Tue.Dec 10, 2024

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The Long COVID Patient Journey: A Complex and Uncertain Road

HCPLive

Navigating the long road of Long COVID requires more than just recovery from an infection, it demands specialized, multifaceted care to address persistent and often invisible neurological symptoms.

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New gene therapy reverses heart failure in large animal model

Medical Xpress - Cardiology

A new gene therapy can reverse the effects of heart failure and restore heart function in a large animal model. The therapy increases the amount of blood the heart can pump and dramatically improves survival, in what a paper describing the results calls "an unprecedented recovery of cardiac function.

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Adults aged 50 – 80 years Often Experience Loneliness, Social isolation

HCPLive

A recent study found that loneliness among adults aged 50 80 increased from 2018 to 2022 and dropped in 2023 and 2024.

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Scientists create first-ever blood-generating heart organoid

Medical Xpress - Cardiology

How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers are increasingly focusing on so-called organoids. These mini-organs, just a few millimeters in size, consist of groups of cells cultivated in the laboratory that can form organ-like structures.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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ACC ECDP for Diagnosis and Management of Myocarditis: Key Points

American College of Cardiology

The following are key points to remember from a 2024 American College of Cardiology (ACC) expert consensus decision pathway (ECDP) on strategies and criteria for the diagnosis and management of myocarditis.

Article 74
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Endothelial cells lining veins in lungs contribute to repair of blood vessels after injury, researchers discover

Medical Xpress - Cardiology

Veins in the lungs, or pulmonary veins, play a critical role not only in lung functioning but also in maintaining sufficient oxygen in tissues throughout the body. When a person sustains a pulmonary injury from an illness such as influenza or COVID, repair of blood vessels and the creation of new ones is vital to meet oxygen demands; however, research in these areas remains underexplored.

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PRICE-2: Hypovolaemic Phlebotomy Reduces Blood Transfusions After Liver Resection

HCPLive

Hypovolaemic phlebotomy reduced perioperative blood transfusion and improved operative conditions versus usual care in patients undergoing liver resection.

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State-of-the-Art Review Provides Strategies to Address Post-TAVR CDs and PPI

American College of Cardiology

A State-of-the-Art review published in JACC: Cardiovascular Interventions covers the epidemiology, clinical implications, risk factors and preventive strategies for new-onset conduction disturbances (CDs) and the need for permanent pacemaker implantation (PPI) after TAVR, which the authors note are a limitation of this therapy.

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Study Finds Bimekizumab Improves Genital, Scalp, Nail Psoriasis at 52-Weeks

HCPLive

These 52-week data highlight bimekizumabs efficacy in the scalp, nail, and genital region for psoriasis, along with Dermatology Life Quality Index (DLQI) improvements.

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ACC Issues Guidance For Diagnosing and Managing Myocarditis

American College of Cardiology

The ACC has issued guidance for the diagnosis and management of acute myocarditis in adult patients, delivering a streamlined decision-making framework that reflects recent advancements in clinical practice. The 2024 ACC Expert Consensus Decision Pathway (ECDP) on Strategies and Criteria for the Diagnosis and Management of Myocarditis, published in JACC, includes a 5-step care pathway, as well as recommendations for returning to strenuous physical activity and opportunities to close knowledge ga

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Study Highlights Advances in Understanding Risk, Prevention Measures for Atopic Dermatitis

HCPLive

Investigators looked at the effects of the exposome among patients with atopic dermatitis in order to better understand the influence of such elements as obesity and microorganisms.

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NT-proBNP and Troponin I in Cardiac Function

American College of Cardiology

How do N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) and I (hs-CTnI) predict long-term changes in cardiac structure and function in older adults?

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A forgotten job function of a Physician

Dr. S. Venkatesan MD

Visit the post for more.

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Reshaping the Use of Transcatheter Mitral Valve Repair in Patients With Heart Failure: the RESHAPE-HF2 Trial

American College of Cardiology

The RESHAPE-HF2 (Randomized Investigation of the MitraClip Device in Heart Failure: Second Trial in Patients With Clinically Significant Functional Mitral Regurgitation) trial was an international, open-label, multicenter, randomized controlled trial designed to provide additional information regarding the safety and effectiveness of M-TEER in this patient population.

