Thu.Aug 15, 2024

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Medicare Unveils First 10 Negotiated Drug Prices

Med Page Today

(MedPage Today) -- Sitagliptin (Januvia) saw the greatest drop in price among the list of 10 drugs whose new prices were announced Thursday under Medicare's drug price negotiation program. The price negotiation program was passed in 2022 as part.

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Genetic link between Alzheimer's and heart disease confirmed

Science Daily - Heart Disease

Researchers have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.

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7 Things Employers and Educators Should Consider When Selecting a Certification Partner

Learning + Leading

There are key criteria to consider when selecting a resource partner for your allied healthcare learning, skills development and certification needs. While each program is different, this guide can help any administrator navigate the complex decision-making process to identify a partner able to support their objectives.

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Upadacitinib Superior to Dupilumab, Placebo in Skin Clearance for Atopic Dermatitis

HCPLive

The results of this analysis can inform clinical decision-making conversations held between patients with eczema and their physicians.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Patient Care Technicians: The Key to Solving Nursing Burnout and Turnover

Learning + Leading

“At the end of their rope.” That’s how 29.4% of surveyed nurses said they feel on a weekly basis. For some, it’s every day. Many more reported feeling “emotionally drained,” “used up” or “fatigued.” Whatever the nomenclature, it all points to the same thing: burnout.

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Lebrikizumab Provides Lasting Relief for Itch and Sleep in Atopic Dermatitis

HCPLive

In an interview, Raj Chovatiya, MD, PhD, highlights the effectiveness of lebrikizumab, providing stable improvements by week 52.

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Patient Reported Outcomes Favor Concizumab Prophylaxis in Hemophilia A or B

HCPLive

Analysis of the Phase 3 explorer7 study indicates a preference for concizumab prophylaxis over no prophylaxis in patients with hemophilia A or B with inhibitors.

Outcomes 105
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Kate Middleton Update; First Mask Ban in U.S.; Sudden Cardiac Arrest Survival

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Royal-watchers got a rare public video message from the Princess of Wales Kate Middleton, who is expected to continue chemotherapy in the near future. (Daily Mail.

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Physical Activity Identified as Critical Factor in Lowering MAFLD Risk

HCPLive

A new study found physical activity held more weight in the link between the joint exposure of sleep duration, metabolic equivalent of task, and Healthy Eating Index -2015 and MAFLD.

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Researchers confirm genetic link between Alzheimer's and heart disease

Medical Xpress - Cardiology

Researchers at Edith Cowan University's (ECU's) Centre for Precision Health have uncovered a significant genetic connection between Alzheimer's disease (AD) and several coronary artery disease (CAD) related disorders and lipid classes, offering opportunities to improve health outcomes across two of the more common causes of death in Australia.

Research 101
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Assessing PBC Treatment Options, Determining Sequencing

HCPLive

In this video segment, Reau, Trivedi, and Hirschfield discuss the EMA opinion on obeticholic acid and its impact on discussions about second-line therapies amid the influx of new treatment options available for patients.

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Peripheral gating of mechanosensation by glial diazepam binding inhibitor

Journal of Clinical Investigation - Cardiology

We report that diazepam binding inhibitor (DBI) is a glial messenger mediating crosstalk between satellite glial cells (SGCs) and sensory neurons in the dorsal root ganglion (DRG). DBI is highly expressed in SGCs of mice, rats, and humans, but not in sensory neurons or most other DRG-resident cells. Knockdown of DBI results in a robust mechanical hypersensitivity without major effects on other sensory modalities.

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FDA to Challenge Food Industry to Take Up New Sodium Targets

Med Page Today

(MedPage Today) -- The food industry can expect new voluntary sodium reduction targets from the FDA for commercially processed, packaged, and prepared foods. As part of its overall initiative to reduce sodium consumption on the population level.

