Mon.Jan 15, 2024

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Ultromics Announces Partnership to Expedite Development of Echo AI Algorithm for Early Detection of Cardiac Amyloidosis

DAIC

Image courtesy of Ultromics milla1cf Mon, 01/15/2024 - 12:54 January 15, 2024 — Ultromics , a patient outcomes-focused AI-driven health technology company with roots at the University of Oxford, UK, has entered into an agreement with Pfizer to support the validation and FDA clearance of its AI-based technology for the detection of cardiac amyloidosis.

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Erectile Dysfunction Drugs Plus Nitrates Still a Losing Combination, Study Shows

Med Page Today

(MedPage Today) -- As expected, men taking nitrates for stable coronary artery disease (CAD) fared poorly if they added certain erectile dysfunction (ED) drugs to their medicine cabinet, a Swedish population-based study found. Compared with nitrate.

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Cardiac Safety Research Consortium Announces Think Tank Program with FDA Regulators, Industry and Academia Focused on Cardiac Remote Monitoring Trials and AI

DAIC

A public-private partnership Think Tank, focused on leveraging remote monitoring for cardiac safety in clinical trials, has been announced by the Cardiac Safety Research Consortium, CSRC, to be held Feb. 29-Mar. 1, 2024 in San Diego, CA, and will include representatives from the FDA, academia and industry. Image courtesy: CSRC christine.book Mon, 01/15/2024 - 13:36 January 15, 2024 — A public-private partnership Think Tank, scheduled for Feb. 29-March 1, will be presented by the Cardiac Safety R

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Vigilant monitoring is needed to manage cardiac risks in patients using antipsychotics, doctors say

Science Daily - Heart Disease

The use of the antipsychotic drugs quetiapine and haloperidol is associated with an increased risk of ventricular arrhythmias and sudden cardiac death (SCD) caused by drug-induced QT prolongation, reports a new study. Caution is advised to manage cardiac risks in patients prescribed these medications, the authors of the study and an accompanying editorial say.

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Goldstein Selected to Help Lead Statewide Task Force Addressing Heart Disease and Stroke

DAIC

Larry Goldstein, M.D., chair of the University of Kentucky Department of Neurology. Photo by Shaun Ring. milla1cf Mon, 01/15/2024 - 12:47 January 15, 2024 — Larry Goldstein , M.D. , chair of the University of Kentucky Department of Neurology , has been selected to serve as co-chair of The Kentucky Heart Disease and Stroke Prevention (KHDSP) Task Force representing stroke systems of care across the state.

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Artificial Intelligence Closes Care Gaps in Diabetic Eye Exams

HCPLive

Autonomous AI increases diabetic eye exam completion rates in a diverse population of youth with diabetes.

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Toby Vincent Reaches 20 Years of Service Excellence

Cassling

As Director of Project Management at Cassling, Toby Vincent has seen more projects through to completion than maybe anyone. And it’s his perseverance and willingness to get every detail ironed out early on that has enabled him to achieve remarkable growth with Cassling over the past two decades. As Toby celebrates 20 years with the company, those who know him best were willing to share just what makes Toby such an indispensable part of our team.

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Erectile dysfunction medications may increase risk of death when combined with common chest pain medication

Medical Xpress - Cardiology

Phosphodiesterase type 5 inhibitors (PDE5i)—an erectile dysfunction drug sold under the names Viagra, Levitra, Cialis, and others—are a common medical treatment for erectile dysfunction (ED) in men with cardiovascular disease (CVD). However, a new Swedish study published in the Journal of the American College of Cardiology suggests that patients are at higher risk for morbidity and mortality over time when PDE5is and nitrate medication are both prescribed.

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Gout Linked to a Significantly Higher Likelihood of Migraines

HCPLive

Patients with gout had a 1.26-fold higher likelihood of experiencing migraines when compared with those without gout.

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Clinical predictors of left ventricular thrombus after myocardial infarction as detected by magnetic resonance imaging

Frontiers in Cardiovascular Medicine

Background The diagnosis of a left ventricular (LV) thrombus in patients with ST-segment elevation myocardial infarction (STEMI) remains challenging. The aim of the current study is to characterize clinical predictors for LV thrombus formation, as detected by cardiac magnetic resonance imaging (CMRI). Methods We retrospectively evaluated 337 consecutive STEMI patients.

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Patients with Gout Have Greater Risk of Benign Prostatic Hyperplasia

HCPLive

Benign prostatic hyperplasia was 1.13-fold higher in those with gout when compared with controls.

