Tue.Apr 09, 2024

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Elder Male with Syncope

EMS 12-Lead

David Didlake @DidlakeDW EMS personnel responded to the residence of an 81 y/o Male with syncope. His spouse had called 911 after she heard a loud “thud” in the adjacent room. He was found altered, hypotensive, and with a large hematoma to the left periorbital region. No 12 Lead ECG was captured, but telemetry did reveal the following: The spouse offers a pertinent medical history to include HTN and HLD, and furthermore states that he hasn’t previously complained of any chest discomfort, or shor

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Third-Generation PCSK9 Inhibitor Cuts Cholesterol With Single, Small, Monthly Shot

Med Page Today

(MedPage Today) -- ATLANTA -- A novel PCSK9 inhibitor safely reduced LDL cholesterol levels with just a single, quick, once-monthly dose, the phase III LIBerate-HR trial showed. Lerodalcibep reduced LDL cholesterol by 56% more than placebo from.

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Cardiology Team Performs Novel Heart Artery Repair with Newly Approved Device

DAIC

Image courtesy of UC Davis Health milla1cf Tue, 04/09/2024 - 16:47 April 9, 2024 — UC Davis Health cardiology team members are among the first in the country to treat patients with tricuspid regurgitation , or a leaky heart valve, by using a groundbreaking catheter. The minimally invasive procedure, a transcatheter edge-to-edge repair (TEER), is made possible with a new medical device called the Abbott TriClip™ system.

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Oral Appliance for Sleep Apnea Noninferior to CPAP for Reducing Arterial BP

Med Page Today

(MedPage Today) -- ATLANTA -- An oral appliance for people with obstructive sleep apnea (OSA) was noninferior to continuous positive airway pressure (CPAP) for reducing 24-hour mean arterial blood pressure (BP) in patients with hypertension and.

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Cathie Biga is New American College of Cardiology President

DAIC

Cathie Biga, MSN, FACC, today became president of the American College of Cardiology and made history as the organization’s first non-physician president. Image courtesy of ACC milla1cf Tue, 04/09/2024 - 16:51 April 9, 2024 — Cathie Biga , MSN, FACC, today became president of the American College of Cardiology and made history as the organization’s first non-physician president.

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Cardiovascular disease and cancer: shared risk factors and mechanisms

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01017-x Patients with cardiovascular disease (CVD) have an increased risk of cancer, and patients with cancer have an increased risk of CVD. In this Review, the authors discuss the shared modifiable risk factors and the shared pathophysiological mechanisms underlying the bidirectional relationship between these two prevalent diseases.

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News from EHRA 2024: International Experts Agree on Standards for Catheter Ablation of Atrial Fibrillation

DAIC

An international consensus statement on how to treat atrial fibrillation with catheter or surgical ablation has been published in EP Europace, a journal of the European Society of Cardiology (ESC), and was recently presented at EHRA 2024, a scientific congress held April 7-9 in Berlin, Germany. Four heart rhythm organizations from around the globe developed the statement.

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ACE Inhibitor Not Protective Against Heart Damage from Chemotherapy

DAIC

milla1cf Tue, 04/09/2024 - 08:00 April 9, 2024 — Patients who took an angiotensin-converting enzyme (ACE) inhibitor while undergoing cancer treatment with high-dose anthracycline chemotherapy did not show any difference in troponin T levels, a biomarker associated with heart damage, at one month after their last chemotherapy dose compared with those who did not take an ACE inhibitor , according to a study presented at the American College of Cardiology’s Annual Scientific Session.

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Nasal spray safely treats recurrent abnormal heart rhythms, clinical trial suggests

Science Daily - Heart Disease

A clinical trial showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study provides real-world evidence that a wide range of patients can safely and effectively use the experimental drug, called etripamil, to treat recurrent paroxysmal supraventricular tachycardia (PSVT) episodes at home, potentially sparing them the need for repeated hospital trips for mor

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Study reveals mechanism linking heart disease to cancer development

Medical Xpress - Cardiology

Researchers at Tel Aviv University (TAU) and the Leviev Cardiothoracic and Vascular Center at the Sheba Medical Center have found a mechanism responsible for increasing the risk of developing cancer among patients with heart disease: Small extracellular bubbles, or vesicles (sEVs), secreted from the sick heart to heal itself, are released into the bloodstream and promote the growth of cancer cells throughout the body.

