Fri.Mar 14, 2025

article thumbnail

CareDx Launches Two Expanded Indications for AlloSure Testing Services

DAIC

tim.hodson Fri, 03/14/2025 - 11:42 March 11, 2025 CareDx, Inc. The Transplant Company recently announced that AlloSureis now commercially available for pediatric heart transplant patients of all ages and patients who have received a simultaneous pancreas-kidney (SPK) transplant. Both indications are approved by the New York State Clinical Laboratory Evaluation Program, demonstrating that AlloSure has met the most rigorous validation standards for laboratory developed tests (LDTs).

article thumbnail

Physiology Friday #261: Combining High-intensity Training with Frequent Activity Breaks Maximizes Cardiovascular Benefits

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

article thumbnail

Hereditary Transthyretin Cardiac Amyloidosis With the p.V142I Variant: Mechanistic Insights and Diagnostic Challenges

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background.

article thumbnail

Pharmacists delivering hypertension care services: a systematic review and meta-analysis of randomized controlled trials

Frontiers in Cardiovascular Medicine

BackgroundCommunity-based models of care with the involvement of pharmacists and other nonphysician healthcare professionals can help improve blood pressure (BP) control. We aimed to synthesize the evidence of effectiveness of pharmacist interventions on BP among patients with hypertension.MethodsWe performed systematic searches to identify randomized controlled trials (RCTs) assessing the effect of pharmacist interventions on BP among outpatients (latest search, March 2024).

article thumbnail

Genetic Insights Into Hemorrhagic Stroke and Vascular Malformations: Pathogenesis and Emerging Therapeutic Strategies

Stroke Journal

Stroke, Ahead of Print. Brain arteriovenous malformations (AVMs), cerebral cavernous malformations (CCMs), and intracranial aneurysms are major causes of hemorrhagic stroke, yet noninvasive therapies to prevent growth or rupture are lacking. Understanding the genetic basis of these malformations is critical for uncovering underlying mechanisms, developing targeted prevention strategies, and identifying novel therapeutic targets.

article thumbnail

Detection of arterial remodeling using epicardial adipose tissue assessment from CT calcium scoring scan

Frontiers in Cardiovascular Medicine

IntroductionNon-contrast CT calcium scoring (CTCS) exams have been widely used to assess coronary artery disease. However, their clinical applications in predicting coronary arterial remodeling remain unknown. This study aimed to develop a novel machine learning model to predict positive remodeling (PR) from CTCS scans and evaluate its clinical value in predicting major adverse cardiovascular events (MACE).MethodsWe analyzed data from 1,324 patients who underwent both CTCS and CT angiography.

article thumbnail

Cardiac Sonography: How AI and Other Innovations Are Changing Ultrasound

Cassling

AI is making its mark across healthcare fields, with over 1,000 AI models now cleared by the FDA. A large portion of these advancements directly impact cardiologymore specifically, cardiac sonography. Interpreting cardiac ultrasounds has become more complex and time-consuming for clinicians: With the shift toward a more quantitative analysis, there are more parameters for clinicians to measure.

More Trending

article thumbnail

Resuscitation in out-of-hospital cardiac arrest—how quickly it is done may be more important than who does it

Medical Xpress - Cardiology

Out-of-hospital cardiac arrest (OHCA) in people experiencing a heart attack is a time-dependent medical emergency requiring immediate cardiopulmonary resuscitation (CPR).

article thumbnail

Integrated meta-analysis and network pharmacology analysis: evaluation of Zhigancao decoction as treatment for diabetic cardiomyopathy

Frontiers in Cardiovascular Medicine

BackgroundZhigancao Decoction (ZGCD) is derived from Treatise on Febrile Diseases and is traditionally prescribed for treating a variety of cardiovascular conditions. As of now, there are no data to support its use as a treatment for diabetic cardiomyopathy (DCM) and the mechanism behind the effect is unclear as well. In the present study, clinical evidence for the efficacy of ZGCD in patients with DCM was examined using a meta-analysis and its underlying anti-DCM molecular mechanisms were explo

article thumbnail

SCAI Scientific Sessions 2025 to Feature Presentations on TAVR, PAD and PE 

DAIC

tim.hodson Fri, 03/14/2025 - 16:12 SCAI Scientific Sessions 2025 will take place May 1 to 3, attheWalter E. Washington Convention Center in Washington, DC. Some of the late-breaking topics that will be covered include transcatheter aortic valve replacement (TAVR), peripheral artery disease (PAD), and pulmonary embolism (PE): Impact of Age on Procedural Timing for Asymptomatic Severe Aortic Stenosis: Results from the Early TAVR Trial The PERFORMANCE II Trial: A Prospective Multicenter Single Arm

