Wed.Jun 05, 2024

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Higher blood pressure is associated with poorer cognition in adolescence

Science Daily - Heart Disease

Adolescents with elevated blood pressure and arterial stiffness may experience poorer cognitive functions, according to a recent study. Young people with higher blood pressure performed worse, especially in tasks that measured attention and learning. In addition, arterial stiffness was reflected in weaker working memory. In view of the findings, the importance of preventing high blood pressure and arterial stiffness in childhood and adolescence is emphasized.

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Edwards Lifesciences to Sell Critical Care to BD

DAIC

Getty Images milla1cf Wed, 06/05/2024 - 20:33 June 5, 2024 — Edwards Lifesciences announced it has entered into a definitive agreement to sell its Critical Care product group to BD (Becton, Dickinson and Company), in an all-cash transaction valued at $4.2 billion. With this agreement, Edwards is no longer pursuing the previously announced spin-off of Critical Care.

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Brain-Protected TAVR Results in Fewer Real-World Disabling Strokes

Med Page Today

(MedPage Today) -- NEW YORK CITY -- Researchers eked out evidence of a small clinical benefit with the Sentinel cerebral embolic protection (CEP) device in transcatheter aortic valve replacement (TAVR) -- and pointed to the patients more likely.

TAVR 105
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Normal angiogram one week prior. Must be myocarditis then?

Dr. Smith's ECG Blog

Written by Magnus Nossen The patient in todays case is a 50 year old male. He has a medical hx notable for hypertension, hyperlipidemia and previous tobacco use disorder. The patient presented due to chest pain that was typical in nature, retrosternal and radiating to the left arm and neck. He denied any exertional chest pain. The below ECG was recorded.

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Study reveals how 'forever chemicals' may impact heart health in older women

Science Daily - Heart Disease

New research has linked multiple types of per- and polyfluoroalkyl substances (PFAS, also known as 'forever chemicals') with increased risk of cardiovascular diseases in postmenopausal women. Specifically, the study reveals how PFAS chemicals interact with pro-inflammatory pathways in older women, providing potential explanations for the increased risk.

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Allison Brager, PhD: Exercise’s Impact on Cardiovascular Health, Circadian Clock

HCPLive

In an interview at SLEEP 2024, Brager talked about the benefits of exercise on cardiovascular health and sleep.

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Magnesium Disorders

The New England Journal of Medicine

This review focuses on recent discoveries in how magnesium functions in the body, concentrating on hypomagnesemia, the most common clinical magnesium disorder. Hypermagnesemia is rare and seen mainly in patients with kidney disease.

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New study suggests that amyloid contributes to calcific aortic valve disease development

Science Daily - Heart Disease

Researchers have now proposed a molecular mechanism that links amyloid deposition in the aortic valve with degenerative calcification. They also theorize that other risk factors for CAVD, such as high blood levels of lipoprotein, can contribute to calcification both directly and indirectly through the mechanisms that involve amyloid accumulation.

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Diabetes Dialogue: GLAM and CRISTAL, Updates in Pregnancy

HCPLive

In this episode, hosts provide their audience with an overview of a pair of new studies on the topic of diabetes in pregnancy: the GLAM and CRISTAL studies.

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Nocturnal hypoxemic burden and micro- and macrovascular disease in patients with type 2 diabetes

Cardiovascular Diabetology

Micro- and macrovascular diseases are common in patients with type 2 diabetes mellitus (T2D) and may be partly caused by nocturnal hypoxemia. The study aimed to characterize the composition of nocturnal hypoxe.

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ENDO 2024 Roundup: Teen GLP-1 Coverage; Novel CAH Drug; Hot Flash Risks

Med Page Today

(MedPage Today) -- BOSTON -- Some of the latest research advancements in hormonal health presented at the Endocrine Society's ENDO 2024 included a daily male birth control gel, semaglutide's taste sensitivity-boosting properties, and a novel.

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Changes in the combination of the triglyceride-glucose index and obesity indicators estimate the risk of cardiovascular disease

Cardiovascular Diabetology

Cardiovascular disease (CVD) is closely associated with the triglyceride glucose (TyG) index and its related indicators, particularly its combination with obesity indices. However, there is limited research on.

