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tim.hodson Fri, 03/14/2025 - 11:42 March 11, 2025 CareDx, Inc. The Transplant Company recently announced that AlloSureis now commercially available for pediatric heart transplant patients of all ages and patients who have received a simultaneous pancreas-kidney (SPK) transplant. Both indications are approved by the New York State Clinical Laboratory Evaluation Program, demonstrating that AlloSure has met the most rigorous validation standards for laboratory developed tests (LDTs).
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Circulation: Heart Failure, Ahead of Print. The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.
BackgroundCommunity-based models of care with the involvement of pharmacists and other nonphysician healthcare professionals can help improve blood pressure (BP) control. We aimed to synthesize the evidence of effectiveness of pharmacist interventions on BP among patients with hypertension.MethodsWe performed systematic searches to identify randomized controlled trials (RCTs) assessing the effect of pharmacist interventions on BP among outpatients (latest search, March 2024).
Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets.
IntroductionNon-contrast CT calcium scoring (CTCS) exams have been widely used to assess coronary artery disease. However, their clinical applications in predicting coronary arterial remodeling remain unknown. This study aimed to develop a novel machine learning model to predict positive remodeling (PR) from CTCS scans and evaluate its clinical value in predicting major adverse cardiovascular events (MACE).MethodsWe analyzed data from 1,324 patients who underwent both CTCS and CT angiography.
AI is making its mark across healthcare fields, with over 1,000 AI models now cleared by the FDA. A large portion of these advancements directly impact cardiologymore specifically, cardiac sonography. Interpreting cardiac ultrasounds has become more complex and time-consuming for clinicians: With the shift toward a more quantitative analysis, there are more parameters for clinicians to measure.
BackgroundObesity is a global epidemic and a major risk factor for cardiovascular diseases. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery, but its effect on cardiac functions remains unclear. This study aims to investigate the impact of weight loss after LSG on the left ventricular myocardial work (LVMW) in obese patients and explore the clinical value of the left ventricular pressure - strain loop (LV - PSL).MethodsThirty - eight obese patients (body mass index30kg/m2)
BackgroundObesity is a global epidemic and a major risk factor for cardiovascular diseases. Laparoscopic sleeve gastrectomy (LSG) is an effective bariatric surgery, but its effect on cardiac functions remains unclear. This study aims to investigate the impact of weight loss after LSG on the left ventricular myocardial work (LVMW) in obese patients and explore the clinical value of the left ventricular pressure - strain loop (LV - PSL).MethodsThirty - eight obese patients (body mass index30kg/m2)
Out-of-hospital cardiac arrest (OHCA) in people experiencing a heart attack is a time-dependent medical emergency requiring immediate cardiopulmonary resuscitation (CPR).
BackgroundZhigancao Decoction (ZGCD) is derived from Treatise on Febrile Diseases and is traditionally prescribed for treating a variety of cardiovascular conditions. As of now, there are no data to support its use as a treatment for diabetic cardiomyopathy (DCM) and the mechanism behind the effect is unclear as well. In the present study, clinical evidence for the efficacy of ZGCD in patients with DCM was examined using a meta-analysis and its underlying anti-DCM molecular mechanisms were explo
tim.hodson Fri, 03/14/2025 - 16:12 SCAI Scientific Sessions 2025 will take place May 1 to 3, attheWalter E. Washington Convention Center in Washington, DC. Some of the late-breaking topics that will be covered include transcatheter aortic valve replacement (TAVR), peripheral artery disease (PAD), and pulmonary embolism (PE): Impact of Age on Procedural Timing for Asymptomatic Severe Aortic Stenosis: Results from the Early TAVR Trial The PERFORMANCE II Trial: A Prospective Multicenter Single Arm
IntroductionIcosapent ethyl (IPE) is indicated for the treatment of severe hypertriglyceridemia (triglycerides 500mg/dl) and for reducing the risk of cardiovascular (CV) events in statin-treated adults with moderately elevated triglycerides (150499mg/dl) and established CV disease [secondary prevention (SP)] or diabetes with CV risk factors [primary prevention (PP)].
(MedPage Today) -- A familiar biomarker emerged as a potential predictor of sudden cardiac arrest (SCA) in young people, which remained hard to explain even with genetic testing. Although SCA was rare in a Korean population-based study -- occurring.
In the opening segment of this 6-part HCPLive RX Review, experts reflect on resmetiroms FDA approval for MASH and clinical challenges to implementing it.
