Tue.Mar 19, 2024

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Early Stroke Scare With Bivalent COVID Vaccines Unsupported by Large Study

Med Page Today

(MedPage Today) -- Investigation of an early signal for stroke associated with COVID-19 bivalent vaccines turned into suspicion of high-dose or adjuvanted flu shots instead, based on a large U.S. population-based study. When researchers inspected.

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Spontaneous Coronary Artery Dissection: A Focus on Post-Dissection Care for the Vascular Medicine Clinician

Frontiers in Cardiovascular Medicine

Spontaneous coronary artery dissection (SCAD) is an uncommon condition which is increasingly recognized as a cause of significant morbidity. SCAD can cause acute coronary syndrome and myocardial infarction (MI), as well as sudden cardiac death. It presents similarly to atherosclerotic MI although typically in patients with few or no atherosclerotic risk factors, and particularly in women.

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Glucose Changes in Type 1 Diabetes May Affect Thinking Speed

Med Page Today

(MedPage Today) -- In type 1 diabetes, glucose fluctuations were linked with cognitive processing speed, but not sustained attention, researchers reported. According to data collected every 5 minutes from continuous glucose monitors, large fluctuations.

Diabetes 122
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Ep 192 ED Adult Asthma Management Strategies For Improved Prognosis – A Stepwise Approach

ECG Cases

In this part 1 of our 2-part podcast series on Asthma Management we explore a systematic approach to managing patients presenting to the ED with asthma exacerbations. Our discussion will emphasize the critical role of a thorough history and physical examination in effectively stratifying patient risk and guiding treatment/disposition decisions. Additionally, we'll examine the importance of providing comprehensive discharge medications and instructions to mitigate both mortality and morbidity ass

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ACC Clinical Trials Research Program REACH(es) New Heights

DAIC

Getty Images milla1cf Tue, 03/19/2024 - 19:09 March 19, 2024 — The American College of Cardiology ( ACC ) has selected 50 learners for its 2024 – 2025 Clinical Trials Research (CTR) program , of whom 28 structural heart cardiologists and surgeons will participate in the CTR’s new Project REACH. This incoming cohort of learners will participate in a year-long curriculum designed to advance their skills and careers in clinical trials research and ensure that all individuals have the opportunity

Research 105
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FDA Grants Clearance to Sequel's twiist AID System for Type 1 Diabetes

HCPLive

The FDA has cleared Sequel's twiist, a novel automated insulin delivery system, expanding patient choice for individuals with type 1 diabetes.

Diabetes 116
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Heat exposure may increase inflammation and impair the immune system

American Heart News - Heart News

Research Highlights: Exposure to high heat may impair the cells of the immune system that remember specific viruses and germs and over-produce signaling molecules that can lead to inflammation. Previous research testing participants’ blood on hot.

More Trending

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Sugary drinks, fruit juices linked to higher risk of developing Type 2 diabetes among boys

American Heart News - Heart News

Research Highlights: Preliminary findings from a long-term study of children in Massachusetts have potentially linked regularly drinking sugary drinks and fruit juices (8 ounces or more daily) during childhood and adolescence to a higher risk of.

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Study Details Rising Trends in Deceased Kidney Donation Differing by Age, Ethnicity

HCPLive

Previous reports suggest poor and unchanging rates of deceased kidney donation, though use of a recent metric for deaths compatible with donation yielded positive trends from 2003-2021.

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Optimizing antithrombotic therapy in patients with coexisting cardiovascular and gastrointestinal disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 20 March 2024; doi:10.1038/s41569-024-01003-3 In this Review, the authors address considerations for enteral antithrombotic therapy in patients with cardiovascular disease and gastrointestinal comorbidities, who often have an increased risk of gastrointestinal bleeding. Approaches include tailoring of antithrombotic regimens and gastrointestinal-protection strategies.

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An 80 year old woman with Left Bundle Branch Block (LBBB) and pleuritic chest pain

Dr. Smith's ECG Blog

This case was sent by Amandeep (Deep) Singh at Highland Hospital, part of Alameda Health System. The patient presented to an outside hospital An 80yo female per triage “patient presents with chest pain, also hurts to breathe” PMH: CAD, s/p stent placement, CHF, atrial fibrillation, pacemaker (placed 1 month earlier), LBBB. HPI: Abrupt onset of substernal chest pain associated with nausea/vomiting 30 min PTA.

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Time-restricted eating may raise cardiovascular death risk in the long term

Medical Xpress - Cardiology

A popular weight loss strategy that limits the hours during which calories can be consumed may nearly double a person's long-term risk of dying from cardiovascular disease, new research finds, especially among people with underlying cardiovascular disease or cancer.

