Science Daily - Heart Disease

NOVEMBER 9, 2023

Allergic responses to common foods such as dairy and peanuts can increase the risk for heart disease and cardiovascular death as much or more than smoking, new research suggests. And these dangerous allergic responses can strike both people with food allergies and those with no obvious allergy symptoms.

Heart Disease 106

Heart Disease Research 106

Dr. Smith's ECG Blog

NOVEMBER 9, 2023

A 60-something yo female presented w/ exertional chest pain for 3 days. She had a recent positive stress test about one week ago. Pain was 8/10 and constant. She has been experiencing progressively worsening exertional dyspnea and chest tightness mostly when climbing up flights of stairs since early September. She underwent exercise echocardiogram in mid October where she exercised for nearly 7 minutes on the standard Bruce protocol and had typical anginal pain and shortness of breath.

Chest Pain 81

Chest Pain Echocardiogram Exercise Ischemia 81

Science Daily - Heart Disease

NOVEMBER 9, 2023

Replacing sitting with as little as a few minutes of moderate exercise a day tangibly improves heart health, according to new research.

Exercise 107

Exercise Research 107

Open Heart

NOVEMBER 9, 2023

Objectives The advent of conversational artificial intelligence (AI) systems employing large language models such as ChatGPT has sparked public, professional and academic debates on the capabilities of such technologies. This mixed-methods study sets out to review and systematically explore the capabilities of ChatGPT to adequately provide health advice to patients when prompted regarding four topics from the field of cardiovascular diseases.

Article 52

Article Academic Education Cardiovascular Disease 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionVertebro‐vertebral arteriovenous fistula (VV‐AVF) is a rare vascular malformation with abnormal high flow shunt between extracranial vertebral artery and an adjacent vertebral vein plexus without intervening capillaries.1 While seen in both adult and pediatric populations, the majority of the VV‐AVFs seen in childhood are largely congenital, seen in the setting of connective tissue diseases such as

Pediatrics 40

Pediatrics Embolism ICU Congenital 40

Open Heart

NOVEMBER 9, 2023

Objective Electrode patch position may not be critical for success when cardioverting atrial fibrillation (AF), but the relevance of applied electrical energy is unclarified. Our objective was to perform a meta-analysis of randomised trials to examine the dose–response relation between energy level and cardioversion success by electrode position in elective cardioversion.

Atrial Fibrillation 52

Atrial Fibrillation 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionOsler‐Weber‐Rendu disease, also known as hereditary hemorrhagic telangiectasia (HTT), is a developmental vascular disease characterized by multiple arteriovenous malformations (AVMs) due to genetic defects in endothelial angiogenesis pathways. HHT is a clinical diagnosis based on the fulfillment of the Curacao Diagnostic Criteria, including involvement of internal organs with AVMs, significant recur

Hemorrhage 40

Hemorrhage Aneurysm Pulmonary Embolism 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCerebrospinal‐venous fistulae (CSF‐VFs) represent a pathologic, low‐flow direct connection between the intrathecal space, usually at the level of a diverticular dilation of a nerve root sleeve, and the thoracolumbar venous system. They can cause CSF hypovolemia resulting in an often‐debilitating intracranial hypotension syndrome.

Embolism 40

Embolism Hospital Stroke Strokes 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3182-3189, December 1, 2023. The identification of a variant in theHDAC9gene as a risk factor for large-artery atherosclerotic stroke, and subsequently coronary artery disease, has opened novel treatment pathways for stroke and more widely atherosclerotic disease. This article describes the pathway from gene discovery to novel therapeutic approaches that are now entering man.HDAC9expression is elevated in human atherosclerotic plaque, while in animal and cellul

Stroke 40

Stroke Strokes Atherosclerosis Coronary Artery Disease 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe role of artificial intelligence (AI) in clinical medicine is ever‐increasing and in time‐dependent, tissue‐based evaluation and treatment of ischemic stroke, AI is clearly proving its utility. In the past decade, scientific publications evaluating the use of AI in stroke care have increased exponentially and information on level of evidence is limited.We aim to systematically review the use of A

Stroke 40

Stroke Strokes Article Research 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3128-3137, December 1, 2023. BACKGROUND:Both social service resources and stroke prevalence vary by geography, and health care resources are scarcer in rural areas. We assessed whether distributions of resources relevant to stroke survivors were clustered around areas of the highest stroke prevalence in Ohio and whether this is varied by rurality using an ecological study design.METHODS:Census tract (CT)–level self-reported stroke prevalence estimates (Centers

Stroke 40

Stroke Strokes Risk Factors Education 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionAccording to the World Health Organization, Stroke is the 2nd leading cause of death, responsible for approximately 11% of total deaths worldwide (1). In Nigeria, stroke accounts for 4% ‐ 17% of medical deaths (2).Effective stroke management is essential to reduce morbidity and mortality.

