Mon.Nov 25, 2024

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Alexei Grom, MD: Exploring Safer Treatment Options for Refractory Macrophage Activation Syndrome

HCPLive

Emapalumab may improve outcomes in patients with MAS whose disease didn’t respond to steroid therapy and mitigate the need for more toxic therapies.

Outcomes 118
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Popular diabetes and obesity drugs also protect kidneys, study shows

Science Daily - Heart Disease

The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.

Diabetes 111
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Vitamin D Deficiency More Common in Lupus Nephritis Than Lupus Without Kidney Disease

HCPLive

Hypovitaminosis D was more prevalent in patients with lupus nephritis compared to patients with systemic lupus erythematosus without kidney disease.

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Top hospitals for cardiac care: Healthgrades

Becker's Hospital Review - Cardiology

Healthgrades published its 2025 Specialty Excellence Awards recipients Oct. 22. Of those, 97 hospitals were recognized for delivering superior clinical outcomes in cardiac care for heart bypass surgery, coronary interventional procedures, heart attack treatment, heart failure treatment and heart valve surgery.

Hospital 105
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Novel Quality Index Linked to Reduced Hospital Admissions for Gout

HCPLive

The Urate-Lowering Therapy to Acute Treatment Ratio (ULTrA) was linked to fewer gout-related hospital admissions.

Hospital 111
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Clinical trial finds combined procedures better for persistent atrial fibrillation

Medical Xpress - Cardiology

Research conducted across 12 hospitals in China has discovered that combining linear ablation with ethanol infusion via the vein of Marshall (EIVOM) alongside pulmonary vein isolation (PVI) significantly improves sinus rhythm maintenance in patients suffering from persistent atrial fibrillation.

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Impact of IgAN on Quality of Life

HCPLive

Panelists discuss how IgA nephropathy affects patients’ quality of life, addressing both the physical symptoms and the emotional challenges associated with the condition.

More Trending

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Early Detection of CKD in Stages 2 and 3

HCPLive

Panelists discuss how early detection of chronic kidney disease (CKD) in stages 2 and 3 can improve patient outcomes across various specialties, including nephrology, cardiology, and primary care.

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A stroke changed a teacher's life: How a new electrical device is helping her move

Medical Xpress - Cardiology

As her students finished their online exam, Arlet Lara got up to make a cafe con leche.

Stroke 76
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Home Sotalol for Arrhythmia Management Using Remote ECG Monitoring

American College of Cardiology

Is a pharmacist-led home sotalol loading protocol using an ambulatory electrocardiographic (ECG) device for adverse event monitoring feasible, safe, and efficacious?

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Abnormal resting heart rate over long term may predict future heart failure or death

Medical Xpress - Cardiology

Adults whose resting heart rate follows an atypical pattern as they age may face a greater risk of developing heart failure or dying from any cause than people whose heart rates follow a normal trajectory, new research suggests.

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Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes

Cardiovascular Diabetology

Type 1 diabetes increases the risk of coronary artery disease (CAD). High-throughput metabolomics may be utilized to identify metabolites associated with disease, thus, providing insight into disease pathophys.

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Perspective: Pathological transdifferentiation—a novel therapeutic target for cardiovascular diseases and chronic inflammation

Frontiers in Cardiovascular Medicine

Pathological transdifferentiation, where differentiated cells aberrantly transform into other cell types that exacerbate disease rather than promote healing, represents a novel and significant concept. This perspective discusses its role and potential targeting in cardiovascular diseases and chronic inflammation. Current therapies mainly focus on mitigating early inflammatory response through proinflammatory cytokines and pathways targeting, including corticosteroids, TNF-α inhibitors, IL-1β mon

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Stroke guidelines updated, with focus on women and GLP-1s

Medical Xpress - Cardiology

Women, especially those who had high blood pressure during pregnancy or entered menopause before age 45, are among those with a greater risk for stroke.

