Wed.Apr 24, 2024

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COVID Vaccine Study Finds Small Signal of Seizure Risk in Young Kids

Med Page Today

(MedPage Today) -- Only myocarditis/pericarditis and seizures occurred at higher rates in adolescents and children vaccinated for COVID-19 when compared with historical rates of those outcomes, according to an analysis of safety data from the FDA.

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Stroke incidence increases with diabetic retinopathy severity and macular edema in type 1 diabetes

Cardiovascular Diabetology

As the retina is suggested to mirror the brain, we hypothesized that diabetic retinopathy and macular edema are indicative of stroke risk in type 1 diabetes and sought to assess this association in individuals.

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Too Ill for Typical Transplants, Woman Gets a Pig Kidney and Heart Pump Instead

Med Page Today

(MedPage Today) -- A 54-year-old New Jersey woman has become the first-ever patient to undergo combined mechanical heart pump and gene-edited pig kidney transplant surgery, doctors announced. The patient, Lisa Pisano, had heart failure and end.

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New Study Reveals 65 and Older Population Lowered Blood Pressure, Cholesterol, and Weight Using Mobile Technology

DAIC

milla1cf Wed, 04/24/2024 - 19:01 April 24, 2024 — Hello Heart , a digital leader in preventive heart health, today announced results from its latest study observing the benefits of scalable, accessible digital health tools for a growing senior population. Presented at the American College of Cardiology 2024 Conference , study results showed an overwhelming majority of seniors aged 65 and over reduced their blood pressure (BP), cholesterol, and weight over a six month period while managing it

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Take the OMI Quiz and Test yourself against the Queen of Hearts

Dr. Smith's ECG Blog

Quiz The PM Cardio Queen of Hearts AI model for ECG interpretation from Powerful Medical is still in its early days. Do you think you can outperform the toddler version of the AI model? Version 2.0 will soon be available with four times the training data. The QoH groups ECGs into OMI and NOT OMI. Each category is subdivided into three levels of confidence.

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Innovative Aspiration Thrombectomy System by Expanse ICE Receives FDA Clearance for Vessels of the Peripheral Arterial and Venous Systems

DAIC

The ICE Aspiration System has received 510(k) clearance from the U.S. Food and Drug Administration (FDA). milla1cf Wed, 04/24/2024 - 19:03 April 24, 2024 — Expanse ICE announced today the ICE Aspiration System has received 510(k) clearance from the U.S. Food and Drug Administration. This announcement introduces a new and exciting player in the peripheral thrombectomy market.

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Audrey Chun, MD: Practical Recommendations to Give Older Patients for Exercise, Cognitive Health

HCPLive

In this interview, Chun discussed recommendations for internal medicine physicians to give older adults for slowing aging as well as evidence for statins.

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More Trending

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Good heart health in middle age may preserve brain function among Black women as they age

American Heart News - Heart News

Research Highlights: Middle-aged Black women with better heart health were less likely to show a decline in mental function compared with middle-aged Black women with worse heart health. In this study, heart health was unrelated to cognitive decline.

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Solving the riddle of the sphingolipids in coronary artery disease

Science Daily - Heart Disease

Investigators have uncovered a way to unleash in blood vessels the protective effects of a type of fat-related molecule known as a sphingolipid, suggesting a promising new strategy for the treatment of coronary artery disease.

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Associations between cardiometabolic indices and the risk of diabetic kidney disease in patients with type 2 diabetes

Cardiovascular Diabetology

This study was designed to assess the associations between emerging cardiometabolic indices—the atherogenic index of plasma (AIP), the stress hyperglycemia ratio (SHR), the triglyceride-glucose (TyG) index, an.

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Does Ejection Fraction Make or Break Afib Ablation in Heart Failure Patients?

Med Page Today

(MedPage Today) -- The efficacy of catheter ablation for heart failure (HF) patients with atrial fibrillation (Afib or AF) hinged on the phenotype of disease, researchers reported based on a meta-analysis. Compared with conventional rate or rhythm.