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Resmetirom (Rezdiffra) Now Available in the US Pharmacies, Marks Turning Point in NASH Management

HCPLive

Madrigal Pharmaceuticals announced resmetirom is available in the US beginning on April 9, 2024, ushering in a new era of NASH management.

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A 29 year old male with chest pain, ST Elevation, and very elevated troponin T

Dr. Smith's ECG Blog

By Magnus Nossen This ECG is from a young man with no risk factors for CAD, he presented with chest pain. How would you assess this ECG? How confident are you in your assessment? What is your next step? Note: lead format is Cabrera I was sent this ECG in real time. The patient is a young adult male with chest pain. The chest pain was described as pressure like and radiation to both arms and the jaw.

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Acetaminophen Use During Pregnancy is Not Linked to a Child’s Risk of Autism or ADHD

HCPLive

Sibling control analyses showed acetaminophen use during pregnancy was not associated with an offspring’s risk of autism, ADHD, or intellectual disability.

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Cardiology team performs novel heart artery repair with newly approved device

Science Daily - Heart Disease

Medical researchers have performed a successful transcatheter tricuspid valve repair procedure with a groundbreaking catheter.

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Clinical trial finds nasal spray safely treats recurrent abnormal heart rhythms

Medical Xpress - Cardiology

A clinical trial led by Weill Cornell Medicine investigators showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms.

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Canonical and non-canonical roles of complement in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01016-y In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment of atherosclerotic cardiovascular disease.

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For PCI, Intravascular Ultrasound Guidance Bests Angiography Guidance

Med Page Today

(MedPage Today) -- ATLANTA -- The use of intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) in patients with acute coronary syndromes resulted in better outcomes compared with angiography-guided therapy, a randomized.

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Obicetrapib Works Synergistically with Ezetimibe in Statin Users, Study Finds

HCPLive

Christie Ballantyne, MD, discusses new data from the ROSE2 trial examining the potential synergistic effects of obicetrapib with ezetimibe in high-intensity statin users.

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Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study

Cardiovascular Diabetology

Hypertension and chronic kidney disease (CKD) pose significant public health challenges, sharing intertwined pathophysiological mechanisms. Prediabetes is recognized as a precursor to diabetes and is often acc.

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9 Biosimilars for Intravitreal nAMD, DME Treatment

HCPLive

A number of biosimilar options to treat the common retina diseases are in development globally. Here’s a highlight of 9 with supporting late-stage data.

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Clarifying the Natural History of Transthyretin Cardiac Amyloidosis: Insights From the ATTRibute-CM Trial

American College of Cardiology

In the phase 3 ATTRibute-CM trial, whose results were published in the New England Journal of Medicine, acoramidis was compared with placebo in patients with symptomatic transthyretin (TTR) cardiac amyloidosis.

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Study Highlights Factors Affecting Antibiotic Prescribing Practices for Acne Treatment

HCPLive

This study’s investigators point to the necessity of adapting an antibiotic stewardship program for acne treatment, with evaluation being done in dermatology practices to assess performance.

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Salt substitution may reduce all-cause, cardiovascular mortality

Medical Xpress - Cardiology

Salt substitution may reduce all-cause or cardiovascular mortality, according to a review published online April 9 in the Annals of Internal Medicine.

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Post-COVID Transplants, Long COVID Impacts with Kenneth McCurry, MD & Maryam Valapour, MD, MPP

HCPLive

In the latest Lungcast, Drs. McCurry and Valapour answered several questions on the candidacy of post-infectious COVID-19 patients for lung transplantation and on long COVID.

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Self-Expanding Valve Outperforms Balloon-Expandable Valve for TAVR in Patients with Small Valve Annulus

DAIC

milla1cf Tue, 04/09/2024 - 06:00 April 9, 2024 — People with a small aortic annulus, a part of the heart’s anatomy where the left ventricle meets the aorta, who underwent transcatheter aortic valve replacement ( TAVR ) with a supra-annular self-expanding valve saw similar clinical outcomes and superior valve performance at one year compared with those who underwent TAVR with a balloon-expandable valve, according to research presented at the American College of Cardiology ’s Annual Scientific Ses

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Study Debunks Association Between Hepatitis C, Prostate Cancer

HCPLive

An analysis of NHANES data found no significant association between HCV infection and risk of prostate cancer, contrary to findings from previous research.

