Tue.May 28, 2024

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Ep 195 Management of Subarachnoid Hemorrhage

ECG Cases

Once the diagnosis of nontraumatic subarachnoid hemorrhage (SAH) has been made, our job is not done. Mortality in SAH patients can be up to 30% even without neurological deficit. Paying attention to the time-sensitive details of ED management of SAH patients can have a significant impact on their outcome. In this second part of our 2-part podcast series on subarachnoid hemorrhage with Dr.

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Fatherhood's hidden heart health toll

Science Daily - Heart Disease

Heart disease is the leading cause of death among men, and being a father may put men at an even greater risk of poor heart health later in life, reports a new study. The study of 2,814 men between the ages of 45 and 84 found cardiovascular health in older age was worse for fathers compared to non-fathers. Study participants' heart health was rated based on their diet, physical activity, smoking habits, weight, blood pressure, and level of lipids and glucose in their blood.

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Fish Oil Benefits or Harms; Statins at Age 85+; Doc's Hunger Strike for Bed Space

Med Page Today

(MedPage Today) -- Whether fish oil supplements hurt or help may depend on the person's existing cardiovascular health. (BMJ Medicine) Statins were consistently associated with reduced cardiovascular risks for those older than 85 without excess.

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Heart Failure Patients Who Do Yoga Have Stronger Hearts and Can be More Active

DAIC

milla1cf Tue, 05/28/2024 - 07:00 May 28, 2024 — Yoga focused on breathing, meditation, and relaxation is linked with symptom improvement in patients with heart failure, according to research presented at Heart Failure 2024 , a scientific congress of the European Society of Cardiology (ESC). 1 “Patients who practiced yoga on top of taking their medications felt better, were able to do more, and had stronger hearts than those who only took drugs for their heart failure,” said study author Dr.

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Major Depressive Disorder Is the Most Observed Psychiatric Comorbidity in RA

HCPLive

As the severity of rheumatoid arthritis disease activity increases, so does the prevalence of depression, a new study found.

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WTBS 30 Lessons on Emergency Medicine Leadership: The Role of The Leader

ECG Cases

Dr. Howard Ovens reflects on the role of leader in the EM in this 2nd part of a 2-part Waiting to Be Seen blog series on EM leadership. He touches on mentoring, being committed, aligning with patients' interests, being a role model and a few quick takes on some controversial issues in EM. The post WTBS 30 Lessons on Emergency Medicine Leadership: The Role of The Leader appeared first on Emergency Medicine Cases.

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How Psoriatic Arthritis Presentation, Treatment Has Evolved

HCPLive

Benjamin J. Smith, DMSc, PA-C, discusses the importance of defining comorbidities in diagnosing PsA, as well as prescribing biologics.

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Optimizing Diabetes Therapies with New Classifications

HCPLive

Ji Hyun “CJ” Chun, MPAS, PA-C, BC-ADM, explains how the adoption of 5 new diabetes subtypes may foster precision care.

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Researchers have located the brain network responsible for stuttering

Science Daily - Stroke

An international research group succeeded in identifying the probable origin of stuttering in the brain.

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Alan Bonder, MD: Phase 2 Data for Combination Obeticholic Acid, Bezafibrate in PBC

HCPLive

Bonder explains key therapeutic targets in primary biliary cholangitis and why combination obeticholic acid and bezafibrate may be a promising option.

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Incidence of stroke, subsequent clinical outcomes and health care resource utilization in people with type 2 diabetes: a real-world database study in France: “INSIST” study

Cardiovascular Diabetology

People with type 2 diabetes (T2D) are at elevated risk of cardiovascular disease (CVD) including stroke, yet existing real-world evidence (RWE) on the clinical and economic burden of stroke in this population.

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FDA Approves First Interchangeable Biosimilar to Eculizumab for PNH and aHUS

HCPLive

The FDA approved eculizumab-aeeb (Bkemv) as an interchangeable biosimilar to eculizumab (Soliris) for treating PNH and aHUS, marking the agency’s 53rd biosimilar approval.

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Mount Sinai Heart president honored with international cardiology award

Becker's Hospital Review - Cardiology

Valentin Fuster, MD, PhD, president of Mount Sinai Heart and physician-in-chief of the Mount Sinai Hospital, was honored with the World Heart Federation's Lifetime Achievement Award for 2024.

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Zodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia

The New England Journal of Medicine

This phase 2b trial of a short interfering RNA that targets ANGPTL3 showed substantive dose-dependent lowering of triglyceride levels.

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Ixekizumab Significantly Improves Symptom Burden in PsA

HCPLive

After initiating treatment with ixekizumab, tender and swollen joint counts, pain, fatigue, and body surface area affected by psoriasis were significantly improved.

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Correlation between the triglyceride-glucose index and left ventricular global longitudinal strain in patients with chronic heart failure: a cross-sectional study

Cardiovascular Diabetology

Left ventricular global longitudinal strain (GLS) holds greater diagnostic and prognostic value than left ventricular ejection fraction (LVEF) in the heart failure (HF) patients. The triglyceride-glucose (TyG).

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MUIR: Plozasiran Reduces Triglyceride Levels in Mixed Hyperlipidemia

HCPLive

Phase 2b study results show that investigational plozasiran significantly reduced triglyceride-rich lipoproteins in patients with mixed hyperlipidemia.

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Comparison of triglyceride glucose index and modified triglyceride glucose indices in prediction of cardiovascular diseases in middle aged and older Chinese adults

Cardiovascular Diabetology

Triglyceride and glucose (TyG) index, a surrogate marker of insulin resistance, has been validated as a predictor of cardiovascular disease. However, effects of TyG-related indices combined with obesity marker.

