Dr. Paddy Barrett
NOVEMBER 1, 2024
“But what can I do to make a difference?” This is one of the most common questions I get as a cardiologist when talking about preventing heart disease and living longer. As a doctor, there are many things I can do, and only a doctor can do: Prescribe medications Order certain diagnostic tests. Perform or arrange medical procedures. And so on.
HCPLive
NOVEMBER 1, 2024
Headline results from part 1 of the phase 3 ESSENCE trial highlight semaglutide 2.4 mg’s benefits for fibrosis and steatohepatitis in patients with MASH.
Med Page Today
NOVEMBER 1, 2024
(MedPage Today) -- High-dose supplements of docosahexaenoic acid (DHA), an omega-3 fatty acid, penetrated the brain in both APOE4 carriers and non-carriers before dementia onset, the placebo-controlled PreventE4 trial showed. The treatment did.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Multiple sclerosis (MS) is a chronic disease characterized by dysregulated self-reactive immune responses that damage the neurons’ myelin sheath, leading to progressive disability. The primary therapeutic option, immunosuppressants, inhibits pathogenic anti-myelin responses but depresses the immune system. Antigen-specific monocyte-derived autologous tolerogenic dendritic cells (tolDCs) offer alternative therapeutic approaches to restore tolerance to autoantigens without causing generalized immu
HCPLive
NOVEMBER 1, 2024
Anthony Kerbage, MD, describes disparities in 21 IBS clinical trials whose data was used to support the FDA approvals of 7 IBS-C and IBS-D drugs.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Endometriosis, characterized by the presence of endometrial-like tissue outside the uterus, is a condition associated with pain and infertility. In this issue of the JCI, Lv et al. illuminate the critical pathophysiological role of the ten-eleven translocation 3 (TET3) in endometriosis. TET3 expression levels were higher in macrophages of endometriotic lesions compared with control endometrial tissue, implicating TET3 as a contributing factor in the chronic inflammation that occurs in endometrio
Journal of Cardiothoracic Surgery
NOVEMBER 1, 2024
This study aims to examine the relationship between left atrial appendage closure (LAAC) and post-operative atrial fibrillation (POAF) in cardiac surgery patients with no pre-operative atrial fibrillation (AF).
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
NOVEMBER 1, 2024
This interview following Fall Clinical highlights new phase 3 data on patient-reported outcomes from the ARRECTOR study evaluating roflumilast foam for psoriasis.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Intestinal dysmotility syndromes have been epidemiologically associated with several antecedent bacterial and viral infections. To model this phenotype, we previously infected mice with the neurotropic flavivirus West Nile virus (WNV) and demonstrated intestinal transit defects. Here, we found that within 1 week of WNV infection, enteric neurons and glia became damaged, resulting in sustained reductions of neuronal cells and their networks of connecting fibers.
HCPLive
NOVEMBER 1, 2024
In a recent phase 2a trial, SPN-820, a novel intracellular moderator of mTORC1, decreased suicidal ideation by 80%.
American College of Cardiology
NOVEMBER 1, 2024
The Centers for Medicare and Medicaid Services (CMS) released the 2025 Medicare Physician Fee Schedule (PFS) final rule and the 2025 Hospital Outpatient Prospective Payment System (OPPS) and Ambulatory Surgery Center (ASC) final rule on Nov. 1. Of note, the 2025 PFS conversion factor is $32.3465, a reduction of 2.83% from $33.2875 in 2024. Overall, PFS reimbursement for cardiovascular services is projected to remain flat compared with 2024, with changes to policies and individual services roughl
HCPLive
NOVEMBER 1, 2024
This conference review highlights several of the most notable stories and recent data covered by HCPLive at the Fall Clinical Dermatology Conference.
Cardiovascular Diabetology
NOVEMBER 1, 2024
There has been a concerning rise in the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) following noncardiac surgeries (NCS), significantly impacting surgical outcomes and patient.
HCPLive
NOVEMBER 1, 2024
Panelists discuss recent insights into the mechanisms involved in chronic spontaneous urticaria (CSU) pathogenesis, emphasizing how the identification of novel mast cell activation pathways enhances our understanding of the condition, particularly highlighting the role of Burton tyrosine kinase (BTK) as a key mediator in mast cell degranulation and histamine release.
Cardiovascular Diabetology
NOVEMBER 1, 2024
Dysglycemia and insulin resistance increase type 2 diabetes (T2D) and cardiovascular disease (CVD) risk, yet associations with specific glucose-insulin homeostatic biomarkers have been inconsistent. Vitamin D.
HCPLive
NOVEMBER 1, 2024
Panelists discuss the clinical diagnosis of chronic spontaneous urticaria (CSU), outlining the necessary steps for assessment, including the evaluation of wheals, hives, and angioedema, while addressing how the chronic and spontaneous characteristics of the disease can complicate the diagnostic process.
Cardiovascular Diabetology
NOVEMBER 1, 2024
Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 2 diabetes mellitus, and its mechanisms are complex and poorly understood. Despite growing evidence suggesting that ferroptosis pla.
HCPLive
NOVEMBER 1, 2024
EMERGENT-4 and EMERGENT-5, phase 3, 52-week trials, showed xanomeline trospium chloride significantly improved schizophrenia symptoms across 52 weeks.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Treatment with T cells genetically engineered to express tumor-reactive T cell receptors (TCRs), known as TCR-gene therapy (TCR-T), is a promising immunotherapeutic approach for patients with cancer. The identification of optimal TCRs to use and tumor antigens to target are key considerations for TCR-T. In this issue of the JCI, Bear and colleagues report on their use of in vitro assays to characterize four HLA-A*03:01– or HLA-A*11:01–restricted TCRs targeting the oncogenic KRAS G12V mutation.
