Mon.Jul 15, 2024

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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145
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COVID May Affect Type 1 Diabetes in Kids, and Not in a Good Way

Med Page Today

(MedPage Today) -- COVID-19 may accelerate progression of presymptomatic type 1 diabetes in youth, a German study suggested. Incidence of clinical type 1 diabetes nearly doubled after the pandemic started among 591 youth ages 1 to 16 known to.

COVID-19 145
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HeartBeam’s Artificial Intelligence Algorithm Combined with Vectorcardiography (VCG) Outperforms Expert Cardiologists in Detecting Arrhythmias

DAIC

mtaschetta-millane Mon, 07/15/2024 - 11:18 July 15, 2024 — HeartBeam, Inc. , a medical technology company focused on transforming cardiac care through the power of personalized insights, today announced new study data demonstrating that HeartBeam AI combined with vectorcardiography (VCG) outperformed an expert panel of heart rhythm cardiologists in detecting atrial flutter.

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

American Heart News - Heart News

Research Highlights: A comparison of two tools for calculating cardiovascular disease risk found that if only the current 10-year risk thresholds are applied, fewer adults may be recommended for blood pressure-lowering medication. The tools, The.

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

Science Daily - Heart Disease

According to a new study, both 30-year risk for cardiovascular disease in addition to 10-year risk may be considered in making decisions about when to initiate high blood pressure medication.

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Circadian disruption, clock genes, and metabolic health

Journal of Clinical Investigation - Cardiology

A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal and human research to suggest that the expression of core circadian genes, such as circadian locomotor output cycles kaput gene (CLOCK), brain and muscle ARNT-Like 1 gene (BMAL1), period (PER), and cyptochrome (CRY), and the consequent expression

Diabetes 145
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Edwards Lifesciences to Acquire Innovalve

DAIC

Getty Images mtaschetta-millane Mon, 07/15/2024 - 11:06 July 15, 2024 — Edwards Lifesciences announced it has exercised its option to acquire Innovalve Bio Medical Ltd. , an early-stage transcatheter mitral valve replacement (TMVR) company, following its initial investment in 2017. Since that time, Innovalve has demonstrated progress in its program with promising early clinical experience.

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Strategic Deal to Deliver Virtual Value-based Cardiology Care Announced by Guidehealth and Story Health

DAIC

A strategic deal to deliver virtual value-based cardiology care to health systems has been announced by the Dallas, TX-based executive team at Guidehealth, a provider of AI-enabled healthcare services and Story Health, a Cupertino, CA-based digital company involved in specialty care delivery. Image courtesy: Guidehealth christine.book Mon, 07/15/2024 - 12:20 July 15, 2024 — Guidehealth , an artificial intelligence (AI)-enabled healthcare services company, has announced a strategic deal with Stor

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HBV, HCV Screening Disparities Among Low-Income US Veterans

HCPLive

An analysis of data from the NV-HOPE study calls attention to lower rates of HBV and HCV screening among low-income US veterans versus the general US veteran population.

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Pemafibrate Takes a Small Step Forward in Diabetic Foot Ulcers After CVD Flop

Med Page Today

(MedPage Today) -- Pemafibrate was tied to potential prevention of leg and foot ulcers in type 2 diabetes, a silver lining to the PROMINENT trial's otherwise disappointing cardiovascular results. In an exploratory analysis, pemafibrate was tied.

Diabetes 114
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VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models

Journal of Clinical Investigation - Cardiology

Pathogenic variants in valosin-containing protein (VCP) cause multisystem proteinopathy (MSP), a disease characterized by multiple clinical phenotypes including inclusion body myopathy, Paget’s disease of the bone, and frontotemporal dementia (FTD). How such diverse phenotypes are driven by pathogenic VCP variants is not known. We found that these diseases exhibit a common pathologic feature: ubiquitinated intranuclear inclusions affecting myocytes, osteoclasts, and neurons.