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AI Chatbots Show Promise as Patient Information Source for Glaucoma

HCPLive

Article intelligence chatbots, including ChatGPT and Bard, varied in accuracy, comprehensiveness, and readability on glaucoma questions adapted from patient brochures.

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Targeting immune cell recruitment in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01023-z In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.

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Patient Factors Predictive of Colchicine-Related Adverse Events in Gout

HCPLive

An observational study in the UK investigated the risk of adverse events related to colchicine prophylaxis after receiving allopurinol for gout.

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The MI Overdiagnosis Problem

CardiacWire

Over 750k people are diagnosed with myocardial infarction in the United States every year, and a new JAMA paper suggests that far more of those patients are incorrectly diagnosed than many might expect. Because of the clinical and medicolegal consequences of incorrectly discharging an MI patient, medical practices and clinical research have largely focused on addressing MI underdiagnosis.

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Phase 3 Data on Brilaroxazine for Schizophrenia with Larry Ereshefsky, PharmD

HCPLive

In an interview with HCPLive, Larry Ereshefsky, PharmD discussed the phase 3 RECOVER trial assessing brilaroxazine at 50 mg and 15 mg for acute schziophrenia.

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PRO/CON Debate: Atrial Fibrillation Ablation in Older Adults With Heart Failure and Reduced Ejection Fraction: Please Ablate

American College of Cardiology

The PRO portion of the currently featured PRO/CON debate between Dr. Brian Olshansky and Dr. John Mandrola presents a significant conundrum within the fields of electrophysiology and geriatric cardiology.

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Guselkumab, Risankizumab Boast Longest Drug Survival Among IL-17, IL-23 Inhibitors

HCPLive

A recent meta-analysis of more than 60 studies suggests guselkumab and risankizumab had the longest drug survival of IL-17 and IL-23 inhibitors for psoriasis.

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Inorganic Nitrates to Protect Against Contrast-Induced Nephropathy

American College of Cardiology

What is the efficacy of inorganic nitrate in the prevention of contrast-induced nephropathy (CIN) in high-risk patients presenting with acute coronary syndromes (ACS)?

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Calliditas Announces Open Label Extension Results for Budesonide (Nefecon) in IgA Nephropathy

HCPLive

Positive topline results showed treatment response consistent with NefIgArd findings, regardless of whether participants had previously been treated with Nefecon or placebo.

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Effects of the stress hyperglycemia ratio on long-term mortality in patients with triple-vessel disease and acute coronary syndrome

Cardiovascular Diabetology

Risk assessment for triple-vessel disease (TVD) remain challenging. Stress hyperglycemia represents the regulation of glucose metabolism in response to stress, and stress hyperglycemia ratio (SHR) is recently.

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2024 State of the Air: Record Highs in US Particle Pollution, with John Balmes, MD

HCPLive

Balmes discusses the latest annual State of the Air Report, which shows that 131 million Americans are living in areas with failing air quality grades.

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METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes

Journal of Cardiothoracic Surgery

Hypoxia/reoxygenation (H/R) induces cardiomyocyte ferroptosis, a core remodeling event in myocardial ischemia/reperfusion injury. Methyltransferase-like 14 (METTL14) emerges as a writer of N6-methyladenosine (.

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Caren Solomon, MD, MPH: Health Impacts of Climate Change, Health Care’s Contribution

HCPLive

Solomon explains how the health care system contributes to climate change and the direct health impacts seen as a result, based on her session at ACP.

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Characterisation of the octogenarians presenting to the diagnostic heart failure clinic: SHEAF registry

Open Heart

Introduction Heart failure (HF) incidence is increasing in older adults with high hospitalisation and mortality rates. Treatment is complicated by side effects and comorbidities. We investigated the clinical characteristics of octogenarians presenting to the HF clinic. Methods Data were collected on octogenarians (80–89 years) referred to the HF clinic in two periods.

