Fri.Sep 20, 2024

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Physiology Friday #237: An Evolutionary Perspective on Why Exercise Promotes Longevity

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This week, I’m sharing one of my favorite articles I’ve ever written. I published it a few years ago, but since then have gained quite a few new subscribers. If you’re new, I hope you enjoy it for the first time. If you’re a long-time reader, I hope you re-enjoy it! I’ll be back next week with the usual coverage of a brand-new study.

Exercise 109
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Nancy Reau, MD: Obeticholic Acid’s Future in PBC After FDA Advisory Committee Meeting

HCPLive

Reau explains the importance of second- and third-line treatment in PBC and the potential implications of no longer having OCA after a negative FDA advisory committee meeting.

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Stroke rates increasing in individuals living with SCD despite treatment guidelines

Science Daily - Heart Disease

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD) despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a new study.

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Moving Beyond the Joint: The Interplay Between Gout and Kidney Disease

HCPLive

Nehad Soloman, MD, FACR; Andrew Sharobeem, DO, FACR, and Sunil Patel, MD, explore the nephrologist's vital role in gout diagnosis, treatment options for gout patients with chronic kidney disease, and strategies for managing refractory gout and its associated challenges.

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Study suggests hypertensive people can lower risk of developing dementia by drinking coffee regularly

Medical Xpress - Cardiology

A team of public health researchers at Ningxia Medical University, in China, has found, via analysis of health record data, that some regular coffee drinkers with high blood pressure may have a lower risk of developing dementia than people who do not drink coffee. Their study is published in Scientific Reports.

Dementia 109
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Why Measuring ApoB Is The Key To Preventing Heart Disease.

Dr. Paddy Barrett

Preventing heart disease is possible. You just need to know how. To prevent heart disease, you need to know what causes it, how to measure the relevant factors and what to do about them. When we say heart disease, what we really mean is plaque in the artery wall. This Is Known As Atherosclerosis. The fundamental cause of atherosclerosis is when a cholesterol particle crosses into the artery wall from the bloodstream, gets stuck, and sets off an inflammatory process 1.

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FDA Approves Arimoclomol, First Drug for Niemann-Pick Disease, Type C

HCPLive

Arimoclomol, in combination with miglustat, is approved to treat neurological symptoms associated with NPC in adults and children aged ≥2 years.

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More Trending

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C4d Independently Predicts Disease Progression in Primary IgA Nephropathy

HCPLive

Study results suggest C4d is associated with worse renal survival and disease progression to kidney failure in patients with primary IgA nephropathy.

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New approach to defibrillation may improve cardiac arrest outcomes

Medical Xpress - Cardiology

Joshua Lupton, M.D., has no memory of his own cardiac arrest in 2016. He only knows that first responders resuscitated his heart with a shock from a defibrillator, ultimately leading to his complete recovery and putting him among fewer than one in 10 people nationwide who survive cardiac arrest outside of a hospital.

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Arthritis Incidence in Psoriasis Higher Than EHR Records Suggest

HCPLive

Extended follow-up with more cases is ongoing and will allow risk factors for psoriatic arthritis to also be further explored.

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Long-term Health-related Quality of Life and Rhythm-Outcomes of Catheter Ablation versus Antiarrhythmic Drugs in Patients with Atrial Fibrillation.

HeartRhythm

Data on long-term effects of catheter ablation versus antiarrhythmic drugs (AAD) on health-related quality of life (HRQoL) and atrial fibrillation (AF) burden are limited.

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AI Language Model Distinguishes Fibromyalgia From Other Chronic Pain Conditions

HCPLive

The model gave special emphasis to words noting pain, fatigue and depressed moods.

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FTC Sues Top Pharmacy Benefit Managers Over Insulin Prices

Med Page Today

(MedPage Today) -- The federal government is suing three big pharmacy benefit managers (PBMs) over a system of drug rebates that regulators say has made the price of insulin soar for patients with diabetes. Three companies that process about 80.

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Tom C. Nguyen, MD: Evolving Roles of TAVR, SAVR in Aortic Valve Disease

HCPLive

As advancements in valvular technology progress, Nguyen highlights the need for long-term data and multidisciplinary collaboration to improve patient outcomes.

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ACC CardiaCast: Pulse Check: Health Equity, Inclusion and Diversity

American College of Cardiology

In this episode, Andrea Price, MS, AACC hosts Demetria Bolden, PhD, MBA, CPTD, Osama Ibrahim, MD, FACC and Bailey Estes, MSN, AGNP-C for the final installment of the PAD series focused on the impact of social determinants of health for the PAD patient population.

