Mon.Jan 22, 2024

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Emergency cardiovascular care impact goal outlines 3 target needs

American Heart News - Heart News

Statement Highlights: Despite significant advances in research, education, clinical practice and community-based programs, survival from cardiac arrest remains low. Significant disparities also exist in cardiac arrest outcomes. This scientific.

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Resynchronization-defibrillation for heart failure shows long-term benefits

Cardiology Update

The Resynchronization–Defibrillation for Ambulatory Heart Failure Trial (RAFT; NCT00251251 ) demonstrated a greater 5-year mortality benefit for patients receiving cardiac-resynchronization therapy (CRT) compared to those receiving implantable cardioverter–defibrillators (ICDs). However, the impact of CRT on long-term survival remained uncertain. [link] Patients with New York Heart Association (NYHA) class II or III heart failure, a left ventricular ejection fraction of 30% or less, and a QRS du

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AskBio Announces Initiation of Phase 2 GenePHIT Trial in Congestive Heart Failure (CHF)

DAIC

Getty Images milla1cf Mon, 01/22/2024 - 14:53 January 22, 2024 — Asklepios BioPharmaceutical , Inc. (AskBio), a gene therapy company wholly owned and independently operated as a subsidiary of Bayer AG , announced that it is initiating GenePHIT (Gene PHosphatase Inhibition Therapy), a Phase 2 trial of AB-1002 (also known as NAN-101 ) for the treatment of congestive heart failure (CHF).

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Geovanni Faddoul, MD: IgAN Recurrence After Kidney Transplantation

HCPLive

Geovanni Faddoul, MD, discusses findings from his recent study examining the impact of induction and maintenance therapy on IgAN recurrence, graft survival, and mortality in kidney transplantation.

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Three Researchers Awarded $1 million Each to Study New Heart Disease Treatments, Causes

DAIC

Getty Images milla1cf Mon, 01/22/2024 - 14:58 January 22, 2024 — A physician-scientist from Massachusetts researching whether chemicals naturally occurring in foods could help treat heart disease, a genetics expert from Pennsylvania exploring the molecular mechanisms of lipid metabolism and cardiovascular diseases and a California-based professor of cardiovascular medicine studying how vaping impacts the development of abdominal aortic aneurysms are the most recent American Heart Association

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Association found between dark chocolate consumption, reduced risk of essential hypertension

Medical Xpress - Cardiology

A team of cardiologists at Shaoxing People's Hospital, working with a colleague from Zhuji People's Hospital, both in China, has found an association between consumption of dark chocolate and reductions in the risk of essential hypertension.

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ACC Disappointed by Lack of Medicare Fix in Recent Continuing Resolution

DAIC

Getty Images milla1cf Mon, 01/22/2024 - 15:03 January 22, 2024 — The American College of Cardiology is again urging members of Congress to retroactively eliminate the 3.37% cut to the Medicare Physician Fee Schedule currently in effect and preserve patient access to care: “Less than three weeks into the new year, Congress has already left clinicians holding the bag again on Medicare payment reform.

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Monoclonal Antibodies May Cause Serious Harm for Patients with Alzheimer

HCPLive

Myloid-reducing monoclonal antibodies for patients with Alzheimer have harmful risks, such as cerebral edema, hemorrhage, serious adverse events, and death, according to a new study.

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Team develops bioengineered material to rapidly stop bleeding in patients on blood thinners

Medical Xpress - Cardiology

More than 11 million people in the United States take anticoagulation or antiplatelet medications, such as heparin or aspirin, to treat serious conditions like heart attack and stroke. However, these medications also put patients at risk of life-threatening bleeding in the case of injury or during surgery.

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Sitting and Early Death; Dana-Farber Retracts Multiple Papers; Winter Weather Deaths

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Prolonged sitting at work was associated with a 16% higher risk of all-cause mortality and 34% higher risk of death from cardiovascular disease, a cohort study from.

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Fibroblast-like cells promote plaque stability in response to anti-IL-1? therapy

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00993-4 Anti-inflammatory therapy involving IL-1β inhibition might reduce the risk of cardiovascular events in individuals with clonal haematopoiesis by increasing the number of fibroblast-like cells in the fibrous cap region of atherosclerotic plaques, thereby stabilizing the plaque and reducing the likelihood of rupture.

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Emergency cardiovascular care impact goal outlines three target needs

Medical Xpress - Cardiology

Only 10% of people who experience a cardiac arrest survive. In new challenge goals outlined in the American Heart Association Emergency Cardiovascular Care 2030 Impact Goals and Call to Action to Improve Cardiac Arrest Outcomes, the American Heart Association's volunteer advisory Emergency Cardiovascular Care Committee makes the case for doubling survivorship to 20%.