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Abatacept Treatment May Slow Atherosclerosis Progression

HCPLive

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

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Aetiology and predictors of major bleeding events in patients with heart failure with reduced ejection fraction undergoing percutaneous coronary intervention

Open Heart

Objectives We sought to determine the relationship between the degree of left ventricular ejection fraction (LVEF) impairment and the frequency and type of bleeding events after percutaneous coronary intervention (PCI). Design This was an observational retrospective cohort analysis. Patients who underwent PCI from 2009 to 2017 were identified from our institutional National Cardiovascular Disease Registry (NCDR) CathPCI database.

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Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques

Frontiers in Cardiovascular Medicine

BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. It is known that extracellular vesicles (EVs) are important in intercellular communication in atherosclerotic disorders and carry many components of their cells of origin, including microRNAs (miRNAs).

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Surveillance Imaging and Management of Cardiac Sarcoidosis after Advanced Heart Failure Therapies

The American Journal of Cardiology

Publication date: Available online 23 April 2024 Source: The American Journal of Cardiology Author(s): Richa Gupta, Francisca Bermudez, Tania Vora, Navid Homayouni, Gaby Weissman, Ajay Kadakkal, Nana Afari-Armah, Sriram Rao, Phillip H. Lam, Maria E. Rodrigo, Mark Hofmeyer, Mrinalini Krishnan, Keki Balsara, Samer S. Najjar, Farooq H.

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Intervention for critical aortic stenosis in Hutchinson-Gilford progeria syndrome

Frontiers in Cardiovascular Medicine

Hutchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare genetic premature aging disease that is historically fatal in teenage years, secondary to severe accelerated atherosclerosis. The only approved treatment is the farnesyltransferase inhibitor lonafarnib, which improves vascular structure and function, extending average untreated lifespan of 14.5 years by 4.3 years (30%).

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Which coronary artery is called widow maker artery and why?

All About Cardiovascular System and Disorders

Coronary arteries are blood vessels supplying oxygenated blood to the heart muscle. LAD is short for left anterior descending coronary artery. LAD is usually the largest branch of the left main coronary artery which supplies the major portion of the left ventricle. Hence blockage of LAD can cause a major heart attack, which can sometimes be fatal. That is why LAD has been called a widow maker artery.

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Eagle’s Eye View: Cardiac Sarcoidosis, Ischemic Stroke in Women with Atrial Fibrillation, TAVR and Native Aortic Regurgitation

American College of Cardiology

In this week’s View, Dr. Eagle looks at a scientific statement from the American Heart Association on the diagnosis and management of cardiac sarcoidosis. He then examines the temporal trends and clinical implications of ischemic stroke in women with atrial fibrillation.

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Postoperative serum mir-28-5p level has predictive value for the prognosis after endovascular abdominal aortic aneurysm repair

Journal of Cardiothoracic Surgery

We explored the clinical significance of miR-28-5p pre- and post-endovascular abdominal aortic aneurysm repair (EVAR) in abdominal aortic aneurysm (AAA) patients.

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PRO/CON Debate: Atrial Fibrillation Ablation in Older Adults With Heart Failure and Reduced Ejection Fraction: I Politely Disagree

American College of Cardiology

The CON portion of the PRO/CON debate between Drs. Brian Olshansky and John Mandrola currently featured presents a conundrum within the fields of electrophysiology and geriatric cardiology.

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Proposed Golimumab Biosimilar AVT05 Meets Primary Endpoints in Moderate to Severe RA

HCPLive

At the end of the trial, the study met its primary outcome, indicating therapeutic equivalence between the biosimilar (AVT05) and reference golimumab.

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Good heart health in middle age may preserve brain function among Black women as they age

Science Daily - Heart Disease

Cognitive decline among Black women linked to poor heart health in middle age.

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Sleep of Psoriasis Patients Improves with Intensive Topical Treatment

HCPLive

A new study found intensive topical therapy improves deep sleep and REM sleep for patients with psoriasis and atopic dermatitis after 2 weeks.

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