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Zane had three open heart surgeries before he turned 3. And surprisingly, he had a more routine care journey than his brother, Zeke. Zeke and Zane were both diagnosed with hypoplastic left heart syndrome (HLHS) before birth. As far as congenital heart diseases go, HLHS falls on the rarer end of the spectrum. The odds that either boy would have the condition are low roughly 1 in every 3,800 babies are born with it.
A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end-organ dysfunction. It is believed that a self-propagating spiral of events follows as a result of hypoperfusion, ischaemia and inflammation, leading to end-organ dysfunction.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Panelists discuss how, despite being preventable and treatable, chronic obstructive pulmonary disease (COPD) has emerged as a major global health challenge due to widespread exposure to risk factors, particularly tobacco smoke, which remains the primary cause despite declining smoking rates in some regions. Early environmental exposures play a crucial roleworkplace pollutants, air pollution, and secondhand smoke can damage developing lungs, whereas genetic factors like 1-antitrypsin deficiency i
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Recently, sarcopenia has been linked to unfavorable outcomes in various surgical procedures, including lung cancer surgery. This study aimed to investigate the impact of respiratory sarcopenia (RS) on postoper.
We know TAVI is in the striking distance , to literally take over most aortic valve interventions. From a humble beginning from very high surgical risk with prohibitive comorbidity, now it has almost touched the totally asymptomatic, relatively morbid-free patients. Thanks to the hardware, expertise, and motivation from multiple forces. While the numbers increase, still the debate between SAVR and TAVR is riddled with speculation, skepticism, and absolute confidence.
(MedPage Today) -- Many online sellers of compounded GLP-1 receptor agonists may be misleading customers, a cross-sectional study suggested. Out of 79 websites that sold a compounded GLP-1 agent, 11 (13.9%) failed to mention the medications were.
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(MedPage Today) -- Many online sellers of compounded GLP-1 receptor agonists may be misleading customers, a cross-sectional study suggested. Out of 79 websites that sold a compounded GLP-1 agent, 11 (13.9%) failed to mention the medications were.
Fetuses of pregnant people who gained excess weight in the first trimester of pregnancy show signs of excess fat distribution in the upper arm and in the abdomen, according to a new study. These findings may inform efforts to prevent excessive weight gain early in life, a risk factor for adult obesity and related conditions, such as heart disease, high blood pressure and diabetes.
Panelists discuss how chronic obstructive pulmonary disease (COPD) management follows a stepwise approach, beginning with bronchodilators (typically short-acting 2-agonists/long-acting 2-agonists) and progressing to combination therapy with long-acting muscarinic antagonists/inhaled corticosteroids based on symptom severity. Current unmet needs include more targeted anti-inflammatory treatments, better biomarkers for phenotyping, and therapies to halt disease progression, particularly for those
Despite the success cardiac rehabilitation has shown at reducing heart-related deaths and hospital readmissions, higher out-of-pocket costs may prevent patients from participating in the program, a Michigan Medicine study suggests.
For children battling both congenital heart defects (CHD) and cancer, the road to recovery is far more precarious than previously understood, according to a study published in the Journal of the National Cancer Institute.
This systematic review and meta-analysis highlighted several key findings on use of probiotics as a treatment of pediatric patients with allergies to food.
Journal of the American Heart Association, Ahead of Print. BackgroundPulmonary vein stenosis in children is associated with a poor prognosis. However, the cause and risk factors for mortality remain uncertain.MethodsThis retrospective, singlecenter study identified children with primary and secondary pulmonary vein stenosis through a cardiac catheterization database.
A team of researchers led by the University of California San Diego and Stanford University has developed a noninvasive method to monitor the electrical activity inside heart muscle cells from the outside, avoiding the need to physically penetrate the cells.
Predictors of weaning failure from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock. RRT, renal replacement therapy. Abstract Aims This study aimed to investigate incidence and predictors of weaning failure and in-hospital death after successful weaning from veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiogenic shock (CS).