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Factors influencing hospitalization or emergency department visits and mortality in type 2 diabetes following the onset of new cardiovascular diagnoses in a population-based study

Cardiovascular Diabetology

Individuals with type 2 diabetes (T2D) are at increased risk of developing cardiovascular disease (CVD) which necessitates monitoring of risk factors and appropriate pharmacotherapy. This study aimed to identi.

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Medicare Patients with nAMD Endure Significant Disease Burden

HCPLive

Despite the availability of anti-VEGF therapies, there is still a notable disease burden in older adults with vision-threatening retinal diseases.

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A basaloid carcinoma with multilocular thymic cyst mimicking a mediastinal teratoma

Journal of Cardiothoracic Surgery

This case report details a rare thymic basaloid carcinoma initially misinterpreted as a mediastinal teratoma, underscoring the diagnostic challenges posed by such tumors. A 71-year-old female presented with an.

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Know About Cardiogenic Shock

All About Cardiovascular System and Disorders

When the heart is not able to pump enough blood for the needs of the body and the blood pressure falls, it is known as cardiogenic shock. Most important cause of cardiogenic shock is a heart attack. It is more likely to occur in those who are older, having blocks in multiple blood vessels of the heart, and in those with a previous heart attack. Cardiogenic shock is a potentially life threatening condition and needs urgent treatment.

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The characteristics and prognosis of different disease patterns of multiple primary lung cancers categorized according to the 8th edition lung cancer staging system

Journal of Cardiothoracic Surgery

The 8th edition lung cancer staging system was the first to describe the detailed diagnosis and staging of multiple primary lung cancers (MPLC). However, the characteristics and prognosis of MPLC categorized a.

Cancer 52
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New Drug Fails to Improve Diabetes-Related Heart Failure

DAIC

milla1cf Tue, 04/09/2024 - 16:39 April 9, 2024 — One of the first studies to attempt to treat early-stage heart failure in patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not taking SGLT2 inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart.

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Novel Biannual Antihypertensive Shows Potential for Combination Therapy

Med Page Today

(MedPage Today) -- ATLANTA -- The novel RNA silencer zilebesiran reduced blood pressure (BP) when added to a diuretic, calcium channel blocker, or maximum-dose angiotensin receptor blocker, the phase II KARDIA-2 trial showed. At 3 months, the.

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Ninerafaxstat Well-Tolerated and Safe for Nonobstructive Hypertrophic Cardiomyopathy

DAIC

milla1cf Tue, 04/09/2024 - 12:00 Apirl 9, 2024 — The investigational drug ninerafaxstat showed a good tolerability and safety profile, along with evidence of improvements in symptoms and exercise capacity among people with nonobstructive hypertrophic cardiomyopathy (HCM), according to results of a 12-week phase 2 trial presented at the American College of Cardiology’s Annual Scientific Session.

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Radial Cath Kits Recalled; siRNAs for Lipid Lowering; Smartphone HF Detection

Med Page Today

(MedPage Today) -- Gamification of daily step goals and financial incentives resulted in increased physical activity over 1 year. (Circulation) Ambulatory heart rate varies widely between healthy middle-aged individuals and cannot be predicted.

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Study Shows Web App Effective in Determining Access to Statins Without a Prescription

DAIC

milla1cf Tue, 04/09/2024 - 07:00 April 9, 2024 — Using a web application to qualify individuals for treatment with a nonprescription statin closely matched the results of clinician assessments in determining a person’s eligibility for taking statins to lower cholesterol, according to research presented at the American College of Cardiology ’s Annual Scientific Session.

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Highlights of ACC 2024

Cardiology Update

The American College of Cardiology (ACC) held its 73 rd annual scientific session and expo April 6-8, 2024 in Atlanta, Georgia. Here is our curated list of the top sessions. EMPACT-MI 1 ( NCT04509674 ) studied the effects of empagliflozin in patients who have experienced myocardial infarction (MI). Investigators assessed if empagliflozin could lower the risk of hospitalization for heart failure (HF) or death from cardiovascular disease (CVD).