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Degenerative mitral valve disease is common. Up to a quarter of patients with degenerative mitral valve disease may be asymptomatic despite having severe valve regurgitation. Current guideline indications for intervention in asymptomatic patient are centred on left ventricular dimensions and ejection fraction and may include consideration in atrial fibrillation, pulmonary hypertension and those with left atrial dilatation.
BackgroundHeart failure (HF) is a leading cause of morbidity and mortality worldwide. Various factors can exacerbate disease progression in patients with HF and negatively impact treatment outcomes. This study aims to evaluate the pooled prevalence and contributing factors associated with poor heart failure treatment outcomes in Ethiopia.MethodsA systematic review and meta-analysis were conducted using five databases: Google Scholar, ScienceDirect, Hinari, PubMed, and Scopus.
IntroductionBased on office blood pressure (BP) values, hypertension is categorized into three stages: stage 1 (140159/9099mmHg), stage 2 (160179/100109mmHg), and stage 3 (180/110mmHg). Malignant hypertension (MHT) is characterized by extreme BP elevation (systolic blood pressure above 200mmHg and diastolic blood pressure above 130mmHg) and acute microvascular damage affecting various organs, particularly the retinas, brain, and kidneys.ObjectivesThe pathogenesis, predisposing variables, therapy
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
(MedPage Today) -- Hypertensive disorders of pregnancy -- gestational hypertension, preeclampsia, or eclampsia -- were tied to an increased risk of new-onset neurologic disorders years after giving birth, Swedish registry data showed. Women.
(MedPage Today) -- The FDA has approved the first generic form of liraglutide (Victoza), a once-daily injectable for improving glycemic control in patients ages 10 and older with type 2 diabetes, used as an adjunct to diet and exercise. This is.
Giving more blood to anemic patients after a heart attack may save lives, according to a Rutgers Healthled study. The study, published in NEJM Evidence, affirms research conducted in 2023 that suggested mortality rate or recurrent heart attacks were more frequent in anemic patients who received less blood.
Everyone knows the health risks of carrying too much fat around the waist and hips, but UVA Health scientists are developing a noninvasive way to assess the health risks of unseen fat around the heart.
Panelists discuss how the reduction of proteinuria is integral to the broader treatment goals for IgA nephropathy, highlighting evidence that supports its role in preventing long-term kidney damage.
What an amazing year 2024 was in terms of advances in cardiovascular care! With more than 882,000 users, ACC.org continues to be a critical resource for cardiovascular clinicians around the world!
Concizumab marks the first subcutaneous injection treatment for hemophilia A or B with inhibitors, demonstrating an 86% reduction in bleeds in pivotal trial data.
The goal of the SURMOUNT-1 trial was to assess the efficacy and safety of tirzepatide, a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist versus placebo in overweight or obese adults without diabetes.
The goal of the EMPA-KIDNEY trial was to assess the safety and efficacy of empagliflozin in improving cardiac and renal outcomes among patients with chronic kidney disease (CKD).
Panelists discuss how clinicians can effectively shift treatment strategies for IgA nephropathy from merely managing symptoms to actively targeting the root causes of the disease.
In this weeks special edition of Eagles Eye View, Dr. Eagle looks at the top trials, journal scans, and clinical developments in cardiology that have changed your practice and will continue to change clinical care in the future.
A study shows that a lower non-HDL/HDL cholesterol ratio is linked to greater anemia prevalence. A threshold of 4.28 shows a 15% anemia risk drop per unit increase below this value.
BackgroundPercutaneous mechanical thrombectomy (PMT) is increasingly used in the treatment of intermediate and high-risk acute pulmonary embolism (PE), and the treatment of high-risk PE with the aid of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has also been reported. However, there are few reports of VA-ECOM-assisted PMT in the treatment of high-risk PE.
Physicians at Emory University Hospital performed the first-ever surgical implantation in the United States of a brand-new type of heart pump designed to help save patients with heart failure, using a smaller, more comfortable device.
Hypertension, Ahead of Print. BACKGROUND:Dietary Approaches to Stop Hypertension (DASH) is a recommended first-line treatment for adults with hypertension, yet adherence to DASH is low.PURPOSE:To evaluate the efficacy of a digital health intervention (DHI), compared with attention control, on changes in DASH adherence and blood pressure among adults with hypertension.METHODS:Nourish was a 12-month, parallel, 2-arm, randomized controlled trial of a virtually delivered DHI.
Panelists discuss the key considerations for properly coding chronic kidney disease (CKD) diagnoses, with a particular focus on the nuances involved in coding for early-stage CKD.
Left bundle branch area pacing (LBBAP) needs confirmation of left conduction system capture assessed by testing of different electrical parameters. Guidelines recommend the use of an electrophysiological recording-system (EP-RS) to guide conduction system pacing (CSP) procedures. However, some experienced centers perform LBBAP procedures without an EP-RS.
Panelists discuss how chronic spontaneous urticaria involves autoantibody-mediated mast cell activation and degranulation, with BTK serving as a critical signaling molecule in both mast cells and B cells that produce pathogenic autoantibodies.
ABSTRACT Background Anemia is frequently observed as a comorbidity in atrial fibrillation (AF), especially in elderly patients and in those on anticoagulation. This has been associated with poor clinical outcomes. We aim to investigate the impact of anemia on clinical outcomes in patients with AF on oral anticoagulation. Methods We comprehensively searched PubMed, WOS, SCOPUS, EMBASE, and CENTRAL through March 2024 and conducted a prognostic systematic review and meta-analysis.
The panel of experts addresses potential challenges in the adoption of peroxisome proliferator-activated receptor (PPAR) agonists for primary biliary cholangitis (PBC), including barriers to access, patient selection, and long-term treatment considerations.
ABSTRACT Introduction Catheter ablation of persistent atrial fibrillation yields sub-optimal success rates partly due to the considerable heterogeneity within the patient population. Identifying distinct patient phenotypes based on post-ablation prognosis could improve patient selection for additional therapies and optimize treatment strategies. Methods We studied all patients who underwent catheter ablation of persistent atrial fibrillation in the DECAAF II trial.
The panel of experts offers expert insights and concluding thoughts on the management of primary biliary cholangitis (PBC), emphasizing the importance of personalized treatment strategies, monitoring, and the evolving role of new therapies in improving patient outcomes.
Both parents of children with hypertension and treating clinicians are aware of the importance of addressing pediatric hypertension but show significant mistrust in clinic blood pressure measurements, according to a study published online Dec. 13 in JAMA Network Open.
Panelists discuss how NCQA guidelines apply to chronic kidney disease (CKD) management and the role of the KDIGO heat map in enhancing clinical practice.
Human and microbial proteins found in feces could help doctors detect a long-term risk of deadly cardiovascular conditions in otherwise healthy patients, avoiding the need for costly and invasive diagnostic procedures.
Panelists discuss how the reduction of proteinuria is integral to the broader treatment goals for IgA nephropathy, highlighting evidence that supports its role in preventing long-term kidney damage.
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