Thu.Dec 05, 2024

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Finally – the end (of the trial process)

Dr. Malcolm Kendrick

And so, we reach the final end to the court case. You may think it all finished months ago, not so. The final, final act is when we have the reading of the Statement in Open Court (SIOC). This took place Thursday the 5 th of December 2024. Which is five years and nine months after the articles in the Mail on Sunday were published. I could not talk or write about the SIOC before it happened, or the Judge would be most upset and angry.

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Case Report: Surgical treatment of type B aortic dissection in an adult with double aortic arch

Frontiers in Cardiovascular Medicine

BackgroundDouble aortic arch (DAA) with type B aortic dissection in adults is a rare aortic vascular disease. The abnormal anatomical structure of the aortic arch in such patients presents significant challenges in the selection of surgical approaches, and there is a notable lack of exploration into endovascular repair approaches that simultaneously preserve asymptomatic vascular rings.Case descriptionA 43-year-old female patient was admitted due to recurrent chest and back pain lasting for over

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Cleerly Raises $106 Million in Series C Extension Funding

DAIC

tim.hodson Thu, 12/05/2024 - 11:59 Dec. 4, 2024 – Cleerly has successfully closed its latest Series C extension funding round, raising a total of $106 million. This funding round was led by global software investor Insight Partners and joined by Battery Ventures with participation from pre-existing investors. With this new funding, Cleerly will continue to scale its commercial growth and clinical evidence generation, helping health care professionals improve outcomes for patients across

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Advice from a cardiologist: Cardiac arrest vs. heart attacks

Medical Xpress - Cardiology

Sudden cardiac arrest may occur in various conditions when someone, while active (playing basketball or walking with friends), collapses and passes out. Their blood pressure drops, and often their heart stops. This may be caused by a lethal arrhythmia, which is when the heart beats abnormally and does not efficiently pump anymore. If the heart is not pumping, blood is not getting to the brain, and that's what causes the collapse.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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System Integration: How AI Is Weaving Itself into Neurology

HCPLive

Perspective from neurologists on the current and future applications for artificial intelligence across a bevy of neurologic conditions.

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Muscle Loss May Portend Future Dementia

Med Page Today

(MedPage Today) -- Older individuals with apparent skeletal muscle mass loss were at greater risk of developing dementia, researchers found. People with low temporalis muscle mass -- a set of jawbone muscles linked to changes in whole-body skeletal.

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Empagliflozin Linked to Lower Risk of Diabetic Retinopathy Progression

Med Page Today

(MedPage Today) -- Use of empagliflozin (Jardiance) was not linked to a lower risk of incident nonproliferative diabetic retinopathy compared with dipeptidyl peptidase-4 (DPP-4) inhibitors among patients with type 2 diabetes, but the SGLT2 inhibitor.

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Cardiovascular disease symptoms surprisingly high in young refugees

Medical Xpress - Cardiology

Many individuals seeking asylum in the United States show increased stress and pain symptoms that are associated with indications of cardiovascular disease, according to Weill Cornell Medicine researchers.

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Adherence to Physical Activity Recommendations Among Stroke Survivors in the United States

Stroke Journal

Stroke, Volume 56, Issue 1 , Page 113-121, January 1, 2025. BACKGROUND:Physical activity is an effective modifiable behavior for preventing recurrent strokes. This study aims to determine the adherence to physical activity recommendations among stroke survivors in the United States. We further compared our findings with the adherence observed among myocardial infarction (MI) survivors and healthy adults, each assessed against distinct physical activity guidelines specific to their respective pop

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Outpatient worsening of heart failure and mortality in transthyretin amyloid cardiomyopathy

European Journal of Heart Failure

Breakdown of the study population by worsening heart failure (WHF) event proportions (oral diuretic intensification or heart failure [HF] hospitalization) and KaplanMeier curve of all-cause mortality after WHF event shown, relative to a patient group that did not have any WHF events. Oral diuretic intensification was significantly prognostic of mortality amongst patients with transthyretin cardiomyopathy and occurred more often than HF hospitalization.

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Untangling GLP-1 Risks: Are Side Effects Overblown?

Med Page Today

(MedPage Today) -- In part two of this three-part Instagram Live discussion, MedPage Today editor-in-chief Jeremy Faust, MD, Karl Nadolsky, DO, and Fatima Cody Stanford, MD, MPH, MPA, MBA, dive into the complexities of GLP-1 receptor agonists.

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Study Highlights Global Data on Food Allergy-Related Airline Travel Concerns

HCPLive

These data highlight some of the most notable findings related to airline travel issues among those with food allergies or with family members with such allergies.

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Orthostatic and Standing Hypertension and Risk of Cardiovascular Disease

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Orthostatic hypertension is an emerging risk factor for adverse events. Recent consensus statements combine an increase in blood pressure upon standing with standing hypertension, but whether these 2 components have similar risk associations with cardiovascular disease (CVD) is unknown.METHODS:The ARIC study (Atherosclerosis Risk in Communities) measured supine and standing blood pressure during visit 1 (19871989).

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A Pillared Approach: A Suite of Therapies for a Spectrum of Metabolic Disease

HCPLive

A look into how SGLT2 inhibitors, GLP-1 RAs, and nsMRAs have redefined the management of cardio-kidney-metabolic diseases.

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Higher AFib Procedure Volumes Associated With Increased Procedural Success, Lower MAE Rates

American College of Cardiology

Higher hospital and physician atrial fibrillation (AFib) ablation procedure volumes were associated with increased acute procedural success and lower rates of major adverse events (MAEs), according to a study published in Heart Rhythm.

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Study Finds Nemolizumab Significantly Improved Signs, Symptoms in Prurigo Nodularis

HCPLive

The phase 3 OLYMPIA 1 study highlights the benefits among those with prurigo nodularis of targeting interleukin-31 signaling using nemolizumab.

