Tue.Oct 22, 2024

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IV Fluid Shortage May Impact Surgeries Around the U.S. for Weeks

Med Page Today

(MedPage Today) -- Surgery schedules around the country may be washed out for several more weeks while a crucial IV and sterile fluids factory remains shut down for hurricane-related damage. People often plan non-emergency surgeries in the fall.

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EM Quick Hits 60 Post-Tonsillectomy Hemorrhage, Post-CABG Infections, Bougie Tips, Pelvic Fracture Bleeds, Debriefing: Why, When & How

ECG Cases

On this month's EM Quick Hits podcast: Kevin Wasko on post-tonsillectomy hemorrhage management, Brit Long on assessment and management of post-CABG surgical incision infections, Anand Swaminathan on evidence, pitfalls and tips on using Bougies, Leah Flannigan on when to suspect vascular injury in patients with low energy mechanism pelvic fractures, Andrew Petrosoniak on debriefing after cases: why, when and how.

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Why you should use the Queen of Hearts and record serial ECGs more often. If you wait for troponin.

Dr. Smith's ECG Blog

This was sent to me by a French colleague, Olivier Peyronie "Yesterday we received a 62 yo man with diabetes, hypertension and smoker. He reported typical chest pain since 4H AM and arrived at our ED at 10h with ongoing chest pain. The first ECG (10h14) showed TWI in inferior leads." Time zero: What do you think? Queen of Hearts Diagnosis: Not OMI with High Confidence (but in French!

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Hypotension With Sacubitril/Valsartan Use in HFrEF

American College of Cardiology

Among patients with heart failure and reduced ejection fraction (HFrEF) started on sacubitril/valsartan, what is the association between asymptomatic versus symptomatic hypotension and clinical outcomes?

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The State of Cardiology Employment

CardiacWire

MedAxiom released its 12th annual Cardiovascular Provider Compensation and Production Report , providing an in-depth look at the current state of working in cardiology. The massive 60-page report (n=5,663 providers, 202 programs, 2023 data) outlined four notable employment trends… Rising PE Ownership – Nearly 50% of surveyed private practice groups were also part of a private equity portfolio, up from zero a few years ago.

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Private Equity's Tighter Grip; ApoB Inhibitors vs Liver? Promising New RDN System

Med Page Today

(MedPage Today) -- Nearly half of all cardiology private practices were under private equity as of 2023, and there was a slight decrease in the proportion of groups owned by hospital systems, according to a MedAxiom compensation report. Constant.

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New Presentation of Ustekinumab Biosimilar Approved for Crohn’s, Ulcerative Colitis

HCPLive

Ustekinumab-aekn is set to enter the US market no later than February 21, 2025, as per a settlement and license agreement between Janssen, Teva, and Alvotech.

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Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularization

American College of Cardiology

The goal of the DEFINE-FLAIR trial was to evaluate if functional lesion assessment by instantaneous wave-free ratio (iFR) would be noninferior to fractional flow reserve (FFR) among patients with stable angina or acute coronary syndromes.

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Impact of diabetes mellitus on right ventricular dysfunction and ventricular interdependence in hypertensive patients with heart failure with reduced ejection fraction assessed via 3.0 T cardiac MRI

Cardiovascular Diabetology

Hypertension (HTN) and diabetes mellitus (DM) are two common comorbidities of heart failure with reduced ejection fraction (HFrEF), each of which can cause right ventricular (RV) dysfunction. The aim of this s.

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Translation of pathophysiological mechanisms of atrial fibrosis into new diagnostic and therapeutic approaches

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 October 2024; doi:10.1038/s41569-024-01088-w In this Review, Schotten and colleagues summarize the latest knowledge on the molecular and cellular mechanisms of atrial fibrosis, describe the electrophysiological manifestations of atrial fibrosis, critically appraise the diagnostic tools to quantify atrial fibrosis, discuss emerging therapeutic interventions, and highlight knowledge gaps and future research directions.

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Combined effect of anion gap and red cell distribution width on the risk of acute kidney injury after cardiac surgery

Journal of Cardiothoracic Surgery

This study was to analyze the roles of red blood cell distribution width (RDW), anion gap (AG) levels and their combined effects on the risk of acute kidney injury (AKI) following cardiac surgery.

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OpenEP and EP Workbench for electrophysiology data analysis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 October 2024; doi:10.1038/s41569-024-01092-0 In this Tools of the Trade article, Bodagh and Williams highlight the utility of OpenEP, an open-source platform that offers standardized solutions for storage and analysis of electroanatomic mapping data.

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Can surgery prevent a stroke?

CTVS

Did you know that one in four adults will suffer a stroke at some point in their life? A stroke occurs when the carotid arteries, the two main arteries that supply blood to the brain, become narrowed and restrict its flow. This often results from plaque build-up within the arteries known as carotid disease.

