Fri.Oct 25, 2024

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Physiology Friday #241: How Caffeine Dose and Timing Affect Our Sleep Physiology

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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ECG Blog #453 — Is this Wellens' Syndrome?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a middle-aged man who presented with a 2 week history of progressively increasing CP ( C hest P ain ) with exertion. He had his most severe episode of CP the day before he was seen with this ECG. His CP was much less compared to the day before — but it had not yet completely resolved. An initial Troponin drawn less than 1 hour after the ECG in Figure-1 was recorded was over 10,000.

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New Phase 3b Findings Show Guselkumab Leads to Significant Skin Clearance for Psoriasis

HCPLive

These data demonstrated guselkumab’s success for the majority of patients with low body surface area (BSA) moderate plaque psoriasis and special site involvement.

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A Case of Broca's Aphasia

Med Page Today

(MedPage Today) -- On Sept. 14, 2000, at the age of 72, Lester Schwartz, a psychoanalyst working in New York City, underwent a simple operation for a benign fatty tumor in his stomach. He woke up the next morning in the hospital and realized he.

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Jennifer Lai Yee, MD, PhD, MPH: Honing in on Sparsentan’s Benefit in Genetic FSGS

HCPLive

Yee discussed how the data show a benefit in this hard-to-treat population, which was not seen in the heterogeneous FSGS group.

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Primary Prevention Takes Center Stage at the 19th Annual Cardiometabolic Health Congress (CMHC)

Cardiometabolic Health Congress

The 19th Annual CMHC transformed Boston into the epicenter of cardiometabolic health and risk reduction from October 17-19, 2024, bringing together healthcare professionals from around the globe for the largest event of its kind in the US. The Hilton Boston Park Plaza became a hub of innovation, education, and collaboration, uniting nearly 500 clinicians under a shared mission: to redefine cardiometabolic care.

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Ladan Zand, MD: Obinutuzumab a Promising Option for Refractory, Primary FSGS

HCPLive

Zand discussed interim 12-month findings from an open-label, phase 2 trial currently ongoing for patients with refractory primary focal segmental glomerulosclerosis.

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More Trending

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AND017 Receives FDA Orphan Drug Designation for Sickle Cell Disease

HCPLive

On October 25, 2024, Kind Pharmaceutical announced receipt of FDA Orphan Drug Designation for AND017 in the treatment of sickle cell disease.

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Outcomes of Discontinuing Drug Treatment in HFrEF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on the consequences of discontinuing long-term drug treatment in patients with heart failure and reduced ejection fraction (HFrEF).

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Shawn Kwatra, MD: Making the Connection Between Prurigo Nodularis, Atopic Dermatitis, and Itch

HCPLive

In this interview, Kwatra highlighted several key takeaways from his talks on prurigo nodularis, atopic dermatitis, and itch at the Fall Clinical Dermatology Conference.

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Researchers uncover novel role of protein GPNMB in heart repair

Science Daily - Heart Disease

Scientists have identified the protein GPNMB as a critical regulator in the heart's healing process after a heart attack.

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Finerenone Use Reduces UACR, New-Onset Macroalbuminuria in Heart Failure Patients

HCPLive

New FINEARTS-HF data shows that finerenone reduces albuminuria in patients with HFmrEF or HFpEF, but without significant eGFR changes.

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STS Leadership Institute 2025-26

Society of Thoracic Surgeons - Surgeon

Event STS Leadership Institute 2025-26 kchalko Fri, 10/25/2024 - 10:48 Event dates Apr 1, 2025 – Jan 30, 2026 Location Zoom, Chicago, and New Orleans The STS Leadership Institute helps members in their first 15 years of practice to develop the skills necessary to lead teams in and out of the OR, strategize personal and professional goals, negotiate a career path, and influence change in the workplace.

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Long-Term Tralokinumab Safe, Effective After 6 Years for Atopic Dermatitis

HCPLive

These data were presented at Fall Clinical, highlighting the reductions in Eczema Area and Severity Index scores and the overall long-term safety profile of tralokinumab-ldrm.

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5 Books That Have Impacted My Philosophy On Life

Dr. Paddy Barrett

I am regularly asked to recommend books that have influenced my thinking on life and health. None of the books I recommend concern exercise, nutrition, sleep, medicine, or health. They are all books on what I call ‘Soul Span’ or how to live a life of meaning and purpose. Lifespan and healthspan are the domains of science and facts. Soul span is the domain of philosophy, literature and art.

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KAT-AKI: Tailored EHR Alerts Fail to Improve AKI Management in Hospitalized Patients

HCPLive

Yale's KAT-AKI trial found personalized EHR alerts for AKI management improved clinician actions but didn't reduce progression, dialysis, or mortality rates in patients.

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Automated Extraction of Stroke Severity From Unstructured Electronic Health Records Using Natural Language Processing

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundMulticenter electronic health records can support quality improvement and comparative effectiveness research in stroke. However, limitations of electronic health record–based research include challenges in abstracting key clinical variables, including stroke severity, along with missing data.

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Semaglutide Shows Promise, Reduces UACR in Nondiabetic Kidney Disease

HCPLive

New research indicates semaglutide reduced albuminuria and body weight in CKD patients without diabetes, highlighting its potential renal benefits.

