Fri.Jan 19, 2024

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Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

Cardiovascular Diabetology

Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and.

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Achieving Diabetes Remission, For No Matter How Long, Can Lower Kidney, Cardiovascular Risk

HCPLive

Evidence from the Look AHEAD study suggests achieving remission in type 2 diabetes is associated with risk reductions in chronic kidney disease and cardiovascular disease.

Diabetes 111
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First Patients Enrolled in the Gore VBX Forward Clinical Study

DAIC

milla1cf Fri, 01/19/2024 - 10:43 January 19, 2024 — W. L. Gore & Associates, Inc. announced that the first patients have been enrolled in the Gore VBX FORWARD Clinical Study ( NCT05811364 ), a global prospective, multicenter, randomized controlled trial to compare the GORE VIABAHN VBX Balloon Expandable Endoprosthesis (VBX Stent Graft) to bare metal stenting for patients with complex iliac occlusive disease.

Stents 107
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Corticosteroids Induce Remission in Patients With IgA Nephropathy, Moderate Proteinuria

HCPLive

Patients with IgAN and urine protein levels of 0.75–3.5 g/d treated with corticosteroids exhibited significantly greater overall and complete remission rates compared to those who received supportive care.

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Orchestra BioMed Announces Initiation of BACKBEAT Pivotal Study of AVIM Therapy in Hypertensive Pacemaker Patients

DAIC

milla1cf Fri, 01/19/2024 - 10:55 January 19, 2024 — Orchestra BioMed , a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, today announced the first patient was randomized in the BACKBEAT pivotal study in late December 2023. The BACKBEAT pivotal study will evaluate the efficacy and safety of atrioventricular interval modulation (“AVIM”) therapy (also known as BackBeat CNT), for the treatment of pacemaker-indicated patients with uncont

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Cost-effectiveness of stepwise provisional versus systematic dual stenting strategies in patients with distal bifurcation left main stem lesions: economic analysis of the EBC MAIN trial

Open Heart

Background In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting.

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Smidt Heart Institute Sudden Cardiac Arrest Expert Receives 2024 Distinguished Scientist Award

DAIC

Sumeet Chugh, MD, shown at work in his Cedars-Sinai laboratory, is the recipient of the American College of Cardiology 2024 Distinguished Scientist Award-Clinical Domain. Photo by Cedars-Sinai. milla1cf Fri, 01/19/2024 - 10:38 January 19, 2024 — Heart rhythm expert Sumeet Chugh, MD , associate director of the Smidt Heart Institute at Cedars-Sinai , is the recipient of this year’s American College of Cardiology ( ACC ) Distinguished Scientist Award-Clinical Domain.

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Severe Stroke at Age 24; Nurses' $100,000 Bonus; Paxlovid Insider Trading Conviction

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Rapper Snoop Dogg's 24-year-old daughter, Cori Broadus, suffered a "severe" stroke. (People) A Justice Department report blamed "cascading failures of leadership.

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Diabetes mellitus is associated to high-risk late gadolinium enhancement and worse outcomes in patients with nonischemic dilated cardiomyopathy

Cardiovascular Diabetology

Diabetes mellitus (DM) is associated with a worse prognosis in patients with heart failure. Our aim was to analyze the clinical and imaging features of patients with DM and their association with outcomes in c.

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Scientists discover first therapeutic target for preserving heart function in patients with pulmonary hypertension

Medical Xpress - Cardiology

A research team has discovered a possible therapeutic target for pulmonary hypertension. The study, published in the journal Science Advances, identifies the first therapeutic target that can be modulated to preserve cardiac function in pulmonary hypertension, providing hope in the fight against this rare but fatal disease for which there is currently no cure.

Pulmonary 101
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Study Pinpoints Critical, Unnecessary Components of CBT for Insomnia

HCPLive

A new study found critical components of CBT-I are cognitive restructuring, third-wave components, sleep restrictions, and stimulus control.

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Multiplexed MRM-based proteomics for identification of circulating proteins as biomarkers of cardiovascular damage progression associated with diabetes mellitus

Cardiovascular Diabetology

Type 2 diabetes mellitus (T2DM) increases the risk of coronary heart disease (CHD) by 2–4 fold, and is associated with endothelial dysfunction, dyslipidaemia, insulin resistance, and chronic hyperglycaemia. Th.

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FDA Adds Boxed Warning to Denosumab (Prolia) for Severe Hypocalcemia

HCPLive

On January 19, 2024, the FDA announced the addition of a Boxed Warning to the labeling of denosumab (Prolia), citing evidence of an increased risk of severe hypocalcemia in patients with chronic kidney disease.