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WTBS 29 Four Key Learnings from a Career in Emergency Medicine Leadership

ECG Cases

In this Waiting to Be Seen blog Dr. Howard Ovens outlines 4 key learnings from his extensive career in EM leadership: Be a good clinician, get substantial real-world experience, take a long-term view of benefits and risks and get along with your counterparts in the leadership dyad. The post WTBS 29 Four Key Learnings from a Career in Emergency Medicine Leadership appeared first on Emergency Medicine Cases.

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Medications for Type 2 diabetes, weight loss & kidney health not always provided as needed

American Heart News - Heart News

Research Highlights: Three independent, preliminary research studies have found that new Type 2 diabetes and weight-loss medications are often not prescribed or provided to patients as needed. One study of adults who had insurance covering the cost.

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Automatic and interpretable prediction of the site of origin in outflow tract ventricular arrhythmias: machine learning integrating electrocardiograms and clinical data

Frontiers in Cardiovascular Medicine

The treatment of outflow tract ventricular arrhythmias (OTVA) through radiofrequency ablation requires the precise identification of the site of origin (SOO). Pinpointing the SOO enhances the likelihood of a successful procedure, reducing intervention times and recurrence rates. Current clinical methods to identify the SOO are based on qualitative analysis of pre-operative electrocardiograms (ECG), heavily relying on physician’s expertise.

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Skin of Color Underrepresentation Highlighted in Review of Artificial Intelligence Use in Dermatology

HCPLive

These data indicate that, despite the promise held by AI in dermatological care improvement, training, validation, and ethical issues must be further evaluated before it is integrated further.

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Ticagrelor or Clopidogrel Monotherapy vs DAPT After PCI

JAMA Cardiology

This systematic review and individual patient data meta-analysis assesses the risks and benefits of ticagrelor monotherapy or clopidogrel monotherapy compared with standard dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).

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Details in pregnancy history shed light on risk of dying of cardiovascular disease

Medical Xpress - Cardiology

Pregnancy leads to a lot of radical changes within the body. The entire cardiovascular system reorganizes itself to sustain life for a second person inside the womb. The heart starts beating faster, and the total amount of blood in the body doubles. Mothers grow an entirely new organ, the placenta, to feed and protect the growing baby. All of this is normal, healthy, and safe.

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Whole genome sequencing in paediatric channelopathy and cardiomyopathy

Frontiers in Cardiovascular Medicine

Background Precision medicine in paediatric cardiac channelopathy and cardiomyopathy has a rapid advancement over the past years. Compared to conventional gene panel and exome-based testing, whole genome sequencing (WGS) offers additional coverage at the promoter, intronic regions and the mitochondrial genome. However, the data on use of WGS to evaluate the genetic cause of these cardiovascular conditions in children and adolescents are limited.

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Endeavor Health to move open-heart surgeries to new heart institute

Becker's Hospital Review - Cardiology

Evanston, Ill.-based Endeavor Health is discontinuing open-heart surgeries at two hospitals as it plans to open a cardiovascular institute at another of its hospitals in May. Once open, all heart surgeries will take place at Glenbrook Hospital in Glenview, Ill., The Evanston RoundTable reported March 18.

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Influence of acidic metabolic environment on differentiation of stem cell-derived cardiomyocytes

Frontiers in Cardiovascular Medicine

Stem cell-based myocardial regeneration is a frontier topic in the treatment of myocardial infarction. Manipulating the metabolic microenvironment of stem cells can influence their differentiation into cardiomyocytes, which have promising clinical applications. pH is an important indicator of the metabolic environment during cardiomyocyte development.

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Exercise and Sports Participation in Complex Congenital Heart Disease in Teenagers and Adults

American College of Cardiology

Developments in cardiovascular (CV) surgery and related care have led to the improved survival of patients with congenital heart disease (CHD) and more teenagers and adults living with congenital heart disease (ACHD).

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A cost-sensitive deep neural network-based prediction model for the mortality in acute myocardial infarction patients with hypertension on imbalanced data

Frontiers in Cardiovascular Medicine

Background and objectives Hypertension is one of the most serious risk factors and the leading cause of mortality in patients with cardiovascular diseases (CVDs). It is necessary to accurately predict the mortality of patients suffering from CVDs with hypertension. Therefore, this paper proposes a novel cost-sensitive deep neural network (CSDNN)-based mortality prediction model for out-of-hospital acute myocardial infarction (AMI) patients with hypertension on imbalanced data.

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Mental health conditions up for partners, children of stroke survivors

Medical Xpress - Cardiology

The risks for mental health conditions are higher for partners and adult children of stroke survivors, according to a study published in JAMA Network Open.

