The Rise, Fall (and Future?) of MDMA-Assisted Therapy
HCPLive
DECEMBER 23, 2024
MDMA-assisted therapy, a source of hope for many, went on a tumultuous journey in 2024, going from historichype to setbacks.
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Prevalence and predictors of poor heart failure treatment outcomes in Ethiopia: a systematic review and meta-analysis
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
BackgroundHeart failure (HF) is a leading cause of morbidity and mortality worldwide. Various factors can exacerbate disease progression in patients with HF and negatively impact treatment outcomes. This study aims to evaluate the pooled prevalence and contributing factors associated with poor heart failure treatment outcomes in Ethiopia.MethodsA systematic review and meta-analysis were conducted using five databases: Google Scholar, ScienceDirect, Hinari, PubMed, and Scopus.
First Generic of Once-Daily GLP-1 Injection Approved for Diabetes
Med Page Today
DECEMBER 23, 2024
(MedPage Today) -- The FDA has approved the first generic form of liraglutide (Victoza), a once-daily injectable for improving glycemic control in patients ages 10 and older with type 2 diabetes, used as an adjunct to diet and exercise. This is.
FDA Approves Generic Once-Daily GLP-1 RA for Type 2 Diabetes in Pediatric, Adult Patients
HCPLive
DECEMBER 23, 2024
The FDA's approval marks the second generic approval referencing a GLP-1 receptor agonist in as many months for the agency.
Top ACC Content in 2024
American College of Cardiology
DECEMBER 23, 2024
What an amazing year 2024 was in terms of advances in cardiovascular care! With more than 882,000 users, ACC.org continues to be a critical resource for cardiovascular clinicians around the world!
Use of Ibuprofen, Other NSAIDs During Pregnancy Could Increase Risk of Childhood CKD
HCPLive
DECEMBER 23, 2024
Gestational exposure to certain NSAIDs during different trimesters of pregnancy was associated with an increased risk of childhood CKD.
Malignant hypertension: current challenges, prevention strategies, and future perspectives
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
IntroductionBased on office blood pressure (BP) values, hypertension is categorized into three stages: stage 1 (140159/9099mmHg), stage 2 (160179/100109mmHg), and stage 3 (180/110mmHg). Malignant hypertension (MHT) is characterized by extreme BP elevation (systolic blood pressure above 200mmHg and diastolic blood pressure above 130mmHg) and acute microvascular damage affecting various organs, particularly the retinas, brain, and kidneys.ObjectivesThe pathogenesis, predisposing variables, therapy
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VA-ECOM assisted percutaneous mechanical thrombectomy treatment high-risk pulmonary embolism
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
BackgroundPercutaneous mechanical thrombectomy (PMT) is increasingly used in the treatment of intermediate and high-risk acute pulmonary embolism (PE), and the treatment of high-risk PE with the aid of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has also been reported. However, there are few reports of VA-ECOM-assisted PMT in the treatment of high-risk PE.
Evolving use and clinical outcomes of coronary intravascular lithotripsy: insights from an international, multicentre registry
Heart BMJ
DECEMBER 23, 2024
Background Intravascular lithotripsy (IVL) is increasingly used for treatment of coronary artery calcification. This study aimed to evaluate contemporary utilisation patterns, safety and efficacy of IVL in an unselected real-world patient cohort. Methods We included 454 patients undergoing IVL from May 2019 to February 2024 across seven centres in two European countries.
Experts' Perspectives: Top Stories in Cardiology for 2024
HCPLive
DECEMBER 23, 2024
To celebrate the close of 2024, we surveyed top cardiologist on what they view as the biggest storyline in their field from the past year.
New-Onset Epilepsy, Migraine Tied to Hypertensive Disorders of Pregnancy
Med Page Today
DECEMBER 23, 2024
(MedPage Today) -- Hypertensive disorders of pregnancy -- gestational hypertension, preeclampsia, or eclampsia -- were tied to an increased risk of new-onset neurologic disorders years after giving birth, Swedish registry data showed. Women.
Study Highlights 5-Year Real-World Survival of Dupilumab for Atopic Dermatitis
HCPLive
DECEMBER 23, 2024
These data expanded upon limited real-world data on retention of dupilumab past 2 years of treatment for patients with atopic dermatitis.
Impact of the COVID-19 pandemic on incidence of coronary heart disease in Bavaria, Germany: an analysis of health claims data
Heart BMJ
DECEMBER 23, 2024
Background Inconsistent findings about the impact of the COVID-19 pandemic on cardiovascular disease diagnosis and consultations have been reported internationally. The objective of this study was to analyse the impact of the pandemic period (2020–2021) on the incidence rate of coronary heart disease (CHD) compared with the pre-pandemic period (2012–2019) in Bavaria, Germany.
