Fri.Oct 25, 2024

article thumbnail

Physiology Friday #241: How Caffeine Dose and Timing Affect Our Sleep Physiology

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

article thumbnail

Jennifer Lai Yee, MD, PhD, MPH: Honing in on Sparsentan’s Benefit in Genetic FSGS

HCPLive

Yee discussed how the data show a benefit in this hard-to-treat population, which was not seen in the heterogeneous FSGS group.

119
119
article thumbnail

A Case of Broca's Aphasia

Med Page Today

(MedPage Today) -- On Sept. 14, 2000, at the age of 72, Lester Schwartz, a psychoanalyst working in New York City, underwent a simple operation for a benign fatty tumor in his stomach. He woke up the next morning in the hospital and realized he.

Hospital 117
article thumbnail

Shawn Kwatra, MD: Making the Connection Between Prurigo Nodularis, Atopic Dermatitis, and Itch

HCPLive

In this interview, Kwatra highlighted several key takeaways from his talks on prurigo nodularis, atopic dermatitis, and itch at the Fall Clinical Dermatology Conference.

115
115
article thumbnail

Stroke Survivors With Afib Could Start DOACs Earlier

Med Page Today

(MedPage Today) -- It was safe to start direct oral anticoagulant (DOAC) therapy without delay after acute ischemic stroke in people with atrial fibrillation (Afib), according to the OPTIMAS randomized trial. Stroke survivors randomized to early.

AFIB 109
article thumbnail

New Phase 3b Findings Show Guselkumab Leads to Significant Skin Clearance for Psoriasis

HCPLive

These data demonstrated guselkumab’s success for the majority of patients with low body surface area (BSA) moderate plaque psoriasis and special site involvement.

Plaque 110
article thumbnail

Researchers uncover novel role of protein GPNMB in heart repair

Medical Xpress - Cardiology

UCLA scientists have identified the protein GPNMB as a critical regulator in the heart's healing process after a heart attack.

More Trending

article thumbnail

Can social expectations of masculinity be bad for cardiovascular health?

Medical Xpress - Cardiology

Cardiovascular disease remains a top cause of sickness and death in the U.S. and worldwide. Doctors and researchers have it especially high on their radar because it's more modifiable and preventable than many other diseases and causes of death.

article thumbnail

AND017 Receives FDA Orphan Drug Designation for Sickle Cell Disease

HCPLive

On October 25, 2024, Kind Pharmaceutical announced receipt of FDA Orphan Drug Designation for AND017 in the treatment of sickle cell disease.

article thumbnail

ECG Blog #453 — Is this Wellens' Syndrome?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a middle-aged man who presented with a 2 week history of progressively increasing CP ( C hest P ain ) with exertion. He had his most severe episode of CP the day before he was seen with this ECG. His CP was much less compared to the day before — but it had not yet completely resolved. An initial Troponin drawn less than 1 hour after the ECG in Figure-1 was recorded was over 10,000.

Blog 94
article thumbnail

Bringing CSU Back Under The House of Dermatology

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) affects approximately 0.5% to 1% of the population, predominantly impacting women and often presenting with variable wheals and angioedema.

98
article thumbnail

Evidence Mounts for Triple Single-Pill Combination Therapy for Hypertension

NEJM Journal Watch - Cardiology

A trio of trials provide more evidence for the safety and efficacy of SPCs to lower blood pressure.

article thumbnail

Ladan Zand, MD: Obinutuzumab a Promising Option for Refractory, Primary FSGS

HCPLive

Zand discussed interim 12-month findings from an open-label, phase 2 trial currently ongoing for patients with refractory primary focal segmental glomerulosclerosis.

92
article thumbnail

Smart ultrasound pulse train accurately visualizes fast blood flow

Medical Xpress - Cardiology

Charlotte Nawijn, Ph.D. candidate at the University of Twente, has developed a new technique to improve ultrasound images of blood flow. Using a smart ultrasound pulse train, she reduced noise in contrast ultrasound images. Nawijn obtained her Ph.D. on this subject on 24 October with the defense of her dissertation "Bubbles and Waves for Ultrasound Imaging and Therapy.

article thumbnail

Finerenone Use Reduces UACR, New-Onset Macroalbuminuria in Heart Failure Patients

HCPLive

New FINEARTS-HF data shows that finerenone reduces albuminuria in patients with HFmrEF or HFpEF, but without significant eGFR changes.

article thumbnail

Analyzing heart and kidney outcomes after canagliflozin treatment in older adults

Medical Xpress - Cardiology

Sodium-glucose co-transporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular and kidney outcomes in patients with type 2 diabetes, but it is unclear whether their effects differ based on patients' age.

article thumbnail

Outcomes of Discontinuing Drug Treatment in HFrEF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on the consequences of discontinuing long-term drug treatment in patients with heart failure and reduced ejection fraction (HFrEF).

article thumbnail

Semaglutide Shows Promise, Reduces UACR in Nondiabetic Kidney Disease

HCPLive

New research indicates semaglutide reduced albuminuria and body weight in CKD patients without diabetes, highlighting its potential renal benefits.

article thumbnail

Primary Prevention Takes Center Stage at the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

The 19th Annual CMHC transformed Boston into the epicenter of cardiometabolic health and risk reduction from October 17-19, 2024, bringing together healthcare professionals from around the globe for the largest event of its kind in the US. The Hilton Boston Park Plaza became a hub of innovation, education, and collaboration, uniting nearly 500 clinicians under a shared mission: to redefine cardiometabolic care.

CME 64
article thumbnail

New Phase 3 Data Shows High Rate of Atopic Dermatitis Clearance Using Tapinarof Cream 1%

HCPLive

These long-term extension trial data from ADORING 3 highlight tapinarof cream’s efficacy in adults and children aged 2 years and older with atopic dermatitis.