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Genetic Variation of Enzyme hCAZYme May Affect IBS Response to Low-Carb Diet

HCPLive

A new study revealed patients with genetic variation of hCAZyme enzymes were more likely to reach success with low-carb diets to relieve IBS symptoms than those without.

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Peripheral Artery Disease: Implications For Health and Quality of Life

American College of Cardiology

Peripheral artery disease (PAD) represents a significant global health burden, affecting >200 million people and accounting for approximately 10-15% of the population >50 years of age.

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Fall Clinical Dermatology 2024 | Conference Preview

HCPLive

This overview highlights our upcoming conference coverage at the Fall Clinical Dermatology Conference in Las Vegas.

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Effect of Antihypertensive Timing on Mortality and Morbidity: BedMed and BedMed-Frail Trials

American College of Cardiology

In this interview, Drs. Anthony DeMaria and Scott Garrison review the BedMed and BedMed-Frail trials findings which proved the emphasis to patients is taking BP medication when they are least likely to forget, irrelevant of time of day.

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Brain-Gut Behavioral Treatments May Ease IBS Abdominal Pain, Needs More Research

HCPLive

Brain-gut behavioral treatments, such as CBT and hypnotherapy, may alleviate abdominal pain in IBS, though no single therapy proves superior to others.

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RELAXin in Acute Heart Failure-2

American College of Cardiology

The goal of the RELAX-AHF-2 trial was to assess the safety and efficacy of serelaxin compared with placebo in reducing cardiovascular (CV) mortality in patients presenting with acute heart failure.

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Clinical Quiz: Diagnosing, Managing Common Focal Liver Lesions

HCPLive

Test your knowledge of the 2024 American College of Gastroenterology focal liver lesion diagnosis and management guidelines with this clinical quiz!

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Precision Medicine to Guide Blood Pressure Control

JAMA Cardiology

Hypertension is the leading modifiable risk factor for cardiovascular disease (CVD) in the US, affects 122 million adults, and is projected to exceed 180 million adults by 2050. Yet, control of blood pressure (BP) remains dismal with less than half of adults achieving control with disproportionately lower rates among non-Hispanic Black adults compared with non-Hispanic White adults.

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Ahmad Masri, MD, MS: Establishing Proof-of-Concept of Gene Editing in ATTR-CM

HCPLive

Masri previewed data to be presented at the AHA 2024 Scientific Sessions and shared his excitement for the ongoing phase 3 trial of NTLA-2001.

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Utility of a Systolic Blood Pressure Polygenic Risk Score With Chlorthalidone Response

JAMA Cardiology

This genetic association study uses data from Black participants in the the Genetics of Hypertension Associated Treatments (GenHAT) study to investigate the ability of systolic blood pressure polygenic risk scores to predict antihypertensive treatment response and apparent treatment-resistant hypertension.

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Dupilumab Leads to Complete Remission of Hand Eczema, Quality of Life Improvement

HCPLive

This analysis reconfirms the efficacy of dupilumab using a single-center design, a large sample size, and patients with chronic hand eczema.

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Methods and Techniques to Optimize Energy Delivery Using the Circular Array Pulsed Field Ablation Catheter

HeartRhythm

Pulsed field ablation (PFA) is a novel method of cardiac ablation in which electrical fields are used to create microscopic pores in the cardiomyocyte cell membrane resulting in cell death. Unlike traditional thermal radiofrequency and cryoablation technologies, PFA is cardiomyocyte preferential, reducing the risk of collateral damage to the esophagus and phrenic nerve.

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Exercise Training Improves Cognitive Function and Neurovascular Control in Patients With Heart Failure With Reduced Ejection Fraction and Permanent Atrial Fibrillation: A Secondary Analysis of the Exercise Training in Heart Failure With Reduced Ejection Fraction and Permanent Atrial Fibrillation: A Randomized Clinical Trial

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.

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Multielectrode catheter-induced ectopy mapping: a novel technique for ablation of infrequent premature ventricular contractions

HeartRhythm

Ablation of infrequent premature ventricular complexes (PVC) is challenging.

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Following the Dynamic Changes of Coronary Atherosclerosis: An Uphill Battle

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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The global, regional, and national burden of myocarditis in 204 countries and territories, 1990–2021: Results from the Global Burden of Disease Study 2021

European Journal of Heart Failure

Aims To estimate the global burden of myocarditis in the general population from 1990 to 2021. Methods and results Data on myocarditis were retrieved from the Global Burden of Disease Study 2021. Incidence, deaths, and disability-adjusted life years (DALYs), along with their age-standardized rates (ASRs) per 100 000 population, were used to measure the burden of myocarditis.

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Does the Use of Direct Oral Anticoagulants Influence the Incidence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism?

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.