Mon.Jan 27, 2025

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Heart disease remains leading cause of death as key health risk factors continue to rise

American Heart News - Heart News

Highlights: According to the American Heart Association's 2025 Heart Disease and Stroke Statistics Update, heart disease remains the leading cause of death in the U.S. While medical advances have helped more people live longer with cardiovascular.

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15 hospitals chosen for heart failure education program

Becker's Hospital Review - Cardiology

In partnership with Abbott, the American Heart Association has launched a $3 million initiative to address knowledge gaps found within heart failure treatment education that may be contributing to cardiovascular care disparities.

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Heart disease remains leading cause of death as key health risk factors continue to rise

Science Daily - Heart Disease

Heart disease remains the leading cause of death in the U.S.

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Man on carnivore diet develops yellowish nodules on his hands, feet and elbows

Medical Xpress - Cardiology

A trio of cardiologists, two at Tampa General Hospital and the third at the University of Texas' MD Anderson Cancer Center, have reported an incident of an adult man developing yellowish nodules on his hands, feet and elbows after adopting a carnivore diet.

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Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01126-1 In this Review, Fabiani and colleagues summarize the management of anthracycline cardiotoxicity, including mechanisms, classification, risk stratification, prevention, diagnosis and treatment. The authors also discuss permissive treatment strategies and the use of cardioprotective drugs.

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High-Quality Diet, Physical Activity Could Help Reduce MASLD and MetALD Risk

HCPLive

Greater levels of physical activity and higher diet quality were linked to a reduced risk of MASLD, MetALD, and compensated advanced chronic liver disease.

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2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Circulation

Circulation, Ahead of Print. BACKGROUND:The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health.

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Can sleep position affect your heart and brain health?

Medical Xpress - Cardiology

There's no question about whether sleep is important for heart and brain health. Study after study has shown that it is.

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Clinicians Challenge USPSTF Iron Deficiency Screening Recommendations in Pregnancy

HCPLive

Peter Kranke, MD, MBA, MME, and colleagues call for clarifications to the August 2024 recommendations with more real-world considerations.

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The molecular structure of LDL has finally been elucidated

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01128-z Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time.

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Relationship Between RNF213 p.R4810K and Echocardiographic Findings in Patients with Cerebrovascular Diseases: A Multicenter Prospective Cohort Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundRING finger protein 213 (RNF213) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Recent evidence suggests its potential association with extracranial cardiovascular diseases, including pulmonary hypertension. We hypothesized that insidious abnormal cardiac functions are detected inRNF213p.R4810K carriers with cerebrovascular diseases.Methods and ResultsWe invest

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Mechanical AVR Associated With Significant Survival Benefit Vs. Bioprosthetic AVR in Patients ≤60 Years

American College of Cardiology

Mechanical surgical aortic valve replacement (AVR) was associated with lower all-cause mortality in patients 60 years old compared with bioprosthetic AVR, according to a study on the longitudinal survival difference among more than 100,000 patients presented at the Society of Thoracic Surgeons (STS) Annual Meeting.

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Fibromyalgia Common in People With IBD

HCPLive

People with inflammatory bowel disease and FM tended to have a higher disease duration and reported higher rates of fatigue and lower QoL.

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GLP-1s are reshaping cardiovascular care: Cedars-Sinai

Becker's Hospital Review - Cardiology

Cedars-Sinai experts are advocating for patients to have access to GLP-1 medications such as semaglutide as a key component to caring for and preventing cardiovascular disease.

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Race-Neutral Approach to Pulmonary Function Testing with Meredith McCormack, MD, and Loretta Que, MD

HCPLive

This months Lungcast features a discussion on pulmonary function tests and the controversial practice of using race-based normal values.

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Colchicine in acute coronary syndromes: the present and the possible future

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01124-3 Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization. We discuss major clinical trials and guidelines on the use of colchicine in patients with coronary syndromes, especially acute coronary syndromes, in whom results have been conflicting.

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Efruxifermin Reverses MASH Compensated Cirrhosis in Phase 2b SYMMETRY Study

HCPLive

Preliminary topline week 96 results showed statistically significant reversal of MASH compensated cirrhosis with efruxifermin in complete and ITT analyses.

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Vasoactive Medications In Acute Heart Failure: What We Do Not Know Could Indeed Hurt Us

Circulation: Cardiovascular Quality & Outcomes

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print.

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Food Allergies Have No Negative Effect on School Performance

HCPLive

A study found no negative effect of food allergies on school performance, with better grades in severe cases, but results were nonsignificant in sibling analyses.

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Potential therapeutic target for atherosclerosis found in insulin-like growth factor-binding protein 6

Medical Xpress - Cardiology

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target for suppressing endothelial inflammation and atherosclerosis. Their work was published in Nature Cardiovascular Research.