TAVR 52
article thumbnail

Cross-Sectional analysis of demographic and clinical characteristics of patients in the United States using icosapent ethyl

Frontiers in Cardiovascular Medicine

IntroductionIcosapent ethyl (IPE) is indicated for the treatment of severe hypertriglyceridemia (triglycerides 500mg/dl) and for reducing the risk of cardiovascular (CV) events in statin-treated adults with moderately elevated triglycerides (150499mg/dl) and established CV disease [secondary prevention (SP)] or diabetes with CV risk factors [primary prevention (PP)].

article thumbnail

Considering Patient Priorities in PsA Care, with Philip Mease, MD

HCPLive

Mease discussed recent research on what matters in PsA care between patients and clinicians.

article thumbnail

Proteinuria Linked to Sudden Cardiac Arrest in Young Adults

Med Page Today

(MedPage Today) -- A familiar biomarker emerged as a potential predictor of sudden cardiac arrest (SCA) in young people, which remained hard to explain even with genetic testing. Although SCA was rare in a Korean population-based study -- occurring.

article thumbnail

New Findings on Tildrakizumab for Nail Psoriasis, with Paul Yamauchi, MD, PhD

HCPLive

This interview with Yamauchi highlights phase 3b findings on tildrakizumab among patients with moderate-to-severe nail psoriasis.

85
article thumbnail

Risk in Repose: Sedentary Behavior and Genetic Susceptibility to Cardiovascular Disease

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

article thumbnail

Reflecting on Resmetirom’s Historic FDA Approval for MASH

HCPLive

In the opening segment of this 6-part HCPLive RX Review, experts reflect on resmetiroms FDA approval for MASH and clinical challenges to implementing it.

72
article thumbnail

Impact of Rurality and Geographical Accessibility on Stroke Care and Outcomes

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Providing equitable health care to rural stroke patients is challenging and associated with less intervention and poorer outcomes. We assessed how several distinct patient-related geographic classifications influenced stroke care and outcomes in Scotland, United Kingdom.METHODS:We conducted a population-level data-linkage study of ischemic stroke patients admitted to the hospital (20102018).

article thumbnail

Post-Transplant Alcohol Use Disorder Resources Lacking at Most Centers, Survey Finds

HCPLive

Liver transplants for alcohol-associated liver disease and alcohol-associated hepatitis have increased, but many centers lack necessary resources for care.

article thumbnail

Hepatopulmonary Syndrome or Portopulmonary Hypertension? Two Contrasting Cases of Exertional Hypoxemia From Liver Disease

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.

article thumbnail

Food Insecurity in US Tied to 41% Higher CVD Risk Over 2 Decades

HCPLive

Food insecurity remained associated with incident CVD after adjustment for socioeconomic factors among participants in the 2000-2020 CARDIA study period.

59
article thumbnail

Short-term DAPT, PCI & High Bleeding Risk; Dapagliflozin, Non-Pharmacologic Treatment of HF

American College of Cardiology

In this weeks View, Dr. Eagle looks at a sex-based analysis of short-term dual antiplatelet therapy (DAPT) in patients receiving percutaneous coronary intervention (PCI) who are deemed at high-risk for bleeding.

article thumbnail

The Future of MASH Care: New Agents in Clinical Development

HCPLive

In the third segment of this 6-part HCPLive RX Review, experts discuss investigational therapies in the MASH pipeline and the use of combination therapy.

59
article thumbnail

What happens when you give morphine for chest pain in ACS? And what is pseudo-normalization of T-waves?

Dr. Smith's ECG Blog

Written by Magnus Nossen, with edits by Smith The patient in today's case is a 70-year-old farmer. He has a history of coronary artery disease and a STEMI two years prior that was treated with primary PCI. He contacted EMS due to acute onset chest pain and feeling unwell and fatigued. He was given ASA and sublingual NTG and taken to the ED. At the time of this initial ED ECG, his symptoms were improving ECG #1 on admission to the ED The patient was not seen quickly in the ED as it was a busy shi

article thumbnail

Anemia Prevalence Higher in Females than Males Living with HIV

HCPLive

Anemia was linked to lower waist circumference, lower albumin levels, and treatment regimens in females, but not males.

