Tue.Feb 20, 2024

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Dietary Thiamine Linked With Cognition

Med Page Today

(MedPage Today) -- Dietary thiamine (vitamin B1) intake was linked with cognition in older adults, a longitudinal analysis in China suggested. Over a median follow-up of 5.9 years, cognitive decline risk was minimal at dietary thiamine intake.

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Crisis Response Planning Can Reduce Suicide Risk for PTSD Among Veterans

HCPLive

A new study found crisis response planning for PTSD among military veterans had lower onset of suicidal ideation than veterans with self-guided safety planning.

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Tachycardia and hyperkalemia. What will happen after therapy with 1 gram of Ca gluconate and some bicarbonate?

Dr. Smith's ECG Blog

A 20-something type, 1 diabetic presented by EMS with altered mental status. Blood pressure was 117/80, pulse 161, Resp 45, SpO2 100 on oxygen. Here is the 12-lead ECG: Wide complex tachycardia What do you think? The providers thought that this wide QRS was purely due to (severe) hyperkalemia. They treated with 4 ampules (200 mL) of bicarb and 1 gram of calcium gluconate.

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Common hair loss and prostate drug may also cut heart disease risk in men and mice

Science Daily - Heart Disease

The drug finasteride, also known as Propecia or Proscar, treats male pattern baldness and enlarged prostate in millions of men worldwide. But a new study suggests the drug may also provide a surprising and life-saving benefit: lowering cholesterol and cutting the overall risk of cardiovascular disease.

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Hackensack Meridian Jersey Shore University Medical Center Providing State-of-the-Art Medtronic APOLLO Clinical Trial Treating Heart Valve Disease

DAIC

Pictured is the TMVR procedure milla1cf Tue, 02/20/2024 - 15:19 February 20, 2024 — As New Jersey’s leading provider of high-quality cardiac procedures and diagnostic testing and an academic institution, Hackensack Meridian Jersey Shore University Medical Center provides patients with state-of-the-art clinical trials in the management of heart valve disease and congestive heart failure.

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Sublingual Acute Stroke Neuroprotectant Dazzles in Phase III Trial

Med Page Today

(MedPage Today) -- For acute ischemic stroke within 48 hours of onset, the novel sublingual combination of edaravone (Radicava) with dexborneol appeared to dramatically improve functional outcomes in the phase III TASTE-SL trial from China. The.

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High platelet adrenergic activity and concomitant activation of the pituitary/medullar axis as alarming laboratory parameters in ACS survivors—the STRESS-AMI study

Frontiers in Cardiovascular Medicine

Introduction Kinetics of stress-related biological parameters were determined in acute coronary syndrome (ACS) patients undergoing complex cardiovascular rehabilitation. Methods We determined platelet functionality in the absence/presence of a selective alpha-2 adrenergic receptor inhibitor, atipemazole parallel with salivary cortisol levels at enrolment, and at 3- and 12-months follow-up in 75 ACS patients with percutaneous coronary intervention.

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Intravascular lithotripsy (IVL) enabled the percutaneous closure of a severely calcified paravalvular leak regurgitation following implantation of a self-expandable transcatheter aortic valve: a case report

Frontiers in Cardiovascular Medicine

Background Closure of paravalvular leak (PVL) regurgitation after self-expandable (SE) transcatheter aortic valve implantation (TAVI) may be more challenging than after balloon-expandable (BE) valve implantation. Case summary An 85-year-old woman suffering from long-standing atrial fibrillation and severe symptomatic aortic stenosis underwent SE TAVI (26 mm Evolut™ R®, Medtronic Inc., MN, USA).

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Black Youth, Females with Autism Have Greater Odds of Being Placed in Foster Care

HCPLive

Among youth with intellectual disabilities and autism, black children and females are more likely to be placed in foster care, a new study found.

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Vitamin once recommended for lowering cholesterol linked to CV disease

Becker's Hospital Review - Cardiology

Niacin , a common B vitamin once recommended to patients as a way to help lower cholesterol, has been linked to cardiovascular disease, Cleveland Clinic researchers announced Feb. 19.

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TAVR Pioneer Dies; Allograft Rejection Criteria Need Work; Overeating Protein & CVD

Med Page Today

(MedPage Today) -- Alain Cribier, MD, who performed the first transcatheter aortic valve replacement (TAVR) in 2002, died last week at age 79, the American College of Cardiology announced. Higher lipoprotein(a) went hand in hand with increased.