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Danicopan a Safe Option for Breakthrough Bleeds in PNH

HCPLive

Danicopan add-on therapy demonstrated more favorable safety in the ALPHA trial than pegcetacoplan did in the PEGASUS trial in a new analysis.

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Poll: Mavacamten Use in Hypertrophic Cardiomyopathy

American College of Cardiology

A 63-year-old woman presents to the office for a second opinion on chronic chest pain and heart failure management. She has a medical history of mixed connective tissue disease, obstructive sleep apnea, hepatic steatosis, and long-standing hypertension diagnosed in her twenties.

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Bringing It All Back Home: Reshaping Ophthalmology's Clinic with Home OCT

HCPLive

The FDA-approved Scanly, a home-based OCT device, revolutionizes nAMD care by empowering patients with self-monitoring and enhancing personalized treatment.

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ACCEL Lite: Top Takeaways from 2024: Preventive Cardiology with Noel Bairey Merz, MD, FACC

American College of Cardiology

In this interview, Noel Bairey Merz, MD, FACC, and Alison L. Bailey, MD FACC, discuss the Top Preventive Cardiology Takeaways from 2024. Dr. Bairey Merz discusses the SELECT and SUMMIT trials, the impact of cardiac interventions on the carbon footprint, and more.

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Study Identifies Depression Treatment Gaps by Ethnicity, Age, Suicidal Risk

HCPLive

A study found only 38% of patients in the large US academic health system screened for depression received antidepressants or mental health referrals.

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Elevated Donor-Derived Cell-Free DNA Levels Are Associated With Reduced Myocardial Blood Flow but Not Angiographic Cardiac Allograft Vasculopathy: The EVIDENT Study

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Cardiac allograft vasculopathy (CAV) leads to impaired myocardial blood flow (MBF), increasing the risk of cardiovascular death or retransplant among heart transplantation (HT) recipients. Data on elevation in donor-derived cell-free DNA (dd-cfDNA) and CAV in the absence of rejection are mixed. We sought to test the hypothesis that CAV with reduced MBF (RMBF) is associated with elevated dd-cfDNA.METHODS:A retrospective review was conducted o

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First Line Care in CRC

HCPLive

Vivek Kaul, MD, discusses how primary care providers can effectively communicate the importance of colorectal cancer screening and guide patients in selecting the most suitable option, and the significant role of patient preferences and adherence in this decision-making process, while also addressing future innovations in screening methods.

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Machine Learning–Based Prediction for In‐Hospital Mortality After Acute Intracerebral Hemorrhage Using Real‐World Clinical and Image Data

Journal of the American Heart Association

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. BACKGROUNDMachine learning (ML) techniques are widely employed across various domains to achieve accurate predictions. This study assessed the effectiveness of ML in predicting early mortality risk among patients with acute intracerebral hemorrhage (ICH) in realworld settings.METHODS AND RESULTSMLbased models were developed to predict inhospital mortality in 527 patients with ICH using raw brain imaging data from

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Role of PCPs in Proactively Discussing CRC Screening With Patients

HCPLive

Vivek Kaul, MD, discusses how primary care providers can effectively communicate the importance of colorectal cancer screening and guide patients in selecting the most suitable option, and the significant role of patient preferences and adherence in this decision-making process, while also addressing future innovations in screening methods.

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Opportunistic assessment of aortic calcium predicts major adverse cardiovascular events

Medical Xpress - Cardiology

A fully automated algorithm to quantify aortic artery calcification (AAC) on computed tomography (CT) scans performed for other clinical purposes (opportunistic CT) can predict the risk for subsequent major adverse cardiovascular events (MACE), according to a study presented at the annual meeting of the Radiological Society of North America, held from Dec. 1 to 5 in Chicago.

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Marlyn Mayo, MD: Improving Pruritus Management in PBC Care

HCPLive

Mayo explains current shortcomings of pruritus care in PBC and what the additions of elafibranor, seladelpar, and other agents in development may offer.

