Fri.Feb 09, 2024

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Double diabetes—when type 1 diabetes meets type 2 diabetes: definition, pathogenesis and recognition

Cardiovascular Diabetology

Currently, the differentiation between type 1 diabetes (T1D) and type 2 diabetes (T2D) is not straightforward, and the features of both types of diabetes coexist in one subject. This situation triggered the ne.

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Senators Thrash Pharma CEOs for Pricing Drugs Higher in the U.S.

Med Page Today

(MedPage Today) -- Senators pummeled the CEOs of three of the largest pharmaceutical companies with demands that they explain why one in four Americans can't afford their prescription drugs, prices of which are higher in the U.S. compared with.

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Immune genes are altered in Alzheimer's patients' blood

Science Daily - Stroke

A new study has found the immune system in the blood of Alzheimer's patients is epigenetically altered. That means the patients' behavior or environment has caused changes that affect the way their genes work. Many of these altered immune genes are the same ones that increase an individual's risk for Alzheimer's. Scientists now theorize the cause could be a previous viral infection, environmental pollutants or other lifestyle factors and behaviors.

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ECG Blog #416 — Is the Rhythm and ECG related?

Ken Grauer, MD

Imagine the only information provided for the ECG in Figure-1 — is that it was obtained from a 60-year old man with new CP ( C hest P ain ). QUESTIONS: In view of this brief history — How would YOU interpret this ECG in Figure-1 ? Is the cardiac rhythm related to the 12-lead ECG? Figure-1: The initial ECG in today’s case. MY Thoughts on the ECG in Figure-1: The goal of practicing clinicians is to interpret both parts of the tracing in Figure-1 ( = the cardiac rhythm and the 12-lead ECG ) — in an

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ISC 2024 News: Late-Breaking Science Findings from EMBOLISE Clinical Trial Reveals Blocking Artery Supplying the Brain Covering After Subdural Hematoma Reduced Repeat Surgery

DAIC

Preliminary late-breaking science presented today, the final day of the American Stroke Association’s International Stroke Conference 2024, ISC 2024, focused on findings from the EMBOLISE clinical trial, presented by Jason Davies, M.D., Ph.D., an associate professor in the departments of neurosurgery and biomedical informatics at the State University of New York, Buffalo.

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Chest pain with anterior ST depression: look what happens if you use posterior leads.

Dr. Smith's ECG Blog

Written by Jesse McLaren A 65 year old with a history of atrial flutter, CABG and end-stage renal disease on dialysis presented with 3 days of fluctuating chest pain, which was ongoing at triage. What do you think? Do you need posterior leads? There’s atrial flutter with controlled ventricular response, a non-specific intra-ventricular conduction delay, borderline right axis, normal R wave progression and normal voltages.

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Blocking artery supplying the brain covering after subdural hematoma reduced repeat surgery

American Heart News - Stroke News

Research Highlights: In the EMBOLISE clinical trial, obstructing (or blocking) an artery that supplies blood to the dura, the protective covering of the brain, along with surgery to remove pooled blood reduced the chances by nearly 3-fold that blood.

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The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database

Cardiovascular Diabetology

The TyG-BMI index, which is a reliable indicator of insulin resistance (IR), has been found to have a significant correlation with the occurrence of cardiovascular events. However, there still lacks study on t.

BMI 105
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Insomnia, Shorter Sleep Duration Linked to the Risk of Autoimmune Arthritis

HCPLive

Multivariable analyses found genetic predispositions to overall rheumatoid arthritis with decreased sleep duration, as well as a significant genetic association between seropositive rheumatoid arthritis and insomnia symptoms.

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Smidt Heart Institute Physicians Advance Transcatheter Tricuspid Valve Replacement

DAIC

Physicians in the Smidt Heart Institute at Cedars-Sinai have pioneered using a catheter-based approach to treat patients with tricuspid valve disease. Image by Getty. milla1cf Fri, 02/09/2024 - 08:45 February 9, 2024 — Physicians in the Smidt Heart Institute at Cedars-Sinai have achieved two significant firsts: completing the institute’s 100 th minimally invasive tricuspid valve replacement and performing the first-ever implantation of a new bioprosthetic tricuspid valve following its approva

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IHL-675A: Advancing Towards Innovative Arthritis Solutions, with Mark Bleackley, PhD

HCPLive

Mark Bleackley, PhD, discusses the upcoming phase 2 trial of IHL-675A designed to explore arthritis treatment through dual-drug comparison, promising global expansion, and its impact on patients’ pain relief.

