Fri.Jun 07, 2024

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ECG #433 — Which Lead Convinced Me?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a previously healthy older man — who presented to the ED ( E mergency D epartment ) with new but atypical CP ( C hest P ain ) for several hours. QUESTIONS: Given this history — How would YOU interpret this ECG? Which lead is the most concerning? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Sugar Substitute Linked to Heart, Thrombotic Risk

Med Page Today

(MedPage Today) -- The popular low-calorie sweetener xylitol was linked to increased cardiovascular and thrombotic risk, a series of experiments showed. Metabolomic studies linked xylitol intake to higher risk for major adverse cardiovascular.

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Judite Blanc, PhD: VR on Maternal Stress, Sleep Reduction in Women of Color

HCPLive

During SLEEP 2024, Judite Blanc, PhD, discussed her team’s ongoing study assessing whether an education VR program improves maternal stress and sleep among women of color.

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Quick Test Helps Detect Dementia

Med Page Today

(MedPage Today) -- A quick cognitive assessment tool helped improve dementia-related care in primary care patients, a randomized controlled trial showed. Compared with standard care, the 5-Cog system tripled the odds that a patient would receive.

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BioCardia Announces United States Patent Issuance on Intramyocardial Delivery of Cell Aggregates to the Heart Including Minimally Invasive Radial Artery Approach

DAIC

milla1cf Fri, 06/07/2024 - 14:55 June 7, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced that the Unites States Patent Office has granted Patent No: 11,986,611 titled “Radial and Transendocardial Delivery Catheter,” with a patent term that will expire in 2036.

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How does oxygen depletion disrupt memory formation in the brain?

Science Daily - Stroke

When we learn something new, our brain cells (neurons) communicate with each other through electrical and chemical signals. If the same group of neurons communicate together often, the connections between them get stronger. This process helps our brains learn and remember things and is known as long-term potentiation or LTP. Another type of LTP occurs when the brain is deprived of oxygen temporarily -- anoxia-induced long-term potentiationor aLTP. aLTP blocks the former process, thereby impairin

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New Data for Medtronic CoreValve/Evolut TAVR Systems Reinforces Excellent Valve Performance

DAIC

milla1cf Fri, 06/07/2024 - 14:50 June 7, 2024 — Medtronic today announced new data from the CoreValve Evolut Clinical Program , reinforcing the positive performance of the Evolut transcatheter aortic valve replacement (TAVR) System compared to surgical aortic valve replacement (SAVR) and other TAVR valves. Two analyses were presented as late-breaking data at the New York Valves Structural Heart Summit, including a secondary analysis of the SMall Annuli Randomized To Evolut or SAPIEN (SMART

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In Memoriam: Stuart J. Connolly, MD

DAIC

June 7, 2024 — It is with great sadness that the Diagnostic and Interventional Cardiology (DAIC) team has learned of the passing of arrhythmia medicine pioneer Stuart J. Connolly, MD, on June 2. According to his obituary published in the Hamilton Spectator, he completed a Bachelor of Philosophy at McGill University, then a Master of Philosophy at Fordham University, then returned to McGill where he graduated from medical school in 1977.

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Chest pain with serial ECGs – can you guess the sequence?

Dr. Smith's ECG Blog

Written by Jesse McLaren A 45-year-old presented with 24 hours of intermittent chest pain. Below are serial ECGs focusing on the inferior leads and aVL. Can you guess the sequence? First, what’s the interpretation of each ECG on its own? #1 There’s T wave inversion in III/aVF and a taller T wave in aVL and V2. On it’s own this is nonspecific, but in the right context this could be diagonal occlusion (if active chest pain) or infero-posterior reperfusion (if resolved chest pain). #2 Normal ECG #3

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New Study Suggests that Amyloid Contributes to Calcific Aortic Valve Disease Development

DAIC

Getty Images milla1cf Fri, 06/07/2024 - 15:10 June 7, 2024 — Calcific aortic valve disease (CAVD) is the major heart valve disease that afflicts nearly 10 million patients globally with an annual mortality exceeding 100,000, and the numbers continue to rise. In CAVD, microcrystals of hydroxyapatite (a calcium phosphate mineral) deposit onto the heart valve leaflets and impair cardiac function.

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Advancements in Pediatric Psoriasis Treatment, with Lisa Swanson, MD

HCPLive

Lisa Swanson, MD, discusses the recent advancements in pediatric dermatology and emphasizes the importance of correctly diagnosing conditions to improve patient outcomes.

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Search for Missing Doctor; Energy Drinks and Sudden Death; Unusual Pandemic Cancers

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Concern is growing as Greek authorities continue to search for Michael Mosley, MD, a British weight-loss doctor and television personality who went missing Wednesday.

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High-Impact Chronic Pain in Sickle Cell Linked to Poor Health Outcomes

HCPLive

High-impact chronic pain is a severely affected subgroup in SCD and is associated with greater pain burden and worse health outcomes.

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To Understand Heart Disease, You Need To Understand This.

Dr. Paddy Barrett

Heart disease does not kill people. Heart attacks do. Appreciating this distinction is critical to understanding heart disease. Heart disease is the presence of plaque or atherosclerosis in the coronary arteries. (Heart disease can, of course, refer to many other heart-related conditions, but in general, the terms heart disease and coronary artery disease or atherosclerosis are typically used interchangeably ) A heart attack occurs when plaque ruptures in the artery, forming a clot that blocks b

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Full GRACE Results Shed Further Light on Effects of Relacorilant in Hypercortisolism

HCPLive

At Heart in Diabetes, full results of the GRACE trial detailed the benefits of relacorilant use from both parts of the 2-part, phase 3 trial.

