Sun.Mar 16, 2025

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Development and validation of a machine learning model for online predicting the risk of in heart failure: based on the routine blood test and their derived parameters

Frontiers in Cardiovascular Medicine

BackgroundHeart failure (HF), a core component of cardiovascular diseases, is characterized by high morbidity and mortality worldwide. By collecting and analyzing routine blood data, machine learning models were built to identify the patterns of changes in blood indicators related to HF.MethodsWe conducted a statistical analysis of routine blood data from 226 patients who visited Zhejiang Provincial Hospital of Traditional Chinese Medicine (Hubin) between May 1, 2024, and June 30, 2024.

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Diabetes Dialogue: Impact of NovoCare Pharmacy, LillyDirect Self Pay on GLP-1 RA Access

HCPLive

In this episode, hosts discuss the impact of recently launched direct, cash pay options for people using semaglutide and tirzepatide.

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Mitochondria associated membranes in dilated cardiomyopathy: connecting pathogenesis and cellular dysfunction

Frontiers in Cardiovascular Medicine

Dilated cardiomyopathy (DCM) is a leading cause of heart failure, yet therapeutic options remain limited. While traditional research has focused on mechanisms such as energy deficits and calcium dysregulation, increasing evidence suggests that mitochondria-associated membranes (MAMs) could provide new insights into understanding and treating DCM. In this narrative review, we summarize the key role of MAMs, crucial endoplasmic reticulum (ER)-mitochondria interfaces, in regulating cellular process

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Constructive wallowing after a serious diagnosis

Heart Sisters

“There is one thing even worse than wallowing in despair – and that is NOT wallowing in it ” – Dr.

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Multiple coronary artery perforation as a fatal complication during the management of an undeflatable stent balloon: a case report

Frontiers in Cardiovascular Medicine

BackgroundAn undeflatable stent balloon following its inflation during percutaneous coronary intervention (PCI) is a rare and unpredictable complication that can lead to serious consequences. Currently, there is no standardized protocol for managing this issue.Case presentationAn 83-year-old man presented with chest pain. Coronary angiography showed a chronic total occlusion (CTO)-like lesion in the proximal left anterior descending coronary artery (LAD).

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Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study

Cardiovascular Diabetology

Metabolic syndrome (MetS) is a known contributor to increased cardiovascular risk and all-cause mortality. Recent literatures suggested that higher hemoglobin (Hb) levels were associated with Mets, left ventri.

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HCPLive 5 Stories in Under 5: Week of 03/09

HCPLive

An audio recap of the top 5 stories in healthcare news from the week of 03/09-03/16

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Determinants of left atrial reservoir strain and diagnostic potential for cardiac amyloidosis in pathological left ventricular hypertrophy

Cardiovascular Ultrasound

Left ventricular (LV) long-axis shortening at the cardiac base is a determinant of left atrial (LA) reservoir function. Cardiac amyloidosis (CA) is characteristic of amyloid deposition predominantly in the LV.

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Correction to: Tadalafil for Treatment of Combined Postcapillary and Precapillary Pulmonary Hypertension in Patients With Heart Failure and Preserved Ejection Fraction: A Randomized Controlled Phase 3 Study

Circulation

Circulation, Volume 151, Issue 11 , Page e763-e763, March 18, 2025.

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The Vestigial Fold in Humans: Characterization of a Potential Novel Target for Selective Cardiac Sympathetic Denervation

HeartRhythm

The vestigial fold is an epicardial structure related to the posterior hilum of the heart, containing the remnant of the left superior vena cava. It is the superior continuation of the ligament/vein of Marshall. While neural structures along the human ligament/vein of Marshall have been characterized, those within the human vestigial fold remain unexplored.

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Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy

Circulation

Circulation, Volume 151, Issue 11 , Page e762-e762, March 18, 2025.

