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Journal of the American Heart Association, Ahead of Print. BackgroundIschemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent stroke models. However, reperfusion therapies remain the only clinically efficacious intervention to date. Rigor and reproducibility are now recognized as critical to bridge the preclinicalclinical disconnect.
Journal of the American Heart Association, Ahead of Print. Pulmonary arterial hypertension is a disease of the pulmonary vasculature, resulting in elevated pressure in the pulmonary arteries and disrupting the physiological coordination between the right heart and the pulmonary circulation. Exercise intolerance is one of the primary symptons of pulmonary arterial hypertension, significantly impacting the quality of life.
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Brugada syndrome (BrS) is associated with an increased risk of ventricular fibrillation (VF), leading to sudden cardiac death. Pharmacological treatments, including quinidine, cilostazol, and bepridil, offer alternative approaches for VF prevention, particularly for patients experiencing recurrent VF after implantable cardioverter defibrillator (ICD) implantation.1 However, variations in the efficacy of these drugs remain unclear, particularly regarding low-dose quinidine.
In this analysis, investigators conclude that health-related quality of life and clinical burdens are greater among patients with hidradenitis suppurativa and draining tunnels.
(MedPage Today) -- LOS ANGELES -- The HOPE trial made another case for extending the therapeutic window for IV thrombolysis in acute ischemic stroke, potentially widening the pool of people eligible for therapy. Among patients with stroke clots.
(MedPage Today) -- LOS ANGELES -- The HOPE trial made another case for extending the therapeutic window for IV thrombolysis in acute ischemic stroke, potentially widening the pool of people eligible for therapy. Among patients with stroke clots.
A new study found antidepressant use drops by nearly 50% during pregnancy, but without increased psychotherapy, raising concerns about untreated depression risks.
Journal of the American Heart Association, Ahead of Print. BackgroundThe clinical impact of enzyme replacement therapy on advanced Fabry disease cardiomyopathy appears to be limited. The pathologic mechanisms involved are still unclear.Methods and ResultsTen male patients with advanced Fabry disease cardiomyopathy on enzyme replacement therapy, whose disease progressed from maximal wall thickness of 15.42.2 to 19.32.1 mm in 8.61.4 years of followup, underwent left ventricular endomyocardial biop
Journal of the American Heart Association, Ahead of Print. BackgroundClinical trials showed that glucagonlike peptide1 receptor agonist (GLP1RA) significantly improved the control of diabetes and reduced body weight compared with dipeptidyl peptidase 4 inhibitor (DPP4i). However, it is unclear whether GLP1RA is effective compared with DPP4i in patients with heart failure (HF) with type 2 diabetes (T2D).
Pulsed field ablation (PFA) is a promising novel method of atrial ablation with preclinical data suggesting it to be a viable option for ventricular arrhythmias.
Journal of the American Heart Association, Ahead of Print. BackgroundCoronary microvascular dysfunction has been associated with adverse cardiovascular events following acute myocardial infarction. This study evaluates the role of the angiographyderived index of microcirculatory resistance (angioIMR) in predicting myocardial damage in patients with STsegmentelevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI).Methods and ResultsIn this post hoc analysis of
Journal of the American Heart Association, Ahead of Print. BackgroundDespite the wellknown importance of witnessed arrest and bystander cardiopulmonary resuscitation (CPR) for outofhospital cardiac arrest outcomes, previous studies have shown significant statistical inconsistencies. We hypothesized an interaction effect and conducted stratified analyses to investigate whether witnessed arrest is more important than bystander CPR.MethodsThis study enrolled patients with outofhospital cardiac arre
Publication date: Available online 7 February 2025 Source: The American Journal of Cardiology Author(s): Nicholas Fialka, Ryaan EL-Andari, Jimmy Kang, Yongzhe Hong, Finlay A.
