Mon.Feb 05, 2024

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Even With Alzheimer's Pathology, Healthy Lifestyles May Preserve Cognition

Med Page Today

(MedPage Today) -- Cognitive function was better for older adults with healthy lifestyles even if they had Alzheimer's or other dementia-related pathologies, autopsy data showed. A 1-point increase in a healthy lifestyle score was associated with.

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Scientist shows focused ultrasound can reach deep into the brain to relieve pain

Science Daily - Heart Disease

Scientists have found soundwaves from low-intensity focused ultrasound aimed at a place deep in the brain called the insula can reduce both the perception of pain and other effects of pain, such as heart rate changes.

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New weight loss medication may help lower blood pressure in adults with obesity

American Heart News - Heart News

Research Highlights: The weight loss medication tirzepatide significantly lowered the systolic blood pressure of nearly 500 adults who had obesity and took the medication for 36 weeks, or about eight months, in a subset of an international clinical.

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Durable Weight Loss Follows Just a Few Injections of Novel Drug

Med Page Today

(MedPage Today) -- A once-monthly injectable weight management agent safely induced durable weight loss in a phase I human trial. At the highest dose tested, patients with overweight or obesity lost 14.5% of their body weight by day 85, Murielle.

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New Study Finds Tirzepatide Use Lowered Blood Pressure in Patients with Obesity

HCPLive

Tirzepatide, a dual GLP-1/GIP agonist approved for diabetes and obesity, was associated with significant blood pressure reductions in an analysis of the SURMOUNT-1 trial.

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Study finds new treatment to reverse inflammation and arterial blockages in rheumatoid arthritis

Science Daily - Heart Disease

Researchers have found that the molecule RvT4 enhances the body's natural defenses against atherosclerosis (hardening of the arteries) in patients with rheumatoid arthritis.

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Hydroxychloroquine, Leflunomide Improve Proteinuria, Renal Function in IgAN

HCPLive

Hydroxychloroquine and leflunomide were found to be safe and effective for treating IgAN, with study results showing the use of both immunosuppressants in combination with a renin-angiotensin system inhibitor proved most effective in improving proteinuria and stabilizing renal function.

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Nipocalimab Demonstrates Clinical Efficacy in Generalized Myasthenia Gravis, Sjögren's Syndrome Treatment

HCPLive

Promising results of the phase 2 and 3 trials offer hope for patients with chronic and debilitating autoantibody-driven diseases.

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New weight loss medication may help lower blood pressure in adults with obesity

Science Daily - Heart Disease

Weight loss medication reduced both day and nighttime blood pressure levels, finds new study.

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Anti-VEGF Treatment Reduces Mortality Risk in Older Adults with nAMD

HCPLive

Long-term anti-VEGF treatment for nAMD was linked to a reduction in mortality risk, with a slight increase in CVD risk, across 16-years of follow-up in Denmark.

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Pharmacological Management of Cardiac Arrhythmias in the Fetal and Neonatal Periods: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Disorders of the cardiac rhythm may occur in both the fetus and neonate. Because of the immature myocardium, the hemodynamic consequences of either bradyarrhythmias or tachyarrhythmias may be far more significant than in mature physiological states. Treatment options are limited in the fetus and neonate because of limited vascular access, patient size, and the significant risk/benefit ratio of any intervention.

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American Academy of Dermatology Reveals New Acne Vulgaris Guidelines

HCPLive

In new guidelines by the AAD, 18 new evidence-based recommendations and 5 practice statements were described for patients 9 years of age and older with acne.

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Comparing Low- or Standard-Dose Alteplase in Endovascular Thrombectomy: Insights From a Nationwide Registry

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Timely intravenous thrombolysis and endovascular thrombectomy are the standard reperfusion treatments for large vessel occlusion stroke. Currently, it is unknown whether a low-dose thrombolytic agent (0.6 mg/kg alteplase) can offer similar efficacy to the standard dose (0.9 mg/kg alteplase).METHODS:We enrolled consecutive patients in the multicenter Taiwan Registry of Endovascular Thrombectomy for Acute Ischemic Stroke who had received combined thrombolysis (wi

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Case Report: Incidental finding of an atresia of the inferior vena cava—a challenge for cardiac surgery

Frontiers in Cardiovascular Medicine

Inferior vena cava atresia is a rare and usually asymptomatic condition. However, when these patients undergo cardiac surgery, it can present an unexpected and challenging situation for the surgeon. Specifically, adequate venous drainage during cardiopulmonary bypass (CPB) is a critical issue here and may require an extension of cannulation strategies.