Stroke 40

Stroke Strokes Thrombolysis Blood Pressure 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3046-3053, December 1, 2023. BACKGROUND:Stroke is a leading cause of mortality and permanent disability in China, with large and unexplained geographic variations in rates of different stroke types. Chronic hepatitis B virus infection is prevalent among Chinese adults and may play a role in stroke cause.METHODS:The prospective China Kadoorie Biobank included >500 000 adults aged 30 to 79 years who were recruited from 10 (5 urban and 5 rural) geographical

Stroke 40

Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionStroke is the most common manifestation of cerebrovascular disease, which requires prompt diagnosis and treatment. As one of the most prevalent causes of death, the third‐major source of illness, and the primary cause of long‐term disability, it is regarded as one of the most significant global health issues.

Cerebrovascular Disease 40

Cerebrovascular Disease Dementia Stroke Strokes 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3138-3140, December 1, 2023.

Stroke 40

Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionTenecteplase is increasingly being used as a first‐line treatment for acute ischemic stroke after several randomized studies demonstrated its safety and efficacy, resulting in a massive increase in the number of published studies on this topic. Our aim was to investigate the most impactful authors and relevant journals that have been instrumental in validating this treatment, in hopes of identifying

Research 40

Research Myocardial Infarction Embolism Pulmonary 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 2972-2980, December 1, 2023. BACKGROUND:Survivors of intracerebral hemorrhage (ICH) face an increased risk of ischemic cardiovascular events. Current ICH guidelines do not provide definitive recommendations regarding the use of antithrombotic and statin therapies. We, therefore, sought to study practice patterns and factors associated with the use of such medications after ICH.METHODS:This was a cross-sectional study of patients with ICH in the Get With The Gui

Hemorrhage 40

Hemorrhage Stroke Strokes Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThe nuclei in the periaqueductal gray of the midbrain are critical structures that coordinate and control vertical and torsional gaze, as well as crucial components of the vestibulo‐occular reflex. These structures are so fine that they may be missed on routine imaging however, they represent distinct localizations for the neurological exam, with lesions of these structures being important clinical

Stroke 40

Stroke Strokes 40

Stroke Journal

NOVEMBER 9, 2023

Stroke, Volume 54, Issue 12 , Page 3002-3011, December 1, 2023. BACKGROUND:There is limited information on the delivery of acute stroke therapies and secondary preventive measures and clinical outcomes over time in young adults with acute ischemic stroke. This study investigated whether advances in these treatments improved outcomes in this population.METHODS:Using a prospective multicenter stroke registry in Korea, young adults (aged 18–50 years) with acute ischemic stroke hospitalized between

Stroke 40

Stroke Strokes Outcomes Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionTransient Ischemic Attack (TIA) is a common neurologic condition characterized by temporary, focal cerebral ischemia that results in reversible neurological deficits without tissue infarction. Type 2 Diabetes Mellitus (T2DM) is a rapidly growing global health problem with increasing prevalence.

Diabetes 40

Diabetes Coronary Artery Disease Atrial Fibrillation Dementia 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionMechanical thrombectomy (MT) has demonstrated a significant improvement in functional outcomes for patients with anterior circulation strokes and large‐vessel occlusion (LVO). However, despite successful recanalization, certain patients still experience large hemispheric ischemia (LHI), necessitating decompressive hemicraniectomy (DHC).

Stroke 40

Stroke Strokes Outcomes Circulation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionRecombinant tissue plasminogen activator (rtPA) is the only approved treatment for acute ischemic stroke (AIS) patients, however, only a minuscule percentage of patients receive rtPA [1, 2]. In some cases, the reason for patients' exclusion from rtPA is due to risk factors and comorbidities [1, 2].

Obesity 40

Obesity Risk Factors Stroke Strokes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEndovascular intervention has become the mainstay of treatment for acute ischemic stroke. However, in certain cases, open surgery is the only option to achieve revascularization. This study presented two patients with symptomatic common carotid artery occlusion (CCAO) who subsequently underwent subclavian‐carotid artery bypass surgery using the polytetrafluorethylene graft.

Outcomes 40

Outcomes Coronary Artery Disease Chest Pain Aortic 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIn‐vitro evaluation (analysis in a bench top flow model) is the gold standard and a regulatory requirement for pre‐clinical investigation of devices being developed for endovascular thrombectomy (EVT). In‐silico evaluation (computer simulated analysis in a virtual stroke model) has the potential to test and optimize large number of stent‐retriever design variations in a relatively time and cost‐effe

Stents 40

Stents Stent Blood Clot Anatomy 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionLarge randomized clinical trials have established the superiority of Mechanical Thrombectomy (MT) for the treatment of Large Vessel occlusion (LVO) in patients with Acute Ischemic stroke (AIS) in terms of revascularization rates and clinical outcomes as compared to IV‐tPA alone.(1, 2, 3) However, Data regarding outcomes of mechanical thrombectomy in patients with low platelets is limited and shows c

Outcomes 40

Outcomes Stroke Strokes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionAcute large vessel occlusions (LVOs) represent one‐third of acute ischemic strokes (AIS). LVOs are associated with high mortality and severe functional deficits. Several factors have been reported to play a role in improving outcomes after Endovascular Thrombectomy (EVT).