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Case Report: A case report of myocardial fibrosis activation assessment after unstable angina using 68Ga-FAPI-04 PET/CT

Frontiers in Cardiovascular Medicine

Myocardial ischemia may induce myocardial fibrosis, a condition that progressively leads to ventricular remodeling, heightening the risk of heart failure. The timely detection of myocardial fibrosis is crucial for intervention and improved outcomes. 68 Ga-FAPI-04 PET/CT shows promise in assessing fibroblast activation in patients with early myocardial infarction characterized by prolonged myocardial ischemia.

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Racial and Ethnic Disparities in Cardiac Surgery: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on racial and ethnic disparities in perioperative health care among patients undergoing cardiac surgery.

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Automated titanium fastener vs. hand-tied knots for prosthesis fixation in infective endocarditis

Frontiers in Cardiovascular Medicine

Objectives To date, there is no evidence regarding the safety of automated titanium fastener compared with hand-tied knots for prosthesis fixation in infective endocarditis. Methods Between January 2016 and December 2022, a total of 220 patients requiring surgery for infective endocarditis were included in this retrospective analysis. The primary study endpoint was re-endocarditis during follow-up.

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Initiation of ULT During Gout Flare Does Not Impact Severity, Duration

HCPLive

There were no differences in patient-rated pain scores, time to flare resolution, and the risk of recurrent flare in patients initiating urate-lowering therapy during treatment and those delaying treatment.

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Implantable cardiac monitors: artificial intelligence and signal processing reduce remote ECG review workload and preserve arrhythmia detection sensitivity

Frontiers in Cardiovascular Medicine

Introduction Implantable cardiac monitors (ICMs) provide long-term arrhythmia monitoring, but high rates of false detections increase the review burden. The new “SmartECG” algorithm filters false detections. Using large real-world data sets, we aimed to quantify the reduction in workload and any loss in sensitivity from this new algorithm. Methods Patients with a BioMonitor IIIm and any device indication were included from three clinical projects.

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The American Heart Association Emergency Cardiovascular Care 2030 Impact Goals and Call to Action to Improve Cardiac Arrest Outcomes: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Every 10 years, the American Heart Association (AHA) Emergency Cardiovascular Care Committee establishes goals to improve survival from cardiac arrest. These goals align with broader AHA Impact Goals and support the AHA’s advocacy efforts and strategic investments in research, education, clinical care, and quality improvement programs.

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Combinatorial immune checkpoint blockade increases myocardial expression of NLRP-3 and secretion of H-FABP, NT-Pro-BNP, interleukin-1? and interleukin-6: biochemical implications in cardio-immuno-oncology

Frontiers in Cardiovascular Medicine

Background Immune checkpoint blockade in monotherapy or combinatorial regimens with chemotherapy or radiotherapy have become an integral part of oncology in recent years. Monoclonal antibodies against CTLA-4 or PD-1 or PDL-1 are the most studied ICIs in randomized clinical trials, however, more recently, an anti-LAG3 (Lymphocyte activation gene-3) antibody, Relatlimab, has been approved by FDA in combination with Nivolumab for metastatic melanoma therapy.

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Phase 3b Findings on Guselkumab Indicate Rapid Scalp Psoriasis Clearance in Patients of Color

HCPLive

These data were announced by Johnson & Johnson this week and show several encouraging findings regarding guselkumab’s use among patients of different skin types.

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Non-essential heavy metal effects in cardiovascular diseases: an overview of systematic reviews

Frontiers in Cardiovascular Medicine

Introduction Cardiovascular diseases (CVDs) are the most important cause of premature death and disability worldwide. Environmental degradation and cardiovascular diseases are two keys to health challenges, characterized by a constant evolution in an industrialized world that exploits natural resources regardless of the consequences for health. The etiological risk factors of CVDs are widely known and include dyslipidemia, obesity, diabetes, and chronic cigarette consumption.

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Lower Plasma Ferritin Associated with Heart Failure in Adults Without Anemia

HCPLive

Observational data from the ARIC study reveals that lower plasma levels correlate with an increased risk of incident heart failure and diastolic dysfunction.

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Aortic arch branch-prioritized reconstruction for type A aortic dissection surgery

Frontiers in Cardiovascular Medicine

Background Acute Stanford type A aortic dissection (STAAD) is a fatal condition requiring urgent surgical intervention. Owing to the complexity of the surgical process, various complications, such as neurological disorders, are common. In this study, we prioritized the reconstruction of aortic arch branches during surgery and investigated the association between prioritizing the branches and the postoperative outcomes of patients with STAAD.