Stroke, Ahead of Print. BACKGROUND:Providing equitable health care to rural stroke patients is challenging and associated with less intervention and poorer outcomes. We assessed how several distinct patient-related geographic classifications influenced stroke care and outcomes in Scotland, United Kingdom.METHODS:We conducted a population-level data-linkage study of ischemic stroke patients admitted to the hospital (20102018).
Liver transplants for alcohol-associated liver disease and alcohol-associated hepatitis have increased, but many centers lack necessary resources for care.
Food insecurity remained associated with incident CVD after adjustment for socioeconomic factors among participants in the 2000-2020 CARDIA study period.
In this weeks View, Dr. Eagle looks at a sex-based analysis of short-term dual antiplatelet therapy (DAPT) in patients receiving percutaneous coronary intervention (PCI) who are deemed at high-risk for bleeding.
In the third segment of this 6-part HCPLive RX Review, experts discuss investigational therapies in the MASH pipeline and the use of combination therapy.
Written by Magnus Nossen, with edits by Smith The patient in today's case is a 70-year-old farmer. He has a history of coronary artery disease and a STEMI two years prior that was treated with primary PCI. He contacted EMS due to acute onset chest pain and feeling unwell and fatigued. He was given ASA and sublingual NTG and taken to the ED. At the time of this initial ED ECG, his symptoms were improving ECG #1 on admission to the ED The patient was not seen quickly in the ED as it was a busy shi
IntroductionObstructive sleep apnea (OSA) is a prevalent sleep disorder with a high rate of undiagnosed patients, primarily due to the complexity of its diagnosis made by polysomnography (PSG). Considering the severe comorbidities associated with OSA, especially in the cardiovascular system, the development of early screening tools for this disease is imperative.
A panelist discusses how they first noticed their hair loss through unexplained balding patches, which led to an eventual diagnosis of alopecia areata after consulting with a dermatologist who identified the autoimmune condition through physical examination and scalp analysis.
You are shown the ECG in Figure-1 without the benefit of any history. QUESTION: This tracing was interpreted as sinus tachycardia with some kind of BBB ( B undle B ranch B lock ). What kind of BBB is this? Figure-1: The initial ECG in today's case. What kind of BBB is this? ( To improve visualization I've digitized the original ECG using PMcardio ).
A panelist discusses how ritlecitinib can be recommended for alopecia areata after previous treatments proved ineffective, initially raising questions about the medication's safety profile, potential adverse effects, and realistic timeline for hair regrowth.
(MedPage Today) -- Despite substantial health benefits, two GLP-1 receptor agonists weren't cost-effective at their current prices, according to an economic evaluation that compared four anti-obesity medications. Net prices of tirzepatide (Mounjaro.
A new study highlights key risk factors of cold-induced anaphylaxis, including genetic markers and elevated IgE, expanding on findings from the COLD-CE study.
OCT, the magical intraluminal coronary vision, has been a great innovation that helps us to decode many uncertainties in the morphology, behavior and vulnerability of coronary plaques. It is used widely in pre- or post-PCI or even asssit during the implantation of stents. The role of OCT/IVUS is sometimes deemed critical in dealing with left main and bifurcation lesions.
Real-world data from the EMERGE LAA postapproval study suggests it might be time to rethink the discharge medications prescribed to patients after LAAO. Current antithrombotic recommendations call for both aspirin and clopidogrel (or another antiplatelet drug) for six months, with therapy continuation as prescribed by a physician. Oral anticoagulation is usually for patients whose residual flow around the LAA implant is more than 5 mm.
BackgroundLeft atrial appendage closure (LAAC) is an alternative to oral anticoagulation for stroke prevention in non-valvular atrial fibrillation (AF). Selecting the appropriate size of Watchman device is very important intra-procedure. There are several methods have been reported to measure the left atrial appendage (LAA), but each of them has its limitations.ObjectiveWe investigated the efficacy and safety of using the novel steel ball method compared to using the traditional sheath method an
In the second segment of this 6-part HCPLive RX Review, experts discuss unmet needs in MASH care, even with resmetirom available as a treatment option.
BackgroundAcute myocardial infarction commonly occurs in patients with coronary artery disease, but rarely, it can develop under a hypercoagulable state. Aplastic anemia can be accompanied by paroxysmal nocturnal hemoglobinuria clones or transform into paroxysmal nocturnal hemoglobinuria with a significantly elevated prothrombotic state. These thrombotic complications predominantly arise in veins rather than in arteries.
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