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Ophthalmology Month in Review: May 2024

HCPLive

This month-in-review features an exclusive interview with Srinivas R. Sadda, MD, and promising data from studies on geographic atrophy, diabetic macular ischemia, diabetic retinopathy, and AMD.

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Insulin resistance assessed by estimated glucose disposal rate and risk of incident cardiovascular diseases among individuals without diabetes: findings from a nationwide, population based, prospective cohort study

Cardiovascular Diabetology

Recent studies have suggested that insulin resistance (IR) contributes to the development of cardiovascular diseases (CVD), and the estimated glucose disposal rate (eGDR) is considered to be a reliable surroga.

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Nephrology Month in Review: May 2024

HCPLive

In our nephrology month in review for May 2024, we spotlight the biggest news from the NKF and ERA meetings, including the latest updates in IgA nephropathy, C3 glomerulopathy, chronic kidney disease, and more!

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Joint effects of CD8A and ICOS in Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS)

Journal of Cardiothoracic Surgery

Long QT Syndrome (LQTS) and Beckwith-Wiedemann Syndrome (BWS) are complex disorders with unclear origins, underscoring the need for in-depth molecular investigations into their mechanisms. The main aim of this.

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ELATIVE: Elafibranor Slows Disease Progression, Improves Itch-Related QoL in PBC

HCPLive

Late-breaking phase 3 data presented at EASL show elafibranor’s impact on managing PBC progression and improving itch-related quality of life in patients with pruritus.

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POLR1D silencing suppresses lung cancer cells proliferation and migration via inhibition of PI3K-Akt pathway

Journal of Cardiothoracic Surgery

The most common type of cancer that leads to death worldwide is lung cancer. Despite significant surgery and chemotherapy improvements, lung cancer patient’s survival rate is still poor. The RNA polymerase I s.

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FDA Awards Breakthrough Device Designation to AI Platform for Classifying Skin Cancer

HCPLive

The VIO Skin Platform by Enspectra Health was designed to assess lesions indicating either basal cell carcinoma or squamous cell carcinoma.

Cancer 64
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Prevalence and outcomes of patients with SMuRF-less acute coronary syndrome undergoing percutaneous coronary intervention

Open Heart

Background There is increasing awareness that patients without standard modifiable risk factors (SMuRFs; diabetes, hypercholesterolaemia, hypertension and smoking) may represent a unique subset of patients with acute coronary syndrome (ACS). We aimed to investigate the prevalence and outcomes of patients with SMuRF-less ACS undergoing percutaneous coronary intervention (PCI) compared with those with SMuRFs.

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Sairam Parthasarathy, MD: Researching Sleep Disturbances’ Impact on Immunity

HCPLive

Parthasarathy discussed next steps for research on the relationship between sleep disturbances and immunity in an interview with HCPLive at SLEEP 2024.

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Case Report: Coil embolization of ascending aortic pseudoaneurysm in patient with Behcet's disease

Frontiers in Cardiovascular Medicine

BackgroundBehcet's disease (BD) is a systematic vasculitis that affects vessels with various sizes, presenting as venous thrombosis and arterial pseudoaneurysms. The most severe manifestation in BD is ascending aortic pseudoaneurysm, which is associated with high risks of rupture and mortality.Case presentationWe present a case of ascending aortic pseudoaneurysm in a 50-year-old patient with BD.

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Medication Adherence in Patients with High LDL Cholesterol

HCPLive

The panel explores issues surrounding medication adherence and the potential for improved patient engagement. They emphasize that poor medication adherence increases the risk of cardiovascular events and discuss factors such as drug cost, timing of administration, and the importance of adopting a patient-centric approach to optimize treatment success.

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Cardiology Board Exam Pass Rates are Down. How Can You Pass? 

BoardVitals - Cardiovascular

The journey to becoming a board-certified cardiologist includes the American Board of Internal Medicine (ABIM) subspecialty examination in cardiovascular disease. While this exam was always known for being challenging, a recent trend of declining pass rates has made preparing for the test more important than ever. What is driving the drop in pass rates, and how can you ensure you are ready for exam day?

