Thu.Jan 02, 2025

article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Science Daily - Heart Disease

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

article thumbnail

Torsade in a patient with left bundle branch block: is there a long QT? (And: Left Bundle Pacing).

Dr. Smith's ECG Blog

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

article thumbnail

Cellular interactions help explain vascular complications due to COVID-19 virus infection

Medical Xpress - Cardiology

COVID-19 is a respiratory disease primarily affecting the lungs. However, the SARS-CoV-2 virus that causes COVID-19 surprised doctors and scientists by causing an unusually large percentage of patients to experience vascular complicationsissues related to blood flow, such as blood clots, heart attacks, and strokes.

COVID-19 134
article thumbnail

Phase 3 KOASTAL-1 Trial Fails to Show Navacaprant Significantly Improves MDD

HCPLive

Although the oral navacaprant 80 mg failed to bring statistically significant improvements in depression symptoms, the study showed females respond better than males.

119
119
article thumbnail

Just two hours of exercise a week can bring you huge cardiovascular health benefits

Medical Xpress - Cardiology

There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.

Exercise 115
article thumbnail

Rheumatoid Arthritis Heart Failure Risk Driven by Increased HFpEF Risk

HCPLive

Other recent research presented at ACR 2024 found increased CVD risk with glucocorticosteroid use.

article thumbnail

Zebrafish protein unlocks dormant genes for heart repair

Medical Xpress - Cardiology

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Research 111

More Trending

article thumbnail

Beware the snowstorm: Shoveling could trigger heart attacks, expert says

Medical Xpress - Cardiology

Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.

article thumbnail

Get A Look At What's Inside The Heart Health Formula

Dr. Paddy Barrett

What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.

article thumbnail

Patients with heart disease may be at increased risk for advanced breast cancer

Medical Xpress - Cardiology

Cardiovascular disease (CVD) and cancer are the two leading causes of death in the U.S. According to researchers from The University of Texas MD Anderson Cancer Center, patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis CVD compared to those with early-stage cancer at diagnosis.

Cancer 104
article thumbnail

Heart muscle can regenerate in some patients, study suggests

Becker's Hospital Review - Cardiology

Some heart failure patients with artificial hearts have been able to regenerate heart muscle, potentially paving the way for future heart failure treatment options, according to a study published Nov. 21 in Circulation.

article thumbnail

How do GLP-1s boost weight loss and heart health?

Medical Xpress - Cardiology

Weight loss tops many folks' list of New Year's resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.

96
article thumbnail

COVID-19 May Increase Risk of Vitiligo, Chronic Urticaria, Alopecia Areata

HCPLive

These data highlight long-term complications related to COVID-19 in terms of skin conditions, a continuing concern for many patients.

article thumbnail

What is cardiac arrest? Why is it so deadly?

Medical Xpress - Cardiology

Cardiac arrest is when the heart stops abruptly with little or no warning. It is often fatal. According to American Heart Association data, 9 out of every 10 people who experience cardiac arrest outside of a hospital die.

article thumbnail

Patients with heart disease may be at increased risk for advanced breast cancer

Science Daily - Heart Disease

Patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis cardiovascular disease (CVD) compared to those with early-stage cancer at diagnosis.

Cancer 68
article thumbnail

Nearly 65% of Patients with RA, PsA Had Asymptomatic Pulmonary Involvement

HCPLive

A recent study identified the prevalence of asymptomatic pulmonary involvement in patients with newly diagnosed RA or PsA, highlighting the need to reevaluate screening protocols.

article thumbnail

ECMO-assisted bilateral uniportal thoracoscopic carinal resection and reconstruction: a case report

Journal of Cardiothoracic Surgery

Carinal resection and reconstruction are complex surgical procedures often necessitated by tumors or other pathologies involving the tracheobronchial junction. Traditional approaches to these surgeries are hig.

59
article thumbnail

Peanut IgE Stronger Predictor of Remission Than Age After Oral Immunotherapy

HCPLive

In this analysis, baseline peanut sIgE was shown to be a stronger predictor of remission after peanut OIT than age at the beginning of immunotherapy treatment.

64
article thumbnail

Pseudoaneurysm of the descending aorta two decades after aortic coarctation repair: a case report

Journal of Cardiothoracic Surgery

Pseudoaneurysm after coarctation of the aorta (CoA) repair is a rare but severe complication. Contributing factors may include infection, hypertension, aortic wall weakness, and turbulent blood flow at the rep.

Aortic 59
article thumbnail

Diabetes Dialogue: Insights on INHALE-1 and CATALYST Trials

HCPLive

In this episode, hosts discuss a slight dip in US obesity rates, the use of inhaled insulin, and the benefit of mifepristone for HbA1c reduction.

article thumbnail

2025 STS/EACTS/LACES Latin America Cardiovascular Surgery Conference

Society of Thoracic Surgeons - Congenital

Event 2025 STS/EACTS/LACES Latin America Cardiovascular Surgery Conference gmckinney Thu, 01/02/2025 - 11:11 Event dates Dec 46, 2025 Location Lima, Peru A world-class, international event that will explore the latest developments and best practices in coronary artery disease, congenital heart disease, thoracic aortic disease, atrial fibrillation, and the surgical management of heart failure.

article thumbnail

Hepatology Month in Review: December 2024

HCPLive

The December month in review spotlights hepatic FDA news as well as the latest research in viral hepatitis and MASH.

article thumbnail

2025 Advances in Quality & Outcomes: A Data Managers Meeting

Society of Thoracic Surgeons - Allied Health

Event 2025 Advances in Quality & Outcomes: A Data Managers Meeting gmckinney Thu, 01/02/2025 - 11:08 Event dates Oct 13, 2025 Location San Antonio, TX AQO 2025 will offer a unique opportunity to explore techniques for optimizing data collection using case scenarios and driving quality improvement. Head for San Antonio this October to attend the premier gathering of STS National Database professionals as they share valuable research and important clinical findings with hundreds of peers.