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Initial Findings Concerning the Latest Self-expandable Evolut FX Valve: A Report Using OCEAN-TAVI Registry Data

The American Journal of Cardiology

Publication date: Available online 24 October 2024 Source: The American Journal of Cardiology Author(s): Fumiaki Yashima, Masanori Yamamoto, Shinichi Shirai, Norio Tada, Toru Naganuma, Masahiro Yamawaki, Futoshi Yamanaka, Kazuki Mizutani, Masahiko Noguchi, Hiroshi Ueno, Kensuke Takagi, Yohei Ohno, Masaki Izumo, Hidetaka Nishina, Hiroto Suzuyama, Kazumasa Yamasaki, Kenji Nishioka, Daisuke Hachinohe, Yasushi Fuku, Toshiaki Otsuka

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New Phase 3 Data Shows High Rate of Atopic Dermatitis Clearance Using Tapinarof Cream 1%

HCPLive

These long-term extension trial data from ADORING 3 highlight tapinarof cream’s efficacy in adults and children aged 2 years and older with atopic dermatitis.

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Comparison of Outcome After Percutaneous Coronary Intervention for De Novo and In-Stent Restenosis Indications.

The American Journal of Cardiology

Publication date: Available online 24 October 2024 Source: The American Journal of Cardiology Author(s): Lars Jakobsen, Evald H Christiansen, Phillip Freeman, Johnny Kahlert, Karsten Veien, Michael Maeng, Julia Ellert, Steen D Kristensen, Martin K Christensen, Christian J Terkelsen, Troels Thim, Jens Flensted Lassen, Mikkel Hougaard, Ashkan Eftekhari, Rebekka V Jensen, Nicolaj B Støttrup, Jeppe G Rasmussen, Anders Junker, Lisette O Jensen

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New Phase 3b Findings Suggest Lebrikizumab Improved Skin, Itch for Atopic Dermatitis

HCPLive

These data from the ADapt study, presented at Fall Clinical, suggest improvements among patients with eczema given lebrikizumab-lbkz who had been previously treated with dupilumab.

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Small Left Ventricular Chamber Size And Mortality In A Large General Population

The American Journal of Cardiology

Publication date: Available online 24 October 2024 Source: The American Journal of Cardiology Author(s): David Leibowitz, Donna Zwas, Offer Amir, Israel Gotsman

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Bringing CSU Back Under The House of Dermatology

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) affects approximately 0.5% to 1% of the population, predominantly impacting women and often presenting with variable wheals and angioedema.

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Evidence Mounts for Triple Single-Pill Combination Therapy for Hypertension

NEJM Journal Watch - Cardiology

A trio of trials provide more evidence for the safety and efficacy of SPCs to lower blood pressure.

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Bringing CSU Back Under Tthe House of Dermatology

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) affects approximately 0.5% to 1% of the population, predominantly impacting women and often presenting with variable wheals and angioedema.

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Understanding the Chronicity of CSU

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) is defined as the spontaneous appearance of wheals or angioedema lasting more than six 6 weeks, which can significantly impact patients' clinical health and psychosocial well-being.

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Overview of CSU: Prevalence and Presentations

HCPLive

Panelists discuss the prevalence and clinical manifestations of chronic spontaneous urticaria (CSU), noting that it primarily affects individuals aged 20 to 40, with a prevalence of 0.5% to 1% in the general population and a higher incidence in women, while also addressing the variability in symptoms such as wheals, hives, and angioedema among patients.

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Impact of CSU on Patient Quality of Life

HCPLive

Panelists discuss how chronic spontaneous urticaria (CSU) significantly impacts patients’ overall well-being, both clinically and psychosocially, highlighting increased prevalence of depression, sleep disturbances, absenteeism, and adverse effects on professional life.

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Sunir J. Garg, MD: Impact of Prior DME Treatment on Aflibercept 8 mg Outcomes

HCPLive

At AAO 2024, Garg describes an analysis of the Phase 2/3 PHOTON trial evaluating the effect of DME treatment history on aflibercept 8 mg and 2 mg outcomes.

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Highlighting Recent Therapies for Dermatologists, with James Del Rosso, DO

HCPLive

In this interview segment, Del Rosso highlighted his Fall Clinical presentation takeaways covered in the talk ‘What’s New in the Medicine Chest - Part 2.

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Empagliflozin Benefits on Kidney Disease Progression, Death Continue for 1 Year Post-Discontinuation

HCPLive

After discontinuing therapy, treated participants still had an overall 13% reduction in the risk of kidney disease progression or cardiovascular death.

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Rahul N. Khurana, MD: Phase 1 Results on Vamikibart for Uveitic Macular Edema

HCPLive

At AAO 2024, Khurana discussed rapid visual and structural gains for uveitic macular edema with vamikibart, paving the way for Phase 3 trials.

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Will Herrington, MBBS, MD, MA: Empagliflozin Follow-up Data Informs Clinical Care for CKD

HCPLive

Herrington shared the carryover effects observed in the post-trial follow-up of the phase 3 EMPA-KIDNEY trial.

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