Sun.Feb 04, 2024

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Lawrence Eichenfield, MD: Discussing New Findings on Topical Roflumilast for Atopic Dermatitis

HCPLive

In this interview, Eichenfield discussed the recent pooled analysis from two phase 3 studies looking at once-daily, topical roflumilast for patients 6 and older with eczema.

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Anticoagulants for atrial fibrillation: from warfarin and DOACs to the promise of factor XI inhibitors

Frontiers in Cardiovascular Medicine

Anticoagulation is the mainstay of stroke prevention in appropriate patients with atrial fibrillation. Due to advances in pharmacotherapy the anticoagulants used for this purpose have evolved significantly over the past decades with the aim of optimizing effectiveness while minimizing bleeding risks. Though significant improvements have been made toward this goal, bleeding risk remains the major concern with these therapies.

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Cardiac research: more fun facts

Heart Sisters

Dr. Sian Harding's book "The Exquisite Machine: The New Science of the Heart" is such a good read that it now lives beside my favourite chair where it's handy for re-reading random chapters.

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Clinical assessment of an AI tool for measuring biventricular parameters on cardiac MR

Frontiers in Cardiovascular Medicine

Introduction Cardiac magnetic resonance (CMR) is of diagnostic and prognostic value in a range of cardiopulmonary conditions. Current methods for evaluating CMR studies are laborious and time-consuming, contributing to delays for patients. As the demand for CMR increases, there is a growing need to automate this process. The application of artificial intelligence (AI) to CMR is promising, but the evaluation of these tools in clinical practice has been limited.

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Edwards EVOQUE First FDA-Approved Transcatheter Tricuspid Regurgitation Treatment

CardiacWire

Edwards Lifesciences ended last week with the biggest structural interventions launch that we’ve seen in some time, announcing the FDA approval of its EVOQUE transcatheter tricuspid valve replacement system (TTVR). The EVOQUE is the first TTVR therapy to receive FDA approval, following its European CE Mark in October. The TTVR system is indicated for patients with severe symptomatic tricuspid regurgitation (TR) who haven’t responded to optimal medical therapy.

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Systemic immune–inflammation index for predicting postoperative atrial fibrillation following cardiac surgery: a meta-analysis

Frontiers in Cardiovascular Medicine

Background Postoperative atrial fibrillation (POAF) is a frequent complication that may increase morbidity and mortality risk following cardiac surgery. The systemic immune–inflammation index (SII) is an emerging biomarker that provides an integrated measure of inflammation by incorporating neutrophil, lymphocyte, and platelet counts. Recent studies have reported associations between elevated SII and increased POAF risk; however, significant heterogeneity exists regarding its predictive efficacy

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Transcribing in the digital age: qualitative research practice utilising intelligent speech recognition technology

European Journal of Cardiovascular Nursing

Abstract The digital revolution provides many opportunities for researchers to develop and evolve data collection methods. A key process in qualitative research data collection is the transcription of interviews, focus groups or fieldwork notes. Transcription is the process of converting audio, video or notes into accessible written format for qualitative data analysis.

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Nrf2/HO-1 signaling activation alleviates cigarette smoke-induced inflammation in chronic obstructive pulmonary disease by suppressing NLRP3-mediated pyroptosis

Journal of Cardiothoracic Surgery

This study examined the effect of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway on chronic obstructive pulmonary disease (COPD) and the potential molecular mechanism.

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So close, yet so far away: the relationship between MAM and cardiac disease

Frontiers in Cardiovascular Medicine

Mitochondria-associated membrane (MAM) serve as crucial contact sites between mitochondria and the endoplasmic reticulum (ER). Recent research has highlighted the significance of MAM, which serve as a platform for various protein molecules, in processes such as calcium signaling, ATP production, mitochondrial structure and function, and autophagy. Cardiac diseases caused by any reason can lead to changes in myocardial structure and function, significantly impacting human health.

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Clinical effect of the internal fixation for rib fracture with single utility port complete video-assisted thoracoscopic surgery

Journal of Cardiothoracic Surgery

The internal fixation for rib fracture with single-operation-port (two ports) complete video-assisted thoracoscopic surgery (VATS) is a promising surgical approach for treating multiple rib fractures. The stud.

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Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus

Frontiers in Cardiovascular Medicine

Background Carotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding.

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The impact of goal-directed fluid therapy on postoperative pulmonary complications in patients undergoing thoracic surgery: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery

Pulmonary complications after thoracic surgery are common and associated with significant morbidity and high cost of care. Goal-directed fluid therapy (GDFT) could reduce the incidence of postoperative pulmona.

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Biosimilars Month in Review: January 2024

HCPLive

The biosimilars month in review explores the efficacy and safety of biosimilars in treating uveitis, highlights the FDA’s acceptance of a biologics license application for an ustekinumab biosimilar, and emphasizes the safety and accessibility benefits of biosimilars in rheumatic conditions.