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MIVI Neuroscience Presents Primary Endpoint Results from the EvaQ Trial — at the 2024 International Stroke Conference

DAIC

milla1cf Fri, 02/09/2024 - 09:28 February 9, 2024 — MIVI Neuroscience, Inc. announced the primary endpoint results of its EvaQ Trial , a prospective, multi-center, global, single arm, FDA-regulated IDE trial study to evaluate the safety and effectiveness of the MIVI Q Revascularization System for treating acute ischemic stroke. The data were presented yesterday at the 2024 International Stroke Conference (AZ), a premier event featuring global thought leaders and dedicated to the latest in the s

Stroke 105
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Many US Adults Unaware of Critical Cardiovascular Risk Factors

HCPLive

A recent survey indicates many US adults are unaware of their vital health metrics, highlighting the need for increased education on heart disease prevention.

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AI-Based Decision Support Boosts Post-Stroke Prevention

Med Page Today

(MedPage Today) -- PHOENIX -- An artificial intelligence decision support intervention for acute ischemic stroke patients at Chinese hospitals reduced subsequent vascular events, the GOLDEN BRIDGE II trial showed. The proportion of patients.

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Etanercept Effective for Psoriasis, Rheumatic Disease Among Patients Extending Treatment After 12-Weeks

HCPLive

These findings on both remission and low disease activity suggest that some individuals in routine clinical practice may see benefits after extending treatment with etanercept past 12 weeks.

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Is Thrombectomy Worth It for Isolated Posterior Cerebral Artery Occlusion? Meta?Analysis and Trial Sequential Analysis

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDThrombectomy is well‐established management for acute ischemic stroke involving large vessel occlusion. However. the potential efficacy of thrombectomy for isolated posterior cerebral artery occlusion remains limited. The study aims to evaluate the benefits of thrombectomy for isolated posterior cerebral artery occlusion.METHODSWe searched PubMed, Cochrane, and Embase for articles published until September 2023.

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Fundamentals of Medical Ethics: Ethical Issues in Providing Care in Safety-Net Health Systems

The New England Journal of Medicine

Resource constraints in safety-net systems mean that outlays for care must be measured against opportunity costs. What ethical framework should guide resource allocation and management decisions?

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Fractional flow reserve measurements and long-term mortality—results from the FLORIDA study

Frontiers in Cardiovascular Medicine

Background Randomized evidence suggested improved outcomes in fractional flow reserve (FFR) guidance of coronary revascularization compared to medical therapy in well-defined patient cohorts. However, the impact of FFR-guided revascularization on long-term outcomes of unselected patients with chronic or acute coronary syndromes (ACS) is unknown. Aims The FLORIDA (Fractional FLOw Reserve In cardiovascular DiseAses) study sought to investigate outcomes of FFR-guided vs. angiography-guided treatmen

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States with the healthiest, unhealthiest hearts

Becker's Hospital Review - Cardiology

Discover the top and bottom five states for heart health according to a Forbes report, with Colorado ranking highest at 100 and Arkansas at the lowest

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Late Tenecteplase Not Beneficial for Stroke Patients With LVOs

Med Page Today

(MedPage Today) -- PHOENIX -- Selected stroke patients did not benefit clinically from having the window of tenecteplase therapy extended beyond the first few hours of stroke onset, the randomized TIMELESS trial found. In patients with large.

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Clinician Quiz: Gastrointestinal Evaluation of Iron Deficiency Anemia

HCPLive

Test your knowledge of iron deficiency anemia in this clinician quiz, focused on gastrointestinal evaluation of IDA based on recommendations from the American Gastrointestinal Association's 2020 guidelines.

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Sleep Apnea a Risk Factor For Heart Failure From Cancer Therapy

American College of Cardiology

Sleep apnea is prevalent among patients at higher risk for developing congestive heart failure (CHF) following cancer treatment and could be used as a risk factor to identify patients who would benefit from earlier treatment, according to a study being presented at ACC’s Advancing the Cardiovascular Care of the Oncology Patient course.

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Interchangeability, Adverse Event Considerations for Adalimumab Biosimilars in IBD

HCPLive

Patients who switched from originator adalimumab to a biosimilar experienced more treatment-emergent adverse events compared to those who stuck with the biosimilar or the reference drug.

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Reduction of prevalence of patients meeting the criteria for metabolic syndrome with tirzepatide: a post hoc analysis from the SURPASS Clinical Trial Program

Cardiovascular Diabetology

Metabolic syndrome is characterized as the co-occurrence of interrelated cardiovascular risk factors, including insulin resistance, hyperinsulinemia, abdominal obesity, dyslipidemia and hypertension. Once week.