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Hackensack Meridian hospital's $45M cardiovascular expansion underway

Becker's Hospital Review - Cardiology

Neptune Township, N.J.-based Hackensack Meridian Jersey Shore University Medical Center's cardiovascular expansion project is underway with tentative plans to open later this year.

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A systematic review and meta-analysis of the diagnosis and surgical management of carcinoid heart disease

Frontiers in Cardiovascular Medicine

Introduction Carcinoid heart disease (CHD), a complication of carcinoid syndrome (CS), is a rare condition that can lead to right sided valvular heart disease and has been traditionally associated with a poor prognosis. We conducted a systematic review and meta-analysis to explore the accuracy of biomarkers and echocardiography in diagnosing CHD amongst patients who are already known to have neuroendocrine tumours and to assess whether surgical management of CHD leads to a reduction in mortality

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5 Keys to Patient Education on GLP-1 RAs for Weight Loss

Cardiometabolic Health Congress

As ‘magic’ weight loss drugs capture public attention, you’ve likely seen an uptick in patients asking about GLP-1 RAs for weight loss. As your go-to partner for cardiometabolic risk reduction research, industry news, and practical strategies, we’ve created this highly practical guide to help you educate patients on safe access to GLP-1 RAs for weight loss. #1 Discuss the Risks of Fraudulent Weight Loss Medications Due to the insatiable demand for weight loss and the proven fat-shredding powers

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Increased miR-6132 promotes deep vein thrombosis formation by downregulating FOXP3 expression

Frontiers in Cardiovascular Medicine

Background Deep vein thrombosis (DVT) is associated with aberrant gene expression that is a common peripheral vascular disease. Here, we aimed to elucidate that the epigenetic modification of forkhead box protein 3 (FOXP3) at the post-transcriptional level, which might be the key trigger leading to the down-regulation of FOXP3 expression in DVT. Methods In order to explore the relationship between microRNAs (miRNAs) and FOXP3, mRNA and microRNA microarray analysis were performed.

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Growth Hormone Somatropin is Effective, Does Not Increase Cancer or Diabetes Risk

HCPLive

The biosimilar recombinant human growth hormone, somatropin, was found to be well-tolerated; only 1.6% of pediatric patients had adverse events suspected to be caused by the injection.

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Accuracy of Wearable Heart Rate Monitors

American College of Cardiology

What is the accuracy of commercially available heart rate (HR) monitors during exertion and at rest for patients in sinus rhythm (SR) and atrial fibrillation (AF)?

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Study Identifies 4 Sleep Patterns to See Impact on Long-Term Health

HCPLive

More than half of the participants were identified as insomnia sleepers and nappers, two suboptimal sleep patterns linked with an increased risk of a chronic condition.

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Interpapillary muscle distance independently predicts recurrent mitral regurgitation

Journal of Cardiothoracic Surgery

Ischaemic secondary mitral regurgitation (ISMR) after surgery is due to the displacement of papillary muscles resulting from progressive enlargement of the left ventricle end-diastolic diameter (LVEDD). Our ai.

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Despite Evidence Demonstrating Safety, Statins Underused in MASLD Patients

HCPLive

An analysis of NHANES data suggests fewer than 3 in 10 patients with NAFLD received statin therapy, with only 50% with dyslipidemia receiving statins.

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18F-FDG PET/CT based model for predicting malignancy in pulmonary nodules: a meta-analysis

Journal of Cardiothoracic Surgery

Several studies to date have reported on the development of positron emission tomography (PET)/computed tomography (CT)-based models intended to effectively distinguish between benign and malignant pulmonary n.

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Telemedicine at Syringe Access Programs May Address Barriers, Expand Access to HCV Treatment

HCPLive

A recent survey found telemedicine-based HCV treatment at a syringe access program could improve access to treatment among people who inject drugs.

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Sat Is The New Wednesday

Dr. Paddy Barrett

For the last 20 months in a row, I have sent out a new article to you every Wednesday morning. But Wednesdays will be no more. But don’t worry. You will just have to wait until Saturday morning instead. I have made this change for a variety of reasons but I do hope getting your weekly heart health update at the weekend will make it easier to read.

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How can Warfarin be safe “even in” first trimester of pregnancy ? The story behind the 5 mg cut-off !

Dr. S. Venkatesan MD

The well known pro-coagulant state of pregnancy is an evolutionary protective process to make blood clot quicker, to save fetal loss in early pregnancy and mitigate postpartum bleeding. Still, in many women, this natural adaptive process confers an enhanced thrombotic risk. The molecular mechanisms for this pro-coagulant state are, there is increased factor VII, fibrinogen, reduced protein S.