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25-year trajectories of physical activity and atrial fibrillation risk: results from the ARIC study

Frontiers in Cardiovascular Medicine

BackgroundThe relationship between serial changes in physical activity and the risk of developing atrial fibrillation (AF) has been rarely studied.ObjectivesTo evaluate the association between changes in physical activity over time and the incidence of AF.MethodsA total of 11,828 participants without AF at baseline (visit 1: 1987–1989) from the ARIC Study were included.

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BridgeBio Pharma Receive FDA Nod for Attruby

DAIC

tim.hodson Mon, 11/25/2024 - 18:06 Nov. 22, 2024 — BridgeBio Pharma, Inc. recently announced that the U.S. Food and Drug Administration (FDA) approved Attruby (acoramidis), an orally-administered near-complete (≥90%) stabilizer of Transthyretin (TTR) for the treatment of adults with ATTR-CM to reduce cardiovascular death and cardiovascular-related hospitalization.

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Association of coffee consumption and caffeine metabolism with arrhythmias and cardiac morphology: an observational, genetic and Mendelian Randomization study

HeartRhythm

The association of coffee intake and caffeine metabolism with arrhythmias and cardiac structure is not fully understood.

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Bibliometric analysis of youth myocardial infarction research (1980–2023)

Frontiers in Cardiovascular Medicine

IntroductionCardiovascular diseases include myocardial infarction, a high mortality disease. Myocardial infarction patients are becoming younger, typically defined as patients under 45 years of age. This study analyzes the relevant papers on myocardial infarction in youth in the Web of Science Core Collection (WoSCC) between 1980 and 2023.MethodsIt uses bibliometric methods to systematically understand the current status and development trend of research in this field.

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Cardiac rehabilitation: the gateway for secondary prevention

Heart BMJ

Cardiac rehabilitation (CR) is a multidisciplinary supervised programme which typically consists of tailored exercise and education on lifestyle management and risk factor modification in cardiac patients. Participation in CR reduces morbidity and mortality, while improving quality of life following major cardiovascular events. Despite the benefits of CR, it is underutilised, generally in the 20%–30% range for eligible patients.

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Multi-modal transcriptomics: integrating machine learning and convolutional neural networks to identify immune biomarkers in atherosclerosis

Frontiers in Cardiovascular Medicine

BackgroundAtherosclerosis, a complex chronic vascular disorder with multifactorial etiology, stands as the primary culprit behind consequential cardiovascular events, imposing a substantial societal and economic burden. Nevertheless, our current understanding of its pathogenesis remains imprecise. In this investigation, our objective is to establish computational models elucidating molecular-level markers associated with atherosclerosis.

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Urate-Lowering Therapy Remains Tolerable in Patients with Gout, CKD

HCPLive

Lowering serum urate level to less than 6 mg/dL was not linked to an elevated risk of severe or end-stage kidney disease progression in patients with gout.

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Death after sauna—case report of a heat stroke associated subarachnoid hemorrhage

Frontiers in Cardiovascular Medicine

Heat exposure could cause organ injuries leading to multi-organ failure. This case report describes a cardiopulmonary healthy 61-year-old woman who was admitted to our university hospital in an unconscious state after spending more than 30 min in an 80°C sauna. Initial radiological imaging revealed no pathological findings. Laboratory results revealed a rapidly progressing disseminated intravascular coagulation (“DIC”) and a clinically asymptomatic COVID-19 infection.

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Rheumatologists Recognize the Need to Create Pediatric Enthesitis Scoring Tool

HCPLive

At ACR, HCPLive spoke with Erin Treemarcki on a survey that showed many rheumatologists do not use established enthesitis scoring measures for children.

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CircRNA-mediated regulation of cardiovascular disease

Frontiers in Cardiovascular Medicine

Cardiovascular diseases (CVDs) encompass a range of disorders affecting the heart and blood vessels, such as coronary heart disease, cerebrovascular disease (e.g., stroke), peripheral arterial disease, congenital heart anomalies, deep vein thrombosis, and pulmonary embolism. CVDs are often referred to as the leading cause of mortality worldwide. Recent advancements in deep sequencing have unveiled a plethora of noncoding RNA transcripts, including circular RNAs (circRNAs), which play pivotal rol

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Strict Disease Control Criteria Linked to Increased Work Productivity for Patients with PsA

HCPLive

This post-hoc analysis demonstrated an association between work productivity and stringent disease control criteria for those with psoriatic arthritis.

