Journal of the American Heart Association

NOVEMBER 23, 2023

Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023. BackgroundPatients with nonalcoholic fatty liver disease are at increased risk to develop atherosclerotic cardiovascular diseases. FXR and GPBAR1 are 2 bile acid–activated receptors exploited in the treatment of nonalcoholic fatty liver disease: whether dual GPBAR1/FXR agonists synergize with statins in the treatment of the liver and cardiovascular components of nonalcoholic fatty liver disease is unknown.Methods

Aortic 40

Aortic Aneurysm Plaque Cholesterol 40

HeartRhythm

NOVEMBER 23, 2023

Brugada syndrome (BrS) is an inherited cardiac arrhythmogenic disease that predisposes patients to sudden cardiac death. It is associated with mutations in SCN5A, encoding the cardiac sodium channel alpha subunit (NaV1.5). BrS-related mutations have incomplete penetrance and variable expressivity within families.

Sudden Cardiac Death 40

Sudden Cardiac Death 40

European Journal of Heart Failure

NOVEMBER 23, 2023

Abstract Aims Transthyretin cardiac amyloidosis (ATTR-CA) is an infiltrative cardiomyopathy that commonly presents with concomitant chronic kidney disease. Albuminuria is common in heart failure and associated with worse outcomes, but its prevalence and relationship to outcome in ATTR-CA remains unclear. Methods and Results A total of 1181 patients with ATTR-CA were studied (mean age 78.1±7.9 years; 1022[86.5%] male; median eGFR 59ml/min/1.73m 2 [IQR: 47–74]).

Kidney Disease 40

Kidney Disease Article Biomarkers Heart Failure 40

HeartRhythm

NOVEMBER 23, 2023

Pulsed field ablation (PFA) is a nonthermal method to achieve selective cell death with little inflammation response. However, there are no reports in septal reduction therapy (SRT).

Ablation 40

Ablation 40

European Journal of Heart Failure

NOVEMBER 23, 2023

Clinical presentation, shock severity and mortality in patients with de novo versus acute-on-chronic heart failure-related cardiogenic shock. ACHF-CS, acute-on-chronic failure-related cardiogenic shock; CI, confidence interval; DNHF-CS, de novo heart failure-related cardiogenic shock; HR, hazard ratio. Aims Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of CS cases.

Cardiogenic Shock 40

Cardiogenic Shock Heart Failure Blood Pressure Outcomes 40

Circulation: Arrhythmia and Electrophysiology

NOVEMBER 23, 2023

Circulation: Arrhythmia and Electrophysiology, Ahead of Print. Background:Pulsed field ablation (PFA) has emerged as an alternative to radiofrequency ablation. However, data on focal point-by-point PFA are scarce. The aim of this study was to compare lesion durability and collateral damage between focally delivered unipolar/biphasic PFA versus radiofrequency in swine.Methods:Eighteen swine were randomized to low-dose PFA, high-dose PFA, and radiofrequency using a multimodality generator.

Ablation 40

Ablation Pulmonary Atrial Fibrillation Electrophysiology 40

Circulation

NOVEMBER 23, 2023

Circulation, Ahead of Print. BACKGROUND:Bleeding rates on dual antiplatelet therapy (DAPT) within 1 month after percutaneous coronary intervention (PCI) remain high in clinical practice, particularly in patients with acute coronary syndrome or high bleeding risk. Aspirin-free strategy might result in lower bleeding early after PCI without increasing cardiovascular events, but its efficacy and safety have not yet been proven in randomized trials.METHODS:We randomly assigned 6002 patients with acu

Stent 40

Stent Stents Thrombosis Myocardial Infarction 40

Circulation

NOVEMBER 23, 2023

Circulation, Ahead of Print. BACKGROUND:Frequent premature atrial complexes (PACs) are associated with future incident atrial fibrillation (AF), but whether PACs contribute to development of AF through adverse atrial remodeling has not been studied. This study aimed to explore the effect of frequent PACs from different sites on atrial remodeling in a swine model.METHODS:Forty swine underwent baseline electrophysiologic studies and echocardiography followed by pacemaker implantations and paced PA

Atrial Fibrillation 40

Atrial Fibrillation Electrophysiology Pacemaker Circulation 40

Circulation

NOVEMBER 23, 2023

Circulation, Ahead of Print. BACKGROUND:The majority of people with diabetes are susceptible to cardiac dysfunction and heart failure, and conventional drug therapy cannot correct diabetic cardiomyopathy progression. Herein, we assessed the potential role and therapeutic value of USP28 (ubiquitin-specific protease 28) on the metabolic vulnerability of diabetic cardiomyopathy.METHODS:The type 2 diabetes mouse model was established using db/db leptin receptor–deficient mice and high-fat diet/strep

Diabetes 40

Diabetes Cardiomyopathy Diet Heart Failure 40