Wed.May 22, 2024

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Brain Risks Drop When Diet Includes More Minimally Processed Foods

Med Page Today

(MedPage Today) -- A diet high in ultra-processed foods upped the risk of cognitive impairment or stroke, data from the prospective REGARDS study showed. However, risk of either cognitive decline or stroke fell for people who had higher intake.

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Handed this ECG from triage. What will you do?

Dr. Smith's ECG Blog

Written by Sean Trostel MD I returned to my desk after seeing a patient and saw this screening ECG sitting on my desk to be read. The patient was a man in his 80s with chief complaint listed as: "hyperglycemia, weakness, ground level fall." ECG #1 @ 15:30 What do you think? Slow, irregular rhythm - likely slow atrial fibrillation Very wide QRS measuring ~180 ms in some leads, not fitting LBBB morphology and wider than vast majority of LBBB No signs of OMI, no modified Sgarbossa criteria Peaked T

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GLP-1 Agonist Scripts Jumped 600% for Teens, Young Adults Since 2020

Med Page Today

(MedPage Today) -- The number of adolescents and young adults prescribed a glucagon-like peptide-1 (GLP-1) receptor agonist increased nearly 600% over the past few years, pharmacy data indicated. From 2020 to 2023, the number of individuals ages.

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Ultraprocessed Food Increase Cardiovascular Risk in Children, Study Finds

HCPLive

A recent study suggests that high ultraprocessed food consumption in preschool children is linked to increased cardiometabolic risk factors.

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Extreme temperatures may increase risk of stroke mortality, especially in low-income countries

Science Daily - Stroke

Extreme heat and extreme cold are both associated with increased risks of death from ischemic and hemorrhagic stroke, according to a new study. The researchers found that the link between extreme temperatures and stroke mortality was stronger in low-income countries than in high-income countries.

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FDA Grants Breakthrough Device Designation to Blood Test Measuring Lp(a)

HCPLive

Announced on May 22, 2024, the Roche Diagnostics Tina-quant® Lp(a) assay measures lipoprotein (a) in a person’s bloodstream to evaluate cardiovascular risk.

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Will FDA Advisors Look Past Hypoglycemia Risk With Once-Weekly Insulin?

Med Page Today

(MedPage Today) -- Concerns over hypoglycemia risk with an investigational once-weekly insulin product in patients with type 1 diabetes prompted the FDA to call an advisory committee together to weigh in on the matter. On Friday, the Endocrinologic.

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Signatures of heart attack

Science Daily - Heart Disease

Researchers have mapped the immune response in heart attacks and identified signatures that correlate with the clinical progression.

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High Yield Heart Health

Dr. Paddy Barrett

I want to give you the best opportunity to have optimal cardiovascular health. Most people want the highest-yield information to improve their heart health. Some people want the full masterclass, but most people just want the core content. The Heart Health Formula is the masterclass. And while it has EVERYTHING you need, it does take some time to get through it.

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LDL Cholesterol Lowering: Is There a Risk for Dementia and Hemorrhagic Stroke?

American College of Cardiology

Reduction in low-density lipoprotein cholesterol (LDL-C) levels has consistently demonstrated a reduced risk of atherosclerotic cardiovascular disease (ASCVD). There is extensive evidence from randomized trials that demonstrates the effectiveness of lipid-lowering agents in reducing ASCVD-related events.

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Animal models of Takotsubo syndrome: bridging the gap to the human condition

Frontiers in Cardiovascular Medicine

Modelling human diseases serves as a crucial tool to unveil underlying mechanisms and pathophysiology. Takotsubo syndrome (TS), an acute form of heart failure resembling myocardial infarction, manifests with reversible regional wall motion abnormalities (RWMA) of the ventricles. Despite its mortality and clinical similarity to myocardial infarction, TS aetiology remains elusive, with stress and catecholamines playing central roles.

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Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies

Cardiovascular Diabetology

Numerous meta-analyses have explored the association between the triglyceride-glucose (TyG) index and diverse health outcomes, yet the comprehensive assessment of the scope, validity, and quality of this evide.

