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Background Observational studies have reported that sleep is associated with the risk of major depressive disorder (MDD) and cardiovascular diseases (CVDs). However, the causal relationships among various sleep traits remain contentious, and whether MDD mediates the impact of specific sleep traits on CVDs is unclear. Methods We performed two-sample Mendelian randomisation analyses to explore whether insomnia, sleep time, daytime napping, daytime sleepiness, chronotype, snoring or obstructive sle
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk. Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk factors, to examine the associations, with false discovery rate adjustment for multiple com
Despite being a leading cause of morbidity and mortality among young people, affecting predominantly women, rheumatic heart disease (RHD) remains neglected and understudied. This autoimmune condition arises from a complex continuum that begins with repeated Group A Streptococcal (GAS) pharyngitis, leading to acute rheumatic fever (ARF) that eventually results in damage to the heart, mainly affecting the mitral valve.
Background In patients with tricuspid regurgitation (TR), delayed surgical intervention is associated with poor outcomes, particularly in advanced stages. This study aimed to assess whether earlier tricuspid valve (TV) surgery provides a survival benefit in patients with moderate to severe TR who are considered at low to intermediate risk of adverse clinical or surgical outcomes.
BackgroundThe optimal endpoint for reporting early mortality after cardiac operations for infective endocarditis (IE), as well as the optimal mortality target for surgical risk scores, are unresolved questions.MethodsFive risk scores created specifically to predict early mortality after cardiac operations for definite IE, and the European System for Cardiac Operative Risk Evaluation II, were assessed in terms of calibration, discrimination and accuracy in predicting early mortality following car
The tricuspid valve (TV), historically deemed the ’forgotten valve’, is undergoing a renaissance as mounting evidence highlights its critical role in cardiovascular outcomes. The article by Gwak et al provides a pivotal contribution to this field, illustrating that early surgical intervention for tricuspid regurgitation (TR) in patients with low to intermediate risk yields significant survival benefits. 1 This editorial expands on these findings, weaving them into the broader fabric
(MedPage Today) -- SAN DIEGO -- For patients with traumatic bone fractures, there was no difference between oral aspirin and low-molecular-weight heparin (LMWH) injections as a bleeding prevention strategy, a subpopulation analysis of the randomized.
(MedPage Today) -- SAN DIEGO -- For patients with traumatic bone fractures, there was no difference between oral aspirin and low-molecular-weight heparin (LMWH) injections as a bleeding prevention strategy, a subpopulation analysis of the randomized.
Event Heart Valve Disease Forum 2025 kchalko Thu, 03/13/2025 - 14:32 Event dates Sep 1213, 2025 Location Seoul, Korea STS is pleased to co-present the Heart Valve Disease Forum (HVDF) with the Korean Society for Thoracic and Cardiovascular Surgery, offering the latest knowledge regarding the basics, diagnosis, treatment, and future of valvular heart disease.
Circulation, Ahead of Print. Despite insufficient evidence to support direct-to-consumer genetic testing in routine clinical care, cardiovascular clinicians increasingly face questions about its utility and interpretation because individuals can purchase these tests directly from laboratories. A burgeoning marketplace offers an expanding array of testing options.
These data, presented at AAD 2025, highlight the efficacy of upadacitinib in clearing skin among patients with atopic dermatitis compared to those given dupilumab.
This study aims to elucidate the relationship between thyroid function and surgical prognosis in patients undergoing cardiac and major vascular surgeries.
Emerging evidence reveals a complex association between type 2 diabetes (T2D) and coronary heart disease (CHD), which share common risk factors and biological pathways. This study aims t.
The novel controlled metabolic accelerator significantly reduced fat-specific body weight but showed no improvements in exercise capacity over 19 weeks.
Blood-retinal barrier (BRB) breakdown, a pivotal contributor to multiple retinal vascular diseases, manifests as a progressive increase in vascular permeability induced by various pathological stimuli. The fun.
