Mon.Nov 18, 2024

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Over 50% of U.S. Adults Qualify for Ozempic, Wegovy

Med Page Today

(MedPage Today) -- More than half of all adults in the U.S. are eligible for semaglutide (Ozempic, Wegovy, Rybelsus), researchers estimated. Among 25,531 participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to.

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Anthos Presents New Analysis from P2 AZALEA-TIMI 71 Study

DAIC

tim.hodson Mon, 11/18/2024 - 10:55 Nov. 16, 2024 Anthos Therapeutics, Inc.recently presented new data at the American Heart Association (AHA) Scientific Sessions from its AZALEA-TIMI 71 study that demonstrated the novel factor XI inhibitor abelacimab led to consistent and substantial reductions in bleeding for patients on or off antiplatelet (APT) therapy, as compared to rivaroxaban.

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In a small international trial, novel oral medication muvalaplin lowered Lp(a)

American Heart News - Heart News

Research Highlights: The oral medication muvalaplin may safely lower high levels of lipoprotein(a), also known as Lp(a), an independent, inherited risk factor for cardiovascular disease. Muvalaplin is a small molecule inhibitor that prevents the.

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Electronic Nudges Improved Flu Shot Uptake in Patients With Acute MI History

Med Page Today

(MedPage Today) -- CHICAGO -- Electronic nudges increased uptake of flu vaccines among patients with a history of acute myocardial infarction (MI), results from three Danish randomized trials showed. Among over 2 million patients, a letter explaining.

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IgAN vs Other Glomerular Diseases

HCPLive

Panelists discuss the immune system dysregulation underlying IgA nephropathy and highlight how this mechanism differs from those seen in other glomerular diseases.

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Blood pressure variability linked to accelerated vision loss in glaucoma

Medical Xpress - Cardiology

University of California, San Diego-led research suggests that long-term variability in blood pressure is associated with accelerated worsening of peripheral vision due to the progression of glaucoma.

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Nasal spray version of common diuretic has potential to help treat heart failure

American Heart News - Heart News

Research Highlights: A study testing a new nasal spray form of the medication bumetanide, a commonly prescribed diuretic, was found to be as safe and well-tolerated (meaning with no significant nasal irritation) in healthy adults in comparison to the.

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Study: Statins Mitigate Heart Risks From JAK Inhibitors

Med Page Today

(MedPage Today) -- WASHINGTON -- Patients taking Janus kinase (JAK) inhibitors for rheumatoid arthritis (RA) may not have to worry so much about increased cardiovascular risk -- if they're taking statins, research presented here suggested.

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Rising outdoor temperatures tied to higher risk for atrial fibrillation

Medical Xpress - Cardiology

There is a dose-response relationship between rising outdoor temperatures and increased atrial fibrillation (AF) events, according to a study presented at the American Heart Association Scientific Sessions 2024, held from Nov. 16 to 18 in Chicago.

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Reused Pacemakers Good as New in Early Safety Data

Med Page Today

(MedPage Today) -- CHICAGO -- Secondhand permanent pacemaker use in poorer countries, following thorough cleaning and repackaging, has not resulted in patient harm so far, according to the My Heart Your Heart trialists. In patients who could.

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Charting the future of cardiology with large language model artificial intelligence

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 November 2024; doi:10.1038/s41569-024-01105-y Large language models represent a transformative leap in artificial intelligence and natural language processing, offering exciting potential across cardiology, from clinical care to education and research. However, several crucial challenges limit the practical implementation of large language models in cardiology.

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Dr. Stephen Nicholls and Dr. C. Michael Gibson Discuss: A Randomized Phase 2 Trial of Muvalaplin: An Oral Disrupter of the Assembly of Lipoprotein(a) Particles (KRAKEN)

Clinical Trial Results

Disclosures: TBD

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Wei Zhang, MD, PhD: Naltrexone’s GI, Liver Safety for Alcohol Use Disorder Treatment

HCPLive

Zhang explains the safety of different FDA-approved alcohol use disorder drugs in patients with alcohol-associated liver disease.

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Number of cardiologists jumping to hospital practice doubles: Study

Becker's Hospital Review - Cardiology

Between 2008 and 2019, the share of cardiologists practicing in a hospital, as opposed to an independent practice, increased from 26% to 63%, according to a study published Nov. 15 in the Journal of the American College of Cardiology.

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GLP-1 Receptor Agonists Along With SGLT2 Inhibitors for HFpEF

American College of Cardiology

What is the incremental benefit in patients with heart failure and preserved ejection fraction (HFpEF) of glucagon-like peptide-1 receptor agonists (GLP-1 RA) combined with sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with type 2 diabetes mellitus (T2DM) and body mass index (BMI) ≥27?

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Cholesterol is not the only lipid involved in trans fat-driven cardiovascular disease

Science Daily - Heart Disease

Salk scientists have tracked the flow of trans fats using mouse models to describe the molecular mechanisms that cause trans fats to promote atherosclerotic cardiovascular disease (ASCVD), explaining how industrially produced trans-unsaturated fatty acids in our food significantly promote ASCVD and encouraging lawmakers to impose regulations on the use of these fats in food.

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Anti-Obesity Drugs, Lifestyle Interventions Show CV Benefits Beyond Weight Loss

American College of Cardiology

Popular anti-obesity drugs continue to show cardiovascular benefits beyond weight loss, according to new research published in JACC and simultaneously presented at AHA 2024.

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The inconsistencies of genetic markers for predicting heart disease

Medical Xpress - Cardiology

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD). By analyzing a person's DNA, PRSs offer insights into an individual's genetic predisposition for conditions like heart disease, potentially informing a more personalized approach to health care.