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Oral JAK Inhibitors, Steroids Do Not Significantly Differ in Alopecia Hair Regrowth

HCPLive

A systematic review presented at AAPA 2024 showed insignificant differences in treatment outcomes between oral JAK inhibitors and oral steroids based on alopecia outcomes like SALT.

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Ticagrelor or Clopidogrel Monotherapy vs. DAPT After PCI

American College of Cardiology

What are the risks and benefits of ticagrelor monotherapy or clopidogrel monotherapy compared with standard dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI)?

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Does Early Rhythm Control for Atrial Fibrillation Reduce Dementia Risk in Patients with Prior Stroke?

NEJM Journal Watch - Cardiology

Observational data from South Korea show an association between early rhythm control and lower risk for dementia in stroke survivors.

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Caroline Sisson, MMS, PA-C: Updates in Pulmonary Function Testing

HCPLive

Sisson discusses the adoption of 2021 ATS / ERS guidelines, as well as the need for complementary testing and imagine to contextualize the full pulmonary patient.

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Link Between Clonal Hematopoiesis and Stroke in Carotid Stenosis

All About Cardiovascular System and Disorders

About a fifth of all ischemic strokes are attributed to embolization of ruptured atherosclerotic plaque from carotid arterial stenosis. But it has been difficult to predict which person with asymptomatic carotid artery stenosis is likely to progress to symptomatic carotid disease and stroke. Now there is evidence linking clonal hematopoiesis, carotid stenosis and stroke.

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Intestinal Ultrasound’s Value for Assessing Disease Activity in IBD, with Noa Krugliak Cleveland, MD

HCPLive

Krugliak Cleveland explains findings from research she presented at DDW comparing intestinal ultrasound and conventional approaches to disease monitoring in IBD.

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A Lifelike guided journey through the pathophysiology of pulmonary hypertension—from measured metabolites to the mechanism of action of drugs

Frontiers in Cardiovascular Medicine

IntroductionPulmonary hypertension (PH) is a pathological condition that affects approximately 1% of the population. The prognosis for many patients is poor, even after treatment. Our knowledge about the pathophysiological mechanisms that cause or are involved in the progression of PH is incomplete. Additionally, the mechanism of action of many drugs used to treat pulmonary hypertension, including sotatercept, requires elucidation.MethodsUsing our graph-powered knowledge mining software Lifelike

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Examining Results from VICTORION-INITIATE Trial

HCPLive

Michael Koren, MD, discusses the recently released results from the VICTORIAN-INITIATE (V-INITIATE) trial, which were presented at the 2024 American College of Cardiology (ACC) Annual Scientific Session in Atlanta.

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Cardiac Wire’s Top Six Takeaways from HRS 2024

CardiacWire

It might have been graduation time in many parts of Boston last weekend, but an electrophysiology family reunion was taking place in the city’s Seaport district, bringing the latest in EP science, technology, and patient care. We hope everyone who attended HRS 2024 had a blast, and we hope all of you enjoy these top-six takeaways from electrophysiology’s biggest weekend of the year.

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Examining Results from VICTORIAN-INITIATE Trial

HCPLive

Michael Koren, MD, discusses the recently released results from the VICTORIAN-INITIATE (V-INITIATE) trial, which were presented at the 2024 American College of Cardiology (ACC) Annual Scientific Session in Atlanta.

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Mortality Signal Emerges 2 Years After Valve-in-Valve TAVR for Failed SAVR

Med Page Today

(MedPage Today) -- For patients with failed bioprosthetic surgical valves, the choice of valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) carried upfront advantages, but was ultimately associated with a higher risk of late mortality.

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Other Notable Emerging Lipid-Lowering Treatments

HCPLive

Erin Michos, MD, highlights several notable emerging lipid-lowering treatments, including bempedoic acid, the ANGPTL3 inhibitor evinacumab, the MTP inhibitor lomitapide, the ApoB-100 inhibitor mipomersen, and the ApoC-III degradation molecules volanesorsen and olezarsen.

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Make the Diagnosis: No Symptoms, No Discomfort, No Worries?