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Black Individuals’ Sleep Hindered by Police Killing Unarmed Blacks

HCPLive

After a study assessed how sleep was hindered following incidences where the police killed unarmed Black individuals, Black respondents had shorter sleep durations and more very short sleep (< 6 hours) than White participants.

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Determinants of survival following heart transplantation in adults with congenital heart disease

Journal of Cardiothoracic Surgery

Adult patients surviving with congenital heart disease (ACHD) is growing. We examine the factors associated with heart transplant outcomes in this challenging population with complex anatomy requiring redo-sur.

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A NOTIONal truth : Surgical AVR deteriorates faster than TAVI, for some mysterious reasons!

Dr. S. Venkatesan MD

Reviewing NOTION study, the Nordic TAVI 10 year follow up has just been released (Ref 1) : Caution : Non-academic content This study reports the long-term outcome in low-risk individuals who required AVR. The study basically compared the blind and passive deployment of bio-prosthetic aortic valve aided by the catheter skills of new-age cardiologists with sophisticated image backup versus  Open surgical replacement of the aortic valve by experienced cardiac surgeons, after meticulously removing a

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Hybrid operating room with ceiling mounted imaging system assisted pre-operative and intra-operative lung nodule localization for thoracoscopic resections: a 5-year case series

Journal of Cardiothoracic Surgery

Video-assisted thoracoscopic (VATS) lung resections are increasingly popular and localization techniques are necessary to aid resection. We describe our experience with hybrid operating room (OR) cone-beam com.

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Quiz: ACR Guideline for the Treatment of Psoriatic Arthritis

HCPLive

The ACR's Psoriatic Arthritis Guidelines provides comprehensive recommendations for managing active psoriatic arthritis and aims to assist clinicians and patients in making informed decisions tailored to individual situations.

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Tirofiban a Better Option for Ischemic Stroke When Lytics and Thrombectomy Aren't?

Med Page Today

(MedPage Today) -- PHOENIX -- For acute ischemic stroke patients without thrombolytic or thrombectomy options, tirofiban was better than aspirin alone, the TREND trial showed. In non-cardioembolic stroke, starting tirofiban within 24 hours of.

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Physiology Friday #204: Cold Water Immersion and Muscle Hypertrophy: Are You ‘Icing’ Your Gains?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including Zeit Calendar , Examine.com , and my eBook, “VO2 Max Essentials ”, can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Overestimation of HCV Prevalence Hinders Cost-Effectiveness of Universal Screening

HCPLive

HCV seroprevalence and antigen positivity were both low, suggesting universal birth cohort screening may not be necessary or cost-effective.

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CathPCI Registry: Impact of IVL on Calcium Modification Use For PCI

American College of Cardiology

The introduction of coronary intravascular lithotripsy (IVL), a novel calcium modification technology, has had a significant impact on the trends in calcium modification strategies used during PCI, although wide variation across hospitals remains, according to a recent study published in JSCAI.

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Defining the Blanking Period, Using Continuous ECG Monitoring, Following Cryoballoon Pulmonary Vein Isolation

HeartRhythm

Pulmonary vein isolation (PVI) is the cornerstone of atrial fibrillation (AF) ablation. A blanking period (BP) of 3 months is used in clinical trials and practice. However, the optimal BP duration following PVI remains undefined.

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Hospital infections and health-related quality of life after cardiac surgery: a multicenter survey

Journal of Cardiothoracic Surgery

Recent research suggested that hospital infections are a predictive marker for physical non-recovery one year after cardiothoracic surgery. The purpose of this study was to explore whether this risk factor is.

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Circulating Dipeptidyl Peptidase 3 Modulates Systemic and Renal Hemodynamics Through Cleavage of Angiotensin Peptides

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:High circulating DPP3 (dipeptidyl peptidase 3) has been associated with poor prognosis in critically ill patients with circulatory failure. In such situation, DPP3 could play a pathological role, putatively via an excessive angiotensin peptides cleavage. Our objective was to investigate the hemodynamics changes induced by DPP3 in mice and the relation between the observed effects and renin–angiotensin system modulation.Methods:Ten-week-old male C57Bl/6J m

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Association of HIV and HCV Infection With Carotid Artery Plaque Echomorphology in the MACS/WIHS Combined Cohort Study

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:HIV and hepatitis C virus (HCV) are associated with increased risk of carotid artery atherosclerotic plaque and stroke. We examined associations of HIV- and HCV-related factors with echomorphologic features of carotid artery plaque.METHODS:This cross-sectional study included participants from the MACS (Multicenter AIDS Cohort Study)/WIHS (Women’s Interagency HIV Study) Combined Cohort Study who underwent high-resolution B-mode carotid artery ultrasound.

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