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ALPACAR: Zerlasiran vs. Placebo in Reducing Lp(a) Concentration in Patients With ASCVD

American College of Cardiology

Zerlasiran, a short-interfering RNA, was well-tolerated and reduced time-averaged lipoprotein(a) [Lp(a)] concentration by more than 80% during 36 weeks of treatment in patients with atherosclerotic cardiovascular disease (ASCVD).

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Vagus Nerve Stimulation Yields Responses in Refractory Rheumatoid Arthritis

HCPLive

Over one-third of participants had had inadequate responses or intolerance to at least 3 prior b/tsDMARDs.

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Cardiologists say benefits of sport and recreation physical activities outweigh risks, even for individuals with heart disease

Science Daily - Heart Disease

While exercise is generally beneficial for a person's overall health, physical activities may increase the risk of adverse cardiovascular disease events in certain susceptible individuals. However, cardiologists say that the benefits outweigh the risks. Findings from new data reviews detail the risks associated with various types of sport and leisure activities.

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MeiLan Han, MD: Discussing Updates on Dupilumab, Ensifentrine in 2025 GOLD Report

HCPLive

In this interview, Han highlighted new information included in the GOLD 2025 Report regarding utilization of dupilumab and ensifentrine for certain patients with COPD.

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Oral Muvalaplin for Lowering of Lipoprotein(a)

American College of Cardiology

The goal of the KRAKEN trial was to evaluate muvalaplin compared with placebo among patients with high cardiovascular risk and elevated lipoprotein(a).

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Tofacitinib Not Superior to Placebo in Systemic Juvenile Arthritis Double-Blind Trial

HCPLive

However, fewer patients experienced flares in the tofacitinib group than in the placebo group, among other positive findings.

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Intestinal fatty acid binding protein is associated with coronary artery disease in long-term type 1 diabetes—the Dialong study

Cardiovascular Diabetology

Individuals with type 1 diabetes are at increased risk of accelerated atherosclerosis, causing coronary artery disease (CAD). The underlying mechanisms remain unclear, but new theories proposed are damage of g.

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Laure Gossec, MD, PhD: Informing Physician Treatment Choices for Psoriatic Arthritis

HCPLive

Gossec discussed findings from the PsABIOnd study presented at the 2024 ACR Convergence.

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GLP-1 reduced heart failure risk by 46%: 8 study takeaways

Becker's Hospital Review - Cardiology

The GLP-1 tirzepatide, the active ingredient in Eli Lilly's Mounjaro, was found to reduce the risk of heart failure by 46% among individuals with obesity, according to a study published Nov. 16 in The New England Journal of Medicine and presented at the American Heart Association's annual Scientific Sessions.

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Updates to Global Initiative for Chronic Obstructive Lung Disease (GOLD) Report Released

HCPLive

In these updates and new sections, the 2025 GOLD report included highlighted climate change, cardiovascular risk, and pulmonary hypertension.

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Lifestyle & risk factor changes improved AFib symptoms, not burden, over standard care

American Heart News - Heart News

Research Highlights: A clinical trial with adults who have atrial fibrillation (AFib) and an implanted heart device found similar improvements to the amount of time they experienced arrhythmia regardless of whether they received standard care.

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Zerlasiran 60-Week Data Reinforce Lp(a) Reductions Observed in ALPACAR-360

HCPLive

Zerlasiran reduced Lp(a) by over 90% at 60 weeks with consistent efficacy and no serious drug-related adverse events, supporting its phase 3 trial progression.

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A common heart failure medication may help prevent heart damage related to chemotherapy

American Heart News - Heart News

Research Highlights: A widely used heart failure medication called sacubitril/valsartan was associated with a lower risk of heart damage compared to placebo among high-risk cancer patients being treated with anthracycline chemotherapy agents. The risk.

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Elevated Fecal Calprotectin Linked to Often Unnecessary Colonoscopy in Pediatric H. Pylori, with Jessica Lat

HCPLive

HCPLive spoke with Lat at NASPGHAN 2024 about how for communities with high H. pylori prevalence, it is best to test for H. pylori before a colonoscopy.

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A common heart failure medication may help prevent heart damage related to chemotherapy

Science Daily - Heart Disease

A commonly prescribed medication for heart failure was linked to a lower risk of heart damage, or cardiotoxicity, among high-risk cancer patients undergoing chemotherapy treatment using anthracyclines, according to recent research.

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SARAH: Findings Demonstrate Cardioprotective Potential of ARNi in High-Risk Cancer Patients Receiving ATN Therapy

American College of Cardiology

Sacubitril/valsartan was associated with a lower risk cardiotoxicity compared with placebo among high-risk cancer patients being treated with anthracycline (ATN) chemotherapy agents.

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Dr. Stephen Nicholls and Dr. C. Michael Gibson Discuss: Safety and Efficacy of Obicetrapib in Patients With Heterozygous Familial Hypercholesterolemia (BROOKLYN)

Clinical Trial Results

AHA BROOKLYN nov17 Download Disclosures: TBD

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ACC PracticeMadePerfect: Exploring Career Flexibility: Discovering the Power of Financial Freedom

American College of Cardiology

In this episode, Drs. Newton Wiggins, Stanley Lui, and Sandra Lewis discuss the importance of finances and how aligning your financial situation with your values can foster career flexibility and improve clinician well-being.

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Hemodialysis dose and frequency should be considered in subgroup analysis

Cardiovascular Diabetology

The article by Wang et al. titled “Exploring the mortality and cardiovascular outcomes with SGLT-2 inhibitors in patients with T2DM at dialysis commencement: a health global federated network analysis” demonst.

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