New Health Measures in CKD Management
HCPLive
DECEMBER 30, 2024
Panelists discuss the new health measures relevant to chronic kidney disease (CKD) management and their significance in improving patient care and outcomes.
Mon.Dec 30, 2024
105 
Lupus Patients See More Vascular Risk, but It's Modifiable
Med Page Today
DECEMBER 30, 2024
(MedPage Today) -- Atherosclerosis progression was more than twice as common in younger people with systemic lupus erythematosus (SLE) than in healthy controls in a prospective study from Greece, but the rate difference narrowed substantially with.
Prospective Improvements of Existing IgAN Therapies
HCPLive
DECEMBER 30, 2024
Panelists discuss how current treatments for IgA nephropathy often fall short in addressing the root cause, specifically abnormal IgA production and deposition, and highlight the consequences of prioritizing symptom management, such as proteinuria reduction, over targeting the diseases underlying pathology.
Epithelioid hemangioendothelioma prognosis and outcome: report of two challenging cases
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Epithelioid hemangioendothelioma (EHE) is an uncommon vascular malignancy characterized by an unpredictable clinical course and a high potential for recurrence and metastasis. The lack of standard treatment gu.
Allergy Year in Review: 2024
HCPLive
DECEMBER 30, 2024
The field of allergy medicine this year saw a variety of developments, including the FDA approvals of neffy and omalizumab as well as new data on immunotherapy.
The Real Value Of The Heart Health Formula.
Dr. Paddy Barrett
DECEMBER 30, 2024
When medical interventions are being evaluated for cost-effectiveness, the benchmark for one additional quality year of life is $50,000. This is known as a QALY or Quality Adjusted Life Year. If the intervention costs less than $50,000 per year to provide an additional quality year, it is considered cost-effective. Of course, this is a somewhat arbitrary figure, but we have to start somewhere.
Bronchial artery pseudoaneurysm presenting with hemoptysis and hemothorax after pulmonary lobectomy: a case report and literature review
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Bronchial artery pseudoaneurysm is a rare vascular disorder, and cases of bronchial pseudoaneurysms reported after lung surgery are even rarer. The number of reported cases is very limited due to the unclear p.
Sign up to get articles personalized to your interests!
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
More Trending
Preoperative D-dimer level predicts adverse events after coronary endarterectomy combined with coronary artery bypass grafting: a retrospective cohort study
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Little is known about the role of D-dimer (DD) on the prognosis of patients undergoing coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG).
The Top Imaging Trends of 2024
Cassling
DECEMBER 30, 2024
2024 was a year of innovation across the imaging spectrum. When we reviewed our top articles of the year, it became clear that what resonated more than anything else were in-depth looks at technology, the cost of that technology, and the myriad other innovations changing the clinical conversation. Here are the top articles of 2024.
Windsock mitral valve after prior aortic valve endocarditis
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
Windsock deformities, though rare, represent a severe form of valvular aneurysm distinguished by localized balloon-like protrusions of the leaflet body. Here, we present a compelling case of windsock mitral va.
Educational Resources on CKD and Type 2 Diabetes Management
HCPLive
DECEMBER 30, 2024
Panelists discuss how health care providers can effectively utilize white papers and other tools in practice, as well as additional resources available for further learning about chronic kidney disease (CKD) and type 2 diabetes management.
Determining influences of intraoperative s-ketamine on postoperative delirium and cognitive function: methodology is important
Journal of Cardiothoracic Surgery
DECEMBER 30, 2024
The letter to the editor was written in response to the recent article by Wang et al. The influence of low-dose s-ketamine on postoperative delirium and cognitive function in older adults undergoing thoracic.
Unmet Needs in Current IgAN Treatment
HCPLive
DECEMBER 30, 2024
Panelists discuss how the current treatment landscape for IgA nephropathy presents significant unmet needs, particularly in addressing the underlying causes of the disease and improving patient outcomes.
Mechanisms behind the high mortality rate in chronic Chagas cardiomyopathy: Unmasking a three‐headed monster
European Journal of Heart Failure
DECEMBER 30, 2024
Main pathophysiological components influencing mortality in chronic Chagas cardiomyopathy. LV, left ventricular; PVC, premature ventricular contraction; VT, ventricular tachycardia. Chagas disease is a neglected tropical disease caused by the parasite Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC), the most severe form of target organ involvement in Chagas disease, is characterized by a complex pathophysiology and a unique phenotype that differentiates it from other cardiomyopathies, hig
Syncope: Advances in Diagnosis and Treatment 2024
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
Vasovagal syncope advances in therapy. ABSTRACT Aim In light of many recent advances in the field of vasovagal syncope, a selective review has been undertaken of these developments. Methods Recent publications on the following topics were reviewed; understanding of vasovagal syncope pathophysiology, tilt-testing methodology and interpretation, drug, ablation and pacemaker therapy.