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FDA Accepts New Drug Application for Bumetanide Nasal Spray

HCPLive

The regulatory agency has assigned a Prescription Drug User Fee Act (PDUFA) target action date of September 14, 2025.

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A Multicenter, Randomized, Active-Controlled Study to Evaluate the Safety and Tolerability of Two Blinded Doses of Abelacimab Compared With Open-Label Rivaroxaban in Patients With Atrial Fibrillation

American College of Cardiology

The goal of AZALEA-TIMI 71, a phase 2 trial, was to compare the safety and efficacy of 2 doses of abelacimab compared with rivaroxaban among patients with atrial fibrillation (AF) and a moderatehigh risk of stroke.

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Enobosarm Protects Lean Mass in Topline Phase 2b Trial Results

HCPLive

Enobosarm led to a statistically significant benefit in the protection of lean mass in patients with overweight or obesity receiving semaglutide.

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Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01129-y A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.

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FDA Approves Label Update for Viloxazine Capsules to Include New Lactation Data

HCPLive

The FDA approved updated labeling for viloxazine ER capsules as an ADHD treatment, adding lactation data and details on serotonin 5-HT2C receptor activity.

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ACC CardiaCast: PulseCheck: Palliative Care in Patients with Heart Disease: Training Trainees in Skilled Communication

American College of Cardiology

In this episode, Andrea Price, MS, AACC hosts S. Ian Borison, DO, Michelle Churchill, CRNP, ACHPN, and Jill Steiner, MD, MS, FACC to share insights to training our trainees in skilled serious illness communication.

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Exploring the Pediatric Patient and Caregiver Journey

HCPLive

Panelists discuss the patient journey for patients with pediatric atopic dermatitis (AD) and their caregivers, from initial presentation through to diagnosis, emphasizing the challenges and emotional aspects that families experience throughout the process.

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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThere is a wellestablished relationship between liver conditions and cardiovascular diseases. However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level.MethodsIn this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK B

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Multidisciplinary Approaches to Atopic Dermatitis Management and Referrals

HCPLive

Panelists discuss the diagnosis and referral process for patients with pediatric atopic dermatitis (AD) from both the dermatologist and allergy perspectives, including when a child should be referred to a dermatologist and the importance of a multidisciplinary approach to care for optimizing AD management, with insights on the roles each team member plays in patient care.

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Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia With the Circadian Rhythm of Myocardial Infarction

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThe circadian rhythm of myocardial infarction (MI) in patients with obstructive sleep apnea (OSA) remains disputable and no studies have directly evaluated the relationship between nocturnal hypoxemia and the circadian rhythm of MI. The aim of the current study was to evaluate the association of OSA and nocturnal hypoxemia with MI onset during the night.MethodsPatients with MI in the OSAacute coronary syndrome (ACS) project (NC

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Occasional High Fat, High Protein Foods Linked to Decreased Atopic Dermatitis Risk

HCPLive

The findings in this analysis indicate that a balanced, infrequent diet including proteins and fats may provide individuals with a potential strategy for management of atopic dermatitis.

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State of the Heart (and Brain) in 2025

Circulation

Circulation, Ahead of Print.

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Implementing New IgAN Therapies Into Clinical Practice

HCPLive

Panelists discuss how the approval of atrasentan is expected to significantly affect the treatment landscape for IgA nephropathy by offering a novel therapeutic option that targets both proteinuria reduction and the underlying immune dysregulation associated with the disease.

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Mechanical valves offer superior long-term survival for aortic valve replacement patients aged <60, study finds

Medical Xpress - Cardiology

A study presented at the 2025 Society of Thoracic Surgeons (STS) Annual Meeting reveals that mechanical aortic valve replacements (AVRs) provide significant long-term survival benefits for patients aged 60 and younger compared to bioprosthetic valves.

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Shared Decision-Making for IgAN Treatment

HCPLive

Panelists discuss how shared decision-making is essential when considering emerging treatments vs established therapies, emphasizing the importance of aligning treatment choices with patient preferences and values to enhance adherence and optimize outcomes in IgA nephropathy care.

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Surgeon preference factors into survival outcomes analyses for multi- and single-arterial bypass grafting

Medical Xpress - Cardiology

In patients undergoing coronary artery bypass grafting (CABG), a novel analysis evaluating surgeon preference for multi- versus single-arterial grafting may help explain the differing results between prior retrospective analyses and randomized controlled trials regarding long-term survival.

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Cryoballoon Pulmonary Vein Isolation: Double Stack vs. Standard Ablation

HeartRhythm

The results of pulmonary vein isolation are limited by arrhythmia recurrence, which is most often due to a failure to effectuate a durable contiguous circumferential transmural lesion around the pulmonary vein (PV) ostia. We postulated that enhancing the index ablation line through use of multiple cryoballoon diameters would be superior to standard ablation with bonus freeze.