Tue.Nov 19, 2024

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Fitness Level May Offset Genetic Dementia Risk

Med Page Today

(MedPage Today) -- Genetic risk for Alzheimer's disease and dementia appeared to be partly offset by high levels of cardiorespiratory fitness, U.K. Biobank data suggested. Overall, high cardiorespiratory fitness was associated with better global.

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Finding a Role for GLP-1 RAs, Incretin Therapies in Heart Failure, with Muthiah Vaduganathan, MD, MPH

HCPLive

Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.

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LDL Cholesterol–Lowering Strategy in ASCVD

JAMA Cardiology

This systematic review and individual patient data meta-analysis investigates the association of an alternative low-density lipoprotein (LDL) strategy with differences in long-term efficacy and safety in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a high-intensity statin strategy.

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Lipoxin A4 improves cardiac remodeling and function in diabetes-associated cardiac dysfunction

Cardiovascular Diabetology

Diabetic heart disease may eventually lead to heart failure, a leading cause of mortality in diabetic individuals. The lack of effective treatments for diabetes-induced heart failure may result from a failure.

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Opioids Tied to Higher Dementia Risk, but Only After a Point

Med Page Today

(MedPage Today) -- After a certain threshold, cumulative opioid use was associated with higher dementia risk, a study of adults over age 60 in Denmark showed. In a nested case-control study, opioid use above 90 total standardized doses (TSDs.

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Researchers uncover how blood pressure drugs harm kidneys

Medical Xpress - Cardiology

Commonly prescribed drugs used to treat high blood pressure have been shown to, over time, wreck the kidneys' ability to filter and purify blood, but exactly how that dangerous side effect unfolded has been a riddle. University of Virginia School of Medicine researchers say they've solved the mystery.

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A deeper look at long-term effects of COVID-19 on myocardial function in survivors with no prior heart diseases: a GRADE approach systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

ObjectivesThe COVID-19 pandemic has challenged global health systems since December 2019, with the novel virus SARS-CoV-2 causing multi-systemic disease, including heart complications. While acute cardiac effects are well-known, long-term implications are understudied. This review hopes to fill a gap in the literature and provide valuable insights into the long-term cardiac consequences of the virus, which can inform future public health policies and clinical practices.MethodsThis systematic rev

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Small Benefit, Persistent Toxic Risk With Adjuvant Anthracycline in Breast Cancer

Med Page Today

(MedPage Today) -- Adding an anthracycline to adjuvant chemotherapy for TOP2A-normal early breast cancer significantly improved disease-free survival (DFS) but not overall survival (OS) at 10 years, and doubled the risk of heart failure, a randomized.

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More people can survive sports-related cardiac arrest, researcher says

Medical Xpress - Cardiology

Most cases of cardiac arrest during sport are likely to be preventable. In addition, the emergency response with cardiopulmonary resuscitation (CPR) and defibrillators within the sports context can be improved. This has been shown in a thesis from the University of Gothenburg.

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Effects of sacubitril/valsartan according to background beta‐blocker therapy in patients with heart failure and reduced ejection fraction: Insights from PARADIGM‐HF

European Journal of Heart Failure

Effects of sacubitril/valsartan with or without background beta-blocker therapy in patients with heart failure with reduced ejection fraction from PARADIGM-HF. BB, beta-blocker; CI, confidence interval; COPD, chronic obstructive pulmonary disease; CRT, cardiac resynchronization therapy; HF, heart failure; HR, hazard ratio; ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; MRA, mineralocorticoid receptor antagonist; NT-proBNP, N-terminal pro-B-type natriuretic

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Fluctuations in blood pressure over time may be linked to higher sudden cardiac death risk

Medical Xpress - Cardiology

Middle-aged adults with long-term fluctuations in blood pressure may face a higher risk for sudden cardiac death than their peers with more consistent blood pressure readings, a large new study suggests.

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Two Studies Assess Echocardiography Evaluation Performance, Relationship Between Markers of Early LV Dysfunction and Mortality in Aortic Regurgitation

American College of Cardiology

American Society of Echocardiography (ASE) guidelines for echocardiographic evaluation of aortic regurgitation (AR) were found to “display very good performance” in detecting significant AR, according to a study published Nov. 13 in JACC: Cardiovascular Imaging.