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Hemoglobin Levels May Predict Retinopathy of Prematurity Development

HCPLive

Higher hemoglobin levels during early postnatal days may protect against the development of ROP in preterm infants.

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Stress and substance use disorders: risk, relapse, and treatment outcomes

Journal of Clinical Investigation - Cardiology

Stress has long been associated with substance misuse and substance use disorders (SUDs). The past two decades have seen a surge in research aimed at understanding the underlying mechanisms driving this association. This Review introduces a multilevel “adaptive stress response” framework, encompassing a stress baseline, acute reaction, and recovery with return-to-homeostasis phase that occurs at varying response times and across domains of analysis.

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The Future of PBC Management, Pipeline Developments

HCPLive

In this video segment, Reau, Trivedi, and Hirschfield discuss pipeline developments and other advances in primary biliary cholangitis they are most looking forward to.

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New study finds chronic high caffeine consumption may heighten risk for cardiovascular disease

Medical Xpress - Cardiology

From coffee to tea, caffeinated beverages are an integral part of morning routines across the globe, but these popular drinks can be harmful when enjoyed in excess. According to a new study presented at ACC Asia 2024 in Delhi, India, drinking over 400 mg of caffeine per day on most days of the week could increase the susceptibility of otherwise healthy individuals to cardiovascular disease.

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How Hollywood is perpetuating heart attack misconceptions

Becker's Hospital Review - Cardiology

Study reveals how movies perpetuate misconceptions about heart attacks, with limited representation of women and people of color, potentially impacting public

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Study unveils impact of cardiovascular risk factors on genetic predisposition to heart disease

Medical Xpress - Cardiology

Physician-scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have unveiled critical insights into the influence of high-proportion spliced-in titin truncating variants, or hiPSI TTNtv, on cardiovascular disease risk.

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Human genetics and epigenetics of alcohol use disorder

Journal of Clinical Investigation - Cardiology

Alcohol use disorder (AUD) is a prominent contributor to global morbidity and mortality. Its complex etiology involves genetics, epigenetics, and environmental factors. We review progress in understanding the genetics and epigenetics of AUD, summarizing the key findings. Advancements in technology over the decades have elevated research from early candidate gene studies to present-day genome-wide scans, unveiling numerous genetic and epigenetic risk factors for AUD.

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Understanding the role of an omega-3 fatty acid in the prevention of arrhythmias

Medical Xpress - Cardiology

Over the past few decades, scientists have generated a pile of evidence suggesting that a diet rich in saturated fats is enough to cause heart diseases. Besides other problems like diabetes and atherosclerosis, saturated fats have also been linked to life-threatening arrhythmias.

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Rare genetic variants provide a mechanistic basis for immune imbalance in IgG4-related disease

Journal of Clinical Investigation - Cardiology

Autoimmune diseases are commonly associated with a polygenic inheritance pattern. In rare instances, causal monogenic variants have been identified. The study by Liu et al. in this issue of the JCI provides an example of monogenic variants occurring in patients with IgG4-related disease (IgG4-RD). The authors investigated a familial cluster of IgG4-RD that consisted of an affected father and two daughters; the mother was unaffected.

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FDA moves to further reduce salt levels in food

Medical Xpress - Cardiology

Emboldened by success in its initial efforts to cut dietary salt intake by Americans, the U.S. Food and Drug Administration on Thursday announced Phase II of the endeavor.

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Comparing Cardiovascular and Kidney Outcomes with Tirzepatide vs. GLP-1 Agonists

NEJM Journal Watch - Cardiology

This retrospective study showed lower incidence for several adverse outcomes with tirzepatide, with some caveats.

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The important gap community health workers and care managers can fill in high blood pressure care

Medical Xpress - Cardiology

People who experience sustained hunger because of food insecurity aren't thinking about checking their numbers, taking medication or getting to a doctor's appointment, she said. They're focused on where they're going to find their next meal. "Not only do they not have any food, but it's constantly on their minds. And that can result in depression, which is a whole other can of worms that needs urgent attention.