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Attitudinal Anatomy

HeartRhythm

I am writing with regard to the recent article How to best describe the location of the substrates for abnormal cardiac rhythms by Anderson et al1 and the accompanying Note from the Editors.2 I have been a committed user of the anatomic terminology championed by Anderson et al since first learning of the 1999 consensus statement on cardiac nomenclature3 despite the more common use of the attitudinally inappropriate terms among colleagues.

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The Role of Race in Cardiovascular Disease Risk Prediction

Circulation

Circulation, Volume 151, Issue 11 , Page 741-743, March 18, 2025.

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Fractionation of Nanosecond Pulsed Electric Fields Lowers Lethal Dose by Enhancing Cardiomyocyte Membrane Permeability

HeartRhythm

Nanosecond pulsed electric fields (nsPEF) are a promising method for cardiac Pulsed Field Ablation, currently in early clinical trials. However, effective ablation often requires high voltages, more pulses, and higher frequencies, which can raise tissue temperatures due to Joule heating. Fractionated pulse delivery can help mitigate thermal effects and potentially evoke electrosensitization, increasing cell damage.

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The Mysterious Masks of Hypercholesterolemia: A Unique Clinical Case

Circulation

Circulation, Volume 151, Issue 11 , Page 799-803, March 18, 2025.

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Comparison of the characteristics between machine learning and deep learning algorithms for ablation site classification in a novel cloud-based system

HeartRhythm

CARTONET is a cloud-based system for the analysis of ablation procedures using the CARTO system. The current CARTONET R14 model employs deep learning, but its accuracy and positive predictive value (PPV) remain under-evaluated.

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A Young Man With Syncope: What Is the Diagnosis?

Circulation

Circulation, Volume 151, Issue 11 , Page 804-806, March 18, 2025.

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Modified electrocardiogram using only limb leads to record V1 and V6: a simplified approach for left bundle branch area pacing follow-up

HeartRhythm

Left bundle branch area pacing (LBBAP) is being increasingly adopted.1,2 A 12-lead ECG is necessary for evaluating conduction system capture, particularly through the assessment of R-wave peak time in V6 (V6RWPT) and the V6-V1 interpeak interval,3 but is not always available and is time-consuming. Two small studies totaling 30 patients reported placement of the arm electrodes in the V1 position and the leg electrodes in the V6 position using a device programmer, with recording of only pseudo-V1

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Response by Chan et al to Letters Regarding Article, “Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest”

Circulation

Circulation, Volume 151, Issue 11 , Page e714-e715, March 18, 2025.

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Non-linear Relationship and Predictive Value of Systemic Immune-Inflammation Index for Atrial Fibrillation Recurrence After Catheter Ablation in Hypertensive Patients

HeartRhythm

Atrial fibrillation (AF) is a prevalent arrhythmia in hypertensive patients and significantly increases mortality. Chronic inflammation plays a critical role in the pathophysiology of AF.

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Letter by Shang et al Regarding Article, “Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest”

Circulation

Circulation, Volume 151, Issue 11 , Page e712-e713, March 18, 2025.

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Heterogeneity in clinical judgment of septal lead position and capture type in left bundle branch area pacing

HeartRhythm

Determining capture type and septal lead location during left bundle branch area pacing (LBBAP) relies on criteria obtained during implantation. However, during follow-up, the interpretation of left bundle branch (LBB) capture largely depends on QRS morphology, which is not so straightforward in LBBAP.

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Letter by Tamirisa et al Regarding Article, “Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest”

Circulation

Circulation, Volume 151, Issue 11 , Page e710-e711, March 18, 2025.

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Attitudinally Appropriate Nomenclature

HeartRhythm

We thank Dr LaPage for his letter, and we are encouraged to learn that he has been a committed user of the attitudinally appropriate nomenclature since the turn of the century. As he rightly comments, it will take time to shift to the correct terms. We agree with him that, in the interim, it will be necessary to use a fused terminology. In that regard, we have no problem with the use of terms such as right lateral or left lateral.