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Young Adults at Greater Risk of Adverse Events with Clozapine than Older Adults

HCPLive

A new study found individuals aged 18 – 55 with treatment-resistant schizophrenia had significantly greater adverse events than individuals aged ≥ 55 years.

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Efficacy of beta-blockers on blood pressure control and morbidity and mortality endpoints in hypertensives of African ancestry: an individual patient data meta-analysis

Frontiers in Cardiovascular Medicine

Introduction Compared with first-line antihypertensives, beta-blockers (BB) have been reported to lower the central aortic blood pressure suboptimally and are associated with increased stroke risk. This observation has not been investigated in hypertensives of African ancestry. We hypothesised that an individual patient data meta-analysis (IPD-MA) on the efficacy of second- or third-generation beta-blockers (STGBBs) in hypertensives of African descent may provide new insights.

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A long history of gender disparities in heart surgery outcomes: 7 notes

Becker's Hospital Review - Cardiology

Despite more than a decade of advancements in cardiac care and research, women still have a higher risk for death and adverse events after the heart surgery than men, a study of more than 1 million women found.

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Roger A Levy, MD, PhD: The Paradigm Shift in Lupus Nephritis Management

HCPLive

Roger A Levy, MD, PhD, discusses the transformative impact of the KDIGO guidelines, which recommend early initiation of belimumab for lupus nephritis.

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El objetivo de impacto de la atención cardiovascular de emergencia describe 3 necesidades que hay que atender

American Heart News - Heart News

Aspectos destacados de la declaración: A pesar de los importantes avances en la investigación, la educación, la práctica clínica y los programas comunitarios, la supervivencia al paro cardíaco sigue siendo baja. También existen disparidades.

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A Real Discussion on Augmented Reality Surgery

NOVARAD

In the relentless pursuit of enhancing patient outcomes using advanced technology, surgeons have been drawn to the promise of augmented reality (AR) surgery. The prospect of utilizing cutting-edge technology in the operating room is met with enthusiasm, but a critical question lingers: Has augmented reality surgery advanced far enough to be reliable?

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Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography

Journal of Cardiothoracic Surgery

The widespread utilization of chest High-resolution Computed Tomography (HRCT) has prompted detection of pulmonary ground-glass nodules (GGNs) in otherwise asymptomatic individuals. We aimed to establish a sim.

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The role of the molecular autopsy in sudden cardiac death in young individuals

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 January 2024; doi:10.1038/s41569-024-00989-0 A molecular autopsy is undertaken in cases of sudden cardiac death with no definitive cause found after conventional autopsy, with the aim of identifying a pathological genetic variant that could account for the death. Greater awareness of malignant arrhythmias in the absence of structural changes in inherited cardiomyopathies has increased the applicability of molecular autopsies, and resulted in improv

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Video assisted thorascopic assisted correction of left partial anomalous pulmonary venous connection: one case report

Journal of Cardiothoracic Surgery

The left partial anomalous pulmonary vein connection is a rare congenital heart disease, especially with intact atrial septum. Now we reported a case of the left superior pulmonary vein drainage to left innomi.

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Time Per Day Spent in EHR Continues to Rise for Primary Care Providers

HCPLive

A study of EHR workload trends reveals a concerning increase in primary care providers' time spent in the EHR post-pandemic, with providers spending 28 more minutes each workday on EHR-related tasks now relative to 2019.

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The application of extracorporeal membrane oxygenation in emergent airway management - a single-center retrospective study

Journal of Cardiothoracic Surgery

Emergent airway occurrences pose a significant threat to patient life. Extracorporeal membrane oxygenation (ECMO) has been proven to be an effective method for managing emergent airways.

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Predictions and Hopes for Healthcare in 2024

Cassling

As we head into the New Year, we’re starting to see some very positive trends in healthcare. Staffing within the healthcare space has roared back , outpacing basically every other industry. Drug prices continue to weigh on the average consumer, but new rules and negotiation policy have sought to bring some of those down. Life expectancy in the United States has actually experienced an uptick , and the advent of new technologies in even the most cost-effective imaging systems has led hospitals to

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Moving Beyond Symptom Control in CD

HCPLive

Experts discuss the idea that, while symptoms of Crohn’s disease (CD) contribute to a patient’s quality of life, symptom control alone is not sufficient and the focus should be modifying the disease process.

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Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy

American College of Cardiology

The goal of the ATTRibute-CM trial was to compare the safety and efficacy of acoramidis compared with placebo among patients with transthyretin amyloid cardiomyopathy (ATTR-CM).