Tue.Feb 27, 2024

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Living near pubs, bars and fast-food restaurants could be bad for heart health

American Heart News - Heart News

Research Highlights Closer proximity to and a higher number of ready-to-eat food outlets — particularly pubs, bars and fast-food restaurants — may be associated with a greater risk of developing heart failure, according to a study of half a million.

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FDA Issues CRL for Roluperidone for Treatment of Negative Symptoms in Schizophrenia

HCPLive

Minerva Neurosciences announced the receipt of a Complete Response Letter for roluperidone in treatment of negative symptoms in patients with schizophrenia on February 27, 2024 despite clinical trial data indicating improved Negative Symptom Factor Scores and Personal and Social Performance scale scores.

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Novel drug therapies for atrial fibrillation

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 February 2024; doi:10.1038/s41569-024-01004-2 Atrial fibrillation is the most common sustained arrhythmia and imposes a substantial burden on patients and health-care providers. Clinical evidence suggests that antiarrhythmic therapy to restore and maintain sinus rhythm (rhythm control) can reduce adverse cardiovascular outcomes in patients with new-onset atrial fibrillation.

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Fatty liver index is an independent risk factor for all-cause mortality and major cardiovascular events in type 1 diabetes: an 11-year observational study

Cardiovascular Diabetology

Non-alcoholic fatty liver disease (NAFLD), identified by the Fatty Liver Index (FLI), is associated with increased mortality and cardiovascular (CV) outcomes. Whether this also applies to type 1 diabetes (T1D).

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Aria CV Announces First Patient Successfully Implanted with Second-Generation Pulmonary Hypertension System

DAIC

milla1cf Tue, 02/27/2024 - 17:29 February 27, 2024 — Aria CV, Inc , a developer of medical devices treating pulmonary hypertension, today announced the first patient was implanted with the Gen 2 Aria CV Pulmonary Hypertension System as part of the ASPIRE PH clinical trial at Ascension St. Vincent Cardiovascular Research Institute in Indianapolis, Indiana.

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Why Waiting Until Age 50 To Address Risk Factors For Heart Disease Is Too Late.

Dr. Paddy Barrett

Most people only start to worry about cardiovascular risk later in life. This is a bad idea. Here’s why. When you look at the risk of having a heart attack, it is true that the older you are, the greater the odds of having a heart attack 1. So far, so good. But this graph is very misleading. While only 1-2% of those having a heart attack are less than 65 years of age, 1-2% of this very large number means a LOT of heart attacks.

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Bariatric Surgery a Long-Term Winner for Type 2 Diabetes

Med Page Today

(MedPage Today) -- Patients with type 2 diabetes had better glycemic control and higher rates of diabetes remission over the long term with bariatric surgery compared with lifestyle and medical management in the pre-GLP-1 receptor agonist era.

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What to Know About the Factor XIa Inhibitors on the Horizon

Med Page Today

(MedPage Today) -- A novel class of antithrombotic medication, the factor XIa inhibitors, has had a rocky start but is powering through phase III trials, which are now underway. MedPage Today sat down to discuss the novel agents with Graeme Hankey.

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EM Quick Hits 55 – Induction Agents, Gabapentinoids, Neuroprotective Intubation, Approach to Paresthesias, Preventing Burnout

ECG Cases

Anand Swaminathan on an update on the appropriate selection of induction agents. Hans Rosenberg on when to use gabapentinoids for pain control in the ED. Katie Lin on pearls for neuroprotective intubation. Nour Khatib and Hamza Jalal on an approach to paresthesias in the ED. Eric Wortmann on preventing burnout in emergency medicine. Please support EM Cases with a donation [link] The post EM Quick Hits 55 – Induction Agents, Gabapentinoids, Neuroprotective Intubation, Approach to Paresthesi

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Midterm outcomes of transcatheter aortic valve replacement in patients with active cancer

Open Heart

Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. Methods Data from the OCEAN-TAVI, a prospective Japanese registry of TAVR procedures, was analysed to compare prognoses and clinical outcomes in patients with and without active cancer at the time of TAVR.

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History of Sinusitis Raises Risk of Incident Rheumatic Disease

HCPLive

The presence of sinusitis is linked to a 40% heightened risk of a diagnosis of rheumatic disease, particularly in the 5 to 10 years before disease onset.