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Gastroesophageal reflux disease linked to cardiovascular risk factors: New insights from Mendelian randomization study

Medical Xpress - Cardiology

A recent study published in the Journal of Translational Internal Medicine reveals insights into the broader impact of gastroesophageal reflux disease (GERD) on cardiovascular health. By using a rigorous bidirectional Mendelian randomization (MR) approach, the research provides compelling evidence that GERD—a condition traditionally recognized as a digestive disorder characterized by acid reflux and heartburn—may influence key cardiovascular risk factors, including blood pressure, lipid profiles

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Efficacy and safety of sacubitril/valsartan on postoperative atrial fibrillation in adult patients undergoing cardiac surgery: a real-world observational study

Frontiers in Cardiovascular Medicine

BackgroundThe mechanism underlying new-onset postoperative atrial fibrillation (POAF) in adult cardiac surgery is not well understood. However, efficient pharmacological methods to prevent and treat arrhythmic complications are still lacking. In the present study, we explored the efficacy and safety of sacubitril/valsartan (sac/val) in the control of POAF in adult cardiac surgery patients.MethodsBetween January 2021 and December 2021, 667 eligible adult patients who underwent cardiac surgery at

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A. Sidney Barritt, MD: Real-World Data Suggest Benefit of GLP-1 RAs for MASLD

HCPLive

Barritt reviews real-world data about the use and benefits of GLP-1 RAs in patients with MASLD.

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Early coronary angiography in patients with myocardial infarction without ST elevation after out-of-hospital cardiac arrest: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

BackgroundEarly coronary angiography (CAG) in post-cardiac arrest patients without ST-segment elevation is a topic of debate. This meta-analysis aimed to assess its impact on outcomes.MethodsA search of Medline and Cochrane up to February 2023 was conducted to identify randomized controlled trials and observational studies comparing patients undergoing early CAG vs. delayed/no CAG after experiencing out-of-hospital cardiac arrest.

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Kris Kowdley, MD: Elafibranor Remains Safe, Efficacious for PBC Through 3 Years

HCPLive

Kowdley reviews open-label extension data for biochemical response, ALP normalization, and pruritus improvement from the phase 3 ELATIVE study.

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Association of cumulative non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio with the risk of cardiometabolic disease

Frontiers in Cardiovascular Medicine

BackgroundOne measurement of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is considered to be associated with insulin resistance and cardiovascular disease (CVD) risk. This study aimed to exploring the association between cumulative non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol (Cum NHHR) exposure levels and the risk of cardiometabolic disease (CMD).MethodsThis prospective cohort study included 43,735 participants,

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DZP Improves Disease Activity and Reduces Corticosteroid Use in SLE

HCPLive

The phase 3 PHOENYCS GO trial met its primary endpoint in achieving BICLA response at week 48 compared with placebo.

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Prevention and control of cardiovascular disease in “real-world” settings: sustainable implementation of effective policies

Frontiers in Cardiovascular Medicine

Global progress in addressing cardiovascular diseases (CVD) has been insufficient to attain the nine WHO non-communicable disease (NCD) targets and the Sustainable Development Goal (SDG) target of reducing premature NCD mortality by one-third by 2030. Progress has been slowest in low- and middle-income countries (LMIC) where addressing the CVD burden is a foremost development imperative.

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Steps to More Accurately Diagnose Oropharyngeal Dysphagia, with Daniel Duncan, MD

HCPLive

At NASPGHAN 2024, HCPLive spoke with Duncan about how treating infants who appear to have reflux may actually result in greater repeat hospital visits.

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Case Report: Spontaneous recanalization of left anterior descending artery occlusive lesion with OCT-guided drug-coated balloon therapy

Frontiers in Cardiovascular Medicine

In instances where a patient with acute myocardial infarction (AMI) did not undergo immediate reperfusion therapy during the acute phase, there was a risk of the occlusion progressing to chronic and the chances of spontaneous recanalization decreasing. This case report detailed the experience of a 37-year-old male patient who, 45 days post-AMI, still had a blocked left anterior descending (LAD) artery due to the patient's refusal for intervention.

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Optimising remote monitoring for cardiac implantable electronic devices: a UK Delphi consensus

Heart BMJ

Background Remote monitoring (RM) is recommended for the ongoing management of patients with cardiac implantable electronic devices (CIEDs). Despite its benefits, RM adoption has increased the workload for cardiac rhythm management teams. This study used a modified Delphi method to develop a consensus on optimal RM management for adult patients with a CIED in the UK.

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Salvage of cardiopulmonary collapse caused by ethanol sclerotherapy for vascular malformations: clinical experience at a single center and literature review

Frontiers in Cardiovascular Medicine

ObjectiveThis review aims to summarize the salvage experience of cardiopulmonary collapse occurring as a result of absolute ethanol sclerotherapy for vascular malformations.MethodsIn total, we reviewed three cases of cardiopulmonary collapse induced by ethanol sclerotherapy for vascular malformations and described the details of the salvage procedure.

