Sun.Mar 24, 2024

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SGLT2 Inhibitors Could Play a Role in Treating Gout

HCPLive

A new review considers how SGLT2 inhibitors like dapagliflozin and empagliflozin have been shown to clinically improve gout while reducing its cardiometabolic and renal comorbidities.

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It’s not what you have. It’s who you are.

Heart Sisters

Résumé virtues are what you do: the workplace skills you'd talk about when job-hunting. But eulogy virtues are who you are: what people will say about you at your funeral.

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Lupus Patients with Nephritis at Greater Risk of Cholesterol Disorders, Cardiovascular Events

HCPLive

Presence of nephritis in SLE patients is linked to higher cardiovascular risk factors and 3-fold increase in incidence of cardiovascular mortality.

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Microplastics found in artery plaque linked with higher risk of heart attack, stroke and death

Medical Xpress - Cardiology

Microplastics and nanoplastics are everywhere in our environment—including in our oceans and lakes, farmland, and even Arctic ice algae.

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Renal Function Mediates Link Between Lp(a), Adverse Cardiovascular Outcomes

HCPLive

A significant association between Lp(a) and adverse cardiovascular outcomes was altered by renal function in patients undergoing percutaneous coronary intervention.

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Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study

Frontiers in Cardiovascular Medicine

Background The relationship between gut microbiota composition and coronary heart disease (CHD) has been recently reported in several observational studies. However, the causal effect of gut microbiota on coronary heart disease is uncharted. Objective This study attempted to investigate the effect of gut microbiota on coronary heart disease by Mendelian randomization (MR) analysis.

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Weight Loss Drugs Land Medicare Coverage for Cardiovascular Events

CardiacWire

Less than two weeks after Novo Nordisk’s weight-loss drug Wegovy gained expanded FDA approval for cardiovascular event risk reduction, CMS issued a new Medicare Part D guidance that allows coverage of obesity drugs for senior patients with “an additional medically accepted indication”… like cardiovascular disease. Medicare Part D is administered through private payers, and is intended to help Medicare beneficiaries pay for self-administered prescription drugs.

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Enrolment Closes At Midnight!

Dr. Paddy Barrett

The Heart Health Formula is everything I have learned over the last 20 years in clinical practice to: Understand Heart Disease Define Heart Disease Risk Reduce The Risk of Heart Disease This is the formula I use for myself and for my patients. There is a history of early heart disease in my own family, so I am very conscious about doing everything I can to reduce my future risk.

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Jeffrey Cohen, MD: Understanding Pathways, Treatments for Lichenoid Dermatoses

HCPLive

This segment of Cohen’s interview from AAD covered the other talk given by Cohen titled ‘Knowing Lichenoid Dermatoses: Common Pathways and Treatments.

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The protective effects of ruscogenin against lipopolysaccharide-induced myocardial injury in septic mice

Journal of Cardiovascular Pharmacology

Abstract: Sepsis-induced myocardial dysfunction (SIMD) commonly occurs in individuals with sepsis and is a severe complication with high morbidity and mortality rates. The current study aimed to investigate the effects and potential mechanisms of the natural steroidal sapogenin ruscogenin (RUS) against lipopolysaccharide (LPS)-induced myocardial injury in septic mice.

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Soluble Biomarkers of Cerebrovascular Pathologies

Stroke Journal

Stroke, Volume 55, Issue 4 , Page 801-811, April 1, 2024. Vascular contributions to cognitive impairment and dementia (VCID) is an all-encompassing term that describes cognitive impairment due to cerebrovascular origins. With the advancement of imaging and pathological studies, we now understand that VCID is often comorbid with Alzheimer disease. While researchers in the Alzheimer disease field have been working for years to establish and test blood-based biomarkers for Alzheimer disease diagnos

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Comparative effectiveness and safety of intermittent, repeated or continuous use of levosimendan, milrinone, or dobutamine in patients with advanced heart failure: a network and single-arm meta-analysis

Journal of Cardiovascular Pharmacology

Abstract: To synthesize the available evidence regarding differences in the long-term safety and efficacy of intermittent, repeated, or continuous palliative inotropic therapy among patients with advanced heart failure (HF). We systematically searched the PubMed, Embase, and Cochrane Library electronic databases, with a cutoff date of November 23, 2023, for studies reporting outcomes in adult patients with advanced HF treated with intermittent, repeated, or continuous levosimendan, milrinone, or

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Off-Pump Coronary Artery Bypass Grafting Does Not Confer Superior Outcomes Among Frail Patients

The American Journal of Cardiology

Publication date: Available online 23 March 2024 Source: The American Journal of Cardiology Author(s): Sara Sakowitz, Syed Shahyan Bakhtiyar, Joanna Curry, Saad Mallick, Amulya Vadlakonda, Konmal Ali, Yas Sanaiha, Peyman Benharash

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Chronotropic Responses to GLP-1 Receptor Agonists and Sitagliptin in Atria from Diabetic Rats

Journal of Cardiovascular Pharmacology

Abstract: Type 2 Diabetes Mellitus (T2DM) increases the risk of cardiovascular diseases. Therefore, elucidation of the cardiovascular effects of antidiabetics is crucial. Incretin-based therapies are increasingly used for T2DM treatment as monotherapy and in combination. We aimed to study the effects of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs) and sitagliptin on beating rates in isolated atria from diabetic rats.