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Culturally tailored patient education can improve heart health

Medical Xpress - Cardiology

For individuals from diverse backgrounds, managing heart disease effectively often depends on more than access to medical careit requires culturally relevant education. Recent research reveals that adapting patient education to match cultural contexts can significantly improve health outcomes, offering hope in the fight against the world's leading cause of death: cardiovascular disease.

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Pegcetacoplan Demonstrates Control in Both C5i-Experienced and Naïve PNH

HCPLive

Real-world clinical data from the Adelphi PNH II Disease Specific Programme were reported at ASH 2024.

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New study first step in understanding current practice patterns of treatment for sarcoidosis

Medical Xpress - Cardiology

Sarcoidosis is a multi-systemic disease of unknown etiology with a clinical presentation ranging from asymptomatic disease to organ failure. While some patients with sarcoidosis have spontaneous disease remission, others may require treatment for symptom management, organ involvement, and/or risk reduction of disease progression.

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Brugada Phenocopy Induced by BRAF and MEK Inhibitors in a Lung Adenocarcinoma

Journal of Cardiovascular Electrophysiology

ABSTRACT Management of patients with drug-induced type 1 Brugada pattern is complex and controversial. We report the case of a 66-year-old man affected by metastatic lung adenocarcinoma with type 1 Brugada phenocopy at electrocardiogram (ECG) after initiation of an oncological therapy with BRAF and MEK inhibitors.

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New study reveals social factors in pediatric cardiac arrest survival

Medical Xpress - Cardiology

The odds on whether a child survives a cardiac arrest may depend on where they live, according to a new study from the University of Missouri School of Medicine.

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Feasibility and Clinical Efficacy of Focal Pulsed Field Ablation in Patients With Non‐Pulmonary Vein Triggered Atrial Arrhythmia From the Superior Caval Vein

Journal of Cardiovascular Electrophysiology

This case series shows that focal monopolar PFA is feasible and safe for SVC isolation, with temporary phrenic nerve and sinus node injuries resolving during the procedure ABSTRACT Introduction In patients with atrial arrhythmias originating from the superior vena cava (SVC), the use of radiofrequency energy to isolate the SVC is associated with a significant risk of injury both to the phrenic nerve and the sinus node.

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Machine learning approach to identify phenotypes in patients with ischaemic heart failure with reduced ejection fraction

European Journal of Heart Failure

Summary of the machine learning clustering methodology and results of the study. Clusters are identified using machine learning approach in the learning set population evaluating specific combinations of multiple characteristics. Then identified clusters are predicted and tested in the learning set to evaluate their association with outcomes. Finally, the reproducibility of the results of cluster analysis is tested in an external cohort (validation set).

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Brachial‐Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low‐Risk Population

Journal of the American Heart Association

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. BackgroundRecent studies have suggested that increased brachialankle pulse wave velocity (baPWV) is a risk factor for diabetes. Exploring its relationship with insulin resistance is of interest, necessitating further studies across different sexes and age groups.Methods and ResultsThis cohort study involved 119 170 Korean adults with an average age of 39.8 years, none of whom had diabetes at baseline.

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An elderly woman with acute chest pain -- real or fake ST Elevation?

Dr. Smith's ECG Blog

Written by Pendell Meyers An elderly female called EMS with acute chest pain. Her vitals were within normal limits, and here is her EMS ECG: What do you think? Sinus rhythm, and QRS shows likely subtle RBBB, plus LAFB. While some STE could be expected by the large wide S wave in inferior leads, there is is STE and possibly HATW in II, III, and AVF, with reciprocal findings in aVL.

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Cardiology MCQ: Echo Basics

All About Cardiovascular System and Disorders

Doppler echocardiography is best done with the ultrasound beam: A. Parallel to the direction of blood flow B. Perpendicular to the direction of blood flow C. At an angle of 45 degrees to the direction of blood flow D. At an angle of 135 degrees to the direction of blood flow Correct answer: A. Parallel to the direction of blood flow While two dimensional imaging gives better view if the structure being imaged is perpendicular to the beam direction, Doppler estimates the velocity of moving red bl