Med Page Today

A 68-year-old man visited his doctor about a lesion that developed on his mouth over the prior 2 months. On examination, a large, purple papule was seen on his lateral tongue.

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Thinking About Endotypes when Managing Asthma

HCPLive

Medical experts discuss their approach to characterizing asthma, whether they employ a dichotomous classification based on eosinophilic (EOS) or non-eosinophilic driven inflammation, or consider multiple endotypes simultaneously.

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Voiant and Thirona Announce Commercial Partnership for Full Scope Services in Imaging-based Clinical Trials for Pulmonary Diseases

DAIC

milla1cf Wed, 05/22/2024 - 07:00 May 22, 2024 — Voiant (USA) and Thirona (The Netherlands) announced they have entered a global commercial partnership, combining Voiant's expertise in supporting clinical trials in pulmonary drug and treatment development with Thirona's expertise in advanced lung image analysis. Building further on several years of a fruitful cooperation, the two companies are now formally joining forces to provide full scope integral services for clinical trials with AI-powered

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Use of Oral Corticosteroids in Asthma

HCPLive

Sande Okelo, MD, explores the use of corticosteroids and the implications of their long-term use, taking into account the patient quality of life and other factors when determining which patients would derive significant benefit from corticosteroid treatment.

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Study Shows High Volume Exercise Unrelated to Progression of Coronary Artery Calcium

DAIC

milla1cf Wed, 05/22/2024 - 08:00 May 22, 2024 — New research from The Cooper Institute and partners at University of Texas (UT) Southwestern Medical Center, The University of Texas at Tyler and University of Alabama at Birmingham , shows that exercising, even at very high levels, is not related to the progression of coronary artery calcium (CAC), a marker of atherosclerotic cardiovascular disease.

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Top 10 Cardiac Diagnosis Trends in 2024

GEMMS

Advancements in medical technology have revolutionized the diagnosis and treatment of heart diseases, which pose critical chronic conditions that, if left unattended, can have fatal consequences. Through the utilization of early detection and screening technologies, healthcare startups are leading the way in developing predictive and analytical tools to accurately assess the risk of developing heart disorders.

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Early Serum Urate Level Improvement Linked with Response to Febuxostat in Males with Gout

HCPLive

These data may allow for improved identification of individuals with gout who may be likely to require escalation of their febuxostat dose to reach the serum urate target.

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Transcatheter-Based Intervention and Tetralogy of Fallot, Small Left Ventricle and Atrial Fibrillation (Afib), Aspirin Free Treatment Post-PCI

American College of Cardiology

In this week’s View, Dr. Eagle looks at transcatheter-based intervention for tetraology of Fallot. He then examines how a small left ventricle in patients with atrial fibrillation is associated with increased cardiovascular risk.

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Study Compares Benefits of Treating Inverse Psoriasis with IL-17, IL-23 Inhibitors

HCPLive

This retrospective, systematic review highlighted the lack of studies specifically addressing the needs of patients with inverse psoriasis.

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Femoropopliteal Pseudoaneurysms as a Complication of Self-expanding Nitinol Stent-fracture: A Brief Report and Review

The American Journal of Cardiology

Publication date: Available online 21 May 2024 Source: The American Journal of Cardiology Author(s): Kristopher Aten, Deitrich Gerlt, Zachary Rosol, Subhash Banerjee

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Andexanet for Factor Xa Inhibitor-Associated Intracerebral Hemorrhage

American College of Cardiology

What is the effect of andexanet alfa, a reversal agent for factor Xa inhibitors, on hematoma volume expansion in patients with intracerebral hemorrhage?

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Ali Rezaie, MD: Exploring a Palatable Approach to the Elemental Diet

HCPLive

Rezaie reviews findings from a prospective clinical trial of a novel palatable elemental diet, highlighting its 100% compliance rate and strong efficacy.

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Comparison of PolarX and the Arctic Front Cryoballoons for PVI in Patients With Symptomatic Paroxysmal AF

American College of Cardiology

The goal of the COMPARE CRYO trial was to evaluate two different cryoballoons during pulmonary vein isolation among patients undergoing ablation for symptomatic paroxysmal atrial fibrillation.