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Windkessel Effect In Aorta With Experimental Evidence!

All About Cardiovascular System and Disorders

Windkessel effect is applicable to large elastic arteries like aorta, which are situated close to the heart. They have more of elastic tissue than muscular tissue. The term Windkessel comes from German language and means air chamber. Here is an illustration of the Windkessel, used in 18th century, by fire fighters. The additional pressure built up in the air chamber will ensure continuous delivery of water for fire fighting.

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Use of 3D echocardiography facilitates analysis of thrombolytic efficacy in patients with persistent atrial fibrillation

Journal of Cardiovascular Pharmacology

Abstract: This study seeks to identify the anticoagulant efficacy of rivaroxaban treatment on thrombi detected using echocardiography of the left atrial appendage in 275 patients with persistent atrial fibrillation (AF). During follow-up after 9 to 24 weeks of Rivaroxaban treatment, patients were divided into ‘effective group’ (n = 143) and ‘ineffective group’ (n = 132) according to the thrombolytic effect of the drug.

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Time to Tweak the Definition of Type 2 Myocardial Infarction

The American Journal of Cardiology

The Universal definition (UD) of Myocardial Infarction (MI) has been an important contribution to the literature and has, among other aims, helped exp…

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The American Heart Association’s Centennial and Percutaneous Coronary Intervention’s Semi-Centennial

Circulation

Circulation, Volume 149, Issue 13 , Page 973-978, March 26, 2024.

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Stroke Literature Synopses (Preclinical)

Stroke Journal

Stroke, Volume 55, Issue 4 , Page e119-e120, April 1, 2024.

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Retraction of: Abstract 13079: Prevalence and Incidence of Transthyretin Amyloid Cardiomyopathy in the USA From 2004 to 2022: An Observational Database Study

Circulation

Circulation, Volume 149, Issue 13 , Page e1027-e1027, March 26, 2024.

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Correction to: Pericyte Microvesicles as Plasma Biomarkers Reflecting Brain Microvascular Signaling in Patients With Acute Ischemic Stroke

Stroke Journal

Stroke, Volume 55, Issue 4 , Page e131-e131, April 1, 2024.

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Correction to: Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association

Circulation

Circulation, Volume 149, Issue 13 , Page e1023-e1023, March 26, 2024.

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April 2024 Stroke Highlights

Stroke Journal

Stroke, Volume 55, Issue 4 , Page 787-787, April 1, 2024.

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Correction to: 2023 Scientific Sessions Abstract 15684

Circulation

Circulation, Volume 149, Issue 13 , Page e1024-e1024, March 26, 2024.

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In Memoriam: Sidney Starkman

Stroke Journal

Stroke, Volume 55, Issue 4 , Page 785-786, April 1, 2024.

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Correction to: 2023 Scientific Sessions Abstract 18539

Circulation

Circulation, Volume 149, Issue 13 , Page e1025-e1025, March 26, 2024.

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Data Over Dogma in Treatment of Cervical Artery Dissections

Stroke Journal

Stroke, Volume 55, Issue 4 , Page 919-920, April 1, 2024.

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Correction to: International Collaboration Identifies Gene Linked to Congenital Heart Defect

Circulation

Circulation, Volume 149, Issue 13 , Page e1026-e1026, March 26, 2024.

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Introduction to Focused Update Vascular Cognitive Impairment and Dementia: Better Diagnosis, More Avenues for Prevention

Stroke Journal

Stroke, Volume 55, Issue 4 , Page 788-790, April 1, 2024.

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How Can Young Extracellular Matrix Promote Cardiac Regeneration? Versi-Can!

Circulation

Circulation, Volume 149, Issue 13 , Page 1016-1018, March 26, 2024.

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Subclinical Atrial Fibrillation and Anticoagulation: Weighing the Absolute Risks and Benefits

Circulation

Circulation, Volume 149, Issue 13 , Page 989-992, March 26, 2024.

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Atrial Fibrillation: Why Are We Hiding Reality?

Circulation

Circulation, Volume 149, Issue 13 , Page 979-980, March 26, 2024.