Dementia 103
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Switching to Faricimab Effective for Treatment-Naive Wet AMD

HCPLive

A case series analysis indicated that switching from aflibercept to faricimab could be a safe and effective option for patients with treatment-resistant nAMD.

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New study finds cardiovascular outcomes better for patients on home hemodialysis

Medical Xpress - Cardiology

Dialysis patients using a more traditional home hemodialysis procedure have lower incidence of cardiovascular disease than patients using a less invasive peritoneal catheter for dialysis at home, according to a study led by a University of Cincinnati College of Medicine researcher.

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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

Journal of Clinical Investigation - Cardiology

The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis. Here, we examined the role of the MC3R and the melanocortin system in regulating the response to various anorexigenic agents. The genetic deletion or pharmacological inhibition of the MC3R, or subthreshold doses of an MC4R agonist, improved the dose responsiveness to glucagon-like peptide

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Off-the-shelf wearable trackers provide clinically-useful information for patients with heart disease

Science Daily - Heart Disease

Monitoring of heart rate and physical activity using consumer wearable devices was found to have clinical value for comparing the response to two treatments for atrial fibrillation and heart failure.

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Diabetes Dialogue: CATALYST Trial and Hypercortisolism in T2D, with John Buse, MD, PhD

HCPLive

In this episode, John Buse, MD, PhD, discusses the background, expected prevalence, reaction to results, and the importance of the second part of the CATALYST trial.

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Off-the-shelf wearable trackers provide clinically-useful information for patients with heart disease

Medical Xpress - Cardiology

A study published in Nature Medicine examined if a commercially-available fitness tracker and smartphone could continuously monitor the response to medications, and provide clinical information similar to in-person hospital assessment.

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Ascension heart center named after donors

Becker's Hospital Review - Cardiology

"Discover the new Jay & Lori Bergman Heart Hospital at Ascension Saint Joseph-Joliet, honoring the couple's philanthropic legacy and supporting advanced cardiac

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Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis

Journal of Clinical Investigation - Cardiology

Cutaneous leishmaniasis caused by Leishmania parasites exhibits a wide range of clinical manifestations. Although parasites influence disease severity, cytolytic CD8+ T cell responses mediate disease. Although these responses originate in the lymph node, we found that expression of the cytolytic effector molecule granzyme B was restricted to lesional CD8+ T cells in Leishmania-infected mice, suggesting that local cues within inflamed skin induced cytolytic function.

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Study finds long-term stroke survival improving, but racial disparities remain

Medical Xpress - Cardiology

Overall rates of long-term survival following stroke are improving, but Black individuals experience worse long-term outcomes compared to white individuals, according to University of Cincinnati research published online July 15 in Neurology.

Stroke 75
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Patients with Both Psoriasis, Hypertension Have Increased Mortality Likelihood

HCPLive

Individuals with both psoriasis and hypertension have approximately a 2-fold increased mortality risk, which is greater than the mortality risk for psoriasis or hypertension alone.

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BMI variability and cardiovascular outcomes within clinical trial and real-world environments in type 2 diabetes: an IMI2 SOPHIA study

Cardiovascular Diabetology

BMI variability has been associated with increased cardiovascular disease risk in individuals with type 2 diabetes, however comparison between clinical studies and real-world observational evidence has been la.

BMI 59
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Lowering systolic blood pressure below 120 mmHg may reduce dementia risk among Black, Latino populations

Medical Xpress - Cardiology

A new study suggests that reducing systolic blood pressure below the clinically safe threshold of 120 mmHg over time may produce slight health-protective benefits against late-life dementia and help reduce racial and ethnic disparities in both hypertension and hypertension control.

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RA Linked to Reduced Risk of Colorectal Cancer

HCPLive

A new study shows RA is linked to an increased risk of hematological tumors and bladder, lung, and liver cancer compared to the general population.

