Tue.Oct 17, 2023

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EM Quick Hits 52 Infant Vomiting, Orbital Cellulitis, Prehospital TXA in Trauma, Prevention and Treatment of Delirium, Procedural Skills Decay, Altitude Sickness

ECG Cases

In this month's EM Quick Hits podcast: Sarah Reid on an approach to Infant Vomiting, Brit Long on Orbital Cellulitis essentials, Justin Morgenstern on the PATCH trial - Prehospital TXA in Trauma, Christina Shenvi on Prevention and Treatment of Delirium, Jason Hines on Procedural Skills Decay, Aaron Billin on Altitude Sickness. The post EM Quick Hits 52 Infant Vomiting, Orbital Cellulitis, Prehospital TXA in Trauma, Prevention and Treatment of Delirium, Procedural Skills Decay, Altitude Sickness

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Genetic risk scores not useful in predicting disease

Science Daily - Heart Disease

A new study looked at 926 polygenic risk scores for 310 diseases. It found that, on average, only 11% of individuals who develop disease are identified, while at the same time 5% of people who do not develop the disease test positive. Unaffected people usually outnumber those affected which results in far more false than true positive predictions.

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ECG Cases 46 ECG in Fever and Infectious Disease

ECG Cases

In this ECG Cases blog Dr. Jesse McLaren guides us through 10 cases, driving home the points that sepsis is a common cause of rapid Afib and diffuse ST depression with reciprocal ST elevation in aVR, myo/pericarditis is a diagnosis of exclusion, endocarditis or lyme carditis can cause AV block, PE can cause low grade fever and ECG signs of acute RV strain and that fever can unmask Brugada syndrome.

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Beyond Cardiology: Embracing Micro Neurosurgery Excellence

ADN Center of Excellence

At ADN CoE , we have always been committed to providing top-notch medical training, especially in the realm of interventional cardiology. Our mission has been to equip you with the latest techniques and knowledge to enhance patient care and elevate your medical practice. However, as the landscape of healthcare evolves, so do our aspirations and goals.

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Introducing Cardiomatics v5: the world’s 1st MDR Certification for AI-based ECG interpretation

Cardiomatics

Now including AV block detection, fast-track analysis, and a new layout We’re excited to unveil some significant updates, news and improved features of Cardiomatics v5 that help medical professionals interpret ECG easily and quickly with the use of high-accuracy AI. World’s 1st MDR Certification for automated ECG analysis using the power of AI Today we share thrilling news for the MedTech community and cardiologists!

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Beyond Cardiology: Embracing Micro Neurosurgery Excellence

ADN Center of Excellence

At ADN CoE , we have always been committed to providing top-notch medical training, especially in the realm of interventional cardiology. Our mission has been to equip you with the latest techniques and knowledge to enhance patient care and elevate your medical practice. However, as the landscape of healthcare evolves, so do our aspirations and goals.

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How Does Fever Precipitate Arrhythmia in Brugada Syndrome?

All About Cardiovascular System and Disorders

How Does Fever Precipitate Arrhythmia in Brugada Syndrome? In Brugada syndrome dysfunctional voltage gated sodium channels Na V 1.5 have delayed activation and earlier inactivation. This leads to shortening of action potential duration. There is additional shortening of action potential duration at higher temperatures. This is the proposed mechanism of precipitation of arrhythmias in Brugada syndrome during febrile episodes.

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Team finds a stem-cell derived mechanism that could lead to regenerative therapies for heart damage

Science Daily - Heart Disease

A team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, possibly leading to new therapies for heart disease and cardiac damage.

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Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone

Hypertension Journal

Hypertension, Volume 80, Issue 12 , Page 2611-2620, December 1, 2023. BACKGROUND:Thiazide diuretics (TD) are the first-line treatment of hypertension because of its consistent benefit in lowering blood pressure and cardiovascular risk. TD is also known to cause an excess risk of diabetes, which may limit long-term use. Although potassium (K) depletion was thought to be the main mechanism of TD-induced hyperglycemia, TD also triggers magnesium (Mg) depletion.

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Circulating neutrophil?related proteins associate with incident heart failure and cardiac dysfunction: The ARIC study

European Journal of Heart Failure

Associations of colchicine-related plasma proteins, incident heart failure (HF) and cardiac structure and function. HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction. Abstract Aims Neutrophil activity contributes to adverse cardiac remodelling in experimental acute cardiac injury and is modifiable with pharmacologic agents like colchicine.

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ESCRT-III Component CHMP4C Attenuates Cardiac Hypertrophy by Targeting the Endo-Lysosomal Degradation of EGFR

Hypertension Journal

Hypertension, Volume 80, Issue 12 , Page 2674-2686, December 1, 2023. BACKGROUND:Cardiac hypertrophy and subsequent heart failure impose a considerable burden on public health worldwide. Impaired protein degradation, especially endo-lysosome-mediated degradation of membrane proteins, is associated with cardiac hypertrophy progression. CHMP4C (charged multivesicular body protein 4C), a critical constituent of multivesicular bodies, is involved in cellular trafficking and signaling.

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Quantitative Flow Ratio Is Feasible and Accurate Even at Lower Frame Acquisition Rate

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print.

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Menopause, HRT & Cardiovascular Risk

Dr. Paddy Barrett

Females have about a 10-year advantage over males when it comes to the onset of cardiovascular disease 1. On average, females present with heart attacks later in life. Because of these facts, females are considered to be ‘ lower risk ’ when it comes to cardiovascular disease. Which is true for many females. Earlier in life. However … Cardiovascular disease is still the leading cause of death in females in most countries 2. 30% of all heart attacks in females happen at less than

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CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals

Hypertension Journal

Hypertension, Volume 80, Issue 12 , Page 2665-2673, December 1, 2023. BACKGROUND:Disease-causing mutations inCACNA1Dgene occur in aldosterone-producing adenomas and familial hyperaldosteronism. We determined whether single nucleotide polymorphisms inCACNA1Dgene associate with higher aldosterone resulting in salt sensitivity of blood pressure (BP) and increased BP in men and women.METHODS:Data were obtained from the HyperPATH (International Hypertension Pathotypes) cohort, where participants comp

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Outcomes Following Transcatheter Aortic Valve Replacement for Aortic Stenosis in Patients With Type 0 Bicuspid, Type 1 Bicuspid, and Tricuspid Aortic Valves

Circulation: Cardiovascular Interventions

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Data concerning the outcomes of transcatheter aortic valve replacement in type 0 bicuspid aortic stenosis (AS) are scarce. The study aims to compare the outcomes of transcatheter aortic valve replacement for AS in patients with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy.METHODS:We enrolled consecutive patients undergoing transcatheter aortic valve replacement for severe AS between 2012 and 2022 in thi