Med Page Today
DECEMBER 30, 2024
(MedPage Today) -- Atherosclerosis progression was more than twice as common in younger people with systemic lupus erythematosus (SLE) than in healthy controls in a prospective study from Greece, but the rate difference narrowed substantially with.
HCPLive
DECEMBER 30, 2024
Panelists discuss the new health measures relevant to chronic kidney disease (CKD) management and their significance in improving patient care and outcomes.
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Epithelioid hemangioendothelioma (EHE) is an uncommon vascular malignancy characterized by an unpredictable clinical course and a high potential for recurrence and metastasis. The lack of standard treatment gu.
HCPLive
DECEMBER 30, 2024
Panelists discuss how current treatments for IgA nephropathy often fall short in addressing the root cause, specifically abnormal IgA production and deposition, and highlight the consequences of prioritizing symptom management, such as proteinuria reduction, over targeting the diseases underlying pathology.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Bronchial artery pseudoaneurysm is a rare vascular disorder, and cases of bronchial pseudoaneurysms reported after lung surgery are even rarer. The number of reported cases is very limited due to the unclear p.
HCPLive
DECEMBER 30, 2024
The field of allergy medicine this year saw a variety of developments, including the FDA approvals of neffy and omalizumab as well as new data on immunotherapy.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
DECEMBER 30, 2024
This year in review spotlights top rheumatology FDA news from 2024 and new research out of the ACR 2024 Convergence.
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Windsock deformities, though rare, represent a severe form of valvular aneurysm distinguished by localized balloon-like protrusions of the leaflet body. Here, we present a compelling case of windsock mitral va.
Cassling
DECEMBER 30, 2024
2024 was a year of innovation across the imaging spectrum. When we reviewed our top articles of the year, it became clear that what resonated more than anything else were in-depth looks at technology, the cost of that technology, and the myriad other innovations changing the clinical conversation. Here are the top articles of 2024.
HCPLive
DECEMBER 30, 2024
Panelists discuss how health care providers can effectively utilize white papers and other tools in practice, as well as additional resources available for further learning about chronic kidney disease (CKD) and type 2 diabetes management.
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
The letter to the editor was written in response to the recent article by Wang et al. The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic.
HCPLive
DECEMBER 30, 2024
Panelists discuss how the current treatment landscape for IgA nephropathy presents significant unmet needs, particularly in addressing the underlying causes of the disease and improving patient outcomes.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging and muscle diseases impair MuSC function, leading to stem cell exhaustion and regenerative decline that contribute to the progressive loss of skeletal muscle mass and strength. In the absence of clinically available nutritional solutions specifically targeting MuSCs, we used a human myogenic progenitor high-content imaging screen of natural molecules from food to identify nicotinamide (NAM) and pyridoxine (
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
Vasovagal syncope advances in therapy. ABSTRACT Aim In light of many recent advances in the field of vasovagal syncope, a selective review has been undertaken of these developments. Methods Recent publications on the following topics were reviewed; understanding of vasovagal syncope pathophysiology, tilt-testing methodology and interpretation, drug, ablation and pacemaker therapy.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ketone oxidation. However, SGLT2i have multiple in vivo effects and the differential impact of SGLT2i treatment and ketone supplementation on cardiac metabolism remains unclear.
Dr. Paddy Barrett
DECEMBER 30, 2024
When medical interventions are being evaluated for cost-effectiveness, the benchmark for one additional quality year of life is $50,000. This is known as a QALY or Quality Adjusted Life Year. If the intervention costs less than $50,000 per year to provide an additional quality year, it is considered cost-effective. Of course, this is a somewhat arbitrary figure, but we have to start somewhere.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD), an incurable genetic disorder that leads to kidney failure. The disease is caused by the intracellular entrapment of mutant UMOD in kidney epithelial cells, but the precise mechanisms mediating disrupted UMOD trafficking remain elusive.
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
ABSTRACT Introduction Intracardiac echocardiography (ICE) is an essential imaging modality for electrophysiology procedures, allowing intraprocedural monitoring, real-time catheter manipulation guidance, and visualization of complex anatomic structures. Four-dimentional (4D) ICE is the next stage in the evolution of the technology, permitting 360 rotation of the imaging plane, simultaneous multiplanar imaging, and volumetric acquisition, similar to transesophageal echocardiography (TEE).
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice. Sa-induced B10 cells drive antigen-specific vaccine suppression that affects both recalled and de novo developed B cells.
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
Key Question. Atrail electroanatomic voltage mapping (Atrial-EAVM) and late gadolinium enhancement imaging (Atrial-LGE) quantify the functional and anatomic extent of atrial fibrosis, a central component of atrial cardiomyopathy. We aimed to explore the relationships between, and outcomes from, these two contrasting measures. Key Finding. Atrial-EAVM and Atrial-LGE correlated with greatest agreement at high-fibrosis burdens.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Prostate cancer is the second leading cause of male cancer death in the U.S. Current immune checkpoint inhibitorbased immunotherapies have improved survival for many malignancies; however, they have failed to prolong survival for prostate cancer. Siglecs (sialic acidbinding immunoglobulin-like lectins) are expressed on immune cells and regulate their function.