Greater Non-HDL/HDL Cholesterol Ratio Linked to Lower Anemia Rates
HCPLive
DECEMBER 23, 2024
A study shows that a lower non-HDL/HDL cholesterol ratio is linked to greater anemia prevalence. A threshold of 4.28 shows a 15% anemia risk drop per unit increase below this value.
Behavioral and biomedical factors associated with lifestyle modification practices among diagnosed hypertensive patients in pastoral health facilities of southern Ethiopia
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
BackgroundMore than 23 million deaths and 36.5% of disability-adjusted life-years are the result of the direct effects of unhealthy behavior alone. Daily behaviors have strong implications for health outcomes and quality of life. The aim of this study is to determine the behavioral and biomedical factors associated with lifestyle modification practices among diagnosed hypertensive patients in pastoral health facilities of southern Ethiopia.MethodsA facility-based cross-sectional study was conduc
Coding for CKD Diagnosis
HCPLive
DECEMBER 23, 2024
Panelists discuss the key considerations for properly coding chronic kidney disease (CKD) diagnoses, with a particular focus on the nuances involved in coding for early-stage CKD.
Breaking new ground in treatment of coronary calcium
Heart BMJ
DECEMBER 23, 2024
Extracorporeal shock wave lithotripsy (ESWL) is standard of care for the treatment of renal calculi. Fracturing large renal calculi using acoustic energy allows them to be safely passed as smaller fragments therefore avoiding surgical treatment. The adaption of ESWL to the vascular space, termed intravascular lithotripsy (IVL), could be said to have a similar goal and has sparked renewed interest in the percutaneous treatment of calcified coronary artery disease (CCAD).
Chronic Spontaneous Urticaria and Bruton Tyrosine Kinase: A Multispecialty Expert Discussion Primer
HCPLive
DECEMBER 23, 2024
Panelists discuss how chronic spontaneous urticaria involves autoantibody-mediated mast cell activation and degranulation, with BTK serving as a critical signaling molecule in both mast cells and B cells that produce pathogenic autoantibodies.
Effects of a Digital Intervention to Improve DASH and Blood Pressure Among US Adults
Hypertension Journal
DECEMBER 23, 2024
Hypertension, Ahead of Print. BACKGROUND:Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low.PURPOSE:To evaluate the efficacy of a digital health intervention (DHI), compared with attention control, on changes in DASH adherence and blood pressure among adults with hypertension.METHODS:Nourish was a 12-month, parallel, 2-arm, randomized controlled trial of a virtually delivered DHI.
Proteinuria Reduction in Long-Term Kidney Damage Prevention
HCPLive
DECEMBER 23, 2024
Panelists discuss how the reduction of proteinuria is integral to the broader treatment goals for IgA nephropathy, highlighting evidence that supports its role in preventing long-term kidney damage.
Impact of the Individual Operator Experience and Learning Curve of a Novel Size Adjustable Cryoballoon
Journal of Cardiovascular Electrophysiology
DECEMBER 23, 2024
ABSTRACT Background Cryoballoon ablation is less operator-dependent than radiofrequency ablation. Recently, size-adjustable cryoballoons (SA-CBs) have become available. We sought to analyze the individual baseline operator experience's impact on procedural results. Methods This multicenter observational study included atrial fibrillation (AF) patients who underwent pulmonary vein (PV) isolation using SA-CBs capable of 28-mm or 31-mm balloon sizes.
Hyperglycemia, Obesity Relevant Risk Factors for Retinopathy in Type 1 Diabetes
HCPLive
DECEMBER 23, 2024
Glycemic control continues to be a major risk factor for diabetic retinopathy, while overweight, obesity, and hypertension are growing in prevalence.
Top Trials, Journal Scans, and Takeaways of 2024
American College of Cardiology
DECEMBER 23, 2024
In this weeks special edition of Eagles Eye View, Dr. Eagle looks at the top trials, journal scans, and clinical developments in cardiology that have changed your practice and will continue to change clinical care in the future.
FDA Approves Concizumab for Hemophilia A or B with Inhibitors
HCPLive
DECEMBER 23, 2024
Concizumab marks the first subcutaneous injection treatment for hemophilia A or B with inhibitors, demonstrating an 86% reduction in bleeds in pivotal trial data.