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Case Report: Temporary pacing using active fixation lead and invasive electrophysiology studies for immune checkpoint inhibitor associated reversible advanced atrioventricular block

Frontiers in Cardiovascular Medicine

A case of immune checkpoint inhibitors (ICIs)-associated myocarditis with reversible advanced atrioventricular block (AVB) was reported. We innovatively used active fixation lead connected to an external device for prolonged temporary pacing until atrioventricular conduction recovered. Invasive electrophysiology studies were performed to evaluate atrioventricular conduction in detail.

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The Electrocardiogram at 100 Years: History and Future

Circulation

Circulation, Volume 149, Issue 6 , Page 411-413, February 6, 2024.

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Oral Metformin Exhibits No Reduction in Geographic Atrophy Progression

HCPLive

Data from the phase 2 METforMIN trial do not support the use of oral metformin for reducing the progression of geographic atrophy.

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Exploring the Promise and Challenges of Artificial Intelligence in Biomedical Research and Clinical Practice

Journal of Cardiovascular Pharmacology

Artificial intelligence (AI) is poised to revolutionize how science, and biomedical research in particular, are done. With AI, problem solving and complex tasks using massive data sets can be performed at a much higher rate and dimensionality level compared to humans. With the ability to handle huge data sets and self-learn, AI is already being exploited in drug design, drug repurposing, toxicology, and material identification.

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What would be the best treatment option for the person with this ECG?

All About Cardiovascular System and Disorders

What would be the best treatment option for the person with this ECG?

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Less Obvious Than One Might Think: Why Is There Grouped Beating?

Circulation

Circulation, Volume 149, Issue 6 , Page 481-483, February 6, 2024.

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First degree AV block, sinus pause, QT prolongation on ECG

All About Cardiovascular System and Disorders

First degree AV block, sinus pause, QT prolongation on ECG

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Giants Hiding in Small Places: A Case of New Onset Heart Failure, Atrioventricular Block, and Ventricular Arrhythmias

Circulation

Circulation, Volume 149, Issue 6 , Page 475-480, February 6, 2024.

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What type of prosthetic valve is seen on this chest X-ray?

All About Cardiovascular System and Disorders

What type of prosthetic valve is seen on this chest X-ray?

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If Action is Delayed, Is Survival Denied? Management of Severe Hypercholesterolemia Is Important and Urgent

Circulation

Circulation, Volume 149, Issue 6 , Page 427-429, February 6, 2024.

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Complete heart block and right ventricular hypertrophy

All About Cardiovascular System and Disorders

Complete heart block and right ventricular hypertrophy

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Aldosterone Synthase Inhibitors and Mineralocorticoid Receptor Antagonists: Competitors or Collaborators?

Circulation

Circulation, Volume 149, Issue 6 , Page 414-416, February 6, 2024.

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Dual chamber pacemaker with leads on Chest X-ray

All About Cardiovascular System and Disorders

Dual chamber pacemaker with leads on Chest X-ray

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Assessment of the Effectiveness of Ticagrelor Preloading in Mitigating Periprocedural Myocardial Injury among Non-ST Elevation Myocardial Infarction Patients Opting for an Early Invasive Approach

Journal of Cardiovascular Pharmacology

An abstract is unavailable. This article is available as a PDF only.

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Sinus bradycardia with junctional escape rhythm

All About Cardiovascular System and Disorders

Sinus bradycardia with junctional escape rhythm

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Clinical effect of vein of Marshall ethanol infusion on mitral isthmus ablation

Frontiers in Cardiovascular Medicine

Purpose This study aimed to investigate the effect of Marshall ethanol infusion (VOM-Et) in the vein on mitral isthmus (MI) ablation. Methods Patients with persistent atrial fibrillation (AF) were grouped into vein of VOM-Et combined with radiofrequency (RF) ablation (VOM-Et-RF) and RF groups. The primary outcome was MI block immediate block rate after surgery.

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Post-operative Chest X-ray for Interpretation

All About Cardiovascular System and Disorders

Post-operative Chest X-ray for Interpretation

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Nerinetide Reduces Early Infarct Growth Among Stroke Patients Undergoing EVT Without Intravenous Alteplase

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDNerinetide treatment was associated with better clinical outcomes among patients with stroke undergoing endovascular treatment who were not treated with concurrent alteplase in the randomized ESCAPE‐NA1 (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke) trial.

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Left anterior descending coronary artery

All About Cardiovascular System and Disorders

Left anterior descending coronary artery

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Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: A phenomics approach

European Journal of Heart Failure

CA125, carbohydrate antigen 125; CTSL, cathepsin L; DKK1, Dickkopf-related protein 1; HBEGF, heparin-binding EGF-like growth factor; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; IL6, interleukin-6; IL6R, interleukin-6 receptor; IL8, interleukin-8; LV, left ventricular; NGF, neurotrophic growth factor; PlGF, placental growth factor; TNFRSF, tumour necrosis factor receptor superfamily.

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LVOT Obstruction – Echocardiogram

All About Cardiovascular System and Disorders

LVOT Obstruction – Echocardiogram

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Findings and conclusion for this ECG?

All About Cardiovascular System and Disorders

Findings and conclusion for this ECG?

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This chest X-ray is suggestive of?

All About Cardiovascular System and Disorders

This chest X-ray is suggestive of?

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What does this ECG show?

All About Cardiovascular System and Disorders

What does this ECG show?