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Prospective Associations of Accelerometer?Measured Machine?Learned Sedentary Behavior With Death Among Older Women: The OPACH Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundSedentary behavior is a recognized mortality risk factor. The novel and validated convolutional neural network hip accelerometer posture algorithm highly accurately classifies sitting and postural changes compared with accelerometer count cut points. We examined the prospective associations of convolutional neural network hip accelerometer posture–classified total sitting time and mean sitting bout duration with all‐cause and c

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FDA Announces Voluntary Recall of Eye Ointments Due to Sterility Concerns

HCPLive

Brassica Pharma Pvt. Ltd. is voluntarily recalling eye ointment products with expiration dates from February 2024 to September 2025.

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Pregnancy History at 40?Years of Age as a Marker of Cardiovascular Risk

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundIndividual pregnancy complications are associated with increased maternal risk of cardiovascular disease. We assessed the link between a woman's total pregnancy history at 40 years of age and her relative risk of dying from atherosclerotic cardiovascular disease (ASCVD).Methods and ResultsThis population‐based prospective study combined several Norwegian registries covering the period 1967 to 2020.

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Deepak Bhatt, MD, MPH: 5 Late-Breaking Trials to Watch at ACC 2024

HCPLive

Deepak Bhatt, MD, MPH, looks ahead to discuss what he is most excited about from the upcoming late-breaking clinical trials sessions at the American College of Cardiology 2024 annual meeting

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Inspired by a legendary surgeon, Cleveland Clinic heart chief advances 'maturing' technologies

Becker's Hospital Review - Cardiology

Lars Svensson, MD, PhD, was on vacation in 1967 when he and his father heard about the first person-to-person heart transplant, performed by South African surgeon Christiaan Barnard.

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Biomarkers of Cardiovascular Risk in Patients With Rheumatoid Arthritis: Results From the TARGET Trial

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundCardiovascular disease remains an important comorbidity in patients with rheumatoid arthritis (RA), but traditional models do not accurately predict cardiovascular risk in patients with RA. The addition of biomarkers could improve prediction.Methods and ResultsThe TARGET (Treatments Against RA and Effect on FDG PET/CT) trial assessed whether different treatment strategies in RA differentially impact cardiovascular risk as measu

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Surya Bhatt, MD: Findings on Dupilumab for Patients with COPD, Type 2 Inflammation

HCPLive

In this Q&A discussion, Bhatt discusses the recent news of dupilumab’s supplemental Biologics License Application for COPD patients with type 2 inflammation, as well as its significance.

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Age and Computed Tomography and Invasive Coronary Angiography in Stable Chest Pain

JAMA Cardiology

This prespecified secondary analysis of the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial investigates the association of age with clinical outcomes after computed tomography and coronary angiography in stable chest pain.

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Heart disease research challenges 'one size fits all' aspirin guidelines

Science Daily - Heart Disease

Findings of a review of data from three clinical trials challenge current best practice for use of the drug for primary prevention of heart disease or stroke -- otherwise known as atherosclerotic cardiovascular disease. The analysis of data from three international clinical trials points to a need for further evidence on best practice among adults already taking aspirin for cardiovascular disease prevention.

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AWAKEN: Recurrent Neonatal AKI Linked To Longer Hospital Stay Than Single Episode

HCPLive

Younger gestational age, lower birthweight, and a more severe initial AKI episode were identified as risk factors for recurrent AKI, which was linked to extended hospitalization.

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Non-insulin-based insulin resistance indexes in predicting atrial fibrillation recurrence following ablation: a retrospective study

Cardiovascular Diabetology

Insulin resistance (IR) is involved in the pathophysiological processes of arrhythmias. Increasing evidence suggests triglyceride and glucose (TyG) index, metabolic score for insulin resistance (METS-IR), trig.

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Association of systemic in?ammation response index with all-cause mortality as well as cardiovascular mortality in patients with chronic kidney disease

Frontiers in Cardiovascular Medicine

Background Chronic Kidney Disease (CKD) stands as a formidable health challenge, recognized not only for its growing prevalence but also for its association with elevated mortality rates. Emerging evidence suggests that CKD is inherently linked to inflammatory processes, marking it as an inflammatory disorder. In this landscape, the systemic inflammatory response index (SIRI) emerges as a novel inflammation marker, yet to be applied for assessing the risk of mortality in CKD patients.

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Fatty Liver, Cardiometabolic Risk Factors Common Among Adults With HCV

HCPLive

Results suggest a high prevalence of fatty liver in adults with chronic HCV, which was significantly associated with central obesity, elevated blood pressure, and metabolic syndrome.