HCPLive
NOVEMBER 1, 2024
This Month in Review captures top FDA news, phase 2b data, and early research in the psychiatry field.
American College of Cardiology
NOVEMBER 1, 2024
Participation in ACC’s Reduce the Risk: PCI Bleed Campaign was associated with a significant reduction of bleeding events following PCI, according to a study published in Circulation: Cardiovascular Interventions.
HCPLive
NOVEMBER 1, 2024
The biosimilars month in review highlights new approvals, new safety findings, and new cost savings with biosimilars.
American College of Cardiology
NOVEMBER 1, 2024
Welcome to the Cardiovascular (CV) Dyad Leadership Strategic Planning Series! In episode two of four, Dr. Tom Draper talks with Mr. Adam DeJong and Dr. Malissa Wood about efforts required in the development phase of a strategic plan document including evaluating current state performance, leveraging external data, and initiating feedback from key stakeholders.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
A hexanucleotide GGGGCC repeat expansion in the non-coding region of the C9orf72 gene is the most common genetic mutation identified in patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The resulting repeat RNA and dipeptide repeat proteins from non-conventional repeat translation have been recognized as important markers associated with the diseases.
NEJM Journal Watch - Cardiology
NOVEMBER 1, 2024
While clinicians cannot modify effects of older age and comorbidities, they can advocate for early revascularization, associated with lower mortality.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Loss of enteric neurons leading to long-term gastrointestinal dysfunction is common to many diseases, and the path to functional recovery is unclear. In this issue of the JCI, Janova et al. report that West Nile virus killed enteric neurons and glia via CD4+ and CD8+ T cells acting through the perforin and Fas ligand pathways. Enteric glial cells contributed to neurogenesis and at least partial replacement of affected neurons.
American College of Cardiology
NOVEMBER 1, 2024
What is the prevalence of and what are the risk factors for sudden cardiac events (SCE) in patients with Fontan circulation?
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
The airway surface liquid (ASL) plays a crucial role in lung defense mechanisms, and its composition and volume are regulated by the airway epithelium. The cystic fibrosis transmembrane conductance regulator (CFTR) is abundantly expressed in a rare airway epithelial cell type called an ionocyte. Recently, we demonstrated that ionocytes can increase liquid absorption through apical CFTR and basolateral barttin/chloride channels, while airway secretory cells mediate liquid secretion through apical
HCPLive
NOVEMBER 1, 2024
SF-36v2 scores also improved by 12 points with semaglutide compared with 6.5 points with placebo.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Immature innate and adaptive immunity and vulnerability of narrower airways to obstruction increase the susceptibility of infants to severe respiratory syncytial virus (RSV) disease. In this issue of the JCI, Zhao et al. illustrated greater intrinsic susceptibility of pediatric versus adult airway epithelial cells to RSV-induced cytopathology. Using precision cut lung slices (PCLS) and air-liquid interface (ALI) airway epithelial cell cultures, the authors showed that impaired STAT3 activation i
Ken Grauer, MD
NOVEMBER 1, 2024
I was sent this ECG recording — and asked for my interpretation of the rhythm in Figure-1. I had little clinical information. QUESTIONS: How was I able to guess the probable correct answer in less than 5 seconds? How was I then able to prove that my guess was correct? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).
Frontiers in Cardiovascular Medicine
NOVEMBER 1, 2024
BackgroundAtherosclerosis is a leading cause of cardiovascular disease worldwide, while carotid atherosclerosis (CAS) is more likely to cause ischemic cerebrovascular events. Emerging evidence suggests that cuproptosis may be associated with an increased risk of atherosclerotic cardiovascular disease. This study aims to explore the potential mechanisms linking cuproptosis and CAS.MethodsThe GSE100927 and GSE43292 datasets were merged to screen for CAS differentially expressed genes (DEGs) and in
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Dysfunction of group 2 innate lymphoid cells (ILC2s) plays an important role in the development of type 2 inflammation–related diseases such as asthma and pulmonary fibrosis. Notably, neural signals are increasingly recognized as pivotal regulators of ILC2s. However, how ILC2s intrinsically modulate their responsiveness to these neural signals is still largely unknown.
Physiologically Speaking
NOVEMBER 1, 2024
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Childhood neuroblastoma with MYCN amplification is classified as high risk and often relapses after intensive treatments. Immune checkpoint blockade therapy against the PD-1/L1 axis shows limited efficacy in patients with neuroblastoma, and the cancer intrinsic immune regulatory network is poorly understood. Here, we leverage genome-wide CRISPR/Cas9 screens and identify H2AFY as a resistance gene to the clinically approved PD-1 blocking antibody nivolumab.
Journal of Clinical Investigation - Cardiology
NOVEMBER 1, 2024
Respiratory syncytial virus (RSV) selectively targets ciliated cells in human bronchial epithelium and can cause bronchiolitis and pneumonia, mostly in infants. To identify molecular targets of intervention during RSV infection in infants, we investigated how age regulates RSV interaction with the bronchial epithelium barrier. Employing precision-cut lung slices and air-liquid interface cultures generated from infant and adult human donors, we found robust RSV virus spread and extensive apoptoti
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