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Multidisciplinary management of cardiovascular disease in women: Delphi consensus

Frontiers in Cardiovascular Medicine

Background Current clinical guidelines on cardiovascular disease (CVD) do not specifically address the female population. The aim of this consensus is to know the opinion of a group of experts on the management of CVD in women. Methods Through a Delphi consensus, 31 experts in cardiology, 9 in gynecology and obstetrics, and 14 primary care physicians, showed their degree of agreement on 44 items on CVD in women divided into the following groups: (1) risk factors and prevention strategies; (2) di

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The Real Secret Of Why Blue Zones Have Exceptional Longevity

Dr. Paddy Barrett

Blue Zones are areas where an unusual percentage of the population live to exceptional old age. Think 100 to 110 plus. These Blue Zones have become incredibly popular topics and have been extensively covered in National Geographic and, more recently, in the Netflix documentary ‘Live To 100: Secrets of the Blue Zones’ The idea of Blue Zones is such a lovely idea.

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Patients with Fibromyalgia, Cognitive Dysfunction Report Significantly Reduced Quality of Life

HCPLive

Patients with fibromyalgia and cognitive dysfunction report feeling a loss of identify and impaired social interaction.

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Physical Activity, Sedentary Time, and Heart Failure Risk in Older Women

JAMA Cardiology

This cohort study investigates the association of accelerometer-measured physical activity and sedentary behavior with incident heart failure in older women.

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BSH 2023: collaboration, coordination and cooperation – 25in25

The British Journal of Cardiology

Multidisciplinary experts in heart failure care from across the UK and wider afield gathered for the recent 26th British Society of Heart Failure (BSH) annual meeting. This year’s programme sought to highlight how collaboration, coordination and cooperation would ultimately be vital for the delivery and success of the flagship 25in25 initiative. The meeting, held at the Queen Elizabeth II Centre, London, on 30th November and 1st December 2023, offered thought-provoking plenary sessions, focused

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Vericiguat Global Study in Subjects With Heart Failure With Reduced Ejection Fraction

American College of Cardiology

The goal of the VICTORIA trial was to evaluate vericiguat compared with placebo among patients with chronic heart failure (CHF) due to reduced ejection fraction (EF). Vericiguat increases soluble guanylate cyclase activity. By stimulating production of cyclic guanosine monophosphate, this may help to improve myocardial and vascular function.

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Interventions for Optimization of Guideline-Directed Medical Therapy

JAMA Cardiology

This study performs a systematic review to identify which types of system-level initiatives are most effective at improving guideline-directed medical therapy use among patients with heart failure with reduced ejection fraction.

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Early and late outcomes after minimally invasive direct coronary artery bypass vs. full sternotomy off-pump coronary artery bypass grafting

Frontiers in Cardiovascular Medicine

Objectives Minimally-invasive direct coronary artery bypass (MIDCAB) is a less-invasive alternative to full sternotomy off-pump coronary artery bypass (FS-OPCAB) revascularization of the left anterior descending artery (LAD). Some studies suggested that MIDCAB is associated with a greater risk of graft occlusion and repeat revascularization than FS-OPCAB LIMA-to-LAD grafting.

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Diabetes Dialogue: Time in Range, CGM Metrics for Predicting Outcomes in Diabetes

HCPLive

Viral Shah, MD, joins Diabetes Dialogue to discuss a recent study examining associations between time in range and other advanced CGM metrics with diabetic retinopathy and the implications for use in predicting other microvascular outcomes.

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High intensity interval training vs. moderate intensity continuous training on aerobic capacity and functional capacity in patients with heart failure: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Background Exercise training is commonly employed as a efficacious supplementary treatment for individuals suffering from heart failure, but the optimal exercise regimen is still controversial. The objective of the review was to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the exercise capacity, cardiac function, quality of life (QoL) and heart rate among patients with heart failure with reduced ejection fraction.

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Ixekizumab Demonstrates Consistent Safety Profile in Long-Term Analysis

HCPLive

Results revealed a consistent safety profile with low rates of discontinuation and no increase in adverse events with prolonged treatment exposure in patients treated with ixekizumab.

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Prognostic value of right ventricular free wall strain in patients with sepsis

Frontiers in Cardiovascular Medicine

Background Right ventricular systolic dysfunction (RVSD) in patients with sepsis is an area of growing interest, but its prognostic significance remains unclear and additional tools are needed to improve our understanding. Right ventricular free wall strain (RV-FWS) is a relatively new parameter to assess RV function. This study aimed to investigate the potential correlation between impaired RV-FWS and prognostic outcomes in patients with sepsis.