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Cardiovascular Updates from AHA Congress 2024 

Cardiometabolic Health Congress

The American Heart Association (AHA) Congress 2024 , held from November 1618, marked a pivotal moment in cardiovascular and metabolic health. As the AHA celebrates its 100th year, the conference reflected on a century of innovation while exploring the future of cardiovascular disease prevention and management. Here are the top highlights: Late-Breaking Science and Key Trials The conference featured 8 late-breaking clinical trials, including: BPROAD Trial : Intensive SBP lowering (<120 mmHg)

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Diabetes Dialogue: Diabetes Tech Updates from November 2024

HCPLive

In this episode, hosts discuss the collaboration between Dexcom and Oura Ring, expanded compatibility of Omnipod 5 with Freestyle Libre 2, and Simplera CGM integration with the InPen.

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Study shows impact of experience on outcomes in cardiac septal reduction procedures

Medical Xpress - Cardiology

Researchers from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have published a study in the Journal of the American Heart Association that focuses on how the volume of procedures influences patient outcomes undergoing septal reduction therapies for hypertrophic obstructive cardiomyopathy.

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Tocilizumab Biosimilar Demonstrates Similar Safety, Efficacy for RA to Reference

HCPLive

Pharmacokinetics and immunogenicity were also similar between reference tocilizumab and CT-P47.

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Researchers develop new coronary risk score for women

Medical Xpress - Cardiology

A new risk score accurately predicts and categorizes the risk of major adverse cardiovascular events, such as heart attack, in women. The findings were published today in Radiology: Cardiothoracic Imaging.

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Study Suggests Fragmented Nocturnal Sleep May Play a Role in MASLD Development

HCPLive

A new study showed patients with MASLD have fragmented nocturnal sleep with frequent awakenings per night and a session on healthy sleep habits did not improve sleep parameters.

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WVU Medicine team performs 1st-of-its-kind robotic heart operation

Becker's Hospital Review - Cardiology

A team at Morgantown, W. Va.-based WVU Medicine's WVU Heart and Vascular Institute performed the world's first combined robotic aortic valve replacement and coronary artery bypass operation.

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The APAC Recap: Cardiomyopathy at CAPP Live 2024 with Greg Duck, PA-C

HCPLive

Greg Duck, PA-C shared insights from his CAPP 2024 presentation on tailoring medical management and effective treatment of methamphetamine-induced cardiomyopathy.

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Mayo Clinic's AI-powered ECG saves thousands in medical costs: Study

Becker's Hospital Review - Cardiology

Using an AI-powered electrocardiogram to diagnose low ejection fraction produced a cost-effectiveness ratio of $27,858 per quality-adjusted life year, according to a study published Oct. 25 in Mayo Clinic Proceedings: Digital Health.

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Jörn Schattenberg, MD: Pegozafermin and Preventing Progression to Cirrhosis in MASH

HCPLive

Schattenberg explains pegozafermin’s mechanism of action and describes the importance of preventing progression to cirrhotic MASH.

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Bristol Myers, American Heart Association launch care-quality initiative

Becker's Hospital Review - Cardiology

Through funding from Bristol Myers Squibbs, the American Heart Association has launched a three-year initiative to improve and standardize care for patients with hypertrophic cardiomyopathy.

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Gastroenterology Month in Review: November 2024

HCPLive

This month in review spotlights GI pipeline updates and news from the 2024 NASPGHAN and ACG annual meetings.

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Interrelation of pericoronary adipose tissue texture and coronary artery disease of the left coronary artery in cardiac photon-counting computed tomography

Frontiers in Cardiovascular Medicine

AimRecent research highlights the role of pericoronary adipose tissue (PCAT) in coronary artery disease (CAD) development. PCAT has been recognized as a metabolically active tissue involved in local inflammation and oxidative stress, potentially impacting CAD initiation and progression. Radiomics texture analysis shows promising results to better understand the link between PCAT quality and CAD risk.

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Examining Treatment Landscape, Options in Hidradenitis Suppurativa

HCPLive

In this 5-part, expert-led series, a pair of dermatologists break down how the FDA approval of bimekizumab impacts the treatment landscape of HS.

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Cost-Effectiveness of Intensive Blood Pressure Control in Youth With Chronic Kidney Disease

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Intensive blood pressure (BP) control in youth with chronic kidney disease (CKD) slows progression, delaying the need for kidney replacement therapy (KRT). Most youth with CKD have hypertension and BP control is difficult to achieve outside of controlled experimental settings. Implementing effective BP control strategies in this population may be cost-saving despite requiring additional resources.

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Understanding, Leveraging IL-17 A/F Inhibition with Bimekizumab in HS

HCPLive

Expert dermatologists discuss the role of IL-17 A/F inhibition in the management of hidradenitis suppurativa.

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Bleeding, stroke, and mortality risk of patients with septic shock receiving anticoagulation for atrial fibrillation

HeartRhythm

There are limited data on the effects of therapeutic anticoagulation (AC) on stroke and bleeding risk in patients with sepsis-induced atrial fibrillation (AF).

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Strengths, Limitations of IL-17 A/F Inhibition in Hidradenitis Suppurativa

HCPLive

In this video series segment, expert dermatologsts prove ide insight into the strengths and limitations of IL-17 A/F inhibition in HS.

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microRNA and Hypertension

Hypertension Journal

Hypertension, Ahead of Print. Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular contextdependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modul

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Safety Profile of Bimekizumab in Hidradenitis Suppurativa

HCPLive

In part 4 of our series, expert dermatologists discuss the safety profile of bimekizumab in HS relative to other disease states and trials.

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