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Anthony Lembo, MD: Exploring Probiotics for IBS Treatment

HCPLive

Lembo describes the potential of a multi-species synbiotic for the treatment of IBS based on findings from an exploratory study he presented at DDW.

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Inhibition of Slc39a14/Slc39a8 reduce vascular calcification via alleviating iron overload induced ferroptosis in vascular smooth muscle cells

Cardiovascular Diabetology

Vascular calcification (VC) is an independent risk factor for cardiovascular diseases. Recently, ferroptosis has been recognised as a novel therapeutic target for cardiovascular diseases. Although an associati.

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A distinct platelet differentiation pathway is involved in age-related thrombocytosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 29 May 2024; doi:10.1038/s41569-024-01043-9 Poscablo and colleagues identify a distinct haematopoietic platelet differentiation pathway that is enriched in ageing mice, which results in platelets that are hyper-reactive compared with canonical platelet populations.

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Uncommon presentations of type A quadricuspid aortic valve in the Septuagenarian

Journal of Cardiothoracic Surgery

Quadricuspid aortic valve (QAV) is a rare congenital anomaly characterized by the presence of four cusps instead of the usual three. It is estimated to occur in less than 0.05% of the population, with Type A (.

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Healthy Woman Survives Stroke After Running Tokyo Marathon

CTVS

CTVS patient and marathon runner, Alejandra Saitas, shared her stroke survival story with Nicole Villalpando from the Austin American Statesman in honor of Stroke Awareness Month to help educate others about the lesser-known symptoms she experienced that took her by surprise. You can read her story below or find it on the Austin American Statesman website here.

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Plozasiran Paves RNA Interference Path to Triglyceride Reduction

Med Page Today

(MedPage Today) -- The liver APOC3-targeted RNA interference agent plozasiran proved its triglyceride-lowering effects in people with mixed hyperlipidemia in the phase IIb MUIR trial. In such individuals, known to be at increased risk of atherosclerotic.

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From Marathon to Hospital: A Patient’s Unexpected Stroke Journey

CTVS

May is American Stroke Awareness Month. A stroke takes place when blood vessels that supply oxygen to the brain become blocked or rupture, resulting in damaged brain cells and potentially even permanent brain damage or death. Sadly, stroke continues to be one of the leading causes of death and disability in our country.

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Long-Term Outcomes for Patients Treated for Hypercortisolism

HCPLive

The panel concludes by discussing the long-term outcomes for patients treated for hypercortisolism, emphasizing the need for further studies and data, and sharing their final thoughts on the disease and its future management.

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Ep 195 ED Management of Spontaneous Subarachnoid Hemorrhage

ECG Cases

Once the diagnosis of nontraumatic subarachnoid hemorrhage (SAH) has been made, our job is not done. Mortality in SAH patients can be up to 30% even without neurological deficit. Paying attention to the time-sensitive details of ED management of SAH patients can have a significant impact on their outcome. In this second part of our 2-part podcast series on subarachnoid hemorrhage with Dr.

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Treat-to-Target Strategy Significantly Improves HRQoL in RA, Other Rheumatic Diseases

HCPLive

Among included RA studies, 83.3% showed significantly better clinical outcomes in patients managed with a T2T strategy compared with usual care.

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Emory AI better predicts success of heart transplants: Study

Becker's Hospital Review - Cardiology

Researchers at Atlanta-based Emory University developed artificial intelligence that they say improves the prediction of successful heart transplants by 10%.

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Relacorilant Meets Primary Endpoint in Phase 3 GRACE Trial for Hypercortisolism

HCPLive

Relacorilant achieves primary endpoint in phase 3 GRACE trial among patients with hypercortisolism and hyperglycemia, hypertension or both, with sNDA expected in Q3 2024.

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Retrograde cerebral perfusion reduces embolic and watershed lesions after acute type a aortic dissection repair with deep hypothermic circulatory arrest

Journal of Cardiothoracic Surgery

To assess whether retrograde cerebral perfusion reduces neurological injury and mortality in patients undergoing surgery for acute type A aortic dissection.

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Deepak Sambhara, MD: Impact of CRT on Aflibercept 8 mg Outcomes in DME

HCPLive

Deepak Sambhara, MD, describes the influence of baseline central retinal thickness on visual outcomes in a post-hoc analysis of the PHOTON study.

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High Throughput Plasma Proteomics and Risk of Heart Failure and Frailty in Late Life

JAMA Cardiology

The cohort study evaluates potential shared pathways between incident heart failure and frailty using large-scale proteomics among participants in the Atherosclerosis Risk In Communities Study.

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Choosing Between Medical and Surgical Options for Hypercortisolism

HCPLive

Medical professionals discuss their ideal patients for surgery, and who would be best suited for pharmacologic intervention.

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Exceptional Genetics, Generalizable Therapeutics, and Coronary Artery Disease

The New England Journal of Medicine

The increasingly widespread availability of genomic sequencing has enabled the identification of persons and families with uniquely favorable traits, including a very low incidence of clinical events. Such exceptional persons across diverse communities are playing an important role in the genesis of medicines for common cardiovascular diseases. The discovery of.

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Top stories: Drug-induced long QT syndrome

HeartRhythm

Drug-induced long QT syndrome and torsades de pointes (TdP) have gained the attention of drug-safety researchers and government regulators, resulting in 14 drugs being removed from the market and many others discarded during development. Yet this increased scrutiny has not prevented >100 QT-prolonging drugs from reaching the market. Clearly, the >200 QT-prolonging drugs now on the market have medical value.

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The Balance Between Honesty and Hope

JAMA Cardiology

This essay describes the author’s experience as the mother of a newborn with a severe illness and the importance of balancing honesty and hope in delivering news to patients.

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