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An Update of Invasive Implanted Hemodynamic Monitoring in Patients With Fontan Circulation

American College of Cardiology

What are the safety, utility, and prognostic implications of invasive implanted hemodynamic monitoring (IHM) using the CardioMEMS™ HF System (Abbott Laboratories, Abbott Park, Illinois) in patients with Fontan circulation (FC)?

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Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Frontiers in Cardiovascular Medicine

Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions.

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PH Labeling of Liquid Synthetic Detergents May Improve Outcomes for Atopic Dermatitis

HCPLive

These findings, to be presented at AAAAI, highlight the importance of labeling different cleansing products used by consumers with eczema.

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Safety and possible anti-inflammatory effect of paclitaxel associated with LDL-like nanoparticles (LDE) in patients with chronic coronary artery disease: a double-blind, placebo-controlled pilot study

Frontiers in Cardiovascular Medicine

Introduction Studies in cholesterol-fed rabbits showed that anti-proliferative chemotherapeutic agents such as paclitaxel associated with solid lipid nanoparticles (LDE) have marked anti-atherosclerotic effects. In addition, association with LDE nearly abolishes paclitaxel toxicity. We investigated whether treatment with LDE-paclitaxel changes plaque progression by coronary CT angiography and is safe in patients with chronic coronary artery disease.

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Stellate Ganglion Block for Refractory Ventricular Arrhythmias

American College of Cardiology

What are the outcomes of the stellate ganglion block (SGB) with respect to recurrence of ventricular tachycardia/ventricular fibrillation (VT/VF)?

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Systems of care for ambulatory management of decompensated heart failure

Frontiers in Cardiovascular Medicine

Heart failure (HF) represents a worldwide health burden and the annual per patient cost to treat HF in the US is estimated at $24,383, with most of this expense driven by HF related hospitalizations. Decompensated HF is a leading cause for hospital admissions and is associated with an increased risk of subsequent morbidity and mortality. Many hospital admissions for decompensated HF are considered preventable with timely recognition and effective intervention.Systems of care that include interve

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Histological, Clinical Disease Activity Linked to Reduced Fertility in Women with IBD

HCPLive

Histological inflammation and clinical IBD activity were both associated with reduced fertility rates compared to histological remission and quiescent IBD.

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A novel hybrid machine learning model for auxiliary diagnosing myocardial ischemia

Frontiers in Cardiovascular Medicine

Introduction Accurate identification of the myocardial texture features of fat around the coronary artery on coronary computed tomography angiography (CCTA) images are crucial to improve clinical diagnostic efficiency of myocardial ischemia (MI). However, current coronary CT examination is difficult to recognize and segment the MI characteristics accurately during earlier period of inflammation.

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Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV

JAMA Cardiology

This substudy of a randomized clinical trial investigates the effects of pitavastatin on noncalcified coronary artery plaque using coronary computed tomography angiography and on inflammatory biomarkers as potential mechanisms for major adverse cardiovascular event prevention.

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HCC, Cirrhosis, HCV Genotype Negatively Impact Response to Salvage Therapy

HCPLive

Retreatment with voxilaprevir/velpatasvir/sofosbuvir in patients with HCV and prior DAA failure is effective but may be impacted by hepatocellular carcinoma, cirrhosis, and genotype 3.

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Why ICDs are less effective in Non Ischemic DCM ?

Dr. S. Venkatesan MD

We wish, our understanding about cardiac contractile physiology is deep and nearly complete. Heart is an irreversibly coupled electro-mechanical organ , right from the fetal days until the final heart beat. In myocardial pathology, the genesis and sustainability of ventricular arrhythmia are intricately related to the degree of LV dysfunction of any cause.

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Role of Small-Molecule Myosin Inhibitors in oHCM Treatment

HCPLive

James L. Januzzi, MD, provides insight on the pathophysiology of obstructive hypertrophic cardiomyopathy (oHCM) and comments on small-molecule myosin inhibitors as an emerging therapeutic option.

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Solving problems at the cath lab

The British Journal of Cardiology

Case description An 80-year-old woman with severe symptomatic aortic stenosis was scheduled for transcatheter aortic valve implantation (TAVI), following Heart Team decision. Pre-procedural computed tomography (CT) angiogram revealed an area-derived annulus diameter of 23.7 mm, and calcium spur which extended from.

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Engaging in More Healthy Lifestyle Behaviors May Reduce Risk of IBS

HCPLive

Adhering to a greater number of healthy lifestyle behaviors was linked to a decreased risk of incident IBS, suggesting lifestyle modifications may help prevent its onset.

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