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Mitral Annulus Calcium Score in Patients With Calcific Mitral Stenosis Undergoing Invasive Hemodynamic Assessment

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundAortic valve calcium score is associated with hemodynamic severity of aortic stenosis. Whether this association is present in calcific mitral stenosis remains unknown.Methods and ResultsThis study was a retrospective analysis of consecutive patients with mitral stenosis secondary to mitral annular calcification (MAC) undergoing transseptal catheterization.

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Artificial Intelligence Model Predicts HCV Patients At Risk of Treatment Failure

HCPLive

The XGBoost machine learning model outperformed other AI and logistic regression models for predicting DAA failure, with an AUROC of 1.000 in the training dataset and 0.803 in the validation dataset.

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Association between the triglyceride-glucose index and impaired cardiovascular fitness in non-diabetic young population

Cardiovascular Diabetology

The triglyceride-glucose (TyG) index has been linked to the onset, progression, and prognosis of cardiovascular disease (CVD) in middle-aged and elderly individuals. Nevertheless, the relationship between the.

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Features of trastuzumab-related cardiac dysfunction: deformation analysis outside left ventricular global longitudinal strain

Frontiers in Cardiovascular Medicine

Background Cancer therapy-related cardiac dysfunction due to trastuzumab has been well-known for many years, and echocardiographic surveillance is recommended every 3 months in patients undergoing trastuzumab treatment, irrespective of the baseline cardiotoxicity risk. However, the potential harm and cost of overscreening in low- and moderate-risk patients have become great concerns.

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Atrial Fibrillation Detection and Ischemic Stroke Recurrence in Cryptogenic Stroke: A Retrospective, Multicenter, Observational Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundAtrial fibrillation (AF) is known to be a strong risk factor for stroke. However, the risk of stroke recurrence in patients with cryptogenic stroke with AF detected after stroke by an insertable cardiac monitor (ICM) is not well known. We sought to evaluate the risk of ischemic stroke recurrence in patients with cryptogenic stroke with and without ICM‐detected AF.Methods and ResultsWe retrospectively reviewed patients with cryp

Stroke 69
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Meta-Analysis of Mineralocorticoid Receptor Antagonists and AF

American College of Cardiology

Are the cardioprotective effects of mineralocorticoid receptor antagonists (MRAs) diminished by heart failure (HF) or atrial fibrillation (AF), and can MRAs prevent AF?

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Impella Versus Intra?Aortic Balloon Pump in Patients With Cardiogenic Shock Treated With Venoarterial Extracorporeal Membrane Oxygenation: An Observational Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundVenoarterial extracorporeal membrane oxygenation (VA‐ECMO) is increasingly used for patients with cardiogenic shock. Although Impella or intra‐aortic balloon pump (IABP) is frequently used for left ventricular unloading (LVU) during VA‐ECMO treatment, there are limited data on comparative outcomes.

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OCD Linked to Increased Risk of Death from Natural and Unnatural Causes

HCPLive

A new study found individuals with OCD had an 82% increased risk of all-cause mortality as well as an increased risk of mortality due to natural causes and unnatural causes.

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Rapid expansion of a left atrial myxoma caused by acute multiple internal hemorrhages: a case report and literature review

Journal of Cardiothoracic Surgery

Left atrial myxoma is the most common benign tumor, with the growth rate remaining unknown because specific symptoms do not present until the tumor grows to a certain size. Early surgical management is perform.

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Etanercept, Adalimumab Biosimilars Demonstrate Similar Safety Profile to Originators

HCPLive

Results showed no differences regarding safety, although the biosimilar group had slightly more discontinuations due to inefficacy.

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Efficacy and safety of intraoperative partial spray of 50% glucose for patients with spontaneous pneumothorax

Journal of Cardiothoracic Surgery

The management for pneumothorax patients involves surgical intervention, nevertheless postoperative recurrences are often encountered. To reduce the rates of recurrence, thoracic surgeons have experimented wit.

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TNF-Inhibitor Biosimilars Prove Effective, Safe in Pediatric Non-infectious Uveitis

HCPLive

Real-life data reveal the effectiveness of TNF-inhibitor biosimilars in minimizing ocular flares and preserving visual acuity in pediatric patients with uveitis.

