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Pathological transdifferentiation, where differentiated cells aberrantly transform into other cell types that exacerbate disease rather than promote healing, represents a novel and significant concept. This perspective discusses its role and potential targeting in cardiovascular diseases and chronic inflammation. Current therapies mainly focus on mitigating early inflammatory response through proinflammatory cytokines and pathways targeting, including corticosteroids, TNF-α inhibitors, IL-1β mon
tim.hodson Mon, 11/25/2024 - 18:06 Nov. 22, 2024 — BridgeBio Pharma, Inc. recently announced that the U.S. Food and Drug Administration (FDA) approved Attruby (acoramidis), an orally-administered near-complete (≥90%) stabilizer of Transthyretin (TTR) for the treatment of adults with ATTR-CM to reduce cardiovascular death and cardiovascular-related hospitalization.
IntroductionCardiovascular diseases include myocardial infarction, a high mortality disease. Myocardial infarction patients are becoming younger, typically defined as patients under 45 years of age. This study analyzes the relevant papers on myocardial infarction in youth in the Web of Science Core Collection (WoSCC) between 1980 and 2023.MethodsIt uses bibliometric methods to systematically understand the current status and development trend of research in this field.
Cardiac rehabilitation (CR) is a multidisciplinary supervised programme which typically consists of tailored exercise and education on lifestyle management and risk factor modification in cardiac patients. Participation in CR reduces morbidity and mortality, while improving quality of life following major cardiovascular events. Despite the benefits of CR, it is underutilised, generally in the 20%–30% range for eligible patients.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Heat exposure could cause organ injuries leading to multi-organ failure. This case report describes a cardiopulmonary healthy 61-year-old woman who was admitted to our university hospital in an unconscious state after spending more than 30 min in an 80°C sauna. Initial radiological imaging revealed no pathological findings. Laboratory results revealed a rapidly progressing disseminated intravascular coagulation (“DIC”) and a clinically asymptomatic COVID-19 infection.
If you’re looking to revisit or explore the sessions from the 19th Annual Cardiometabolic Health Congress (CMHC), we’ve got good news—on-demand access is now available! Below, we answer the most common questions about CMHC On-Demand to help you make the most of this resource and stay updated on key developments in cardiometabolic health. If you attended the 19th Annual Cardiometabolic Health Congress (CMHC), please reach out to info@cardiometabolichealth.org and we will provide you with a compli
The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.
The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.
A set of keys to one’s first car is an unrivalled symbol of personal autonomy and liberation. The elation a teenager feels when getting the car keys for the first time (now more likely to be fobs, phones or fingerprints) is only equaled in intensity by the crushing defeat of being stripped of this privilege when, say, curfew is broken. For people with medical problems, relinquishing one’s driving privileges, in this case for reasons of health and safety, is a difficult, often content
Healthgrades published its 2025 Specialty Excellence Awards recipients Oct. 22. Of those, 97 hospitals were recognized for delivering superior clinical outcomes in cardiac care for heart bypass surgery, coronary interventional procedures, heart attack treatment, heart failure treatment and heart valve surgery.
Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication of diabetes characterized by myocardial hypertrophy, fibrosis, and impaired cardiac function. Fibroblast growth factor 21 (FGF21) has emerg.
Panelists discuss how IgA nephropathy affects patients’ quality of life, addressing both the physical symptoms and the emotional challenges associated with the condition.
Research conducted across 12 hospitals in China has discovered that combining linear ablation with ethanol infusion via the vein of Marshall (EIVOM) alongside pulmonary vein isolation (PVI) significantly improves sinus rhythm maintenance in patients suffering from persistent atrial fibrillation.
Panelists discuss how early detection of chronic kidney disease (CKD) in stages 2 and 3 can improve patient outcomes across various specialties, including nephrology, cardiology, and primary care.
Cardiac implantable electronic device (CIED) infection still lacks standardized and universally accepted diagnostic criteria. Current EHRA criteria1 largely adapt to CIED Infections the Modified Duke criteria2 and ESC 2015 criteria,3 which were developed for native valve endocarditis and later adapted to prosthetic valve endocarditis.
Adults whose resting heart rate follows an atypical pattern as they age may face a greater risk of developing heart failure or dying from any cause than people whose heart rates follow a normal trajectory, new research suggests.
Is a pharmacist-led home sotalol loading protocol using an ambulatory electrocardiographic (ECG) device for adverse event monitoring feasible, safe, and efficacious?
Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophys.
Women, especially those who had high blood pressure during pregnancy or entered menopause before age 45, are among those with a greater risk for stroke.
Lowering serum urate level to less than 6 mg/dL was not linked to an elevated risk of severe or end-stage kidney disease progression in patients with gout.
At ACR, HCPLive spoke with Erin Treemarcki on a survey that showed many rheumatologists do not use established enthesitis scoring measures for children.
The following are key points to remember from a review on national- and state-level prevalence of overweight and obesity among children, adolescents, and adults in the United States (US), 1990–2021, and forecasts up to 2050.
This post-hoc analysis demonstrated an association between work productivity and stringent disease control criteria for those with psoriatic arthritis.
Tricuspid valve replacement (TVR) is required when repair is not feasible, and it continues to be a relatively high-risk procedure owing to the complex medical and/or surgical profile of patients. The choice b.
The Heart Health Formula is available from today until Sunday, Dec 1st. You might have received an email saying today is the LAST day of availability, but it's not. It is the first day. Apologies for the earlier email. This was a scheduling error on our part. But if you want to pick up the Heart Health Formula for 30% off, you can do so from today until Sunday.
These data, presented at ACR 2024, demonstrate that response was maintained at 2 years among those with psoriatic arthritis who responded to bimekizumab at Week 16.
Ninety-five percent of CPR training manikins on the global market are flat-chested, possibly contributing to disproportionate survival outcomes for women after cardiac arrest, according to a study published Nov. 21 in Health Promotional International.
Panelists discuss the importance of screening and monitoring family members of individuals with IgA nephropathy, noting that up to 15% of cases are familial and outlining recommendations for the frequency of such assessments.
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