Wed.Nov 08, 2023

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Inflammatory bowel disease patients have an increased risk of acute coronary syndrome: a systematic review and meta-analysis

Open Heart

Objectives Systemic inflammation is increasingly being recognised as a possible mechanism for acute arterial thrombotic events, including acute coronary syndrome (ACS). Despite this, there is conflicting data on the risk of ACS in patients with inflammatory bowel disease (IBD). We performed a contemporary systematic review and meta-analysis to identify the risk of ACS in patients with IBD.

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7 Ways to Securely Share Cloud Medical Imaging without Hassles of CDs

NOVARAD

Until recently, healthcare professionals and patients mainly used physical media like CDs to share medical images. This method entailed burning the medical images onto a physical CD, which was then handed over or mailed to the recipient. This system was not without its merits. It was simple and in its own way, secure because the data remained offline, reducing the chances of unauthorized access.

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Recor Medical’s Paradise Renal Denervation System Lands FDA Approval

CardiacWire

The renal denervation race hit a major new milestone this week after Recor Medical’s Paradise system became the first to land FDA approval. Renal denervation (RDN) is intended for hypertension that can’t be controlled by conventional therapies, either due to ineffectiveness, side effects, or adherence issues RDN lowers blood pressure by denervating the sympathetic nerves surrounding renal arteries, reducing overactivity that can lead to hypertension Recor’s ultrasound-based Paradise System has b

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Time-restricted Eating for Metabolic Health: Just 'Calorie Counting' in Disguise?

Physiologically Speaking

Greetings! In this post, we’ll take a deep dive into the science of fasting and discuss whether time-restricted eating is “better” than calorie counting for health and weight loss. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. In the ever-evolving landscape of health and wellness — including both evidence-based and pseudoscientifically unsound practices — fasting has

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Ten Years of Incidental, Secondary, and Actionable Findings

The New England Journal of Medicine

In 2013, as sequencing tests that evaluated the genome or its coding regions (the exome) became available to aid in the diagnosis of suspected genetic disorders, the American College of Medical Genetics and Genomics (ACMG) issued a guideline1 that included a set of medically important genes to be.

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Influence of Perivascular Adipose Tissue on Microcirculation: A Link Between Hypertension and Obesity

Hypertension Journal

Hypertension, Ahead of Print. Alterations in microcirculation play a crucial role in the pathogenesis of cardiovascular and metabolic disorders such as obesity and hypertension. The small resistance arteries of these patients show a typical remodeling, as indicated by an increase of media or total wall thickness to lumen diameter ratio that impairs organ flow reserve.

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Intention to Treat: Alzheimer’s Update, Part 1 — ITT Episode 20

The New England Journal of Medicine

In this podcast episode, host Rachel Gotbaum talks with a patient with early-onset Alzheimer’s disease and two dementia experts about frustrations with the current state of Alzheimer’s care.

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Actionable Genotypes and Their Association with Life Span in Iceland

The New England Journal of Medicine

This study examines the relationship of pathogenic and likely pathogenic variants for which preventive or therapeutic measures are available to life span and specific causes of death.

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Proteomic prediction of incident heart failure and its main subtypes

European Journal of Heart Failure

Abstract Aim To examine the ability of serum proteins in predicting future heart failure (HF) events, including HF with reduced or preserved ejection fraction (HFrEF or HFpEF), in relation to event time, and with or without considering established HF-associated clinical variables. Methods and results In the prospective population-based Age, Gene/Environment Susceptibility Reykjavik Study (AGES-RS), 440 individuals developed HF after their first visit with a median follow-up of 5.45 years.

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Major Facilitator Superfamily Domain Containing 5 Inhibition Reduces Lipoprotein(a) Uptake and Calcification in Valvular Heart Disease

Circulation

Circulation, Ahead of Print. BACKGROUND:High circulating levels of Lp(a) (lipoprotein[a]) increase the risk of atherosclerosis and calcific aortic valve disease, affecting millions of patients worldwide. Although atherosclerosis is commonly treated with low-density lipoprotein–targeting therapies, these do not reduce Lp(a) or risk of calcific aortic valve disease, which has no available drug therapies.

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Characteristics and outcomes of patients with atrial versus ventricular secondary tricuspid regurgitation undergoing tricuspid transcatheter edge?to?edge repair – Results from the TriValve registry

European Journal of Heart Failure

Abstract Aim Functional or secondary tricuspid regurgitation (STR) is the most common phenotype of tricuspid regurgitation (TR) with atrial STR (ASTR) and ventricular STR (VSTR) being recently identified as two distinct entities. Data on tricuspid transcatheter edge-to-edge repair (T-TEER) in patients with STR according to phenotype (i.e. ASTR vs. VSTR) are lacking.

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Polycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury

Circulation

Circulation, Volume 148, Issue 24 , Page 1958-1973, December 12, 2023. BACKGROUND:Reducing cardiovascular disease burden among women remains challenging. Epidemiologic studies have indicated that polycystic ovary syndrome (PCOS), the most common endocrine disease in women of reproductive age, is associated with an increased prevalence and extent of coronary artery disease.

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Cardiometabolic Health Congress Becomes First Organization to Offer Certification in Cardiometabolic Health

Cardiometabolic Health Congress

Learners who complete the Foundations of Cardiometabolic Health Certificate Course offered by Cardiometabolic Health Congress are now eligible to sit for a certification exam to become a Certified Cardiometabolic Health Professional (CCHP). Cardiometabolic Health Congress (CMHC) announced today that learners who complete its Foundations of Cardiometabolic Health Certificate Course now have the opportunity to sit for the Certified Cardiometabolic Health Professional (CCHP) examination.

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Comparative cardiovascular outcomes of novel drugs as an addition to conventional triple therapy for heart failure with reduced ejection fraction (HFrEF): a network meta-analysis of randomised controlled trials

Open Heart

Background Currently, there is no head-to-head comparison of novel pharmacological treatments for heart failure with reduced ejection fraction (HFrEF). A network meta-analysis aimed to compare effects of both conventional and alternative drug combinations on time to develop primary composite outcome of cardiovascular death or heart failure hospitalisation (PCO).