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ObjectiveAortic dissection (AD) is a life-threatening cardiovascular emergency. Delayed diagnosis frequently leads to treatment delays, elevated mortality, and complications. This study investigates the factors contributing to the misdiagnosis of AD and proposes strategies for improving its early diagnosis.MethodsA retrospective analysis of 801 patients with AD identified 219 cases for inclusion, which were split into a training set (131 cases) and a validation set (88 cases).
(MedPage Today) -- People that required emergency department (ED) or acute hospital care for cannabis use may have an increased risk of a subsequent dementia diagnosis, a retrospective matched cohort study of 6 million people in Canada suggested.
Cardiovascular disease (CVD) remains a global health burden despite advances in prevention and treatment. Conventional biomarkers, while effective for a number of patient groups, fail to provide personalized diagnosis and prognosis, necessitating the exploration of novel markers. Advancements in sequencing technology have unveiled the role of cell-free DNA (cfDNA) as a reservoir of genetic information from all cells within the body, and associations between elevated cfDNA levels and CVD risk fac
New research suggests increasing the ratio of dietary potassium to sodium intake may be more effective for lowering blood pressure than simply reducing sodium intake.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Chronic heart failure (CHF) combined with depression represents a significant clinical challenge due to the mutual exacerbation of physical and psychological symptoms. This study investigated the therapeutic effects of Zhigancao decoction, a traditional Chinese medicine, in combination with conventional Western treatments in patients with CHF and depression.
Statement Highlights: While the strongest evidence exists that getting sufficient sleep (duration of sleep) is important for overall health , other components of sleep health, such as consistent bedtime, uninterrupted sleep, daytime functioning and.
BackgroundHeart failure (HF) is a multifaceted clinical condition, and our comprehension of its genetic pathogenesis continues to be significantly limited. Consequently, identifying specific genes for HF at the transcriptomic level may enhance early detection and allow for more targeted therapies for these individuals.MethodsHF datasets were acquired from the Gene Expression Omnibus (GEO) database (GSE57338), and through the application of bioinformatics and machine-learning algorithms.
BackgroundHeart failure (HF) is a multifaceted clinical condition, and our comprehension of its genetic pathogenesis continues to be significantly limited. Consequently, identifying specific genes for HF at the transcriptomic level may enhance early detection and allow for more targeted therapies for these individuals.MethodsHF datasets were acquired from the Gene Expression Omnibus (GEO) database (GSE57338), and through the application of bioinformatics and machine-learning algorithms.
Researchers from Rutgers Health and RWJBarnabas Health have developed an artificial intelligence (AI) technology that transforms basic electrocardiogram (ECG) readings of electrical activity into sophisticated heart motion signals normally obtained via echocardiogram, potentially improving how heart disease is detected and monitored.
(MedPage Today) -- Adding ezetimibe (Zetia) therapy to statins early after a heart attack improved outcomes, Swedish national records suggested. With statins almost universally used in this setting, people who also got upfront ezetimibe in the.
People with a certain heart valve abnormality are at increased risk of severe heart rhythm disorders, even after successful valve surgery. This is according to a new study, "Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery" from Karolinska Institutet and Karolinska University Hospital in Sweden, published in the European Heart Journal.
Healthy sleep includes multiple components, such as number of hours of sleep per night, how long it takes to fall asleep, daytime functioning and self-reported sleep satisfaction, and addressing these different dimensions of sleep may help to reduce cardiometabolic health and related risk factors, according to a new scientific statement.
New research from the University of Waterloo suggests increasing the ratio of dietary potassium to sodium intake may be more effective for lowering blood pressure than simply reducing sodium intake.
Patients who receive an add-on medication soon after a heart attack have a significantly better prognosis than those who receive it later, or not all, new research suggests.
The findings of a 2023 analysis by Sobhani et al. highlight the increasing prevalence of pregnancies among patients with Fontan circulation, a population characterized by significant obstetric risk. The physiological demands of pregnancy exacerbate the unique hemodynamic challenges inherent to Fontan physiology.