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Another PCSK9 Drug Proves Its Mettle for Kids With Inherited High Cholesterol

Med Page Today

(MedPage Today) -- For kids with heterozygous familial hypercholesterolemia (HeFH) uncontrolled by statins, adding alirocumab (Praluent) reduced low-density lipoprotein cholesterol (LDL-C), a randomized clinical trial showed. The PCSK9 inhibitor.

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A non-interventional cardiologist’s guide to coronary chronic total occlusions

Frontiers in Cardiovascular Medicine

Coronary chronic total occlusions (CTO) are present in up to one-third of patients with coronary artery disease (CAD). It is thus essential for all clinical cardiologists to possess a basic awareness and understanding of CTOs, including optimal evaluation and management. While percutaneous coronary intervention (PCI) for CTO lesions has many similarities to non-CTO PCI, there are important considerations pertaining to pre-procedural evaluation, interventional techniques, procedural complications

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Lawrence Eichenfield, MD: On Verrica Receiving Permanent J-Code for Cantharidin Treatment of Molluscum

HCPLive

This segment of Eichenfield’s interview features a discussion about the recent announcement of a J-Code for the molluscum contagiosum treatment cantharidin.

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Overexpression of VEGF? as a biomarker of endothelial dysfunction in aortic tissue of ?-GAL-Tg/KO mice and its upregulation in the serum of patients with Fabry’s disease

Frontiers in Cardiovascular Medicine

Introduction Fabry's disease is an X-linked lysosomal storage disorder caused by reduced activity of α-galactosidase A (GAL), leading to premature death on account of renal, cardiac, and vascular organ failure. Accumulation of the GAL substrate globotriaosylceramide (Gb3) in endothelial and smooth muscle cells is associated with early vascular cell damage, suggesting endothelial dysfunction as a driver of cardiorenal organ failure.

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2023 ESH Hypertension Guideline Update: Bringing Us Closer Together Across the Pond

American College of Cardiology

Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.

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A gentler approach to monitor for heart transplant rejection

Frontiers in Cardiovascular Medicine

Despite developments in circulating biomarker and imaging technology in the assessment of cardiovascular disease, the surveillance and diagnosis of heart transplant rejection has continued to rely on histopathologic interpretation of the endomyocardial biopsy. Increasing evidence shows the utility of molecular evaluations, such as donor-specific antibodies and donor-derived cell-free DNA, as well as advanced imaging techniques, such as cardiac magnetic resonance imaging, in the assessment of rej

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The top states, hospitals for cardiac surgery, per Healthgrades

Becker's Hospital Review - Cardiology

Healthgrades released its rankings of the top hospitals for cardiac surgery; only six states met the requirements to have hospitals ranked in the speciality.

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Upper extremity phlegmasia cerulea dolens complicating supra vena cava embolism in a cervical cancer patient: case report

Frontiers in Cardiovascular Medicine

Phlegmasia cerulea dolens (PCD) is a rare yet severe complication of deep vein thrombosis (DVT), characterized by a high amputation rate and mortality. Early diagnosis and treatment are crucial in managing this condition. PCD predominantly affects the lower extremities rather than the upper extremities. We herein present a rare upper extremity PCD case accompanied with supra vena cava and pulmonary embolism in a cervical cancer patient, who presented to our institution with severe pain, edema an

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Tirzepatide's Association With BP Reduction Reinforced With ABPM Data

Med Page Today

(MedPage Today) -- The once-weekly injectable tirzepatide (Mounjaro, Zepbound) was associated with reduced blood pressure (BP) in a prospective substudy of the SURMOUNT-1 trial. Depending on the dose of the combination glucagon-like peptide-1.

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Case Report: Kounis syndrome due to cryptopteran bite

Frontiers in Cardiovascular Medicine

Background Kounis syndrome is an acute coronary syndrome (ACS) caused by allergic reactions, including coronary artery spasm (type I) caused by allergies without coronary predisposing factors, pre-existing coronary atherosclerosis, and coronary artery disease. Anaphylaxis leads to plaque rupture or erosion leading to acute myocardial infarction (type II) and acute coronary stent thrombosis (type III).