Tirzepatide Once Weekly for the Treatment of Obesity
American College of Cardiology
DECEMBER 23, 2024
The goal of the SURMOUNT-1 trial was to assess the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist versus placebo in overweight or obese adults without diabetes.
Outcomes and Adoption of PPAR Agonists in PBC
HCPLive
DECEMBER 23, 2024
The panel of experts addresses potential challenges in the adoption of peroxisome proliferator-activated receptor (PPAR) agonists for primary biliary cholangitis (PBC), including barriers to access, patient selection, and long-term treatment considerations.
Study of Heart and Kidney Protection With Empagliflozin
American College of Cardiology
DECEMBER 23, 2024
The goal of the EMPA-KIDNEY trial was to assess the safety and efficacy of empagliflozin in improving cardiac and renal outcomes among patients with chronic kidney disease (CKD).
Thoughts on the Current State of PBC Management
HCPLive
DECEMBER 23, 2024
The panel of experts offers expert insights and concluding thoughts on the management of primary biliary cholangitis (PBC), emphasizing the importance of personalized treatment strategies, monitoring, and the evolving role of new therapies in improving patient outcomes.
Global EM 7 Global Emergency Medicine Partnerships
ECG Cases
DECEMBER 23, 2024
In this Global EM post we provide examples of Global EM partnerships and tools for developing these partnerships to foster global solidarity in improving emergency medicine as a specialty and help EM societies not only strengthen their systems but also enhance global health outcomes. The post Global EM 7 Global Emergency Medicine Partnerships appeared first on Emergency Medicine Cases.
NCQA Guidelines and the KDIGO Heat Map in CKD Management
HCPLive
DECEMBER 23, 2024
Panelists discuss how NCQA guidelines apply to chronic kidney disease (CKD) management and the role of the KDIGO heat map in enhancing clinical practice.
Changes in systolic blood pressure during hospitalisation and bleeding events after percutaneous coronary intervention
Open Heart
DECEMBER 23, 2024
Background Hypertension is a risk factor for bleeding events and is included in the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile INR, Elderly, Drugs/Alcohol concomitantly) score. However, the effects of blood pressure (BP) and changes in BP on bleeding events in patients undergoing percutaneous coronary intervention (PCI) remain poorly understood.
Oroteinuria Reduction in Long-Term Kidney Damage Prevention
HCPLive
DECEMBER 23, 2024
Panelists discuss how the reduction of proteinuria is integral to the broader treatment goals for IgA nephropathy, highlighting evidence that supports its role in preventing long-term kidney damage.
Management of pregnancy-related disorders to prevent future risk of coronary artery disease
Heart BMJ
DECEMBER 23, 2024
Learning objectives Recognise adverse pregnancy outcomes as sex-specific risk factors for future cardiovascular disease. Incorporate the recommendations regarding cardiovascular screening and optimise cardiovascular risk factors across the pregnancy continuum. Leverage the American Heart Association’s ‘Life’s Essential 8’ as a tool to assess cardiometabolic status and encourage mitigation of modifiable risk factors throughout the pregnancy windows.
Symptoms Management and Targeting the Root Cause of IgAN
HCPLive
DECEMBER 23, 2024
Panelists discuss how clinicians can effectively shift treatment strategies for IgA nephropathy from merely managing symptoms to actively targeting the root causes of the disease.
How comfortable are you with transcutaneous pacing?
Dr. Smith's ECG Blog
DECEMBER 23, 2024
Written by Willy Frick A woman in her 70s is hospitalized with undifferentiated shock after being found down at home. Her family had not heard from her and called EMS. Paramedics found her bradycardic, hypotensive, and tachypneic. She was resuscitated and admitted to ICU for presumed sepsis. Several days into hospitalization, she continued to have occasional episodes of sinus rhythm and sinus bradycardia with periods of Mobitz I AV block and 2:1 block.
Rising Atherogenic Index of Plasma Tied to Increased Psoriasis Risk
HCPLive
DECEMBER 23, 2024
A study indicates that dyslipidemia may be associated with a greater risk of psoriasis development.
Association of the geriatric nutritional risk index with poor outcomes in patients with coronary revascularization: a cohort study
Frontiers in Cardiovascular Medicine
DECEMBER 23, 2024
BackgroundPoor nutritional status may affect outcomes after coronary revascularization, but the association between nutritional status and outcomes in patients undergoing coronary revascularization has not been fully evaluated. This study was based on the MIMIC-IV database to analyze the impact of baseline nutritional status on poor outcomes in patients with coronary revascularization.MethodsPatients with coronary revascularization were screened from the MIMIC-IV database.
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