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Efforts toward Equity: Reviving Hearts — Uniting Communities with Lifesaving Bystander CPR

The New England Journal of Medicine

Medical students and faculty at the University of Pittsburgh have been teaching middle-school students from marginalized racial and ethnic groups how to perform bystander CPR.

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Study Suggests COPD Preventative Measures Needed During Seasonal Virus Circulations

HCPLive

These data indicate the benefits of implementing individual protective measures in winter by patients with COPD.

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Highlights from The National Lipid Association (NLA) Scientific Sessions 

Cardiometabolic Health Congress

The NLA Scientific Sessions (May 30-June 2, 2024) has concluded, providing key insights into lipid management and cardiovascular health. Here are some notable highlights: 1.LOWER Registry 9-Year Data of Lomitapide in HoFH : Dr. James A. Underberg presented data on the safety and efficacy of lomitapide in HoFH (homozygous familial hypercholesterolemia).

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Low Stress Resilience In Adolescence Associated with Increased Psoriasis Risk Among Men

HCPLive

These data suggest that those with psoriasis maintain an innate psychological vulnerability, indicating the necessity of addressing mental well-being in the disease’s management.

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New Position Statement Offers Guidance on 3D-ICE Utilization

American College of Cardiology

Three-dimensional (3D) intracardiac echo (ICE) generates high-quality, near-field images of cardiac structures and holds potential to emerge as a complement or alternative to transesophageal echocardiography (TEE) for intraprocedural guidance of structural heart interventions, according to a position statement published in JACC: Cardiovascular Imaging and discussed as part of the New York Valves Structural Heart Summit 2024.

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Study Finds Black, Hispanic Patients Less Likely to Undergo Lp(a) Testing

HCPLive

A study found that only 0.32% of 1.2 million patients underwent Lp(a) testing, with non-Hispanic Black and Hispanic patients significantly less likely to receive the test compared to White patients.

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Physiology Friday #221: The Optimal Balance of Sleep, Sitting, and Exercise for Metabolic Health

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Josiane Broussard, PhD: Meal Timings Impact on Sleep

HCPLive

At SLEEP 2024, Broussard told HCPLive about how eating time restriction can serve as another as another dietary tool for people who are unsuccessful with other strategies.

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Interactive Online Decision Aid Improves Shared Decision-Making For Patients With Severe Aortic Stenosis

American College of Cardiology

A novel interactive, online decision aid used at the point of care among patients with severe aortic stenosis (AS) was strongly endorsed by patients and clinicians, easy to use and improved the quality of shared decision-making with a treatment decision that reflected patient values.

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Kaitlyn Mayne, MBChB: Impact of Multimorbidity, Polypharmacy on Benefits of SGLT2i in CKD

HCPLive

Kaitlyn Mayne, MBChB, discusses an analysis of the EMPA-Kidney trial examining the effects of multimorbidity, polypharmacy, and quality of life on effects of empagliflozin.

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Fostering Psychological and Mental Health in the CV Workforce: Key Points

American College of Cardiology

The following are key points to remember from an American Heart Association science advisory on fostering psychological safety and supporting mental health among cardiovascular (CV) health care workers.

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Managing Suboptimal Adherence to HIV Medications

HCPLive

The panel discusses strategies to predict patients who will have poor adherence to their HIV medications and how to select the best treatment options for them.

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Updated Guideline for Management of Lower Extremity Peripheral Artery Disease

NEJM Journal Watch - Cardiology

This update of the 2016 guideline includes new options for medical therapies and a focus on health disparities.

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Evolving Treatment Landscape in COPD

HCPLive

Igor Barjaktarevic, MD, PhD, discusses the evolving treatment landscape in COPD, highlighting current treatment approaches and novel therapies on the horizon.

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Pulsed-Field Ablation in Paroxysmal Atrial Fibrillation: 1-Year inspire Outcomes

NEJM Journal Watch - Cardiology

PFA appears safe and effective, but whether it's better than radiofrequency or cryoablation remains unclear.

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HIV Drug Resistance Testing Practices and Patient Education

HCPLive

Experts on HIV provide clinical insights on testing for drug resistance prior to treatment and approaching the topic of resistance with patients.

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Proving SGLT2 Inhibitor-Mediated Improvement in Cardiomyocyte Energetics: Beyond a Reasonable Doubt?

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print.

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Bemnifosbuvir, Ruzasvir Combination Shows 97% SVR12 Rate in Phase 2 Trial for HCV

HCPLive

8 weeks of treatment with combination bemnifosbuvir and ruzasvir showed a 97% SVR rate at 12 weeks post-treatment in a phase 2 lead-in cohort.

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GOLD Treatment Guidelines and Evolving Therapeutic Approaches

HCPLive

Experts on respiratory diseases discuss the GOLD treatment guidelines for COPD and discuss research that is informing treatment strategies.

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Knowledge Levels, Adherence to Medical Advice Critical in Anemia Care

HCPLive

Knowledge, attitudes, and practices remain relevant for disease management among patients with anemia.

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Mobile App Improves Disease Control in Patients with Rheumatic Diseases

HCPLive

Patients in the active counseling group were more likely to achieve low disease activity or remission.

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Josiane Broussard, PhD: Meal Timings Effect on Cardiometabolic Health, Sleep

HCPLive

Broussard discussed the importance of eating during the day at SLEEP 2024.

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