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FDA Accepts NDA Submission for Acoramidis in ATTR-CM

HCPLive

The FDA's acceptance of the NDA for acoramidis in ATTR-CM was announced on February 05, 2024 and assigns a November 2024 PDUFA for the agent.

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Amplitude spectral area of ventricular fibrillation can discriminate survival of patients with out-of-hospital cardiac arrest

Frontiers in Cardiovascular Medicine

Background Evidence of the association between AMplitude Spectral Area (AMSA) of ventricular fibrillation and outcome after out-of-hospital cardiac arrest (OHCA) is limited to short-term follow-up. In this study, we assess whether AMSA can stratify the risk of death or poor neurological outcome at 30 days and 1 year after OHCA in patients with an initial shockable rhythm or with an initial non-shockable rhythm converted to a shockable one.

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Coronary pseudoaneurysm with a superficial mass and accompanying Brucella infection

Journal of Cardiothoracic Surgery

To our knowledge, no previously reported clinical data of a coronary artery fistula forming a pseudoaneurysm and presenting as a anterior chest wall lump. We reported a rare case of Coronary pseudoaneurysm wit.

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Association between hyperuricemia and long-term mortality in patients with hypertension: results from the NHANES 2001–2018

Frontiers in Cardiovascular Medicine

Objective The prevalence of hyperuricemia and hypertension is steadily increasing, and these conditions often share common risk factors. This study aimed to investigate the association among hyperuricemia, hypertension, and all-cause mortality in a nationally representative U.S. population. Methods Data for 38,644 participants were obtained from the National Health and Nutrition Examination Survey (NHANES) 2001–2018.

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What is the correlation between number of doctors in a society & health of population ?

Dr. S. Venkatesan MD

This query is lingering ever since I entered the medical profession. Though, this question might appear absurd , no correct answer is found yet.When we search the literature, the relationship between doctors and health can be 1.linear , 2. non linear, and 3. even inverse. 1 & 2 are ok 3 is forbidden. However, to put it in a nut-shell, healthiness of a society is little to do with Doctor population alone , is well known and I think it needs no proof.

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Efficacy and safety of novel left ventricular pacing leads: 1-year analysis of the NAVIGATOR trial

Open Heart

Objectives Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D (‘S shaped’) and NAVIGO 4LV ARC (‘U shaped’). Methods Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, NCT03279484). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10 weeks, 6, 12 and 24 months post-implant.

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Sleep Month in Review: January 2024

HCPLive

Our January 2024 sleep month in review includes studies regarding periodic limb movements to link to cardiovascular disease and death, sleep apnea serving as a risk factor for uncontrolled, severe asthma, and more.

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A Conversation on Simplifying Longevity with Dr. Howard Luks

Physiologically Speaking

Dr. Howard Luks is a board-certified orthopedic surgeon, chief of sports medicine and arthroscopy, and assistant professor of orthopedic surgery at New York Medical College. Dr. Luks's focus is on injuries that involve the shoulder, knee, ankle, and elbow. You can find him on X at the handle @hjluks. In addition to his expertise in sports medicine, Dr.

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Encouraging Patients for Biologic Use in Early Treatment of CD

HCPLive

Sarah Horst, MD, MPH, and Miguel Regueiro, MD, comment on the changing treatment landscape of CD, as well as share approaches to communicate with patients about starting biologic treatment early on in CD.

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Bedside zero-fluoroscopy temporary permanent pacemaker implantation in the electrical storm treatment under the guidance of EnSite 3D system: a case report

Journal of Cardiothoracic Surgery

Electrical storm (ES) is a clinical emergency characterized by multiple malignant ventricular arrhythmias or ICD discharges within 24 h, requiring early rational management.

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Shared Decision-Making, Routine Monitoring Among Best Practices for Managing EoE

HCPLive

The literature review discusses the rising incidence of eosinophilic esophagitis, highlighting the efficacy of proton pump inhibitors, challenges in diagnosis, and the need for collaborative decision-making in its management.

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Addressing HF in Latin American Women: A Call For Action

American College of Cardiology

Heart failure (HF) and cardiovascular disease have reached epidemic levels in Latin American (LATAM), with rising age-standardized mortality rates, and the disparities seen in women worldwide in terms of diagnosis and treatment are also relevant when it comes to HF in LATAM women.

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Adjunctive Cariprazine Safe for Treating Major Depressive Disorder

HCPLive

A pooled analysis showed patients on cariprazine for major depressive disorder had only mild to moderate treatment-emergent adverse events.

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