Thu.Jan 02, 2025

article thumbnail

Cellular interactions help explain vascular complications due to COVID-19 virus infection

Medical Xpress - Cardiology

COVID-19 is a respiratory disease primarily affecting the lungs. However, the SARS-CoV-2 virus that causes COVID-19 surprised doctors and scientists by causing an unusually large percentage of patients to experience vascular complicationsissues related to blood flow, such as blood clots, heart attacks, and strokes.

COVID-19 127
article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Science Daily - Heart Disease

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

article thumbnail

Phase 3 KOASTAL-1 Trial Fails to Show Navacaprant Significantly Improves MDD

HCPLive

Although the oral navacaprant 80 mg failed to bring statistically significant improvements in depression symptoms, the study showed females respond better than males.

107
107
article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Medical Xpress - Cardiology

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Research 106
article thumbnail

Torsade in a patient with left bundle branch block: is there a long QT? (And: Left Bundle Pacing).

Dr. Smith's ECG Blog

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

article thumbnail

Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats

Journal of Clinical Investigation - Cardiology

Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite and energy homeostasis, presents a logical target for treating anorexia and weight loss.

article thumbnail

Beware the snowstorm: Shoveling could trigger heart attacks, expert says

Medical Xpress - Cardiology

Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.

More Trending

article thumbnail

What is cardiac arrest? Why is it so deadly?

Medical Xpress - Cardiology

Cardiac arrest is when the heart stops abruptly with little or no warning. It is often fatal. According to American Heart Association data, 9 out of every 10 people who experience cardiac arrest outside of a hospital die.

article thumbnail

Patients with heart disease may be at increased risk for advanced breast cancer

Science Daily - Heart Disease

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

Cancer 68
article thumbnail

Just two hours of exercise a week can bring you huge cardiovascular health benefits

Medical Xpress - Cardiology

There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.

article thumbnail

Peanut IgE Stronger Predictor of Remission Than Age After Oral Immunotherapy

HCPLive

In this analysis, baseline peanut sIgE was shown to be a stronger predictor of remission after peanut OIT than age at the beginning of immunotherapy treatment.

64
article thumbnail

How do GLP-1s boost weight loss and heart health?

Medical Xpress - Cardiology

Weight loss tops many folks' list of New Year's resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.

63
article thumbnail

Get A Look At What's Inside The Heart Health Formula

Dr. Paddy Barrett

What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.

article thumbnail

Patients with heart disease may be at increased risk for advanced breast cancer

Medical Xpress - Cardiology

Cardiovascular disease (CVD) and cancer are the two leading causes of death in the U.S. According to researchers from The University of Texas MD Anderson Cancer Center, patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis CVD compared to those with early-stage cancer at diagnosis.

Cancer 61
article thumbnail

ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report

Journal of Cardiothoracic Surgery

Carinal resection and reconstruction are complex surgical procedures often necessitated by tumors or other pathologies involving the tracheobronchial junction. Traditional approaches to these surgeries are hig.

59
article thumbnail

Rheumatoid Arthritis Heart Failure Risk Driven by Increased HFpEF Risk

HCPLive

Other recent research presented at ACR 2024 found increased CVD risk with glucocorticosteroid use.

article thumbnail

Pseudoaneurysm of the descending aorta two decades after aortic coarctation repair: a case report

Journal of Cardiothoracic Surgery

Pseudoaneurysm after coarctation of the aorta (CoA) repair is a rare but severe complication. Contributing factors may include infection, hypertension, aortic wall weakness, and turbulent blood flow at the rep.

Aortic 59
article thumbnail

Nearly 65% of Patients with RA, PsA Had Asymptomatic Pulmonary Involvement

HCPLive

A recent study identified the prevalence of asymptomatic pulmonary involvement in patients with newly diagnosed RA or PsA, highlighting the need to reevaluate screening protocols.

article thumbnail

Application prospect of speckle tracking echocardiography in pacemaker implantation

Frontiers in Cardiovascular Medicine

More than 1 million permanent pacemakers are implanted worldwide each year, half of which are in patients with high-grade atrioventricular block. Pacemakers provide adequate frequency support in the initial stage, but traditional right ventricular (RV) pacing may lead to or aggravate left ventricular dysfunction and arrhythmia. Several potential risk factors for heart failure and arrhythmias after pacemaker surgery have been identified, but their occurrence remains difficult to predict clinicall

article thumbnail

Potassium Nitrate for HFpEF Lacks Benefit for Exercise Capacity, Quality of Life

HCPLive

Potassium nitrate increased blood nitric oxide metabolites but showed no improvement in exercise tolerance or quality of life in a population with HFpEF.

article thumbnail

Research progress on the association between lung cancer and pulmonary embolism

Journal of Cardiothoracic Surgery

Pulmonary embolism (PE), a form of venous thromboembolism, is a frequently observed complication in malignancies, with a notably high incidence in individuals with lung cancer. The presence of PE markedly redu.

article thumbnail

Right ventricular myocardial work: proof-of-concept for the assessment of pressure-strain loops of patients with pre-capillary pulmonary hypertension

Cardiovascular Ultrasound

Right ventricular myocardial work (RVMW) assessed by transthoracic echocardiography allows to study the right ventricular (RV) function using RV pressure-strain loops. The assessment of these novel indexes of.

