Mon.Jan 27, 2025

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Heart disease remains leading cause of death as key health risk factors continue to rise

American Heart News - Heart News

Highlights: According to the American Heart Association's 2025 Heart Disease and Stroke Statistics Update, heart disease remains the leading cause of death in the U.S. While medical advances have helped more people live longer with cardiovascular.

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Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01126-1 In this Review, Fabiani and colleagues summarize the management of anthracycline cardiotoxicity, including mechanisms, classification, risk stratification, prevention, diagnosis and treatment. The authors also discuss permissive treatment strategies and the use of cardioprotective drugs.

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2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association

Circulation

Circulation, Ahead of Print. BACKGROUND:The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health.

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Heart disease remains leading cause of death as key health risk factors continue to rise

Science Daily - Heart Disease

Heart disease remains the leading cause of death in the U.S.

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Cyclophosphamide, Calcineurin Inhibitors Equally Effective for Pediatric Nephrotic Syndrome

HCPLive

Results showed no difference in time to relapse, relapse rates, subsequent immunosuppression use, or kidney function between the medications.

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The molecular structure of LDL has finally been elucidated

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01128-z Two studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time.

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Mechanical AVR Associated With Significant Survival Benefit Vs. Bioprosthetic AVR in Patients ≤60 Years

American College of Cardiology

Mechanical surgical aortic valve replacement (AVR) was associated with lower all-cause mortality in patients 60 years old compared with bioprosthetic AVR, according to a study on the longitudinal survival difference among more than 100,000 patients presented at the Society of Thoracic Surgeons (STS) Annual Meeting.

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15 hospitals chosen for heart failure education program

Becker's Hospital Review - Cardiology

In partnership with Abbott, the American Heart Association has launched a $3 million initiative to address knowledge gaps found within heart failure treatment education that may be contributing to cardiovascular care disparities.

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Efruxifermin Reverses MASH Compensated Cirrhosis in Phase 2b SYMMETRY Study

HCPLive

Preliminary topline week 96 results showed statistically significant reversal of MASH compensated cirrhosis with efruxifermin in complete and ITT analyses.

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GLP-1s are reshaping cardiovascular care: Cedars-Sinai

Becker's Hospital Review - Cardiology

Cedars-Sinai experts are advocating for patients to have access to GLP-1 medications such as semaglutide as a key component to caring for and preventing cardiovascular disease.

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Food Allergies Have No Negative Effect on School Performance

HCPLive

A study found no negative effect of food allergies on school performance, with better grades in severe cases, but results were nonsignificant in sibling analyses.

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Colchicine in acute coronary syndromes: the present and the possible future

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01124-3 Inflammation is a new therapeutic target for the prevention of cardiovascular disease. Colchicine is a potential cheap option to target inflammation and prevent atherosclerotic plaque destabilization. We discuss major clinical trials and guidelines on the use of colchicine in patients with coronary syndromes, especially acute coronary syndromes, in whom results have been conflicting.

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FDA Accepts New Drug Application for Bumetanide Nasal Spray

HCPLive

The regulatory agency has assigned a Prescription Drug User Fee Act (PDUFA) target action date of September 14, 2025.

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A Multicenter, Randomized, Active-Controlled Study to Evaluate the Safety and Tolerability of Two Blinded Doses of Abelacimab Compared With Open-Label Rivaroxaban in Patients With Atrial Fibrillation

American College of Cardiology

The goal of AZALEA-TIMI 71, a phase 2 trial, was to compare the safety and efficacy of 2 doses of abelacimab compared with rivaroxaban among patients with atrial fibrillation (AF) and a moderatehigh risk of stroke.

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Race-Neutral Approach to Pulmonary Function Testing with Meredith McCormack, MD, and Loretta Que, MD

HCPLive

This months Lungcast features a discussion on pulmonary function tests and the controversial practice of using race-based normal values.

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Obesity alters cholesterol homeostasis in regulatory T cells of visceral adipose tissue

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 January 2025; doi:10.1038/s41569-025-01129-y A new study shows how obesity can disrupt a cholesterol metabolism in a particular subset of metabolically protective regulatory T cells in visceral adipose tissue.

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Enobosarm Protects Lean Mass in Topline Phase 2b Trial Results

HCPLive

Enobosarm led to a statistically significant benefit in the protection of lean mass in patients with overweight or obesity receiving semaglutide.

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ACC CardiaCast: PulseCheck: Palliative Care in Patients with Heart Disease: Training Trainees in Skilled Communication

American College of Cardiology

In this episode, Andrea Price, MS, AACC hosts S. Ian Borison, DO, Michelle Churchill, CRNP, ACHPN, and Jill Steiner, MD, MS, FACC to share insights to training our trainees in skilled serious illness communication.

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Clinicians Challenge USPSTF Iron Deficiency Screening Recommendations in Pregnancy

HCPLive

Peter Kranke, MD, MBA, MME, and colleagues call for clarifications to the August 2024 recommendations with more real-world considerations.

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State of the Heart (and Brain) in 2025

Circulation

Circulation, Ahead of Print.

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FDA Approves Label Update for Viloxazine Capsules to Include New Lactation Data

HCPLive

The FDA approved updated labeling for viloxazine ER capsules as an ADHD treatment, adding lactation data and details on serotonin 5-HT2C receptor activity.

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Cryoballoon Pulmonary Vein Isolation: Double Stack vs. Standard Ablation

HeartRhythm

The results of pulmonary vein isolation are limited by arrhythmia recurrence, which is most often due to a failure to effectuate a durable contiguous circumferential transmural lesion around the pulmonary vein (PV) ostia. We postulated that enhancing the index ablation line through use of multiple cryoballoon diameters would be superior to standard ablation with bonus freeze.