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Shifting Treatment Goals, Timelines in Primary Biliary Cholangitis

HCPLive

In this video segment, Reau, Trivedi, and Hirschfield discuss recent shifts in treatment goals for patients with PBC and a new focus on timely intervention with second-line options.

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Call for Papers! Thematic Collection on Artificial Intelligence in Cardiovascular Health

International Journal of Cardiovascular Sciences

The International Journal of Cardiovascular Sciences is pleased to invite Brazilian and international researchers to submit articles for the thematic collection on Artificial Intelligence in Cardiovascular Health , which will be edited by Dr. Erito Marques de Souza Filho and Dr. Roberto Botelho and published in 2025. Artificial Intelligence (AI) is transforming medicine, bringing both opportunities and challenges.

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Study Highlights Efficacy of Dupilumab, Lebrikizumab, Tralokinumab for Atopic Dermatitis

HCPLive

These data highlight the effects on eczema following treatment with dupilumab, tralokinumab, and lebrikizumab in terms of improvements in EASI, IGA, and other measures.

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Combined risk estimates of diabetes and coronary angiography-derived index of microcirculatory resistance in patients with non-ST elevation myocardial infarction

Cardiovascular Diabetology

Diabetes mellitus (DM) and coronary microvascular dysfunction (CMD) increase the risk of adverse cardiac events in patients with non-ST-segment elevation myocardial infarction (NSTEMI). This study aimed to eva.

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Risky Alcohol Use Does Not Impact HCV Treatment Efficacy But Is Linked to Cirrhosis

HCPLive

High-risk alcohol use was linked to greater rates of cirrhosis in patients with HCV but did not significantly impact rates of sustained virologic response.

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Chronic High Caffeine Consumption Impacts Heart Rate, BP Post Activity, Heightens Risk For CVD

American College of Cardiology

Chronic consumption of high levels of caffeine a day can lead to an increase in high heart rate and blood pressure that persists after resting from a step test, increasing the risk of cardiovascular disease (CVD) according to a new study.

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Posttranslationally modified self-peptides promote hypertension in mouse models

Journal of Clinical Investigation - Cardiology

Posttranslational modifications can enhance immunogenicity of self-proteins. In several conditions, including hypertension, systemic lupus erythematosus, and heart failure, isolevuglandins (IsoLGs) are formed by lipid peroxidation and covalently bond with protein lysine residues. Here, we show that the murine class I major histocompatibility complex (MHC-I) variant H-2Db uniquely presents isoLG-modified peptides and developed a computational pipeline that identifies structural features for MHC-I

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Position Statement on CCT Following LAAO: Key Points

American College of Cardiology

The following are key points to remember from a position statement on cardiac computed tomography (CCT) following left atrial appendage occlusion (LAAO).

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Neutrophils insert elastase into hepatocytes to regulate calcium signaling in alcohol-associated hepatitis

Journal of Clinical Investigation - Cardiology

Neutrophil infiltration occurs in a variety of liver diseases, but it is unclear how neutrophils and hepatocytes interact. Neutrophils generally use granule proteases to digest phagocytosed bacteria and foreign substances or neutralize them in neutrophil extracellular traps. In certain pathological states, granule proteases play a destructive role against the host as well.

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BP Levels Impacted By Chronic Occupational Noise Exposure

American College of Cardiology

Chronic noise exposure may increase overall blood pressure (BP), with each year of exposure increasing odds of hypertension by 10%, according to a new study presented at ACC Asia 2024.

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Association between the atherogenic index of plasma trajectory and risk of heart failure among hypertensive patients: a prospective cohort study

Cardiovascular Diabetology

The atherogenic index of plasma (AIP) has been shown to be positively correlated with cardiovascular events. However, it remains unclear whether hypertensive patients with long-term high AIP levels are at grea.