Heart failure with improved versus persistently reduced left ventricular ejection fraction: A comparison of the BIOSTAT‐CHF (European) study with the ASIAN‐HF registry
European Journal of Heart Failure
DECEMBER 30, 2024
Findings of LVEF improvement, clinical outcomes, predictors and a predictive model comparing HFimpEF and persistent HFrEF in BIOSTAT-CHF and validated in the ASIAN-HF registry. Approximately 20-30% of patients with HFrEF improved within 1 year (HFimpEF) with better clinical outcomes. In addition, the predictive model with clinical predictors (absence of IHD and LBBB, smaller LVESD and LA diameter, and higher platelet count) could more accurately predict HFimpEF in patients with HFrEF and be easi
Sex Differences in Participation Restriction in Social Activities Among Older Stroke Survivors: A Nationwide Study
Stroke Journal
DECEMBER 30, 2024
Stroke, Ahead of Print. BACKGROUND:Women experience more poststroke physical activity limitations, but sex differences in social activity participation, an important patient-reported outcome for stroke recovery, remain uncertain.METHODS:Incident stroke survivors aged 65 years were identified from the US NHATS (National Health and Aging Trends Study), 2011-2022.
Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Skeletal muscle relies on resident muscle stem cells (MuSCs) for growth and repair. Aging and muscle diseases impair MuSC function, leading to stem cell exhaustion and regenerative decline that contribute to the progressive loss of skeletal muscle mass and strength. In the absence of clinically available nutritional solutions specifically targeting MuSCs, we used a human myogenic progenitor high-content imaging screen of natural molecules from food to identify nicotinamide (NAM) and pyridoxine (
Preclinical Experience Using 4D Intracardiac Echocardiography to Guide Cardiac Electrophysiology Procedures
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
ABSTRACT Introduction Intracardiac echocardiography (ICE) is an essential imaging modality for electrophysiology procedures, allowing intraprocedural monitoring, real-time catheter manipulation guidance, and visualization of complex anatomic structures. Four-dimentional (4D) ICE is the next stage in the evolution of the technology, permitting 360 rotation of the imaging plane, simultaneous multiplanar imaging, and volumetric acquisition, similar to transesophageal echocardiography (TEE).
SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Previous studies highlight the potential for sodium-glucose cotransporter type 2 (SGLT2) inhibitors (SGLT2i) to exert cardioprotective effects in heart failure by increasing plasma ketones and shifting myocardial fuel utilization toward ketone oxidation. However, SGLT2i have multiple in vivo effects and the differential impact of SGLT2i treatment and ketone supplementation on cardiac metabolism remains unclear.
Quantification of atrial cardiomyopathy disease severity by electroanatomic voltage mapping and cardiac magnetic resonance imaging
Journal of Cardiovascular Electrophysiology
DECEMBER 30, 2024
Key Question. Atrail electroanatomic voltage mapping (Atrial-EAVM) and late gadolinium enhancement imaging (Atrial-LGE) quantify the functional and anatomic extent of atrial fibrosis, a central component of atrial cardiomyopathy. We aimed to explore the relationships between, and outcomes from, these two contrasting measures. Key Finding. Atrial-EAVM and Atrial-LGE correlated with greatest agreement at high-fibrosis burdens.
Disrupted uromodulin trafficking is rescued by targeting TMED cargo receptors
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human urine, play a critical role in the pathogenesis of kidney disease. Monoallelic mutations in the UMOD gene cause autosomal dominant tubulointerstitial kidney disease (ADTKD-UMOD), an incurable genetic disorder that leads to kidney failure. The disease is caused by the intracellular entrapment of mutant UMOD in kidney epithelial cells, but the precise mechanisms mediating disrupted UMOD trafficking remain elusive.
In‐hospital course of patients with heart failure with improved ejection fraction in the DELIVER trial
European Journal of Heart Failure
DECEMBER 30, 2024
In-hospital course of patients with heart failure (HF) with improved ejection fraction (HFimpEF) in DELIVER. LVEF, left ventricular ejection fraction. Aims Patients with heart failure (HF) with improved ejection fraction (HFimpEF) may face residual risks of clinical events that are comparable to those experienced by patients with HF whose left ventricular ejection fraction (LVEF) has consistently been above 40%.