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Causal Links Found Between Schizophrenia, Major Depressive Disorder on IBS

HCPLive

A new study finds causal links between schizophrenia and MDD on IBS, highlighting the need for integrated care addressing both psychiatric and gastrointestinal symptoms.

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Study reveals no link between high-density lipoprotein cholesterol and movement disorders

Medical Xpress - Cardiology

There is no correlation between high-density lipoprotein cholesterol (HDL-C) levels and a patient's risk for developing movement disorders while taking an antipsychotic, according to a study published in the April-June issue of Innovations in Clinical Neuroscience.

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Atypical Clinical Presentations of Blistering Disease, with Donna Culton, MD, PhD

HCPLive

This segment of her interview featured a conversation about the biggest takeaways and notable case series presented in Culton’s talk at Maui Derm NP+PA Fall.

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Top-ranked hospitals for coronary bypass, by state

Becker's Hospital Review - Cardiology

Florida has the most top ranked hospitals for coronary bypass in the U. S. , according to the WebMD Choice Awards.

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Harnessing Telehealth and Home Blood Pressure Monitoring to Improve Hypertension Care

Cardiometabolic Health Congress

Hypertension is a condition that requires continuous monitoring, making it an ideal candidate for telehealth and digital health innovations. In this post, Daichi Shimbo, MD , a preventive cardiologist and professor of medicine at Columbia University Irving Medical Center, and Francoise Marvel, MD , assistant professor of medicine in the Division of Cardiology and core faculty of the Ciccarone Advanced Lipid Disorders Program at Johns Hopkins, share their expertise on how telehealth can improve h

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HepQuant Tests Accurately Assess Primary Sclerosing Cholangitis Disease Severity

HCPLive

With HepQuant DuO and SHUNT tests, investigators could categorize patients with sclerosing cholangitis into low, moderate, and high disease severity subgroups.

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Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR

American College of Cardiology

What is the association of cardiac magnetic resonance (CMR) imagingĂ¢â‚¬â€œderived measurements with clinical outcomes in nonischemic dilated cardiomyopathy (NIDCM)?

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Updates on Benzoyl Peroxide Use for Acne, with James Del Rosso, DO

HCPLive

Del Rosso highlights points from his conference talk on benzoyl peroxide (BPO) use among patients with acne and other updates.

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Top Quality Summit Posters Explore High-Risk NSTEMI Care, Post PCI Creatinine Compliance, More

American College of Cardiology

Award-winning posters presented at ACC Quality Summit 2024 explored improving identification of high-risk NSTEMI patients, enhancing post PCI creatinine compliance, automating registry data collection to improve data quality and process efficiency, strategies to improve data accuracy and compliance, and more.

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To Stop or Not to Stop Aspirin Before Intermediate Risk Noncardiac Surgery

NEJM Journal Watch - Cardiology

In a randomized trial, continued aspirin in the perioperative period did not affect ischemic and major bleeding endpoints, although these patients had more minor bleeding events.

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LV Function Recovery and Outcomes in Takotsubo Syndrome

American College of Cardiology

What are the predictors and what is the prognostic impact of time-to-left ventricular (LV) recovery after Takotsubo syndrome (TTS)?

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Stroke rates increasing in individuals living with sickle cell disease despite treatment guidelines: Study

Medical Xpress - Cardiology

The incidence of stroke continues to increase for adults and children living with sickle cell disease (SCD), despite the Stroke Prevention Trial in Sickle Cell Anemia (STOP) establishing standards of care like transfusions and tests to measure blood flow in the brain for those deemed high-risk, according to a study published in Blood.

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The role of serotonin and serotonergic-related metabolites in pathogenesis of vasovagal syncope

HeartRhythm

Serotonin is an important neurohormone that regulates vascular tone and autonomic reflexes, though its pathophysiological role in vasovagal syncope (VVS) remains uncertain.

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Endovascular therapy improves left ventricular diastolic function in heart failure with preserved ejection fraction

Medical Xpress - Cardiology

For patients with heart failure with preserved ejection fraction (HFpEF), endovascular treatment (EVT) improves left ventricular (LV) diastolic function, according to a study published online Sept. 9 in Circulation: Heart Failure.

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Geographic Variations of Trial Results In a World of Hurt

Circulation: Cardiovascular Quality & Outcomes

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.

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Incidental Premature Ventricular Contractions in Young Athletes: Shape and Size (of Premature Ventricular Contraction burden) Matter

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.