Sat.Oct 26, 2024

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Kidney Compass: Atacicept for IgAN with Jonathan Barratt, PhD, at Kidney Week 2024

HCPLive

Neuen, Wadhwani, and Barratt discuss atacicept promise in IgA nephropathy based on phase 2b ORIGIN OLE results, at-home use, and the future of kidney disease care.

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Metformin and Congenital Abnormalities; Deprescribing in Patients With Dementia

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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VALIANT: Pegcetacoplan Offers Benefit for UPCR, eGFR, C3 Staining in C3G, IC-MPGN

HCPLive

VALIANT trial data support pegcetacoplan as the first effective therapy for proteinuria, C3c staining, and eGFR stability in C3G and IC-MPGN patients.

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What is the mechanism of LBBB in DCM ? How does left bundle branch pacing correct it ?

Dr. S. Venkatesan MD

Here is an attempt for a brief answer that starts with query. 1. The mechanism of LBBB in DCM is 1.Discrete proximal LBBB 2.Diffuse distal LBBB 3. Myocardial LBBB (It is just LBBB morphology due to delayed conduction and not a true LBBB ) 4. It is always a combination of any of the above three Answer :Either 3 or 4 should be the answer I think.It need to be reminded the etiology of cardiomyopathy plays crucial role in determining the cause of LBBB.

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ORIGIN OLE Data Solidify Atacicept Disease-Modifying Potential for IgA Nephropathy

HCPLive

New ORIGIN trial data show atacicept may slow kidney decline in IgA nephropathy to rates seen with healthy aging, with notable reductions in Gd-IgA1 and UPCR.

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Depagliflozin Lowers Risk of Decline in Late-Stage Kidney Disease

HCPLive

The dapagliflozin group had an average eGFR rate of -2.24 mL/min/1.73 m2 compared to -3.67 mL/min/1.73 m2 in the control group after about 1.5 years of follow-up.

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Christopher Bunick, MD, PhD: Facts About Systemic Therapies’ Safety, Mechanism of Action

HCPLive

In this interview, Bunick spoke about the contents of his Fall Clinical Dermatology presentation specifically regarding mechanisms of action and safety of systemic therapies.

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New ‘Level Up’ Data on Upadacitinib (Rinvoq) for Atopic Dermatitis, with Christopher Bunick, MD, PhD

HCPLive

This interview with Bunick highlighted the Level Up phase 3b/4 trial findings regarding upadacitinib treatment of patients with atopic dermatitis.

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Richard Pratley, MD: FLOW Mortality Data and Allocation Strategies for Semaglutide

HCPLive

Richard Pratley, MD, discusses how FLOW mortality data informs the use of semaglutide in patients with chronic kidney disease and type 2 diabetes.

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Semaglutide Shows Benefit in CKD and Type 2 Diabetes Across Kidney Disease Severities

HCPLive

Participants receiving semaglutide had an overall hazard ratio of 0.76 in the composite primary outcome of kidney failure, serious eGFR decline, or death compared to placebo.

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Patient-Reported Outcomes for Roflumilast Foam Highlighted for Seborrheic Dermatitis

HCPLive

These findings from the phase 3 STRATUM trial suggest significant DLQI score improvements as early as the second week of treatment with roflumilast foam.

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Carla Nester, MD: Pegcetacoplan in C3 Glomerulopathy and Primary IC-MPGN

HCPLive

Carla Nester, MD, provides perspective on the results of the VALIANT trial and how it informs the role of pegcetacoplan in C3G and IC-MPGN.

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Julie Refardt, MD, PhD: Current Hyponatremia Clinical Interventions Sufficient

HCPLive

Refardt discussed findings from the largest hyponatremia trial ever conducted, including 2174 participants across 9 European centers.

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