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Heart valve clinics: an expanding role for the clinical scientist's validation of a framework for competency and certification

Open Heart

Background Valvular heart disease (VHD) represents a significant burden on healthcare systems worldwide, necessitating specialised care through multidisciplinary valve clinics. However, there is a lack of a standardised training and certification framework for clinical scientists and specialist physiologists (CSSPs) working within specialist valve clinics (SVCs).

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Presence of Diffuse Cutaneous Disease Linked to Worse HRQOL in Systematic Sclerosis

HCPLive

At ACR, HCPLive spoke with Ashima Makol, MD, about factors linked to a worse health-related quality of life in patients with early systemic sclerosis.

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Nonbacterial Thrombotic Endocarditis: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on nonbacterial thrombotic endocarditis.

Article 53
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SEL-212 Advances Refractory Gout Outcomes with Prolonged Treatment

HCPLive

Clinically meaningful increases in patient-reported outcomes were identified after 3 doses of SEL-212 and strengthened after 3 additional doses.

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Prevalence of Overweight and Obesity in the US: Key Points

American College of Cardiology

The following are key points to remember from a review on national- and state-level prevalence of overweight and obesity among children, adolescents, and adults in the United States (US), 1990–2021, and forecasts up to 2050.

Obesity 53
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Bimekizumab Maintains Efficacy for PsA Up to 2 Years Among Week 16 Responders

HCPLive

These data, presented at ACR 2024, demonstrate that response was maintained at 2 years among those with psoriatic arthritis who responded to bimekizumab at Week 16.

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Your Top Five Questions About CMHC On-Demand, Answered

Cardiometabolic Health Congress

If you’re looking to revisit or explore the sessions from the 19th Annual Cardiometabolic Health Congress (CMHC), we’ve got good news—on-demand access is now available! Below, we answer the most common questions about CMHC On-Demand to help you make the most of this resource and stay updated on key developments in cardiometabolic health. If you attended the 19th Annual Cardiometabolic Health Congress (CMHC), please reach out to info@cardiometabolichealth.org and we will provide you with a compli

CME 52
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Genetic Screening for IgAN

HCPLive

Panelists discuss the importance of screening and monitoring family members of individuals with IgA nephropathy, noting that up to 15% of cases are familial and outlining recommendations for the frequency of such assessments.

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Tricuspid valve replacement with mechanical versus biological prostheses: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery

Tricuspid valve replacement (TVR) is required when repair is not feasible, and it continues to be a relatively high-risk procedure owing to the complex medical and/or surgical profile of patients. The choice b.

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New insights into FGF21 alleviates diabetic cardiomyopathy by suppressing ferroptosis: a commentary

Cardiovascular Diabetology

Diabetic cardiomyopathy (DCM) is a severe cardiovascular complication of diabetes characterized by myocardial hypertrophy, fibrosis, and impaired cardiac function. Fibroblast growth factor 21 (FGF21) has emerg.

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Opps. The FIRST Day. Not The Last Day.

Dr. Paddy Barrett

The Heart Health Formula is available from today until Sunday, Dec 1st. You might have received an email saying today is the LAST day of availability, but it's not. It is the first day. Apologies for the earlier email. This was a scheduling error on our part. But if you want to pick up the Heart Health Formula for 30% off, you can do so from today until Sunday.

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Prognostic value of glycaemic variability for mortality in critically ill atrial fibrillation patients and mortality prediction model using machine learning

Cardiovascular Diabetology

The burden of atrial fibrillation (AF) in the intensive care unit (ICU) remains heavy. Glycaemic control is important in the AF management.