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3D in vitro human atherosclerosis model for high-throughput drug screening

Medical Xpress - Cardiology

A new 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials in a paper titled "Atherosclerotic three-layer nanomatrix vascular sheets for high-throughput therapeutic evaluation.

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Management and outcomes of spontaneous coronary artery dissection: a systematic review of the literature

Frontiers in Cardiovascular Medicine

Background Contemporary management of spontaneous coronary artery dissection (SCAD) is still controversial. This systematic review of the literature aims to explore outcomes in the patients treated with conservative management vs. invasive strategy. Methods The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed when we extensively searched three electronic databases: PubMed, ScienceDirect, and Web of Science, for studies that compared conservativ

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Noisy, low amplitude ECG in a patient with chest pain

Dr. Smith's ECG Blog

Written by Colin Jenkins. Colin is an emergency medicine resident beginning his critical care fellowship in the summer with a strong interest in the role of ECG in critical care and OMI. Edits by Willy Frick. A patient in their 40s with type 1 diabetes mellitus and hyperlipidemia presented to the emergency department with 5 days of “flu-like” illness.

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Long-term results of ablation index guided atrial fibrillation ablation: insights after 5+ years of follow-up from the MPH AF Ablation Registry

Frontiers in Cardiovascular Medicine

Background Catheter ablation (CA) for symptomatic atrial fibrillation (AF) offers the best outcomes for patients. Despite the benefits of CA, a significant proportion of patients suffer a recurrence; hence, there is scope to potentially improve outcomes through technical innovations such as ablation index (AI) guidance during AF ablation. We present real-world 5-year follow-up data of AI-guided pulmonary vein isolation.

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Roflumilast Foam Effective for Seborrheic Dermatitis Patients Inadequately Responding to Steroids

HCPLive

In this subgroup analysis data shown at Winter Clinical, findings indicated IGA success with topical roflumilast foam among seborrheic dermatitis patients.

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Results of the inoperable and operable with aortic valve endocarditis

Frontiers in Cardiovascular Medicine

Objectives To evaluate the results of the inoperable and operable with aortic valve endocarditis, focus on risk factors, significance, and management of destruction of the aortic annulus in aortic valve endocarditis. Methods The retrospective study was completed to investigate patients with aortic valve endocarditis undergoing cardiac surgery between January 2006 and November 2022 at our hospital.

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Common Screening Tool for Cognitive Impairment Falls Short in Diverse Populations

HCPLive

Data from a new study suggests the Montreal Cognitive Assessment cut points should be lowered for both English and Spanish screenings for more accurate cognitive impairment screenings.

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Gender disparities in patients undergoing extracorporeal cardiopulmonary resuscitation

Frontiers in Cardiovascular Medicine

Introduction The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in extracorporeal cardiopulmonary resuscitation (eCPR) has emerged as a treatment option for selected patients who are experiencing refractory cardiac arrest (CA). In the light of increasing availability, the analyses of outcome-relevant predisposing characteristics are of growing importance.

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SPONSORED CONTENT: Webinar on Applying SMART-CT Results to Daily Clinical Practice

DAIC

tim.hodson Mon, 01/15/2024 - 10:48 HeartFlow is offering a free webinar based on a recent study that measured the ability of the of its roadmap analysis to support CCTA reading efficiency, confidence and reproducibility (SMART-CT. The presenters are Michael Morris, MD , and Wesley O’Neal, MD. Morris is Director of Cardiac MR and Cardiac CT at Banner Health , Phoenix, Arizona, and O’Neal, is Director of Cardiac CT and Nuclear Cardiology at Cone Health , Greensboro, North Carolina.

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Cardiovascular health of offspring conceived by assisted reproduction technology: a comprehensive review

Frontiers in Cardiovascular Medicine

Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders.

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Iron-Whey-Protein Microspheres Could Improve Adherence to Oral Iron Therapy

HCPLive

Results of the PRECISION trial suggest use of iron-whey-protein microspheres could aid in improving adherence to oral iron therapy as well as staving off adverse GI events.

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ACC CardiaCast: Conversations with Critical Care Cardiologists: Creating Educational Spaces for the Critical Care Cardiology Community

American College of Cardiology

In this episode, Drs. Thachil and Sinha interview the co-directors and co-founders of the New York University (NYU) Langone Critical Care Cardiology Symposium, Drs. Carlos Alviar and James Horowitz.

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Cardiac dimensions and hemodynamics in healthy juvenile Landrace swine

Cardiovascular Ultrasound

Swine are frequently used as animal model for cardiovascular research, especially in terms of representativity of human anatomy and physiology. Reference values for the most common species used in research are.

