Med Page Today
AUGUST 15, 2024
(MedPage Today) -- Sitagliptin (Januvia) saw the greatest drop in price among the list of 10 drugs whose new prices were announced Thursday under Medicare's drug price negotiation program. The price negotiation program was passed in 2022 as part.
HCPLive
AUGUST 15, 2024
A new study found physical activity held more weight in the link between the joint exposure of sleep duration, metabolic equivalent of task, and Healthy Eating Index -2015 and MAFLD.
Science Daily - Heart Disease
AUGUST 15, 2024
Researchers have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.
HCPLive
AUGUST 15, 2024
Analysis of the Phase 3 explorer7 study indicates a preference for concizumab prophylaxis over no prophylaxis in patients with hemophilia A or B with inhibitors.
Medical Xpress - Cardiology
AUGUST 15, 2024
Researchers at Edith Cowan University's (ECU's) Centre for Precision Health have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.
HCPLive
AUGUST 15, 2024
In this video segment, Reau, Trivedi, and Hirschfield discuss the EMA opinion on obeticholic acid and its impact on discussions about second-line therapies amid the influx of new treatment options available for patients.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
Stress has long been associated with substance misuse and substance use disorders (SUDs). The past two decades have seen a surge in research aimed at understanding the underlying mechanisms driving this association. This Review introduces a multilevel “adaptive stress response” framework, encompassing a stress baseline, acute reaction, and recovery with return-to-homeostasis phase that occurs at varying response times and across domains of analysis.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Becker's Hospital Review - Cardiology
AUGUST 15, 2024
Study reveals how movies perpetuate misconceptions about heart attacks, with limited representation of women and people of color, potentially impacting public
HCPLive
AUGUST 15, 2024
In an interview, Raj Chovatiya, MD, PhD, highlights the effectiveness of lebrikizumab, providing stable improvements by week 52.
Med Page Today
AUGUST 15, 2024
(MedPage Today) -- The food industry can expect new voluntary sodium reduction targets from the FDA for commercially processed, packaged, and prepared foods. As part of its overall initiative to reduce sodium consumption on the population level.
Medical Xpress - Cardiology
AUGUST 15, 2024
Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have unveiled critical insights into the influence of high-proportion spliced-in titin truncating variants, or hiPSI TTNtv, on cardiovascular disease risk.
HCPLive
AUGUST 15, 2024
Higher hemoglobin levels during early postnatal days may protect against the development of ROP in preterm infants.
Medical Xpress - Cardiology
AUGUST 15, 2024
From coffee to tea, caffeinated beverages are an integral part of morning routines across the globe, but these popular drinks can be harmful when enjoyed in excess. According to a new study presented at ACC Asia 2024 in Delhi, India, drinking over 400 mg of caffeine per day on most days of the week could increase the susceptibility of otherwise healthy individuals to cardiovascular disease.
Med Page Today
AUGUST 15, 2024
(MedPage Today) -- Note that some links may require registration or subscription. Royal-watchers got a rare public video message from the Princess of Wales Kate Middleton, who is expected to continue chemotherapy in the near future. (Daily Mail.
HCPLive
AUGUST 15, 2024
In this video segment, Reau, Trivedi, and Hirschfield discuss recent shifts in treatment goals for patients with PBC and a new focus on timely intervention with second-line options.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
Autoimmune diseases are commonly associated with a polygenic inheritance pattern. In rare instances, causal monogenic variants have been identified. The study by Liu et al. in this issue of the JCI provides an example of monogenic variants occurring in patients with IgG4-related disease (IgG4-RD). The authors investigated a familial cluster of IgG4-RD that consisted of an affected father and two daughters; the mother was unaffected.
International Journal of Cardiovascular Sciences
AUGUST 15, 2024
The International Journal of Cardiovascular Sciences is pleased to invite Brazilian and international researchers to submit articles for the thematic collection on Artificial Intelligence in Cardiovascular Health , which will be edited by Dr. Erito Marques de Souza Filho and Dr. Roberto Botelho and published in 2025. Artificial Intelligence (AI) is transforming medicine, bringing both opportunities and challenges.
HCPLive
AUGUST 15, 2024
These data highlight the effects on eczema following treatment with dupilumab, tralokinumab, and lebrikizumab in terms of improvements in EASI, IGA, and other measures.
Medical Xpress - Cardiology
AUGUST 15, 2024
People who experience sustained hunger because of food insecurity aren't thinking about checking their numbers, taking medication or getting to a doctor's appointment, she said. They're focused on where they're going to find their next meal. "Not only do they not have any food, but it's constantly on their minds. And that can result in depression, which is a whole other can of worms that needs urgent attention.
Cardiovascular Diabetology
AUGUST 15, 2024
Diabetes mellitus (DM) and coronary microvascular dysfunction (CMD) increase the risk of adverse cardiac events in patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to eva.
Medical Xpress - Cardiology
AUGUST 15, 2024
Over the past few decades, scientists have generated a pile of evidence suggesting that a diet rich in saturated fats is enough to cause heart diseases. Besides other problems like diabetes and atherosclerosis, saturated fats have also been linked to life-threatening arrhythmias.