The aim of this study was to investigate the difference between perceived and calculated diabetes risks among post-myocardial infarction (AMI) patients using the Finnish Diabetes Risk Score (FINDRISC).
Semaglutide 7.2 mg achieved statistically significant and superior weight loss at 72 weeks versus placebo, hitting the Phase 3b trial's primary endpoint.
Chronic Limb-Threatening Ischemia (CLTI) represents the most advanced stage of Peripheral Artery Disease (PAD) and is associated with dire prognosis, characterized by a substantial risk of limb amputation and.
In this analysis, the investigators sought to assess the ability of a ChatGPT-4-based chatbot in its performance of key functions in a teledermatology platform.
In this second episode in a three-part series of episodes focusing on artificial intelligence (AI) in cardiology, Dr. Effie Andrikopoulou hosts Dr. Nishath Quader and Mr. Demetri Giannikopoulos to discover how innovative AI solutions can tackle one of the biggest challenges facing todays cardiologistsburnout.
Despite the surge in telemental health use in patients with schizophrenia, fewer people in racial or ethnic minority groups had a telemental health visit compared to White people.
Ischemia with nonobstructive coronary arteries (INOCA) has high morbidity, mortality, and poor quality of life. Metabolic syndrome (MetS) is a complex of multiple cardiac metabolic risk factors, significantly.
Grand Blanc, Mich.-based McLaren Health Care has expanded its stroke care network to include Schoolcraft Memorial Hospital in Manistique, Mich., through a stroke-specific telehealth platform.
Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, in turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and DNA methyla.
As an emerging concept, Cardiovascular-kidney-metabolic syndrome (CKM) elucidates the intricate interconnection between metabolic disorders(Mets), cardiovascular disease(CVD), and chronic kidney disease(CKD).
Stroke, Ahead of Print. BACKGROUND:Carotid artery stenting (CAS) is an alternative treatment for patients with carotid artery stenosis who are not eligible for carotid endarterectomy. Dual antiplatelet therapy (DAPT) after CAS aims to prevent ischemic stroke. However, its optimal duration remains unclear. We aimed to determine the optimal duration of DAPT by identifying the differences in clinical events that occur depending on the DAPT maintenance period.METHODS:Data were obtained from the nati
ABSTRACT Atrial flutter (AFL), defined as macro-re-entrant atrial tachycardia, is associated with debilitating symptoms, stroke, heart failure, and increased mortality. AFL is classified into typical, or cavotricuspid isthmus (CTI)-dependent, and atypical, or non-CTI-dependent. Atypical AFL is a heterogenous group of re-entrant atrial tachycardias that most commonly occur in patients with prior heart surgery or catheter ablation.
Efficacy and safety of finerenone in patients with chronic kidney disease and type 2 diabetes by diuretic use: a FIDELITY analysis. CI, confidence interval; CKD, chronic kidney disease; CV, cardiovascular; eGFR, estimated glomerular filtration rate; FIDELIO-DKD, FInerenone in reducing kiDnEy faiLure and dIsease prOgression in Diabetic Kidney Disease; FIDELITY, FInerenone in chronic kiDney diseasE and type 2 diabetes: Combined FIDELIO-DKD and FIGARO-DKD Trial programme analYsis; FIGARO-DKD, FIner
Stroke, Ahead of Print. There is a large burden of stroke in the United States, and extensive systems of care have been established to address it. The resources devoted to stroke centers are analogous to those of trauma centers, both sharing many strict requirements for certification, clinical preparedness, quality improvement, data management, and reporting.
Journal of the American Heart Association, Ahead of Print. BackgroundIntracranial atherosclerotic stenosis is a leading cause of ischemic stroke and recurrent events due to plaque instability. Highresolution magnetic resonance imaging identifies plaque enhancement as a key marker of instability. This study evaluated the efficacy of combined highintensity statins and proprotein convertase subtilisin/kexin type 9 inhibitors in plaque stabilization.MethodsIn this prospective, singlearm study, patie
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