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Deep learning techniques for imaging diagnosis and treatment of aortic aneurysm

Frontiers in Cardiovascular Medicine

Objective This study aims to review the application of deep learning techniques in the imaging diagnosis and treatment of aortic aneurysm (AA), focusing on screening, diagnosis, lesion segmentation, surgical assistance, and prognosis prediction. Methods A comprehensive literature review was conducted, analyzing studies that utilized deep learning models such as Convolutional Neural Networks (CNNs) in various aspects of AA management.

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A Randomized, Double-Blind, Dose-Ranging Study of Zilebesiran in Patients With Mild-to-Moderate Hypertension

American College of Cardiology

The goal of the KARDIA-1 trial was to evaluate zilebesiran compared with placebo among patients with hypertension. Zilebesiran is a subcutaneous injectable that targets hepatic angiotensinogen (AGT) synthesis by RNA interference.

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Case Report: A case of third-degree atrioventricular block associated with primary cardiac lymphoma

Frontiers in Cardiovascular Medicine

Background Primary cardiac lymphoma is an extremely rare malignant lymphoma, with clinical manifestations related to its location. We reported the diagnosis and treatment of primary cardiac lymphoma in a patient presented with atrioventricular block. Case presentation A 64 year-old man was admitted to our hospital because of symptoms of a tired heart and shortness of breath.

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Diabetes Dialogue: ATTD 2024 Preview

HCPLive

Hosts break down their favorite sessions at the upcoming 17th International Conference on Advanced Technologies and Treatments for Diabetes.

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The intersection of heart failure and cancer in women: a review

Frontiers in Cardiovascular Medicine

Cancer and cardiovascular disease represent the two leading causes of morbidity and mortality worldwide. Women continue to enjoy a greater life expectancy than men. However, this comes at a cost with more women developing diabetes, hypertension and coronary artery disease as they age. These traditional cardiovascular risk factors not only increase their lifetime risk of heart failure but also their overall risk of cancer.

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Review Looks at Training Pathways, Competencies For Critical Care Cardiology

American College of Cardiology

As interest in training for critical care cardiology (CCC) continues to rise, a recent study found there is significant heterogeneity in current standardized CCC training paradigms for meeting training competencies and board certifications, reinforcing the unmet need to define competencies in the field, according to a study published Feb. 12 in JACC: Advances.

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Effective health management strategies for patients undergoing valve replacement: a bibliometric analysis of the current research status and future directions

Frontiers in Cardiovascular Medicine

Background Valvular heart disease is a major health concern worldwide. The effective management of patients undergoing valve replacement determines their prognosis. Bibliometric analysis of studies on managing patients with artificial heart valves has not been previously performed. Methods This study analyzed 2,771 publications related to patient management after valve replacement published in the Web of Science Core Collection database between January 1, 2013, and December 31, 2022.

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Viaskin Milk Patch Returns Mixed Results in Phase 1/2 Trial

HCPLive

Viaskin milk patch shows promise in cow’s milk allergy, particularly in children aged 2-11 with 300 μg dose, though the other doses examined failed to prove significant benefit.

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The prognostic value of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in patients with diabetes or prediabetes: insights from NHANES 2005–2018

Cardiovascular Diabetology

The Stress hyperglycemia ratio (SHR) is a novel marker reflecting the true acute hyperglycemia status and is associated with clinical adverse events. The relationship between SHR and mortality in patients with.

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Oral Therapies

HCPLive

This publication was developed independently by MJH Life Sciences Global Medical Affairs. Support for the thought leaders meeting and the publication was provided by Arcutis Biotherapeutics, Inc; The Bristol Myers Squibb Company; Janssen Global Services, LLC; and UCB, Inc.

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Association between different insulin resistance surrogates and all-cause mortality in patients with coronary heart disease and hypertension: NHANES longitudinal cohort study

Cardiovascular Diabetology

Studies on the relationship between insulin resistance (IR) surrogates and long-term all-cause mortality in patients with coronary heart disease (CHD) and hypertension are lacking. This study aimed to explore.

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Novel Biologics in Psoriasis—Safety Considerations

HCPLive

This publication was developed independently by MJH Life Sciences Global Medical Affairs. Support for the thought leaders meeting and the publication was provided by Arcutis Biotherapeutics, Inc; The Bristol Myers Squibb Company; Janssen Global Services, LLC; and UCB, Inc.

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SNAP Benefits and BP Meds; Post-PCI Anticoagulation Flop; CPAP's Potential Harm

Med Page Today

(MedPage Today) -- Receipt of Supplemental Nutrition Assistance Program benefits was associated with better adherence to antihypertensive medications. (JAMA Network Open) A new standard for chest protector equipment is intended to reduce the risk.

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