Learning + Leading
AUGUST 15, 2024
There are key criteria to consider when selecting a resource partner for your allied healthcare learning, skills development and certification needs. While each program is different, this guide can help any administrator navigate the complex decision-making process to identify a partner able to support their objectives.
Medical Xpress - Cardiology
AUGUST 15, 2024
Emboldened by success in its initial efforts to cut dietary salt intake by Americans, the U.S. Food and Drug Administration on Thursday announced Phase II of the endeavor.
Learning + Leading
AUGUST 15, 2024
“At the end of their rope.” That’s how 29.4% of surveyed nurses said they feel on a weekly basis. For some, it’s every day. Many more reported feeling “emotionally drained,” “used up” or “fatigued.” Whatever the nomenclature, it all points to the same thing: burnout.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
Posttranslational modifications can enhance immunogenicity of self-proteins. In several conditions, including hypertension, systemic lupus erythematosus, and heart failure, isolevuglandins (IsoLGs) are formed by lipid peroxidation and covalently bond with protein lysine residues. Here, we show that the murine class I major histocompatibility complex (MHC-I) variant H-2Db uniquely presents isoLG-modified peptides and developed a computational pipeline that identifies structural features for MHC-I
HCPLive
AUGUST 15, 2024
High-risk alcohol use was linked to greater rates of cirrhosis in patients with HCV but did not significantly impact rates of sustained virologic response.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
Neutrophil infiltration occurs in a variety of liver diseases, but it is unclear how neutrophils and hepatocytes interact. Neutrophils generally use granule proteases to digest phagocytosed bacteria and foreign substances or neutralize them in neutrophil extracellular traps. In certain pathological states, granule proteases play a destructive role against the host as well.
Cardiovascular Diabetology
AUGUST 15, 2024
The atherogenic index of plasma (AIP) has been shown to be positively correlated with cardiovascular events. However, it remains unclear whether hypertensive patients with long-term high AIP levels are at grea.
HCPLive
AUGUST 15, 2024
In this video segment, Reau, Trivedi, and Hirschfield discuss the availability of new second-line treatment options and their role in PBC management compared to traditional therapies like UDCA and OCA.
Cardiovascular Diabetology
AUGUST 15, 2024
The binary diagnosis of Metabolic Syndrome(MetS) fails to accurately evaluate its severity, and the association between MetS severity and frailty progression remains inadequately elucidated. This study aims to.
HCPLive
AUGUST 15, 2024
In this video segment, Reau, Trivedi, and Hirschfield discuss how treatment sequencing in PBC has evolved over time with the emergence of new second-line therapies and considerations for determining sequencing.
Cardiovascular Diabetology
AUGUST 15, 2024
Patients with diabetes have an increased risk of developing heart failure with preserved ejection fraction (HFpEF). This study aimed to compare indices of myocardial deformation and perfusion between patients.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
CD44 is associated with a high risk of metastasis, recurrence, and drug resistance in various cancers. Here we report that platelet endothelial aggregation receptor 1 (PEAR1) is a CD44 chaperone protein that protected CD44 from endocytosis-mediated degradation and enhances cleavage of the CD44 intracellular domain (CD44-ICD). Furthermore, we found that lysyl oxidase–like protein 2 (LOXL2), an endogenous ligand of PEAR1, bound to the PEAR1-EMI domain and facilitated the interaction between PEAR1
Cardiovascular Diabetology
AUGUST 15, 2024
Insulin resistance is linked to an increased risk of frailty, yet the comprehensive relationship between the triglyceride glucose-body mass index (TyG-BMI), which reflects weight, and frailty, remains unclear.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
Cell cycle regulation is largely abnormal in cancers. Molecular understanding and therapeutic targeting of the aberrant cell cycle are essential. Here, we identified that an underappreciated serine/threonine kinase, cyclin-dependent kinase–like 3 (CDKL3), crucially drives rapid cell cycle progression and cell growth in cancers. With regard to mechanism, CDKL3 localizes in the nucleus and associates with specific cyclin to directly phosphorylate retinoblastoma (Rb) for quiescence exit.
International Journal of Cardiovascular Sciences
AUGUST 15, 2024
The International Journal of Cardiovascular Sciences is pleased to invite Brazilian and international researchers to submit articles for the thematic collection on Artificial Intelligence in Cardiovascular Health , which will be edited by Dr. Erito Marques de Souza Filho and Dr. Roberto Botelho and published in 2025. Artificial Intelligence (AI) is transforming medicine, bringing both opportunities and challenges.
Journal of Clinical Investigation - Cardiology
AUGUST 15, 2024
We report that diazepam binding inhibitor (DBI) is a glial messenger mediating crosstalk between satellite glial cells (SGCs) and sensory neurons in the dorsal root ganglion (DRG). DBI is highly expressed in SGCs of mice, rats, and humans, but not in sensory neurons or most other DRG-resident cells. Knockdown of DBI results in a robust mechanical hypersensitivity without major effects on other sensory modalities.
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