Pathobiont-driven antibody sialylation through IL-10 undermines vaccination
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
The pathobiont Staphylococcus aureus (Sa) induces nonprotective antibody imprints that underlie ineffective staphylococcal vaccination. However, the mechanism by which Sa modifies antibody activity is not clear. Herein, we demonstrate that IL-10 is the decisive factor that abrogates antibody protection in mice. Sa-induced B10 cells drive antigen-specific vaccine suppression that affects both recalled and de novo developed B cells.
Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters
European Journal of Heart Failure
DECEMBER 30, 2024
Predictive margins plots illustrating the association between peak oxygen consumption (peakVO 2 ) and indexed left ventricular end-diastolic volume (iLVEDV) in the derivation and validation cohorts. HFpEF, heart failure with preserved ejection fraction. Abstract Aims Emerging evidence suggests that smaller left ventricular volumes may identify subjects with lower cardiorespiratory fitness.
Sialylated glycoproteins suppress immune cell killing by binding to Siglec-7 and Siglec-9 in prostate cancer
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Prostate cancer is the second leading cause of male cancer death in the U.S. Current immune checkpoint inhibitorbased immunotherapies have improved survival for many malignancies; however, they have failed to prolong survival for prostate cancer. Siglecs (sialic acidbinding immunoglobulin-like lectins) are expressed on immune cells and regulate their function.
Changes in 6‐min walk test is an independent predictor of death in chronic heart failure with reduced ejection fraction
European Journal of Heart Failure
DECEMBER 30, 2024
Aims Functional capacity provides important clinical information in patients with heart failure (HF) and reduced ejection fraction (HFrEF). The 6-min walk test (6MWT) is a simple and inexpensive tool for assessing functional capacity and risk. Although change in 6MWT is frequently used as a surrogate outcome in HF trials, the association with mortality is unclear.
DNA-PK inhibition enhances neoantigen diversity and increases T cell responses to immunoresistant tumors
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
Effective antitumor T cell activity relies on the expression and MHC presentation of tumor neoantigens. Tumor cells can evade T cell detection by silencing the transcription of antigens or by altering MHC machinery, resulting in inadequate neoantigen-specific T cell activation. We identified the DNAprotein kinase inhibitor (DNA-PKi) NU7441 as a promising immunomodulator that reduced immunosuppressive proteins, while increasing MHC-I expression in a panel of human melanoma cell lines.
Indexing left ventricular end‐systolic dimension to body size: Association with mortality in patients with degenerative mitral regurgitation
European Journal of Heart Failure
DECEMBER 30, 2024
Abstract Aims In patients with degenerative mitral regurgitation (DMR), left ventricular (LV) dysfunction is associated with increased risk of heart failure and excess mortality. LV end-systolic diameter (LVESD) is an established trigger for intervention, yet recommended LVESD thresholds apply poorly to patients with small body size. Whether LV normalization to body surface area (BSA) may be used as a trigger for DMR correction is unknown.
Attenuated kidney oxidative metabolism in young adults with type 1 diabetes
Journal of Clinical Investigation - Cardiology
DECEMBER 30, 2024
BACKGROUND In type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODS Young adults with T1D (n = 30) and healthy controls (HCs) (n = 20) underwent hyperinsulinemic-euglycemic clamp studies, MRI, 11C-acetate PET, kidney biopsies, single-cell RNA-Seq, and spatial metabolomics to assess this relationship.RESULTS Participants with T1D had significantly higher glomerular basement
Is Reperfusion Injury a Largely Intra-Ischemic Injury?
Stroke Journal
DECEMBER 30, 2024
Stroke, Ahead of Print. Reperfusion injury (RI) refers to an array of detrimental cellular and biochemical processes that are widely believed to be triggered by reperfusion following focal cerebral ischemia and to contribute to infarct extension and poor outcome despite complete recanalization. Accordingly, it is widely recommended that therapies targeting RI be administered after recanalization.
Precision prediction of heart failure events in patients with dilated cardiomyopathy and mildly reduced ejection fraction using multi‐parametric cardiovascular magnetic resonance
European Journal of Heart Failure
DECEMBER 30, 2024
In this study, 355 patients with dilated cardiomyopathy (DCM) and mildly reduced left ventricular ejection fraction (LVEF) were characterized using cardiovascular magnetic resonance (CMR), including feature-tracking to calculate left ventricular global longitudinal strain (LV GLS) and late gadolinium enhancement (LGE). Over long-term follow-up, LV GLS>15.4% was associated with a higher cumulative incidence of major heart failure (HF) events, whereas the presence LGE was associated with a high
Let's personalize your content