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10 Trends for 2024 Cardiology EHR Software

GEMMS

As we step into 2024, the evolution of Electronic Health Records (EHR) software continues to shape the future of healthcare. In an era marked by rapid technological advancements, the influence of EHR software on healthcare is more profound than ever. This article outlines the upcoming trends in Cardiology EHR for 2024, highlighting innovative features and strategies that promise to transform your practice, ensuring precision and advancement in care delivery.

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New Patient-Reported Assessment Tool Validated for Use with Chronic Prurigo

HCPLive

This study and its development of the Prurigo Control Test represents the first of its kind to assess chronic prurigo disease control.

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Anxiety and Depression in Adults With Congenital Heart Disease

American College of Cardiology

What is the prevalence of elevated levels of anxiety and depression in adults with congenital heart disease (ACHD)?

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Neal Bhatia, MD: Timing, Adherence, Unmet Needs Among Patients with Actinic Keratosis

HCPLive

This interview segment with Bhatia featured a discussion on addressing both unmet needs and lack of awareness among patients with actinic keratosis.

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Thirty Five Year Follow up of Three Generations of a Family with LMNA Cardiomyopathy

HeartRhythm

The clinical syndrome of combined cardiomyopathy and skeletal myopathy described in 2001 (1) was one of the initial descriptions of LMNA cardiomyopathy, a genetic variant. In 2001, genetic testing failed to detect the abnormality in this family. Three generations were followed clinically for 35 years with the diagnosis only made when a member underwent heart transplant and was found to have a class 1 variant: LMNA Arg321X, later confirmed in other family members.

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Biosimilar QL0911 Increases, Maintains Platelet Counts in Primary Immune Thrombocytopenia

HCPLive

A significantly larger proportion of patients receiving the biosimilar QL0911 achieved a durable platelet response when compared with placebo.

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Administrative Model for Profiling Hospital Performance on Coronary Artery Bypass Graft Surgery: Based on the Chinese Hospital Quality Monitoring System

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundWe aimed to develop an administrative model to profile the performance on the outcomes of coronary artery bypass grafting across hospitals in China.Methods and ResultsThis retrospective study was based on the Chinese Hospital Quality Monitoring System (HQMS) from 2016 to 2020. The coronary artery bypass grafting cases were identified by procedure code, and those of 2016 to 2017 were randomly divided into modeling and validation

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Trans-apical catheter ablation of ventricular tachycardia in a patient with metallic aortic and mitral valves

Journal of Cardiothoracic Surgery

We present a patient with a history of heart failure and metallic aortic and mitral valves surgeries, who required ablation for a drug-refractory left ventricular tachycardia. But the metallic valves prohibite.

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High Prevalence of New Clinically Significant Findings in Patients With Embolic Stroke of Unknown Source Evaluated by Cardiac Magnetic Resonance Imaging

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundEmbolic stroke of unknown source (ESUS) accounts for 1 in 6 ischemic strokes. Current guidelines do not recommend routine cardiac magnetic resonance (CMR) imaging in ESUS, and beyond the identification of cardioembolic sources, there are no data assessing new clinical findings from CMR in ESUS.

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Empirical slow pathway ablation in patients with paroxysmal palpitations and pounding in the neck: A 15-year follow-up

HeartRhythm

ECG documentation of atrioventricular-nodal re-entrant tachycardia (AVNRT) in patients with paroxysmal tachycardia is not always feasible. Even in patients with documented paroxysmal supraventricular tachycardia (SVT), there are chances that sustained AVNRT will not be induced during electrophysiological study (EPS). Pounding in the neck - flapping or bulging sensation and appearance of neck veins -, also called the “frog sign”, is considered as a classical anamnestic symptom, or when visible, s

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One?Year Disability Trajectories and Long?Term Cardiovascular Events, Recurrent Stroke, and Mortality After Ischemic Stroke

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundPatients with stroke are often affected by varying degrees of functional disability and have different evolution patterns in functional disability. However, little is known about the predictive usefulness of disability changes after stroke. We aimed to describe 1‐year disability trajectories and to assess the associations of longitudinal disability trajectories with 24‐month clinical outcomes after ischemic stroke.Methods and R

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Long?term outcomes of cardioneuroablation with and without extra?cardiac vagal stimulation confirmation in severe cardioinhibitory neurocardiogenic syncope

Journal of Cardiovascular Electrophysiology

Abstract Background Cardioneuroablation (CNA) is a novel therapeutic approach for functional bradyarrhythmias, specifically neurocardiogenic syncope or atrial fibrillation, achieved through endocardial radiofrequency catheter ablation of vagal innervation, obviating the need for pacemaker implantation. Originating in the nineties, the first series of CNA procedures was published in 2005.