article thumbnail

Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Journal of Cardiothoracic Surgery

Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. W.

article thumbnail

Peripheral artery disease: The biggest killer you've probably never heard of

Medical Xpress - Cardiology

Imagine putting your socks on one morning and noticing your big toe, which has been painful for a few weeks, has started turning black. A trip to your doctor ends in being referred urgently to a specialist. They tell you a bypass operation of a blocked artery in your thigh is needed to save your foot. This is the reality for far too many people. In the UK, vascular surgeons performed more than 3,500 amputations in 2023.

article thumbnail

Diabetes Dialogue: Insights on INHALE-1 and CATALYST Trials

HCPLive

In this episode, hosts discuss a slight dip in US obesity rates, the use of inhaled insulin, and the benefit of mifepristone for HbA1c reduction.

article thumbnail

Heart muscle can regenerate in some patients, study suggests

Becker's Hospital Review - Cardiology

Some heart failure patients with artificial hearts have been able to regenerate heart muscle, potentially paving the way for future heart failure treatment options, according to a study published Nov. 21 in Circulation.

article thumbnail

Use of Biopsy and Diagnosing New-Onset AD

HCPLive

Panelists discuss how to confirm the diagnosis of atopic dermatitis (AD) when in doubt, emphasizing the importance of clinical evaluation, family history, and skin testing, and share strategies for approaching adult patients with new-onset AD, including thorough patient history and targeted management.

52
article thumbnail

Case Report: Recurrent cardiogenic shock caused by inter-arterial left coronary artery originating from the right coronary sinus, successfully rescued by mechanical circulatory support

Frontiers in Cardiovascular Medicine

A young female patient suffered cardiogenic shock after undergoing surgery for an ectopic pregnancy. Coronary artery computed tomography angiography (CTA) revealed a left main artery (LM) originating from the right coronary sinus and traveling between the aorta and pulmonary artery. We successfully resuscitated the patient with mechanical circulatory support using veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and an intra-aortic balloon pump (IABP).

article thumbnail

Hepatology Month in Review: December 2024

HCPLive

The December month in review spotlights hepatic FDA news as well as the latest research in viral hepatitis and MASH.

article thumbnail

Case Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys–Dietz syndrome

Frontiers in Cardiovascular Medicine

BackgroundLoeysDietz syndrome (LDS) is a clinically and genetically heterogeneous, autosomal dominant aortic aneurysm syndrome with widespread systemic involvement. We present the case of a 16.5-year-old girl with LDS type 2 (LDS2) caused by a heterozygous pathogenic variant, c.1582C>T (p.Arg528Cys), in the transforming growth factor-beta receptor type 2 (TGFBR2) gene who was treated with recombinant growth hormone (rGH) due to coexisting GH deficiency (GHD).

Aortic 52
article thumbnail

Pavan K. (Tem) Bendapudi, MD: Large-Scale Analyses Elucidate Genetic Risk of Thrombosis

HCPLive

Bendapudi gave an overview of 2 studies presented at ASH 2024 from his Harvard lab.

article thumbnail

Mechanisms of postischemic cardiac death and protection following myocardial injury

Journal of Clinical Investigation - Cardiology

Acute myocardial infarction (MI) is a leading cause of death worldwide. Although with current treatment, acute mortality from MI is low, the damage and remodeling associated with MI are responsible for subsequent heart failure. Reducing cell death associated with acute MI would decrease the mortality associated with heart failure. Despite considerable study, the precise mechanism by which ischemia and reperfusion (I/R) trigger cell death is still not fully understood.

article thumbnail

Pegloticase Alongside Methotrexate Improves Uncontrolled Gout in MIRROR Trial

HCPLive

The exploratory MIRROR trial found pegloticase with methotrexate improved clinical assessment and quality of life outcomes in uncontrolled gout.

article thumbnail

Clonal hematopoiesis JAKs up plaque formation

Journal of Clinical Investigation - Cardiology

Clonal hematopoiesis (CH) is a condition in which hematopoietic stem cells (HSCs) acquire mutations seen in leukemia. While individuals with CH generally do not show signs of hematologic disease, the condition becomes more common with age and correlates with age-related diseases, especially cardiovascular disease (CVD). JAK2 mutations in HSCs can lead to CH and correlate with atherosclerosis, but the condition has been difficult to study because of challenges modeling the mutant cells at very lo

Plaque 45
article thumbnail

Gastroenterology Month in Review: December 2024

HCPLive

The December month in review spotlights top GI pipeline updates, FDA news, a feature, and IBS research from the final month of 2024.

article thumbnail

Cerebral Microbleeds and Their Association With Inflammation and Blood-Brain Barrier Leakage in Small Vessel Disease

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:How cerebral microbleeds (CMBs) are formed, and how they cause tissue damage is not fully understood, but it has been suggested they are associated with inflammation, and they could also be related to increased blood-brain barrier (BBB) leakage. We investigated the relationship of CMBs with inflammation and BBB leakage in cerebral small vessel disease, and in particular, whether these 2 processes were increased in the vicinity of CMBs.METHODS:In 54 patients wit

article thumbnail

T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions

Journal of Clinical Investigation - Cardiology

The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus5-fluorouracil (calcipotriol-plus5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus5-FU immunotherapy induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes in humans.

Cancer 124