article thumbnail

Potassium Nitrate for HFpEF Lacks Benefit for Exercise Capacity, Quality of Life

HCPLive

Potassium nitrate increased blood nitric oxide metabolites but showed no improvement in exercise tolerance or quality of life in a population with HFpEF.

article thumbnail

2025 STS Coronary Conference

Society of Thoracic Surgeons - Congenital

Event 2025 STS Coronary Conference gmckinney Thu, 01/02/2025 - 10:57 Event dates Jun 1214, 2025 Location Chicago, IL The 2025 STS Coronary Conference is an innovative international event taking place June 12-14, in Chicago. Abstract submissions will begin soon! Add your name to the interest list if you would like to be notified when abstracts and registration open.

article thumbnail

Pavan K. (Tem) Bendapudi, MD: Large-Scale Analyses Elucidate Genetic Risk of Thrombosis

HCPLive

Bendapudi gave an overview of 2 studies presented at ASH 2024 from his Harvard lab.

article thumbnail

2025 STS Workshop on Robotic Thoracic Surgery

Society of Thoracic Surgeons - Surgeon

Event 2025 STS Workshop on Robotic Thoracic Surgery gmckinney Thu, 01/02/2025 - 10:53 Event dates May 1516, 2025 Location Norcross, GA Save the date! The popular STS Workshop on Robotic Thoracic Surgery will return to the Atlanta area in spring 2025. Details will be available soon! Add your name to the interest list to be among the first informed when registration opens.

52
article thumbnail

Research progress on the association between lung cancer and pulmonary embolism

Journal of Cardiothoracic Surgery

Pulmonary embolism (PE), a form of venous thromboembolism, is a frequently observed complication in malignancies, with a notably high incidence in individuals with lung cancer. The presence of PE markedly redu.

article thumbnail

Right ventricular myocardial work: proof-of-concept for the assessment of pressure-strain loops of patients with pre-capillary pulmonary hypertension

Cardiovascular Ultrasound

Right ventricular myocardial work (RVMW) assessed by transthoracic echocardiography allows to study the right ventricular (RV) function using RV pressure-strain loops. The assessment of these novel indexes of.

article thumbnail

Peripheral artery disease: The biggest killer you've probably never heard of

Medical Xpress - Cardiology

Imagine putting your socks on one morning and noticing your big toe, which has been painful for a few weeks, has started turning black. A trip to your doctor ends in being referred urgently to a specialist. They tell you a bypass operation of a blocked artery in your thigh is needed to save your foot. This is the reality for far too many people. In the UK, vascular surgeons performed more than 3,500 amputations in 2023.

article thumbnail

Use of Biopsy and Diagnosing New-Onset AD

HCPLive

Panelists discuss how to confirm the diagnosis of atopic dermatitis (AD) when in doubt, emphasizing the importance of clinical evaluation, family history, and skin testing, and share strategies for approaching adult patients with new-onset AD, including thorough patient history and targeted management.

52
article thumbnail

Cerebral Microbleeds and Their Association With Inflammation and Blood-Brain Barrier Leakage in Small Vessel Disease

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:How cerebral microbleeds (CMBs) are formed, and how they cause tissue damage is not fully understood, but it has been suggested they are associated with inflammation, and they could also be related to increased blood-brain barrier (BBB) leakage. We investigated the relationship of CMBs with inflammation and BBB leakage in cerebral small vessel disease, and in particular, whether these 2 processes were increased in the vicinity of CMBs.METHODS:In 54 patients wit

article thumbnail

Pegloticase Alongside Methotrexate Improves Uncontrolled Gout in MIRROR Trial

HCPLive

The exploratory MIRROR trial found pegloticase with methotrexate improved clinical assessment and quality of life outcomes in uncontrolled gout.

article thumbnail

Machine Learning Predictions of Recovery in Bilingual Poststroke Aphasia: Aligning Insights With Clinical Evidence

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Predicting treated language improvement (TLI) and transfer to the untreated language (cross-language generalization, CLG) after speech-language therapy in bilingual individuals with poststroke aphasia is crucial for personalized treatment planning. This study evaluated machine learning models to predict TLI and CLG and identified the key predictive features (eg, patient severity, demographics, and treatment variables) aligning with clinical evidence.METHODS:For

article thumbnail

Gastroenterology Month in Review: December 2024

HCPLive

The December month in review spotlights top GI pipeline updates, FDA news, a feature, and IBS research from the final month of 2024.

article thumbnail

ECG Blog #463 — Lots to Explain.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 told only that this tracing was obtained prior to elective electric cardioversion of a patient who had long been in persistent AFlutter ( A trial F lutter ). Serum electrolytes were normal at the time of cardioversion. The patient tolerated cardioversion well and later that day was discharged from the hospital. ( The post-cardioversion tracing will be shown momentarily in Figure-3 ).

Blog 168
article thumbnail

T helper 2 cell–directed immunotherapy eliminates precancerous skin lesions

Journal of Clinical Investigation - Cardiology

The continuous rise in skin cancer incidence highlights an imperative for improved skin cancer prevention. Topical calcipotriol-plus5-fluorouracil (calcipotriol-plus5-FU) immunotherapy effectively eliminates precancerous skin lesions and prevents squamous cell carcinoma (SCC) in patients. However, its mechanism of action remains unclear. Herein, we demonstrate that calcipotriol-plus5-FU immunotherapy induces T helper type 2 (Th2) immunity, eliminating premalignant keratinocytes in humans.

Cancer 134