59
article thumbnail

STS Leadership Institute 2025-26

Society of Thoracic Surgeons - Surgeon

Event STS Leadership Institute 2025-26 kchalko Fri, 10/25/2024 - 10:48 Event dates Apr 1, 2025 – Jan 30, 2026 Location Zoom, Chicago, and New Orleans The STS Leadership Institute helps members in their first 15 years of practice to develop the skills necessary to lead teams in and out of the OR, strategize personal and professional goals, negotiate a career path, and influence change in the workplace.

article thumbnail

KAT-AKI: Tailored EHR Alerts Fail to Improve AKI Management in Hospitalized Patients

HCPLive

Yale's KAT-AKI trial found personalized EHR alerts for AKI management improved clinician actions but didn't reduce progression, dialysis, or mortality rates in patients.

article thumbnail

Monocytes perturbation implicated in the association of stress hyperglycemia with postoperative poor prognosis in non-diabetic patients with Stanford type-A acute aortic dissection

Cardiovascular Diabetology

The study aimed to investigate the interaction of intraoperative stress hyperglycemia with monocyte functions and their impact on major adverse events (MAEs) in acute aortic dissection (AAD) patients who under.

Aortic 52
article thumbnail

Long-Term Tralokinumab Safe, Effective After 6 Years for Atopic Dermatitis

HCPLive

These data were presented at Fall Clinical, highlighting the reductions in Eczema Area and Severity Index scores and the overall long-term safety profile of tralokinumab-ldrm.

59
article thumbnail

ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling

Cardiovascular Diabetology

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are now recommended for patients with heart failure, but the mechanisms that underlie the protective role of SGLT2i in cardiac remodeling remain unclear. Alde.

article thumbnail

Will Herrington, MBBS, MD, MA: Empagliflozin Follow-up Data Informs Clinical Care for CKD

HCPLive

Herrington shared the carryover effects observed in the post-trial follow-up of the phase 3 EMPA-KIDNEY trial.

52
article thumbnail

Endothelial KLF11 is a novel protector against diabetic atherosclerosis

Cardiovascular Diabetology

Atherosclerotic cardiovascular diseases remain the leading cause of mortality in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of atherosclerosis, which is exacerbate.

article thumbnail

Highlighting Recent Therapies for Dermatologists, with James Del Rosso, DO

HCPLive

In this interview segment, Del Rosso highlighted his Fall Clinical presentation takeaways covered in the talk ‘What’s New in the Medicine Chest - Part 2.

52
article thumbnail

Automated Extraction of Stroke Severity From Unstructured Electronic Health Records Using Natural Language Processing

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundMulticenter electronic health records can support quality improvement and comparative effectiveness research in stroke. However, limitations of electronic health record–based research include challenges in abstracting key clinical variables, including stroke severity, along with missing data.

Stroke 45
article thumbnail

Empagliflozin Benefits on Kidney Disease Progression, Death Continue for 1 Year Post-Discontinuation

HCPLive

After discontinuing therapy, treated participants still had an overall 13% reduction in the risk of kidney disease progression or cardiovascular death.

article thumbnail

Applicability of heart failure clinical practice guidelines in low‐ and middle‐income countries

European Journal of Heart Failure

Abstract Aims Clinical practice guidelines are commonly written by professional societies in high-income countries (HIC) with limited anticipation of implementation obstacles in other environments. We used heart failure (HF) guidelines as a paradigm to examine this concern, by conducting a survey to understand clinicians' ability to implement HF guidelines and their perceptions of the current HF guideline applicability in low- and middle-income countries (LMIC).

article thumbnail

New Phase 3b Findings Suggest Lebrikizumab Improved Skin, Itch for Atopic Dermatitis

HCPLive

These data from the ADapt study, presented at Fall Clinical, suggest improvements among patients with eczema given lebrikizumab-lbkz who had been previously treated with dupilumab.

52
article thumbnail

Pitfalls in the World of Evidence-Based Medicine: Should IABP Be en-DANGER-ed by the DanGer Shock Trial?

Circulation: Heart Failure

Circulation: Heart Failure, Volume 17, Issue 12 , Page e012077, December 1, 2024.

article thumbnail

Rahul N. Khurana, MD: Phase 1 Results on Vamikibart for Uveitic Macular Edema

HCPLive

At AAO 2024, Khurana discussed rapid visual and structural gains for uveitic macular edema with vamikibart, paving the way for Phase 3 trials.

52
article thumbnail

Reimagining Cryptogenic Stroke Care: Collaborative Care and Inpatient Insertable Cardiac Monitors for Detection of Atrial Fibrillation

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Volume 4, Issue 6 , November 1, 2024. BackgroundAtrial fibrillation (AF) is a known risk factor of ischemic stroke, and AFrelated stroke is twice more likely to be fatal. Longterm cardiac rhythm monitoring using insertable cardiac monitors (ICMs) has greater diagnostic yield compared with conventional monitoring in detecting AF, and the clinical utility of ICMs is established in cryptogenic stroke, strokes attributable to largeartery atherosclerosis

article thumbnail

Bringing CSU Back Under Tthe House of Dermatology

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) affects approximately 0.5% to 1% of the population, predominantly impacting women and often presenting with variable wheals and angioedema.

52
article thumbnail

Small Left Ventricular Chamber Size And Mortality In A Large General Population

The American Journal of Cardiology

Publication date: Available online 24 October 2024 Source: The American Journal of Cardiology Author(s): David Leibowitz, Donna Zwas, Offer Amir, Israel Gotsman

40