unclear.
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