Counting down the most impactful news at major medical meetings, its the HCPLive Five! This episode focuses on 5 key dermatology updates from the 2025 American Academy of Allergy, Asthma, and Immunology (AAAAI)/World Allergy Organization (WAO) Joint Congress.
Functional single ventricle represents a complex congenital cardiac malformation where ventricular function directly impacts patients quality of life and prognosis. Accurate assessment of ventricular function.
A cardiovascular polypill could be a cost-effective tool for reducing health disparities and improving patient quality of life, according to a Jan. 8 study published in JAMA Cardiology.
After rising for a decade, the cardiac arrest mortality rate in the U.S. is beginning to fall, according to a study published March 9 in The American Journal of Cardiology.
Panelists discuss how rilzabrutinib shows promise in phase 2 trials with rapid improvements in disease activity scores (UAS7 and ISS7) starting from week 1 and a favorable safety profile, setting expectations for the upcoming phase 3 studies to confirm these initial findings.
The new Lorraine and Bill Dodero Limb Preservation Center at Cleveland-based University Hospitals' Harrington Heart & Vascular Institute will be led by the institute's president, Mehdi Shishehbor, DO, PhD.
Panelists discuss how Bruton tyrosine kinase (BTK) inhibitors appear to offer faster symptom relief and higher complete response rates compared with current chronic spontaneous urticaria (CSU) treatments like antihistamines and omalizumab while potentially requiring less frequent dosing and showing favorable safety profiles.
Northern Light Eastern Maine Medical Center in Bangor had the lowest heart attack readmission ratio between July 1, 2020, and June 30, 2023, according to CMS data published Feb. 19.
Journal of the American Heart Association, Ahead of Print. BackgroundProteinuria is a risk factor for cardiovascular events, but its prognostic value for sudden cardiac arrest (SCA) in young individuals remains unproven. We aimed to evaluate whether proteinuria in young people is associated with an increased risk of SCA.Methods and ResultsIndividuals aged between 20 and 39 years who underwent health screening between 2009 and 2012 in South Korea were included (n=6 891 400).
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Cardiac diagnostic testing continues to evolve, and controversies remain regarding the optimal utilization of different procedures. We sought to evaluate changes in long-term utilization trends for a wide range of cardiac diagnostic tests in the context of advancing technologies and updated guidelines.METHODS:Annual cardiac testing volumes from 2010 to 2022 in the Medicare Part B population were compared across tests and by provider
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Very preterm-born infants are at risk for developing bronchopulmonary dysplasia (BPD), a chronic lung disease. Nowadays, the majority of these infants reach adulthood. Very preterm-born young adults are at risk for developing pulmonary arterial (PA) hypertension later in life. An early sign of PA hypertension is increased PA stiffness.
Publication date: Available online 13 March 2025 Source: The American Journal of Cardiology Author(s): Ahmed Kazem, Magdi Zordok, Will Hobbs, Mohamed Salih, Amr Marawan, Dinesh Apala, Sibi Thomas, Robert J Widmer, Salman Allana, Srinivasa Potluri, Karim Al-Azizi
Background Premature ventricular complexes (PVCs) predict coronary heart disease, heart failure, atrial fibrillation and death, all of which are also related to sodium intake. We studied estimated sodium intake and PVC frequency in the randomly selected population-based Swedish CArdioPulmonary bioImage Study cohort. Methods In our cross-sectional study, we included 5636 individuals with 24-hour ECG registration and fasting morning urine sampling.
Background Deterioration of the cardiac conduction system is an important manifestation of cardiac ageing. Cellular ageing is accompanied by telomere shortening and telomere length (TL) is often regarded as a marker of biological ageing, potentially adding information regarding conduction disease over and above chronological age. We therefore sought to evaluate the association between leucocyte telomere length (LTL) on two related, but distinct aspects of the cardiac conduction system: ECG measu
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