52
article thumbnail

The use of heart rate variability, oxygen saturation, and anthropometric data with machine learning to predict the presence and severity of obstructive sleep apnea

Frontiers in Cardiovascular Medicine

IntroductionObstructive sleep apnea (OSA) is a prevalent sleep disorder with a high rate of undiagnosed patients, primarily due to the complexity of its diagnosis made by polysomnography (PSG). Considering the severe comorbidities associated with OSA, especially in the cardiovascular system, the development of early screening tools for this disease is imperative.

article thumbnail

Maria's Patient Journey: Diagnosis and Prior Treatment Experience

HCPLive

A panelist discusses how they first noticed their hair loss through unexplained balding patches, which led to an eventual diagnosis of alopecia areata after consulting with a dermatologist who identified the autoimmune condition through physical examination and scalp analysis.

52
article thumbnail

ECG Blog #473 — Sinus Tach & What Kind of BBB?

Ken Grauer, MD

You are shown the ECG in Figure-1 without the benefit of any history. QUESTION: This tracing was interpreted as sinus tachycardia with some kind of BBB ( B undle B ranch B lock ). What kind of BBB is this? Figure-1: The initial ECG in today's case. What kind of BBB is this? ( To improve visualization I've digitized the original ECG using PMcardio ).

Blog 98
article thumbnail

Maria's Patient Journey: Clinical Trial Experience

HCPLive

A panelist discusses how ritlecitinib can be recommended for alopecia areata after previous treatments proved ineffective, initially raising questions about the medication's safety profile, potential adverse effects, and realistic timeline for hair regrowth.

52
article thumbnail

High Price of GLP-1 Agents Tip Cost-Benefit Scale Unfavorably

Med Page Today

(MedPage Today) -- Despite substantial health benefits, two GLP-1 receptor agonists weren't cost-effective at their current prices, according to an economic evaluation that compared four anti-obesity medications. Net prices of tirzepatide (Mounjaro.

Obesity 59
article thumbnail

Study Links Key Clinical Features, Biomarkers to Cold-Induced Anaphylaxis

HCPLive

A new study highlights key risk factors of cold-induced anaphylaxis, including genetic markers and elevated IgE, expanding on findings from the COLD-CE study.

article thumbnail

OCT assessment of LIMA & SVG grafts : Why is it, an under-used modality ?

Dr. S. Venkatesan MD

OCT, the magical intraluminal coronary vision, has been a great innovation that helps us to decode many uncertainties in the morphology, behavior and vulnerability of coronary plaques. It is used widely in pre- or post-PCI or even asssit during the implantation of stents. The role of OCT/IVUS is sometimes deemed critical in dealing with left main and bifurcation lesions.

Stents 52
article thumbnail

Lifestyle Interventions for MASH Management

HCPLive

In the fourth segment of this 6-part HCPLive RX Review, experts discuss the continued importance of diet and exercise for managing MASH.

Diet 52
article thumbnail

Reconsidering LAAO Postprocedural Management

CardiacWire

Real-world data from the EMERGE LAA postapproval study suggests it might be time to rethink the discharge medications prescribed to patients after LAAO. Current antithrombotic recommendations call for both aspirin and clopidogrel (or another antiplatelet drug) for six months, with therapy continuation as prescribed by a physician. Oral anticoagulation is usually for patients whose residual flow around the LAA implant is more than 5 mm.

article thumbnail

Dose Escalation to Upadacitinib 30 mg Necessary Among Some with Atopic Dermatitis

HCPLive

New data presented at AAD 2024 point to impacts on multiple disease nodes as needed to achieve high levels of efficacy.

64
article thumbnail

A novel method using body surface steel ball as a reference scale to measure the left atrial appendage for optimal selection of Watchman device

Frontiers in Cardiovascular Medicine

BackgroundLeft atrial appendage closure (LAAC) is an alternative to oral anticoagulation for stroke prevention in non-valvular atrial fibrillation (AF). Selecting the appropriate size of Watchman device is very important intra-procedure. There are several methods have been reported to measure the left atrial appendage (LAA), but each of them has its limitations.ObjectiveWe investigated the efficacy and safety of using the novel steel ball method compared to using the traditional sheath method an

article thumbnail

Unmet Needs in MASH Care

HCPLive

In the second segment of this 6-part HCPLive RX Review, experts discuss unmet needs in MASH care, even with resmetirom available as a treatment option.

52
article thumbnail

Short-term recurrent coronary artery thrombosis with acute myocardial infarction in a patient with aplastic anemia–paroxysmal nocturnal hemoglobinuria syndrome: a case report

Frontiers in Cardiovascular Medicine

BackgroundAcute myocardial infarction commonly occurs in patients with coronary artery disease, but rarely, it can develop under a hypercoagulable state. Aplastic anemia can be accompanied by paroxysmal nocturnal hemoglobinuria clones or transform into paroxysmal nocturnal hemoglobinuria with a significantly elevated prothrombotic state. These thrombotic complications predominantly arise in veins rather than in arteries.