Journal of the American Heart Association, Ahead of Print. BackgroundAs the population ages, atrial fibrillation (AF) prevalence increases, but data on optimal oral anticoagulation (OAC) in patients 80 years remain limited. This study tested whether direct OACs offer comparable benefits to vitamin K antagonists in patients 80 years with AF presenting to the emergency department.MethodsThis singlecenter retrospective allcomer study used data from the Heidelberg Registry of Atrial Fibrillation, in
Journal of the American Heart Association, Ahead of Print. BackgroundAtrial fibrillation (AF) significantly increases the ischemic stroke risk. However, the relationship between age at diagnosis of AF and subsequent stroke risk remains poorly understood.Methods and ResultsWe analyzed data from 5 prospective cohorts: ARIC (Atherosclerosis Risk in Communities) study, CHS (Cardiovascular Health Study), CARDIA (Coronary Artery Risk Development in Young Adults), MESA (MultiEthnic Study of Atheroscler
Publication date: Available online 8 February 2025 Source: The American Journal of Cardiology Author(s): Juana Perez Morales, Ana Spaccavento, Marianna Guerchicoff, Lucrecia Burgos, Juan Pablo Costabel, Eugenio Cingolani, Alberto Alves de Lima
Journal of the American Heart Association, Ahead of Print. BackgroundDementia and disability are highly prevalent after spontaneous intracerebral hemorrhage (ICH). Previous studies categorizing ICH by large anatomic boundaries have demonstrated that lobar ICH is associated with dementia, while ICH in the basal ganglia is associated with disability. This study aims to refine our understanding of the association between ICH location and postICH dementia and disability at a voxel level, which could
Written by Jesse McLaren An 80 year old with a history of CHF, ESRD on dialysis, and multiple prior cardiac stents presented to the emergency department with 3 days of intermittent chest pain and shortness of breath that resolved after nitro, which felt like prior episodes of angina. The patient was pain free on arrival, and below are the prior and new ECG.
Journal of the American Heart Association, Ahead of Print. BackgroundUnrecognized or silent myocardial infarction (MI) detected on an ECG is associated with firstever stroke, but the impact on stroke recurrence is unknown. We aimed to determine the association of silent MI with stroke recurrence in patients with a recent ischemic stroke.Methods and ResultsSubjects from the IRIS (Insulin Resistance Intervention After Stroke) trial with an available ECG were included.
Journal of the American Heart Association, Ahead of Print. BackgroundThe melanocortin 1 receptor (MC1R) is abundantly expressed in the skin and leukocytes, where it regulates skin pigmentation and inflammatory responses. Recently, MC1R was also found in the heart, but its functional role has remained unknown. We aimed to investigate whether MC1R is involved in the regulation of pathological or physiological cardiac remodeling.Methods and ResultsRecessive yellow mice, as a model of global MC1R de
Journal of the American Heart Association, Ahead of Print. BackgroundObesity and hypercholesterolemia independently increase cardiovascular disease risk. This analysis evaluated the efficacy and safety of bempedoic acid in people with obesity participating in the CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACLInhibiting Regimen) Outcomes trial.MethodsCLEAR Outcomes randomized 13 970 patients to daily bempedoic acid 180 mg or placebo.
Journal of the American Heart Association, Ahead of Print. BackgroundInflammatory arthritis is recognized to increase cardiovascular disease risk, but its association with degenerative aortic stenosis is not well understood.MethodsThis prospective cohort study used participants from the UK Biobank, focusing on 4 major types of inflammatory arthritis, including rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and gout.
Journal of the American Heart Association, Ahead of Print. BackgroundOur aim was to report the functional outcome of Stanford type A aortic dissection (TAAD) after 1 year as well as morbidity and mortality.Methods and ResultsThis is a retrospective analysis including 642 patients with TAAD from January 2005 to December 2021. Mean age at TAAD was 62 years (95% CI, 6163), and 30% of the population were women.
Journal of the American Heart Association, Ahead of Print. BackgroundWe compared the atherosclerotic cardiovascular disease (ASCVD) risk prediction performance of the American Heart Association's Predicting Risk of Cardiovascular Disease Events (PREVENT) Base and PREVENT Full equations (includes urine albumin/creatinine ratio, glycated hemoglobin, and social deprivation index) with the pooled cohort equations (PCEs).MethodsWe included adults, aged 40 to 75 years, with no history of ASCVD, diabet
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