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Clinical, Prognostic Factors Affecting Concurrent IgAN and Membranous Nephropathy Outcomes

HCPLive

Results of the retrospective study suggested blood pressure, serum IgA, potassium, and segmental glomerulosclerosis may be predictive of the rapid progression of renal endpoints in patients with concurrent IgAN and membranous nephropathy.

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What Is Minimally Invasive Coronary Artery Bypass Surgery?

MIBHS

Coronary artery bypass surgery (CABG) has been a cornerstone in the treatment of coronary artery disease (CAD), providing a lifeline for individuals with blocked or narrowed arteries. Traditionally, CABG involved a sternotomy, a procedure requiring a sizable incision through the chest, but the landscape of cardiac surgery has transformed the way we cure coronary artery disease.

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Vast Majority of Atopic Dermatitis Patients Show EASI Improvement with 4 Weeks of Roflumilast Cream

HCPLive

These data, presented at the Winter Clinical conference, showed that roflumilast cream 0.15% led to positive results for patients with eczema.

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Pathogenic Variants of Scavenger Receptor CD36 Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19)

Circulation

Circulation, Volume 149, Issue 3 , Page 270-273, January 16, 2024.

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Combined Erectile Dysfunction, Chest Pain Drug Use May Increase Mortality Risk

HCPLive

Prescribing phosphodiesterase type 5 inhibitors and nitrates together may increase the risk of morbidity and mortality for patients over time.

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International Collaboration Identifies Gene Linked to Congenital Heart Defect

Circulation

Circulation, Volume 149, Issue 3 , Page 267-269, January 16, 2024.

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Clinical Characteristics of Electrical Storm in Patients With Early Repolarization Syndrome

HeartRhythm

Early repolarization syndrome (ERS) is an idiopathic ventricular fibrillation (VF) associated with inferolateral J waves. While electrical storms (ES) in ERS is not rare, their characteristics and risk factors are not fully understood.

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Coronary Artery Calcification: Current Concepts and Clinical Implications

Circulation

Circulation, Volume 149, Issue 3 , Page 251-266, January 16, 2024. Coronary artery calcification (CAC) accompanies the development of advanced atherosclerosis. Its role in atherosclerosis holds great interest because the presence and burden of coronary calcification provide direct evidence of the presence and extent of coronary artery disease; furthermore, CAC predicts future events independently of concomitant conventional cardiovascular risk factors and to a greater extent than any other nonin

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Clinical Data with Dextromethorphan-bupropion

HCPLive

Dr Greg Mattingly reviews the results of GEMINI and ASCEND trials, which led to approval of dextromethorphan-bupropion.

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Optimal Minimal Stent Area and Impact of Stent Underexpansion in Left Main Up-Front 2-Stent Strategy

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Volume 17, Issue 1 , Page e013006, January 1, 2024. BACKGROUND:We previously reported the use of minimal stent area to predict angiographic in-stent restenosis after drug-eluting stent implantation for unprotected left main (LM) disease. We aimed to evaluate the optimal minimal stent area criteria for up-front LM 2-stenting based on long-term clinical outcomes.METHODS:We identified 292 consecutive patients with LM bifurcation stenosis who were treated u

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Impact of Absolute Myocardial Blood Flow Quantification on the Diagnostic Performance of PET-Based Perfusion Scans Using 82Rubidium

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Volume 17, Issue 1 , Page e016138, January 1, 2024. BACKGROUND:Guidelines propose the inclusion of quantitative measurements from82Rubidium positron emission tomography (RbPET) to discriminate obstructive coronary artery disease (CAD). However, the effect on diagnostic accuracy is unknown. The aim was to investigate the optimal RbPET reading algorithm for improved identification of obstructive CAD.METHODS:Prospectively enrolled patients (N=400) underwent RbPE

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Coronary Sinus Narrowing Improves Coronary Microcirculation Function in Patients With Refractory Angina: A Multicenter Prospective INROAD Study

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Volume 17, Issue 1 , Page e013481, January 1, 2024. BACKGROUND:The underlying mechanisms responsible for the clinical benefits following coronary sinus narrowing and pressure elevation remain unclear. The present study aims to investigate whether coronary sinus narrowing improves the indexes of coronary microcirculatory function.METHODS:Patients with refractory angina who had a clinical indication for reducer implantation underwent invasive physiologica

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Left Atrial Strain to Predict Postoperative Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Grafting

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Volume 17, Issue 1 , Page e015969, January 1, 2024. BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication after cardiac surgery being associated with poorer outcomes. Revealing before the operation of left atrial subtle structural/functional abnormalities may help to identify patients at increased risk of POAF.