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Long-term prognostic value of contemporary stress echocardiography in patients with suspected or known coronary artery disease: systematic review and meta-analysis

Heart BMJ

Background Long-term outcome of contemporary stress echocardiography has not been systematically assessed. Objective To evaluate the association between results of stress echocardiography and patients’ outcomes with suspected coronary artery disease using randomised controlled trials. Methods Multiple electronic databases were searched for studies evaluating long-term outcome (>12 months) of stress echocardiography in patients suspected of coronary artery disease since year 2000.

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Hospitalizations and cardiac sarcoidosis: insights into presentation and diagnosis from the nationwide readmission database

Frontiers in Cardiovascular Medicine

IntroductionCardiac sarcoidosis (CS) is an increasingly recognized cause of cardiac disease. Because the clinical presentation of CS is non-specific, the diagnosis is often delayed. Early detection is essential to initiate treatments that reduce the risk of heart failure (HF) and arrhythmic death. We therefore aimed to describe the features of CS hospitalizations during which the initial diagnosis of CS is made.MethodsWe performed a retrospective analysis of hospitalizations from 2016 to 2019 in

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Career Resources

Society of Thoracic Surgeons - Early Career

Career Resources kgilmartin Tue, 11/19/2024 - 11:49 Search By Topics Aspiring CT Surgeons Blog Career Development Career Development Blog Early Career Leadership Image Podcast #170, S4: A Surgeon's Leadership Journey Dr. Steven Gerndt is a cardiothoracic surgeon, speaker, and leadership mentor who developed the concept “Civilitas,” a system-wide cultural transformation focused on psychological safety and fostering of leadership by example.

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ACCEL Lite: Key Messages from the ACC Board of Trustees Health Equity Action Plan

American College of Cardiology

In this interview, Drs. Richard Chazal and Paul Douglass discuss Achieving Equitable Cardiovascular Care for All: ACC Board of Trustees Health Equity Task Force Action Plan.

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The role of pre-existing left-sided valvular heart disease in the prognosis of patients with acute myocardial infarction

Frontiers in Cardiovascular Medicine

Acute myocardial infarction (AMI) and valvular heart disease (VHD) are the leading causes of cardiovascular morbidity and mortality. The epidemiology of VHD has changed in recent decades with an aging population, increasing risk factors for cardiovascular disease and migration, all of which have a significant implifications for healthcare systems. Due to common pathophysiological mechanisms and risk factors, AMI and VHD often coexist.

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The Six Strategic Goals of the PAD National Action Plan

American College of Cardiology

The 2024 multisociety Guideline for the Management of Lower Extremity Peripheral Artery Disease (PAD) recognizes the implementation of the PAD National Action Plan as a top advocacy priority.

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LEVI-04 Improved Outcomes in Knee Osteoarthritis Compared With Placebo

HCPLive

Over half of patients treated with LEVI-04 had at least a 50% reduction in pain and over 25% had at least a 75% reduction.

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More Lp(a)-Reducing Tx; Cardiac Denervation for Afib; LAA Occluders at 5 Years

Med Page Today

(MedPage Today) -- Lipoprotein(a), or Lp(a), was successfully reduced in phase II trials of muvalaplin and zerlasiran. (JAMA) The possibility of a drug interaction between SGLT2 inhibitors and statins was not supported by rates of rhabdomyolysis.

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Laura Hamant, MD: Standardized Algorithm Increases VTE Prophylaxis Among Children

HCPLive

At NASPGHAN, HCPLive spoke to Hamant about her team’s study that showed their algorithm was linked to increased VTE Prophylaxis among Pediatric IBD.

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How health systems can meet the 'rising tide' of CVD: 5 notes

Becker's Hospital Review - Cardiology

Hospitals and health systems should be bracing for an 8% and 25% increase in demand for inpatient and outpatient cardiac procedures, respectively, over the next 10 years, according to a new report from Vizient analytic company, Sg2.

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Positive Phase 3 Results Announced for JNJ-2113 Treatment of Psoriasis

HCPLive

These data were announced by Protagonist Therapeutics, resulting from the 2 pivotal ICONIC-LEAD and ICONIC-TOTAL studies on the oral peptide icotrokinra.

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Nemours Children’s Health partners with Beebe Health on cardiac care

Becker's Hospital Review - Cardiology

Jacksonville, Fla.-based Nemours Children's Health has opened a new cardiac specialty care clinic at Lewes, Del.-based Beebe Healthcare primary care facility in Selbyville, Del.

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B. longum 3562 Improves IBS Severity in Children but Does Not Persist after Intake

HCPLive

Bifidobacterium longum 35624TM reduces IBS symptom severity in children and adolescents, according to a study presented at NASPGHAN 2024.

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