In children with septic shock, norepinephrine as the first vasoactive agent was linked to lower 30-day mortality than epinephrine, with no renal outcome difference.
Aspectos destacados de la declaracin: Si bien la evidencia ms slida indica que dormir lo suficiente (es decir, la duracin del sueo) es fundamental para la salud general , otros componentes del sueo, como mantener un horario constante para.
The associations between systemic inflammation biomarkers and cardiovascular disease (CVD) remain not well explored. This study aimed to investigate associations between different systemic inflammation biomark.
Amazon.com Inc. equipped some delivery vans in Europe with defibrillators to see if drivers crisscrossing residential areas could speed up aid to heart-attack victims.
Lafayette reflects on recent therapeutic advances in IgA nephropathy and looks ahead to other renal pipeline developments hes looking forward to in 2025.
A single infusion of VERVE-102 gene editing therapy achieved dose-dependent lowering in blood PCSK9 and LDL-C in initial results from the Heart-2 trial.
Healthy sleep includes multiple components, such as number of hours of sleep per night, how long it takes to fall asleep, daytime functioning and self-reported sleep satisfaction, and addressing these different dimensions of sleep may help to reduce cardiometabolic health and related risk factors, according to a new American Heart Association scientific statement published in Circulation: Cardiovascular Quality and Outcomes.
Complications during pregnancy (or adverse pregnancy outcomes), like gestational diabetes and newly developed high blood pressure, act as nature's stress test and may uncover an individual's risk for heart disease later in life, according to new research published in the Journal of the American College of Cardiology titled "Pre-Pregnancy Adiposity, Adverse Pregnancy Outcomes, and Cardiovascular Disease Risk in Midlife.
Circulation: Cardiovascular Interventions, Volume 18, Issue 4 , Page e014919, April 1, 2025. BACKGROUND:Previous studies have shown weak agreement between coronary physiology indices derived from continuous and bolus thermodilution, and suggested greater variability with bolus thermodilution measurements. This study aimed to evaluate the repeatability and correlation of continuous and bolus thermodilutionderived physiology indices in cardiac transplant recipients.METHODS:Paired fractional flow r
In this Q&A, Augsten discusses treatment strategies, challenges, and non-pharmacological interventions for schizophrenia and bipolar I disorder based on recent survey findings.
Transient receptor potential vanilloid 4 (TRPV4), a calcium (Ca2+) permeable channel, is upregulated during myocardial ischemia reperfusion (IR). Although TRPV4 inhibition shows cardioprotective effects, its impact on arrhythmogenesis remains unclear.
Circulation: Heart Failure, Ahead of Print. Acute right ventricular failure (ARVF) is commonly seen in the intensive care unit and constitutes a significant clinical challenge, with associated high in-hospital mortality. Recently, the treatment of ARVF has significantly changed, with the progressive implementation of mechanical circulatory support devices that now represent important tools for clinicians in treating this condition.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Poor sleep health is associated with cardiometabolic disease and related risk factors, including heart disease, stroke, elevated blood pressure and lipid levels, inflammation, glucose intolerance, obesity, physical inactivity, poor diet, unhealthy substance use, poor mental health, and increased all-cause and cardiovascular mortality, and is associated with social determinants of cardiovascular health and health disparities.
Black patients disproportionately started dialysis at low-quality facilities and were less likely to have nephrologists with high-quality primary facilities.
Circulation: Heart Failure, Ahead of Print. BACKGROUND:Hemodynamically guided management of patients with chronic heart failure (HF), using a remote, ambulatory pulmonary artery (PA) pressure monitor, has been shown to reduce mortality and morbidity. These improved outcomes were associated with a reduction in PA pressure. However, several pivotal questions remain unanswered: do systolic, diastolic, or mean PA pressures each predict all-cause mortality?
Panelists discuss how the future of atopic dermatitis treatments is evolving with novel biologics, Janus kinase inhibitors, and precision medicine targeting immune pathways. Advances in gene therapy, microbiome modulation, and personalized treatments offer promising long-term management options.
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