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Overcoming Prior Authorization Barriers in LDL Cholesterol Therapies

HCPLive

Michael Koren, MD addresses the challenges posed by prior authorization and the diminished role of pharmaceutical sales representatives in informing providers about medication advancements, leading to a disconnect in the provider's treatment arsenal.

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Investigating Electrocardiographic Abnormalities in Patients with Coronary Microvascular Dysfunction

The American Journal of Cardiology

Publication date: Available online 4 June 2024 Source: The American Journal of Cardiology Author(s): Ilan Merdler, Andrew P. Hill, Sevket Tolga Ozturk, Matteo Cellamare, Cheng Zhang, Kalyan R. Chitturi, Avantika Banerjee, Lior Lupu, Vaishnavi Sawant, Itsik Ben-Dor, Ron Waksman, Hayder D. Hashim, Brian C.

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Biomarkers and Eosinophil Levels in Severe or Uncontrolled Asthma

HCPLive

The key opinion leaders explore the utilization of biomarkers in guiding the treatment of severe or uncontrolled asthma, discussing the specific role of eosinophils in informing therapeutic decision-making for patients with challenging asthma cases.

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Association of the TyG index with prognosis in surgical intensive care patients: data from the MIMIC-IV

Cardiovascular Diabetology

The triglyceride–glucose (TyG) index, a tool for assessing insulin resistance, is increasingly recognized for its ability to predict cardiovascular and metabolic risks.

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Biologics in Asthma

HCPLive

The expert panel discusses the use of biologics in treating asthma, explaining their mechanisms of action, differences, and target populations, while also examining trends in long-term efficacy and safety for patients with severe or uncontrolled asthma.

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JACC: Advances Reviews Latest Advocacy Efforts to Protect Young Athletes From SCA

American College of Cardiology

By advocating for evidence-based policies like CPR education, AED access and emergency action plan (EAP) implementation, cardiovascular societies like the ACC and American Heart Association are working in tandem with initiatives like the National Football League (NFL)-led Smart Heart Sports Coalition to improve outcomes in young athletes experiencing sudden cardiac arrest (SCA), according to a recent Viewpoint published in JACC: Advances.

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MITIGATE: Inebilizumab Reduces Risk of IgG4-Related Disease Flare

HCPLive

Topline results from the randomized, placebo-controlled Phase 3 clinical trial demonstrated a statistically significant 87% reduction in IgG4-RD flares.

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Anticoagulation in Post-Operative AFib, Non-ST-Elevation Acute Coronary Syndromes, Arrhythmia-Induced Cardiomyopathy

American College of Cardiology

In this week’s View, Dr. Eagle looks at anticoagulation for post-operative atrial fibrillation after isolated coronary artery bypass grafting. He then examines a meta-analysis of invasive vs. conservative management of non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting.

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Rheumatology Month in Review: May 2024

HCPLive

The rheumatology month in review addresses opioid concerns and promotes holistic care in managing chronic conditions.

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Omnipolar Conduction Velocity Mapping for Ventricular Substrate Characterisation: Impact of CV Estimation Method and EGM Type on In-Vivo Conduction Velocity Measurements

HeartRhythm

Areas of abnormal and/or heterogenous conduction velocity (CV) are important ablation targets for ventricular tachycardias. Yet, precise assessment of CV in clinical contact mapping remains challenging. Numerous different CV estimation methods have been proposed.

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Mona Shahriari, MD: Evolving Role of Nonsteroidal Topicals in Plaque Psoriasis

HCPLive

Mona Shahriari, MD, discusses the evolving role of nonsteroidal topical options the management of plaque psoriasis.

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Effect of Cangrelor on Infarct Size in STEMI Treated by PCI

American College of Cardiology

What is the impact of the administration of cangrelor at reperfusion on myocardial infarct (MI) size and microvascular obstruction (MVO) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI)?

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Sodium in Patients’ Diets Linked to Increased Atopic Dermatitis Severity

HCPLive

These data suggest an association between dietary sodium intake and severity of eczema among patients.

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