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Highlights: According to the American Heart Association's 2025 Heart Disease and Stroke Statistics Update, heart disease remains the leading cause of death in the U.S. While medical advances have helped more people live longer with cardiovascular.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01126-1 In this Review, Fabiani and colleagues summarize the management of anthracycline cardiotoxicity, including mechanisms, classification, risk stratification, prevention, diagnosis and treatment. The authors also discuss permissive treatment strategies and the use of cardioprotective drugs.
Circulation, Ahead of Print. BACKGROUND:The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01128-z Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time.
Mechanical surgical aortic valve replacement (AVR) was associated with lower all-cause mortality in patients 60 years old compared with bioprosthetic AVR, according to a study on the longitudinal survival difference among more than 100,000 patients presented at the Society of Thoracic Surgeons (STS) Annual Meeting.
In partnership with Abbott, the American Heart Association has launched a $3 million initiative to address knowledge gaps found within heart failure treatment education that may be contributing to cardiovascular care disparities.
Preliminary topline week 96 results showed statistically significant reversal of MASH compensated cirrhosis with efruxifermin in complete and ITT analyses.
Cedars-Sinai experts are advocating for patients to have access to GLP-1 medications such as semaglutide as a key component to caring for and preventing cardiovascular disease.
A study found no negative effect of food allergies on school performance, with better grades in severe cases, but results were nonsignificant in sibling analyses.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01124-3 Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization. We discuss major clinical trials and guidelines on the use of colchicine in patients with coronary syndromes, especially acute coronary syndromes, in whom results have been conflicting.
The goal of AZALEA-TIMI 71, a phase 2 trial, was to compare the safety and efficacy of 2 doses of abelacimab compared with rivaroxaban among patients with atrial fibrillation (AF) and a moderatehigh risk of stroke.
Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01129-y A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.
In this episode, Andrea Price, MS, AACC hosts S. Ian Borison, DO, Michelle Churchill, CRNP, ACHPN, and Jill Steiner, MD, MS, FACC to share insights to training our trainees in skilled serious illness communication.
The FDA approved updated labeling for viloxazine ER capsules as an ADHD treatment, adding lactation data and details on serotonin 5-HT2C receptor activity.
The results of pulmonary vein isolation are limited by arrhythmia recurrence, which is most often due to a failure to effectuate a durable contiguous circumferential transmural lesion around the pulmonary vein (PV) ostia. We postulated that enhancing the index ablation line through use of multiple cryoballoon diameters would be superior to standard ablation with bonus freeze.
Greater levels of physical activity and higher diet quality were linked to a reduced risk of MASLD, MetALD, and compensated advanced chronic liver disease.
Abstract Aims A single-blinded, multicentred randomized controlled trial (RCT) was employed to examine the effectiveness of a 3-month telephone follow-up, a telephone follow-up with education before discharge, or education only before discharge on the heart failure (HF) knowledge, HF self-care management, and health-related quality of life (HR-QoL) in patients with HF by a nurse specialist.
Panelists discuss the patient journey for patients with pediatric atopic dermatitis (AD) and their caregivers, from initial presentation through to diagnosis, emphasizing the challenges and emotional aspects that families experience throughout the process.
Abstract Aim (i) To explore the attitudes of patients with atrial fibrillation (AF) towards oral anti-coagulation (OAC) for stroke prevention post-intracerebral haemorrhage (ICH) and (ii) to explore factors that influence patients decision-making process for stroke prevention. Methods and results Patients with documented diagnosis of AF and history of a non-traumatic ICH, who were eligible for long-term OAC were recruited from eight hospitals in England, using purposive sampling.
Panelists discuss the diagnosis and referral process for patients with pediatric atopic dermatitis (AD) from both the dermatologist and allergy perspectives, including when a child should be referred to a dermatologist and the importance of a multidisciplinary approach to care for optimizing AD management, with insights on the roles each team member plays in patient care.
Abstract Aims Fluid accumulation is associated with poor outcomes in patients with heart failure (HF). After acute HF, HF nurses provide home care suggestions based on oedema status assessed at outpatient clinics. However, the pattern of serial oedema changes and their associations with patient outcomes are unknown. We investigated the trajectories of bioimpedance analysis (BIA)derived oedema index (EI) changes following acute HF and their prognostic value.
The findings in this analysis indicate that a balanced, infrequent diet including proteins and fats may provide individuals with a potential strategy for management of atopic dermatitis.
Patients with documented spontaneous type-1 (Spont-Type-I) Brugada syndrome (BrS) electrocardiogram (ECG) are at higher risk of arrhythmias compared to those with a drug-induced type I (DI-Type-I) ECG (1). However, the incidence of Spont-Type-I in patients initially diagnosed with a drug test may be underestimated due to the fluctuating nature of ECG (2).
Panelists discuss how the approval of atrasentan is expected to significantly affect the treatment landscape for IgA nephropathy by offering a novel therapeutic option that targets both proteinuria reduction and the underlying immune dysregulation associated with the disease.
Design of the ALLEVIATE-HF study with schematic of win ratio analysis stratified by left ventricular ejection fraction (LVEF) 50% versus LVEF <50%. , change; 6MWT, 6-min walk test; BNP, B-type natriuretic peptide; CIED, cardiac implantable electronic device; CV, cardiovascular; EQ-5D, EuroQol 5-Dimension Questionnaire; HF, heart failure; ICM, insertable cardiac monitor; KCCQ, Kansas City Cardiomyopathy Questionnaire; NT-proBNP: N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart A
Panelists discuss how shared decision-making is essential when considering emerging treatments vs established therapies, emphasizing the importance of aligning treatment choices with patient preferences and values to enhance adherence and optimize outcomes in IgA nephropathy care.
Journal of the American Heart Association, Ahead of Print. BackgroundThere is a wellestablished relationship between liver conditions and cardiovascular diseases. However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level.MethodsIn this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK B
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