Cancer 64
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ACC CardiaCast: The What, Who, When and Why of Lipoprotein(a)

American College of Cardiology

In this episode, Drs. Erin Michos and Christie Ballantyne examine the importance of testing and identifying lipoprotein(a) (Lp[a]) levels in patients, research highlighting trends in populations at risk, and the genetic factors involved in assessment.

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Views on Use of Patient-Reported Outcome Measures for Itch Assessment

HCPLive

These findings highlight clinician versus patient perceptions of chronic pruritus assessment using patient-reported outcome measures.

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Association of atherogenic index of plasma with cardiovascular disease mortality and all-cause mortality in the general US adult population: results from NHANES 2005–2018

Cardiovascular Diabetology

The atherogenic index of plasma (AIP) is a critical metric for predicting cardiovascular outcomes. However, its associations with cardiovascular disease mortality (CVM) and all-cause mortality (ACM) remain unc.

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Oral JAK Inhibitors vs Other Systemic Treatments in Atopic Dermatitis

HCPLive

An academic dermatologist describes how JAK inhibitors compare with other systemic treatments for atopic dermatitis and provides clinical insights on when to use which treatments.

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Analysis of cardiac arrest after coronary artery bypass grafting

Journal of Cardiothoracic Surgery

Cardiac arrest after coronary artery bypass grafting (CABG) is a serious complication with low survival rate. The prognosis of patients with cardiac arrest in the general ward is worse than that in the intensi.

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Submit a Question for My Upcoming Subscriber Q&A!

Physiologically Speaking

Greetings! Do you have burning questions about the best workout routines, tips for optimizing nutrition, or how to maintain your cardiovascular health? Or perhaps you're curious about my daily health practices and what my training routine looks like? Now's your chance to get those answers! I’m excited to announce that I'll be hosting a special Q&A session exclusively for you.

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Analysis of risk factors for complications in echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation

Journal of Cardiothoracic Surgery

The feasibility of percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) for the treatment of hypertrophic obstructive cardiomyopathy (HOCM) has been previously reported. However, limited invest.

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Systemic Treatments in Atopic Dermatitis: Use and Treatment Inertia

HCPLive

Christopher Bunick, MD, PhD, advises on when to consider systemic treatments and the frequency of moving to advanced treatments for patients with moderate to severe atopic dermatitis.

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The Vital Role of Cardiac Rehabilitation After a Heart Event

MIBHS

If you’ve recently experienced a heart attack, heart surgery, or been diagnosed with heart disease, your doctor has likely recommended cardiac rehabilitation. This medically supervised program is designed to help you recover and improve your cardiovascular health through exercise, education, and lifestyle modifications. While cardiac rehab may seem like an added burden during an already challenging time, it plays a crucial role in your recovery and long-term well-being.

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Atopic dermatitis Clinical Trial Endpoints

HCPLive

An atopic dermatitis expert discusses the primary and secondary efficacy endpoints and treatment goals commonly assessed in clinical trials for moderate to severe atopic dermatitis.

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BRCAness, DNA gaps, and gain and loss of PARP inhibitor–induced synthetic lethality

Journal of Clinical Investigation - Cardiology

Mutations in the tumor-suppressor genes BRCA1 and BRCA2 resulting in BRCA1/2 deficiency are frequently identified in breast, ovarian, prostate, pancreatic, and other cancers. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient cancer cells by inducing synthetic lethality, providing an effective biomarker-guided strategy for targeted cancer therapy.

Cancer 78
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Oral JAK Inhibitors in Atopic Dermatitis

HCPLive

Ruth Ann Vleugels, MD, MPH, MBA, provides an overview of oral JAK inhibitors approved for the treatment of atopic dermatitis and describes what makes them an attractive therapeutic option.

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Injectables for high blood pressure are in the works. Could they mean no more daily pills?

Medical Xpress - Cardiology

About one-third of adults have high blood pressure. Two-thirds of these have uncontrolled high blood pressure.