Stroke 40

Stroke Strokes Outcomes Hemorrhage 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionApproximately 3% of all acute ischemic stroke are caused by sub‐occlusive thrombi in the proximal intracranial vasculature. There is a paucity of evidence regarding optimal treatment of this stroke etiology, with most evidence derived from retrospective case series preceding the advent of mechanical thrombectomy.

Stenosis 40

Stenosis Stroke Strokes Hypertension 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEfficacy and safety of intravenous thrombolysis (IVT) in patients undergoing mechanical thrombectomy (MT) is still debatable. However, IVT's efficacy on stent retriever (SR) and aspiration thrombectomy (ASP) outcomes specifically remain unclear. In our meta‐analysis, we aimed to explore the effects of IVT on SR and ASP thrombectomy outcomes.MethodsA systematic literature review was steered using Med

Thrombolysis 40

Thrombolysis Outcomes Embolism Stents 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPrevious studies did not show a difference in terms of safety and efficacy among first‐line stent retriever (SR), contact aspiration (CA), or combined techniques for proximal large vessel occlusion strokes. However, the optimal reperfusion therapy in patients with primary distal medium vessel occlusion (DMVO) strokes is uncertain.

Stroke 40

Stroke Strokes Outcomes Stents 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionMechanical thrombectomy (MT) often fails to achieve successful reperfusion in up to 20% of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) [1, 2]. Rescue strategies options, including balloon angioplasty alone, rescue stenting (RS) alone, or stent with balloon angioplasty, have shown promise in observational studies and meta‐analyses [3, 4].

Stents 40

Stents Stent Angioplasty Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCombined technique mechanical thrombectomy with contact aspiration with stent‐retriever has been shown to lead to comparable final reperfusion rates compared with stent retriever alone. We aimed to explore if anatomical and technical features could have interaction with the chances of reperfusion by each technique.MethodsRetrospective analysis of a prospective mechanical thrombectomy (MT) database.

Stents 40

Stents Stent Risk Factors Circulation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIntracranial atherosclerotic disease (ICAD) is associated with up to 32% of posterior circulation strokes.1 ICAD‐related strokes are at high risk for re‐occlusion following MT. Rescue treatment with stenting, balloon angioplasty, and/or intraarterial thrombolysis or antiplatelets are often required to treat the underlying stenosis.

Stents 40

Stents Stent Circulation Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCarotid artery stenting (CAS) has emerged as a viable alternative to carotid endarterectomy for managing carotid artery stenosis in high‐risk patients (1). While the transfemoral arterial approach (TF) remains the preferred method, it is associated with inherent limitations and potential complications (2‐4).

Stents 40

Stents Stent Myocardial Infarction Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionThere is a higher prevalence of diabetes mellitus type 2 in Hispanics as compared to other ethnic groups in the United States. Diabetes is a risk factor for acute ischemic stroke and also a poor predictor of outcome for many interventional surgeries. We performed this retrospective cohort analysis to assess the impact of poorly controlled diabetes, defined as HbA1C of 9.0% or greater, on the functio

Outcomes 40

Outcomes Angioplasty Atrial Fibrillation Diabetes 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionEmergent percutaneous carotid artery MER approach for acute ischemic large vessel strokes are rare given the risk of complications and seldom reported.Methods75‐year‐old left‐handed functional male (mRs:0) with past medical history of HTN, HLD presented to ED after being found on the floor by his family with slurred speech, new onset right sided weakness, with a last known well of 17 hours.

Anatomy 40

Anatomy Outpatient Ultrasound Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionVessel perforation during thrombectomy is a severe complication and is hypothesized to be more frequent during MeVO thrombectomy. The aim of this study was to compare the incidence and outcome of patients with perforation during MeVO and LVO thrombectomy and to report on the procedural steps that led to perforation.MethodsIn this multicenter retrospective cohort study, data of consecutive patients w

Outcomes 40

Outcomes Stents Stent Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionWe aimed to evaluate the efficacy and safety of mechanical thrombectomy (MT) for medium vessel occlusion (MeVO) with the disabling deficit.MethodsThe study period was from January 2011 to December 2022. Inclusion criteria were 1) within 24 hours of stroke onset, 2) prestroke mRS score ≤1, 3) NIHSS score ≥4 or disabling deficit (complete hemianopia (≥2 on NIHSS), severe aphasia (≥2 on NIHSS), visual

Hemorrhage 40

Hemorrhage Outcomes Stroke Strokes 40