European Journal of Heart Failure
DECEMBER 30, 2024
In-hospital course of patients with heart failure (HF) with improved ejection fraction (HFimpEF) in DELIVER. LVEF, left ventricular ejection fraction. Aims Patients with heart failure (HF) with improved ejection fraction (HFimpEF) may face residual risks of clinical events that are comparable to those experienced by patients with HF whose left ventricular ejection fraction (LVEF) has consistently been above 40%.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Effective antitumor T cell activity relies on the expression and MHC presentation of tumor neoantigens. Tumor cells can evade T cell detection by silencing the transcription of antigens or by altering MHC machinery, resulting in inadequate neoantigen-specific T cell activation. We identified the DNAprotein kinase inhibitor (DNA-PKi) NU7441 as a promising immunomodulator that reduced immunosuppressive proteins, while increasing MHC-I expression in a panel of human melanoma cell lines.
European Journal of Heart Failure
DECEMBER 30, 2024
Predictive margins plots illustrating the association between peak oxygen consumption (peakVO 2 ) and indexed left ventricular end-diastolic volume (iLVEDV) in the derivation and validation cohorts. HFpEF, heart failure with preserved ejection fraction. Abstract Aims Emerging evidence suggests that smaller left ventricular volumes may identify subjects with lower cardiorespiratory fitness.
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
BACKGROUND In type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODS Young adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTS Participants with T1D had significantly higher glomerular basement
European Journal of Heart Failure
DECEMBER 30, 2024
Aims Functional capacity provides important clinical information in patients with heart failure (HF) and reduced ejection fraction (HFrEF). The 6-min walk test (6MWT) is a simple and inexpensive tool for assessing functional capacity and risk. Although change in 6MWT is frequently used as a surrogate outcome in HF trials, the association with mortality is unclear.
Stroke Journal
DECEMBER 30, 2024
Stroke, Ahead of Print. Reperfusion injury (RI) refers to an array of detrimental cellular and biochemical processes that are widely believed to be triggered by reperfusion following focal cerebral ischemia and to contribute to infarct extension and poor outcome despite complete recanalization. Accordingly, it is widely recommended that therapies targeting RI be administered after recanalization.
European Journal of Heart Failure
DECEMBER 30, 2024
Abstract Aims In patients with degenerative mitral regurgitation (DMR), left ventricular (LV) dysfunction is associated with increased risk of heart failure and excess mortality. LV end-systolic diameter (LVESD) is an established trigger for intervention, yet recommended LVESD thresholds apply poorly to patients with small body size. Whether LV normalization to body surface area (BSA) may be used as a trigger for DMR correction is unknown.
Stroke Journal
DECEMBER 30, 2024
Stroke, Ahead of Print. BACKGROUND:Women experience more poststroke physical activity limitations, but sex differences in social activity participation, an important patient-reported outcome for stroke recovery, remain uncertain.METHODS:Incident stroke survivors aged 65 years were identified from the US NHATS (National Health and Aging Trends Study), 2011-2022.
European Journal of Heart Failure
DECEMBER 30, 2024
Main pathophysiological components influencing mortality in chronic Chagas cardiomyopathy. LV, left ventricular; PVC, premature ventricular contraction; VT, ventricular tachycardia. Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC), the most severe form of target organ involvement in Chagas disease, is characterized by a complex pathophysiology and a unique phenotype that differentiates it from other cardiomyopathies, hig
European Journal of Heart Failure
DECEMBER 30, 2024
In this study, 355 patients with dilated cardiomyopathy (DCM) and mildly reduced left ventricular ejection fraction (LVEF) were characterized using cardiovascular magnetic resonance (CMR), including feature-tracking to calculate left ventricular global longitudinal strain (LV GLS) and late gadolinium enhancement (LGE). Over long-term follow-up, LV GLS>15.4% was associated with a higher cumulative incidence of major heart failure (HF) events, whereas the presence LGE was associated with a high
European Journal of Heart Failure
DECEMBER 30, 2024
Findings of LVEF improvement, clinical outcomes, predictors and a predictive model comparing HFimpEF and persistent HFrEF in BIOSTAT-CHF and validated in the ASIAN-HF registry. Approximately 20-30% of patients with HFrEF improved within 1 year (HFimpEF) with better clinical outcomes. In addition, the predictive model with clinical predictors (absence of IHD and LBBB, smaller LVESD and LA diameter, and higher platelet count) could more accurately predict HFimpEF in patients with HFrEF and be easi
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