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High-Quality Diet, Physical Activity Could Help Reduce MASLD and MetALD Risk

HCPLive

Greater levels of physical activity and higher diet quality were linked to a reduced risk of MASLD, MetALD, and compensated advanced chronic liver disease.

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Effectiveness of a multicentre randomized controlled trial with three different nurse-led intervention management programmes for patients with heart failure: the main results of the MEETinCY study

European Journal of Cardiovascular Nursing

Abstract Aims A single-blinded, multicentred randomized controlled trial (RCT) was employed to examine the effectiveness of a 3-month telephone follow-up, a telephone follow-up with education before discharge, or education only before discharge on the heart failure (HF) knowledge, HF self-care management, and health-related quality of life (HR-QoL) in patients with HF by a nurse specialist.

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Exploring the Pediatric Patient and Caregiver Journey

HCPLive

Panelists discuss the patient journey for patients with pediatric atopic dermatitis (AD) and their caregivers, from initial presentation through to diagnosis, emphasizing the challenges and emotional aspects that families experience throughout the process.

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Patients’ views on stroke prevention for atrial fibrillation after an intracerebral haemorrhage: a qualitative study

European Journal of Cardiovascular Nursing

Abstract Aim (i) To explore the attitudes of patients with atrial fibrillation (AF) towards oral anti-coagulation (OAC) for stroke prevention post-intracerebral haemorrhage (ICH) and (ii) to explore factors that influence patients decision-making process for stroke prevention. Methods and results Patients with documented diagnosis of AF and history of a non-traumatic ICH, who were eligible for long-term OAC were recruited from eight hospitals in England, using purposive sampling.

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Multidisciplinary Approaches to Atopic Dermatitis Management and Referrals

HCPLive

Panelists discuss the diagnosis and referral process for patients with pediatric atopic dermatitis (AD) from both the dermatologist and allergy perspectives, including when a child should be referred to a dermatologist and the importance of a multidisciplinary approach to care for optimizing AD management, with insights on the roles each team member plays in patient care.

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Oedema index trajectories at heart failure nurse clinics over 6 months after acute heart failure predict patient outcomes: a retrospective cohort study

European Journal of Cardiovascular Nursing

Abstract Aims Fluid accumulation is associated with poor outcomes in patients with heart failure (HF). After acute HF, HF nurses provide home care suggestions based on oedema status assessed at outpatient clinics. However, the pattern of serial oedema changes and their associations with patient outcomes are unknown. We investigated the trajectories of bioimpedance analysis (BIA)derived oedema index (EI) changes following acute HF and their prognostic value.

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Occasional High Fat, High Protein Foods Linked to Decreased Atopic Dermatitis Risk

HCPLive

The findings in this analysis indicate that a balanced, infrequent diet including proteins and fats may provide individuals with a potential strategy for management of atopic dermatitis.

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Incidence of spontaneous Brugada ECG during follow-up in patients with drug-inducible pattern: a systematic review and meta-analysis

HeartRhythm

Patients with documented spontaneous type-1 (Spont-Type-I) Brugada syndrome (BrS) electrocardiogram (ECG) are at higher risk of arrhythmias compared to those with a drug-induced type I (DI-Type-I) ECG (1). However, the incidence of Spont-Type-I in patients initially diagnosed with a drug test may be underestimated due to the fluctuating nature of ECG (2).

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Implementing New IgAN Therapies Into Clinical Practice

HCPLive

Panelists discuss how the approval of atrasentan is expected to significantly affect the treatment landscape for IgA nephropathy by offering a novel therapeutic option that targets both proteinuria reduction and the underlying immune dysregulation associated with the disease.

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Continuous risk monitoring and management of heart failure: Rationale and design of the ALLEVIATE‐HF trial

European Journal of Heart Failure

Design of the ALLEVIATE-HF study with schematic of win ratio analysis stratified by left ventricular ejection fraction (LVEF) 50% versus LVEF <50%. , change; 6MWT, 6-min walk test; BNP, B-type natriuretic peptide; CIED, cardiac implantable electronic device; CV, cardiovascular; EQ-5D, EuroQol 5-Dimension Questionnaire; HF, heart failure; ICM, insertable cardiac monitor; KCCQ, Kansas City Cardiomyopathy Questionnaire; NT-proBNP: N-terminal pro-B-type natriuretic peptide; NYHA, New York Heart A

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Shared Decision-Making for IgAN Treatment

HCPLive

Panelists discuss how shared decision-making is essential when considering emerging treatments vs established therapies, emphasizing the importance of aligning treatment choices with patient preferences and values to enhance adherence and optimize outcomes in IgA nephropathy care.

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Trying to Reach Earlier: Noninvasive Imaging Findings Suggestive of Pulmonary Vascular Bed Changes in RING Finger Protein 213 p.R4810K Carriers

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Unraveling the Role of Myocardial Inflammation in ATTR-CM: A Targetable Mechanism?

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.

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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundThere is a wellestablished relationship between liver conditions and cardiovascular diseases. However, uncertainty persists regarding the contribution of liver fibrosis to major stroke types including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage at the population level.MethodsIn this large prospective cohort study, participants without previous stroke or coronary heart disease at baseline from the UK B

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Response by Aronson et al to Letter Regarding Article, “Enhancing Sweat Rate Using a Novel Device for the Treatment of Congestion in Heart Failure”

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.